Результаты поиска

Treatments for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): an overview of systematic reviews.

BACKGROUND: Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is a chronic progressive or relapsing and remitting disease tha … unction, and pulmonary fibrosis.According to moderate-quality evidence (2 trials, 77 participants), interferon beta-1a (IFN beta-1a) in comparison to placebo, did not allow more people to withdraw from IVIg. According to moderate-quality evidence, serious adverse events were no more common with IFN beta-1a than with placebo.We know of no other completed trials of im …

Identification of disproportionate reporting signals for ectopic pregnancy in the FAERS database from 2004 to 2024: A real-world pharmacovigilance study.

BACKGROUND: Ectopic pregnancy (EP) is a serious obstetric complication with a rising global incidence, partly related to the increasing use … clomifene showed the strongest disproportionate reporting signals for EP. Sixteen drugs, including interferon beta-1a, mifepristone, and lamivudine, were identified as potential novel safety signals not described in product labeling. The distribution of signal-positive drugs varied across body weight strata, with montelukast and medroxyprogesterone showing notable …

Систематический обзор моноклональной антителной терапии при повторном многоразовом склерозе: компаратор-сортифицированный анализ результатов релапса и инвалидности.

UNLABELLED: " Фон: моноколональная антителная терапия " представляет собой высокоэффективные методы лечения для повторного применения различных форм склероза (MS). Вместе с тем отсутствие непосредственных выборочных испытаний по принципу < < от головы до головы > > и использование разнородных компараторов во всех важнейших исследованиях осложняют сравнительные оценки эффективности. Хотя сетевой метаанализ (НМА) обеспечивает основу для интеграции фактических данных, раздробленная структура имеющейся фактологической базы исключает использование традиционной НМА с глобальным

Совпадение в аннотации оригинала
UNLABELLED: The Background: monoclonal antibody therapies represent high-efficacy treatment options for relapsing forms of multiple sclerosi … or ARR, the evidence network was fragmented into three disconnected components defined by placebo-, interferon beta-1a-, and teriflunomide-controlled trials. Within connected sub-networks, monoclonal antibody therapies consistently demonstrated substantial reductions in ARR relative to their respective comparators, with overlapping confidence intervals suggesting br …

A disproportionality analysis of nervous system adverse events associated with disease-modifying therapies in multiple sclerosis: insights from the FDA adverse event reporting system (FAERS).

BACKGROUND: Disease-modifying therapies (DMTs) have significantly improved the management of multiple sclerosis (MS), but their potential ne … time to onset of AEs varied significantly across DMTs, ranging from 14 days for AL to 816 days for Interferon Beta-1a (IN). Subgroup analyses highlighted variations in AE reporting across different demographics and geographic regions. The sensitivity analysis further confirmed the robustness of our findings, indicating consistent associations between DMTs and sever …

Множественные склерозы наподобие Лесионов, вызываемые радиацией: доклад по делу и систематический обзор литературы.

Справочная информация/цели: Радиотерапия (РТ) по-прежнему имеет решающее значение для лечения как первичного, так и метастатического рака центральной нервной системы. Несмотря на достижения в современных технологиях, которые смягчают некоторые токсичные неблагоприятные последствия, магнитно-резонансные съемки (МРИ) по-прежнему обнаруживают широкий спектр изменений, вызванных радиацией. Радиация может отрицательно сказаться на нейроглиальных клетках и их прекурсорах, что может привести к демиелинации, аналогичной множеству склерозов (MS). Цель настоящего обзора заключается в изучении случаев и

Совпадение в аннотации оригинала
Background/Objectives: Radiotherapy (RT) remains crucial in treating both primary and metastatic central nervous system cancer. Despite adva … radiological recurrence occurred in two of the patients during the follow-up period. Fingolimod and Interferon beta-1a were administered to these two patients. Conclusions: Radiation-induced demyelination is a critical clinical and radiological entity that requires attention from both oncologists and neurologists. Comprehensive follow-up is essential to identify pat …

COVID-19: Underpinning Research for Detection, Therapeutics, and Vaccines Development.

BACKGROUND: The newly emerged coronavirus SARS-CoV-2, first reported in December 2019, has infected about five and a half million people globally and resulted in nearly 9063264 deaths until the 24th of June 2020. Nevertheless, the highly contagious virus has instigated an unimaginably rapid response from scientific and medical communities. OBJECTIVES: Pioneering research on molecular mechanisms underlying the viral transmission, molecular pathogenicity, and potential treatments will be highlighted in this review. The development of antiviral drugs specific to SARS-CoV-2 is a complicated and t

Injectable interferon beta-1b for the treatment of relapsing forms of multiple sclerosis.

