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Therapeutic Efficacy of Traditional Chinese Medicine Syndrome-Based Formulae to Neuropathic Pain Caused by Chemotherapy.

ObjectiveChemotherapy-induced neuropathic pain (CINP) is a troublesome complication of anti-cancer treatment. The aim of this retrospective study was to investigate the effectiveness of classic Chinese herbal formulae (CHF) Huang Qi Gui Zhi Wu Wu Tang (HQGZWWT) and Dang Gui Si Ni Tang (DGSNT) in the treatment of CINP.Materials and methodsDouleur Neuropathique 4 (DN4) and Functional Assessment of Cancer Therapy-General (FACT-G) questionnaires were rated at baseline and after 3-monthly CHF treatment.ResultsBy searching through our medical records of all the CIPN patients from 2018 to 2019, we id

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… Angelicae Sinensis, Wine-Washed Rx. Paeoniae Alba, Rz. Atractylodis blended with Sm. Sesame Nigrum, Ginger-Fried Sm. Coicis, Rx. Glycyrrhizae Preparata, Rz. … Cyperi, Wine-fried Rx. Scutellariae, Rx. Clematidis, Rz. et Rx. Notopterygii, Rx. Glycyrrhizae, Rz. …

Current Perspectives of the Applications of Polyphenols and Flavonoids in Cancer Therapy.

The development of anticancer therapies that involve natural drugs has undergone exponential growth in recent years. Among the natural compounds that produce beneficial effects on human health, polyphenols have shown potential therapeutic applications in cancer due to their protective functions in plants, their use as food additives, and their excellent antioxidant properties. The possibility of combining conventional drugs-which are usually more aggressive than natural compounds-with polyphenols offers very valuable advantages such as the building of more efficient anticancer therapies with l

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… Moreover, products manufactured from these fruits such as tea, wine, or beer also contain polyphenols in significant amounts. … Furthermore, red wine also contains significant amounts of resveratrol. In 1997, Jang et al. were the first researchers that reported the inhibition of skin cancer development in mice by using resveratrol [ 19 ]. …

Ассоциация < < Средиземное питание > > и < < Развитие множественного склероза: систематический обзор и мета-анализ > > .

Множественный склероз (MS) является хроническим воспалительным заболеванием центральной нервной системы. С учетом противоречивых данных о влиянии соблюдения средиземноморской диеты (MedDiet) на развитие НР и отсутствия систематического обзора по этой теме цель настоящего исследования состояла в изучении этой ассоциации. МЕТОДЫ: В соответствии с методами PrISMA и JBI до марта был проведен поиск электронных баз данных через PubMed, Embase, Web of Science и Scopus 2024. В него были включены первоначальные клинические исследования по оценке связи между присоединением к MedDiet и разработкой MS. Ри

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… The Mediterranean diet (MedDiet) is a dietary pattern, which is based on a high intake of fruits, vegetables, whole grains, nuts, seeds, and olive oil as the main source of fat; a moderate intake of dairy products, eggs, fish, and wine; deficient intake of red meat and processed food and it is followed … Key components of the MedDiet, such as olive oil and grapes, either as fresh fruits or as wine, and citrus fruits, were found to be associated with reduced risk of MS. Gut microbiota is suggested to act as the crucial mediator for this (Cavalla and Vercellino 2023 , Conde et al. 2019 ). …

Метаболизм желчной кислоты в множестве склероза поражается и связан с риском подтвержденного ухудшения состояния здоровья.

КОЛИЧЕСТВО: Подлые кислоты (БА) стали важными посредниками в нейроинфламмации и нейродегенерации, которые являются важными особенностями множественного склероза (МС). Цель этого исследования состояла в изучении уровней сыворотки БА у недавно диагностировавшихся людей с MS (PwMS) и изучении их связи с ухудшением положения инвалидов. МЕТОДЫ: Исследование включало 907 ПТМС и 907 Сопоставимый контроль со стороны шведской группы ЭИМС, основанной на населении, с клиническими последующими данными шведского регистра MS. Уровни сыворотки BA были проанализированы с использованием масс-спектрометрии жидк

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… mean ± SD) 6.4 ± 14.2 3.9 ± 9.0 4.9 ± 9.1 Snuff tobacco  Current snuff users (F/M) 13/25 25/39 2/10 Data is presented as mean ± standard deviation or as the number of records a Reported intake during the week leading up to the blood sample collection, volume of different types of alcoholic beverages (wine … consumed 40% alcohol Selected characteristics of study participants from the EIMS cohort ( n  = 1814) Data is presented as mean ± standard deviation or as the number of records a Reported intake during the week leading up to the blood sample collection, volume of different types of alcoholic beverages (wine …

Predicting and Quantifying Antagonistic Effects of Natural Compounds Given with Chemotherapeutic Agents: Applications for High-Throughput Screening.

Natural products have been used for centuries to treat various human ailments. In recent decades, multi-drug combinations that utilize natural products to synergistically enhance the therapeutic effects of cancer drugs have been identified and have shown success in improving treatment outcomes. While drug synergy research is a burgeoning field, there are disagreements on the definitions and mathematical parameters that prevent the standardization and proper usage of the terms synergy, antagonism, and additivity. This contributes to the relatively small amount of data on the antagonistic effect

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… Many of them, including curcumin from turmeric, resveratrol from red wine, isothiocyanates from cruciferous vegetables, and quercetin and ursolic acid from apples have been shown to have profound anti-tumor activity [ 14 , 15 , 16 , 17 , 18 , 19 ]. … Tannic Acid, Gallic Acid, Caffeic Acid Tannic acid, gallic acid, and caffeic acid are natural phenolic compounds present in a wide variety of grains, fruits, vegetables, and beverages, including coffee, wine, tea, berries, and herbs, along with many additional sources. …

Всеобъемлющий и систематический обзор по вопросу о добавке ресвератрола в качестве перспективного кандидата в отношении болезни сетчатки сетчатки: акцент на механизмах действий на основе доклинических исследований.

Resveratrol — естественный полифенолический соединение, демонстрирующее большой потенциал нейрозащиты, борьбы с воспалением и антиоксидацией. Предыдущие исследования показали, что ресвератрол может эффективно лечить различные животные модели болезней сетчатки. ПУРПОСЕ: Цель исследования состояла в том, чтобы использовать экспериментальную модель животных для оценки эффективности лечения заболеваний, связанных с сетчаткой, в рамках различных видов заболеваний, связанных с животным, таких, как ишемия-реперциозная травма, диабетическая ретинопатия, глаукома, хроническая окулярная гипертония, опти

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… Resveratrol (RSV) is a naturally occurring polyphenol and the main bioactive compound in red wine, which has been widely studied at present. … Beyond red wine, resveratrol is abundantly present in various plants, including grapes (particularly the skin and seeds), peanuts, berries, mulberries, and blueberries ( Tian and Liu, 2020 ). …

Polyphenolic natural products as photosensitizers for antimicrobial photodynamic therapy: recent advances and future prospects.

Antimicrobial photodynamic therapy (aPDT) has become a potent contender in the fight against microbial infections, especially in the context of the rising antibiotic resistance crisis. Recently, there has been significant interest in polyphenolic natural products as potential photosensitizers (PSs) in aPDT, given their unique chemical structures and inherent antimicrobial properties. Polyphenolic natural products, abundant and readily obtainable from natural sources, are generally regarded as safe and highly compatible with the human body. This comprehensive review focuses on the latest develo

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… It is abundantly found in various fruits and vegetables such as apples, grapes, onions, and tomatoes, as well as beverages such as tea and red wine, nuts and honey, from different plant sources ( 50 , 84 ). … Resveratrol is commonly found in a variety of dietary substances, such as grapes, berries (cranberries), red wine, nuts (peanuts) and other foods ( 96 – 98 ). …

Unexpected and Deadly: Three Cases of Bone Marrow Necrosis.