Multiple sclerosis (MS) is chronic inflammatory and demyelinating disease with either a progressive (10%-15%) or relapsing-remitting (85%-90%) course. The pathological hallmarks of MS are lesions of both white and grey matter in the central nervous system. The onset of the disease is usually around 30 years of age. The patients experience an acute focal neurologic dysfunction which is not characteristic, followed by partial or complete recovery. Acute episodes of neurologic dysfunction with diverse signs and symptoms will then recur throughout the life of a patient, with periods of partial or

Chronic hepatitis C in elderly patients: clinical, histological and virological features.

Some clinical, histological and virological features, efficacy and safety of interferon (IFN) therapy were evaluated in elderly patients with chronic hepatitis C (CHC). We enrolled 22 patients aged 65-75 (mean age: 68.3 +/- 3.17 years); 15 males and 7 females. In all cases the hepatitis C virus RNA (HCV-RNA) was determined before, during and after the therapy, and HCV sub-types were established; 15 patients underwent hepatobiopsy. At entry, the duration of disease was: 6 patients 1-3 years, 2 patients 4-10 years, 14 patients 11-30 years; alanine-aminotransferase (ALT) = (3.17 +/- 1.15) x N (N

Anti-inflammatory and cognitive effects of interferon-β1a (IFNβ1a) in a rat model of Alzheimer's disease.

BACKGROUND: Aβ1-42 peptide abnormal production is associated with the development and maintenance of neuroinflammation and oxidative stress in brains from Alzheimer disease (AD) patients. Suppression of neuroinflammation may then represent a suitable therapeutic target in AD. We evaluated the efficacy of IFNβ1a in attenuating cognitive impairment and inflammation in an animal model of AD. METHODS: A rat model of AD was obtained by intra-hippocampal injection of Aβ1-42 peptide (23 μg/2 μl). After 6 days, 3.6 μg of IFNβ1a was given subcutaneously (s.c.) for 12 days. Using the novel object recog

Eight-and-a-half syndrome as the first presentation of multiple sclerosis in an Asian male: a case report.

BACKGROUND: Multiple sclerosis is a diffuse chronic demyelinating disease of the central nervous system. It is relatively uncommon in the As … a course of pulsed corticosteroid therapy, and was subsequently placed on maintenance therapy with interferon beta-1a. CONCLUSION: This case illustrates eight-and-a-half syndrome as the first presentation of a diffuse central nervous system pathology. A wide range of differential diagnoses needs to be considered in such a presentation as based on the patient's dem …

Performance of Composite Endpoints Defining Progression Independent of Relapse Activity in Multiple Sclerosis.

OBJECTIVE: The characteristics and utility of composite progression independent of relapse activity (cPIRA; worsening on the Expanded Disability Status Scale [EDSS], or 9-Hole Peg Test, or Timed 25-Foot Walk Test) were evaluated as an endpoint in relapsing multiple sclerosis (RMS) trials using the ENSEMBLE (NCT03085810) and pooled OPERA I/II (NCT01247324/NCT01412333) studies. METHODS: We evaluated: (i) different definitions and the impact of rebaselining post-relapse on cPIRA, (ii) cPIRA and biomarkers (MRI activity and serum neurofilament light [sNfL] levels), (iii) sustainability of cPIRA e

The efficacy and safety of Ivermectin in patients with mild and moderate COVID-19: A structured summary of a study protocol for a randomized controlled trial.

OBJECTIVES: We will evaluate the efficacy and safety of Ivermectin in patients with mild and moderately severe COVID-19. TRIAL DESIGN: This … pinavir/Ritonavir (Heterd Company, India) twice a day for the seven days, plus five doses of 44 mcg Interferon beta-1a (CinnaGen, Iran) every other day. Other supportive and routine care will be the same in both outpatient and inpatient groups. MAIN OUTCOME: The primary outcomes are composite and include the improvement of clinical symptoms and need for hospitaliza …

Surveying haemoperfusion impact on COVID-19 from machine learning using Shapley values.