Bone marrow necrosis (BMN) is a rare pathological diagnosis, with an incidence of 0.3% to 2%. It is most often associated with hematological malignancies and less commonly due to solid tumors, infections, medications, sickle cell disease, chemotherapy, radiotherapy, or idiopathic causes. We reviewed bone marrow biopsies performed in our institution from 2009 to 2019 and found three cases of BMN. Two cases were secondary to neoplastic causes, while the third one was possibly from alcohol abuse.

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… She has a long history of alcohol abuse, consuming two to three bottles of wine daily and had previous admissions for alcohol withdrawal. She had tenderness on the left lower quadrant of her abdomen. …

Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies.

Polyphenols are one of the largest plant-derived natural product and they play an important role in plants' defense as well as in human health and disease. A number of them are pleiotropic molecules and have been shown to regulate signaling pathways, immune response and cell growth and proliferation which all play a role in cancer development. Hematological malignancies on the other hand, are cancers of the blood. While current therapies are efficacious, they are usually expensive and with unwanted side effects. Thus, the search for newer less toxic agents. Polyphenols have been reported to po

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… They are readily found in foods and beverages of plant origin including fruits, vegetables, spices, soy, nuts, coffee, tea, and wine). Regular consumption of polyphenol-rich diets has been associated with many health benefits. … Unlike other flavonoids, they rarely exist as glycosides in plants ( 53 ) flavanols are found in common foods, including cereals, legumes, fruits, vegetables, forages, hops, beers, red wine, tea, cocoa, grapes, and apples. …

Diffuse Large B-Cell Lymphoma Presenting as an Unusual Paraneoplastic Neurologic Syndrome Affecting the Central and Peripheral Nervous Systems.

A 68-year-old man presented with a two-week history of ascending, symmetric, sensory neuropathy concerning an acute inflammatory demyelinating polyneuropathy that briefly responded to intravenous immunoglobulin (IVIg) therapy. The initial workup was negative for acquired causes. After three months of poor response to standard therapies, he was hospitalized for severe disability, unintentional weight loss, and additional, unexplained neurologic symptoms including cerebellar ataxia, dysarthria, and muscle twitching. Positron emission tomography revealed hypermetabolism isolated to the bone marro

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… He denied any smoking history or illicit drug use including intravenous drugs and reported occasional social consumption of 1-2 glasses of wine on weekend nights but denied binge drinking. …

Angioprevention of Urologic Cancers by Plant-Derived Foods.

The number of cancer cases worldwide keeps growing unstoppably, despite the undeniable advances achieved by basic research and clinical practice. Urologic tumors, including some as prevalent as prostate, bladder or kidney tumors, are no exceptions to this rule. Moreover, the fact that many of these tumors are detected in early stages lengthens the duration of their treatment, with a significant increase in health care costs. In this scenario, prevention offers the most cost-effective long-term strategy for the global control of these diseases. Although specialized diets are not the only way to

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… Grapes Grapes, the fruit of Vitis vinifera , are eaten or used to make juice and wine. … Red wine polyphenolic compounds also exhibit antitumoral activities, which could be, at least in part, mediated by their antiangiogenic activity [ 259 , 260 ]. …

Ось miR4261/PAMM в множестве миэломы стимулирует ресорбцию костей.

В рамках этого исследования изучаются механизмы, лежащие в основе заболевания костями миэломы (МБД) в множестве миеломы (МММ), с уделением особого внимания экзосомам миеломы и жидким биопсическим биомаркерам в целях выявления терапевтических целей для снижения остеокластной активности и усиления гомеостазиза костей. Совместная культурная деятельность ОПМ2, РПМ 8226, и NCI-H929 линии миэломы THP-1 Клетки использовались для оценки miR4261 и перокса ироксина, активированного в M-CSF-стимулированных моноцитах (PAMM) через RT-qPCR. Двухлюсиферазы подтвердили, что miR4261 связывает 3Непереведенная о

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… Multinucleated cells (≥ 3 nuclei per cell) with wine-red cytoplasm (TRAP-positive) are visible in the images. … Multinucleated cells (≥ 3 nuclei per cell) with wine-red cytoplasm (TRAP-positive) are visible in the images. …

Clinical Manifestations of Human Exposure to Fungi.

Biological particles, along with inorganic gaseous and particulate pollutants, constitute an ever-present component of the atmosphere and surfaces. Among these particles are fungal species colonizing almost all ecosystems, including the human body. Although inoffensive to most people, fungi can be responsible for several health problems, such as allergic fungal diseases and fungal infections. Worldwide fungal disease incidence is increasing, with new emerging fungal diseases appearing yearly. Reasons for this increase are the expansion of life expectancy, the number of immunocompromised patien

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… . | Pulping contaminated wood Malt worker’s lung | A. clavatus P. granulatum P. citrinum R. stolonifer | Handling moldy grain Wine grower’s lung | B. cinerea | Mold contamination Baker’s lung disease | A. fumigatus | Handling contaminated flour Cheese worker’s lung | P. roqueforti P. casei P. notatum … The exposure to Botrytis cinerea spores provokes wine growers’ or berry sorters’ lungs. This disease affects workers collecting grapes during vintages or handling them in the cellars during wine production [ 104 ]. …

An Appraisal of the Oleocanthal-Rich Extra Virgin Olive Oil (EVOO) and Its Potential Anticancer and Neuroprotective Properties.

Dietary consumption of olive oil represents a key pillar of the Mediterranean diet, which has been shown to exert beneficial effects on human health, such as the prevention of chronic non-communicable diseases like cancers and neurodegenerative diseases, among others. These health benefits are partly mediated by the high-quality extra virgin olive oil (EVOO), which is produced mostly in Mediterranean countries and is directly made from olives, the fruit of the olive tree (Olea europaea L.). Preclinical evidence supports the existence of antioxidant and anti-inflammatory properties exerted by t

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… The PDO label is an EU quality certification that protects foods, agricultural products and wines made within specific geographical areas, under specific physical and biological conditions, and using well-defined production practices [ 11 ]. 2. … It is also interesting to note that the anti-amyloidogenic properties of oleocanthal are similar to some of those exerted by resveratrol (3,5,4′-trihydroxy-trans-stilbene), a naturally occurring polyphenolic phytoalexin mainly found in grape skin, raspberries, mulberries and wine [ 84 ]. …

Свет в диагностике, терапии и хирургии.

Легкие и оптические методы оказывают глубокое воздействие на современную медицину, и в настоящее время в клинической практике используются многочисленные лазеры и оптические устройства для оценки состояния здоровья и лечения заболеваний. Последние достижения в области биомедицинской оптики позволили использовать все более сложные технологии, в частности технологии, которые объединяют фотонику с нанотехнологией, биоматериалами и генной инженерией. В настоящем Обзоре мы вновь обращаемся к основам взаимодействия легкой материи, описываем применение света в визуализации, диагностике, терапии и хир

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… Dermatological and aesthetic treatments Since the laser was invented, efforts have been made to develop more effective lasers for the removal of unwanted skin markings, including tattoos, birth marks, stretch marks, port-wine stains, acne scars and leg veins 9 . … PDL is useful in the treatment of port-wine stains, superficial haemangiomas and other vascular lesions. A cryogen-cooling device is used to limit the temperature rise at the surface of the skin while allowing heat accumulation at the target region underneath 12 . …

Alcohol use, intentions to reduce consumption, and perceived motivations and barriers among cancer survivors.