BACKGROUND: Haemoperfusion (HP) is an innovative extracorporeal therapy that utilizes special cartridges to filter the blood, effectively re … groups among the treatments and medications used remdesivir, adalimumab, tocilizumab, favipiravir, Interferon beta-1a, enoxaparin prophylaxis, enoxaparin full dose, heparin prophylaxis, and heparin full dose (P < 0.05). It seems that haemoperfusion has a positive impact on the reduction of inflammation markers and renal functional such as ferritin and creatinine, r …

Sex-specific pharmacovigilance signals and time-to-onset patterns of drug-related myoclonus and epileptic seizures: a real-world pharmacovigilance analysis.

BACKGROUND: Drug-related myoclonus and epileptic seizures are neurological adverse events that may cause trauma, impaired consciousness, hos … onus and 31.0 days for tramadol-related seizures, but 214.0 days for lamotrigine and 387.0 days for interferon beta-1a. CVARD identified 498 myoclonus-related and 940 seizure-related drugs and reproduced core signals, including clozapine, gabapentin, baclofen, pregabalin, sertraline, bupropion, quetiapine, and olanzapine. CONCLUSION: Integrating signal detection, s …

Bridging pharmacovigilance and genetic insight: investigating drugs and indications for breast cancer risk in women with autoimmune diseases.

BACKGROUND: Women with autoimmune diseases (AIDs) experience chronic immune dysregulation and hormonal fluctuations, both of which may influ … ts with AIDs. The drugs with the highest case reports for positive disproportionality analysis were interferon beta-1a (N: 1731, IC [IC025] 1.56 [1.49]), natalizumab (798, 0.65 [0.54]), and infliximab (741, 0.64 [0.53]). MR results revealed causal links between 9 drug targets and breast cancer risk, such as FDPS (OR: 0.66, p: 1.33E-08), CALCRL (OR: 0.887, p: 4.77E-0 …

["Samurai cannulation" less time-consuming than other techniques for treating iatrogenic type A aortic dissection].

OBJECTIVES: Drug-induced osteoporosis/osteopenia (OP/OPN) has emerged as a significant public health concern affecting bone health. However, … uency, tenofovir and its combinations, esomeprazole, adalimumab, methotrexate, medroxyprogesterone, interferon beta-1A, etanercept, and rituximab were the most frequently reported drugs. In terms of signal strength, tenofovir and its combinations, adefovir, pamidronic acid, and esomeprazole the strongest signals, suggesting that these drugs may represent key risk fa …

Prior treatment status: impact on the efficacy and safety of teriflunomide in multiple sclerosis.

BACKGROUND: In this pooled, post hoc analysis of a phase 2 trial and the phase 3 TEMSO, TOWER, and TENERE clinical trials, long-term efficac … lso assessed. RESULTS: Most frequently received prior DMTs at baseline were glatiramer acetate and interferon beta-1a across treatment groups. Teriflunomide 14 mg significantly reduced ARR versus placebo in the core period, regardless of prior treatment status. In the core and extension periods, adjusted ARRs were low (0.193-0.284) in patients treated with teriflun …

All-cause health care utilization and costs associated with newly diagnosed multiple sclerosis in the United States.

BACKGROUND: Multiple sclerosis (MS) is a costly and crippling neurologic disease. Approximately 250,000 to 400,000 persons in the United Sta … ield on the claim or (b) 1 prescription (medical or pharmacy) claim for injectable MS drug therapy (interferon beta-1a, interferon beta- 1b, glatiramer acetate) for dates of service between January 1, 2004, and December 31, 2006. Natalizumab was not used to identify MS cases, but was used to exclude potential comparison group subjects. The index date for patients wi …

Autophagy induction by the pathogen receptor NECTIN4 and sustained autophagy contribute to peste des petits ruminants virus infectivity.

Macroautophagy/autophagy is an essential cellular response in the fight against intracellular pathogens. Although some viruses can escape from or utilize autophagy to ensure their own replication, the responses of autophagy pathways to viral invasion remain poorly documented. Here, we show that peste des petits ruminants virus (PPRV) infection induces successive autophagic signalling in host cells via distinct and uncoupled molecular pathways. Immediately upon invasion, PPRV induced a first transient wave of autophagy via a mechanism involving the cellular pathogen receptor NECTIN4 and an AKT-

In inpatients with COVID-19, none of remdesivir, hydroxychloroquine, lopinavir, or interferon β-1a differed from standard care for in-hospital mortality.

Pan H, Peto R, Henao-Restrepo AM, et al. Repurposed antiviral drugs for Covid-19-interim WHO Solidarity Trial results. N Engl J Med. 2020. [Epub ahead of print.] 33264556.