PurposeTo characterize alcohol use patterns, awareness of alcohol's oncologic risks, and efforts and intentions to reduce consumption among cancer survivors in New Hampshire and Vermont.MethodsCross-sectional survey of 471 cancer survivors aged ≥21 years enrolled in two state-wide, online panels. Participants reported their current or former alcohol use, completed the Alcohol Use Disorders Identification (AUDIT), and replied to a series of items regarding any efforts to reduce consumption and related motivations and barriers.ResultsAmong 471 survivors, 34.2% of which had an alcohol-related can

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… Three of those items related to alcohol ( drinking beer, drinking wine , or drinking liquor/spirits ). … Yes | 66 (48.2%) | 154 (49.7%) | 0.749 Maybe | 22 (16.1%) | 55 (17.7%) | No | 49 (37.8%) | 101 (32.6%) | Affirmative response that alcohol increases cancer risk, by type: Liquor/spirits | 74 (54.0%) | 153 (49.5%) | 0.439 Beer | 61 (44.5%) | 115 (37.2%) | 0.176 Wine | 51 (37.5%) | 111 (35.9%) | 0.832 …

Phytochemicals in Cancer Treatment and Cancer Prevention-Review on Epidemiological Data and Clinical Trials.

Phytochemicals are a non-nutritive substances that are present in plants and contribute significantly to their flavor and color. These biologically active compounds are classified into five major groups, namely phenolics, carotenoids, organosulfur compounds, nitrogen-containing compounds, and alkaloids, and are known for their potential health benefits in the prevention of various diseases, including cancer. The purpose of this review article is to explore the potential therapeutic benefits of the dietary phytochemicals, such as flavonoids, phenolic acids, phytosterols, carotenoids, and stilbe

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… Fruits (particularly citrus and berries), nuts, and vegetables (such as tomatoes, cabbage, onions, and beans), as well as beverages, such as tea, tisanes (herbal teas), and red wine, are excellent sources of dietary flavonoids. … Both acid subtypes are widely distributed among foods, such as coffee, berries, nuts, tea, wine, olive, pome, and drupe fruits and vegetables. …

Mediterranean-style diet for the primary and secondary prevention of cardiovascular disease.

BACKGROUND: The Seven Countries study in the 1960s showed that populations in the Mediterranean region experienced lower coronary heart dise … oods, including fruits, vegetables and legumes. Additional components included: low to moderate red wine consumption; high consumption of whole grains and cereals; low consumption of meat and meat products and increased consumption of fish; moderate consumption of milk and dairy products. The intervention could be dietary advice, provision of relevant …

Reimagination in art and science: Seeing the familiar in a new light and creating new things that didn't exist before.

Many groundbreaking works in art and science owe their origins to the creative spark ignited by reimagination-the process whereby artists and scientists reinterpret and reframe past and existing knowledge, envisioning it in a new context that reveals new possibilities. Artistic and scientific innovation originating from reimagination brings to mind William Faulkner's famous line, "The past is never dead. It's not even past." [W. Faulkner, Requiem for a Nun (1)].

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… The dining table is adorned with an array of goblets, wine, bananas, cocoa pods, and other foods consumed by Caribbean and African cultures. It would be fun to eavesdrop on the dinner table conversation of these 12 historical figures who were meeting each other for the first time. …

The Herba Patriniae (Caprifoliaceae): A review on traditional uses, phytochemistry, pharmacology and quality control.

ETHNOPHARMACOLOGICAL RELEVANCE: Herba Patriniae has been used for thousands of years in China as a traditional Chinese medicine with heat-clearing and detoxicating effects. It is applied widly for the treatment of rheumatoid arthritis, diarrhea, acute hepatitis, pelvic inflammatory disease and ulcerative colitis in clinic. Two species, namely Patrinia scabiosaefolia Fisch. (PS) and Patrinia villosa Juss. (PV) from the Caprifoliaceae family, are considered as Herba Patriniae in the pharmaceutical industry. AIM OF THE REVIEW: This paper aims to comprehensively outline the traditional uses, bota