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Стойкость к Ocrelizumab по сравнению с другими лекарственными препаратами для нескольких склерозов: результаты немецкого регистра нейротрансфер данных.

ВВЕДЕНИЕ: Устойчивость лечения имеет решающее значение для получения полного терапевтического пособия и может указывать на благоприятные результаты. В рамках этого исследования изучался вопрос о стойкости в реальном мире к воздействию острелизумаба (ОКР) в сравнении с другими методами лечения, позволяющими видоизменить заболевания (ДМТ), и его связь с результатами повторного выброса нескольких склерозов (РРМС) с использованием данных немецкого реестра нейротрансданных (НТД). МЕТОДЫ: Этот ретроспективный когортный анализ охватывал амбулаторных больных, которые с января инициировали ДМТ 2014 и а

Совпадение в аннотации оригинала
INTRODUCTION: Treatment persistence is critical to obtaining full therapeutic benefit and can indicate favorable outcomes. This study examin … between persistence and the risk of relapse, 3-months confirmed disability progression (3mCDP), and sick leave were assessed. RESULTS: Overall, 3907 patients with RRMS were included. OCR users had the highest persistence at 2 years (93%), then oral HA (78%), oral (67%), natalizumab (67%), and injectable therapies (55%). Compared with OCR users, patients ini …

Work-related posttraumatic stress disorder (PTSD) and other emotional diseases as consequence of traumatic events in public transportation: a systematic review.

BACKGROUND: Drivers in public transportation are at risk of experiencing potential traumatic events such as accidents involving persons, collisions, or suicides. In this context, the question arises to what extent psychological traumatization and posttraumatic diseases occur. PURPOSE: The aim of this systematic review was to describe the frequency and nature of work-related posttraumatic disorders, to analyze risk and prognostic factors after potentially traumatic events (accidents resulting in damage to property and/or in injury or death), and address sick leave after such events in the real…

Effects of functional restoration versus 3 hours per week physical therapy: a randomized controlled study.

STUDY DESIGN: Randomized parallel-group comparative trial with a 6-month follow-up period. OBJECTIVE: To compare, in chronic low back pain … trates the effectiveness of a functional restoration program on important outcome measures, such as sick leave, in a country that has a social system that protects people facing difficulties at work.

Seeking care for low back pain in the general population: a two-year follow-up study: results from the MUSIC-Norrtälje Study.

STUDY DESIGN: A 2-year follow-up study was conducted to investigate new patients who sought care for low back pain from all the caregivers in a specific region with a population of approximately 17,000 men and women ages 20 to 59 years. OBJECTIVES: To describe care-seeking behavior for low back pain in a general population; to characterize pain, disability, and sick leave among the patients; and to study predictors of recovery. An additional aim was to find a simple way of classifying low back pain in epidemiologic studies. SUMMARY OF BACKGROUND DATA: Low back pain is very common, but its na…

[Self-reported pattern of illness and hospitalization during pregnancy. Results from a nation-wide questionnaire study].

In a representative questionnaire investigation covering all of Denmark, 3,152 women provided information about their health during a recent pregnancy. Of these, 1,411 (45%) had been ill or had experienced severe complaints related to the pregnancy and 625 (20%) had been hospitalized during pregnancy. The average duration of hospitalization was two weeks with great variations in the various conditions. Women with multiple pregnancies were hospitalized for an average of six weeks. Increased incidence of hypertension and placental insufficiency were found among women over the age of 35 years whe

Effect on healthcare utilization and costs of spinal manual therapy for acute low back pain in routine care: A propensity score matched cohort study.

Spinal manual therapy (SMT) is a popular treatment option for low back pain (LBP). The aim of our analysis was to evaluate the effects of manual therapy delivered by general practitioners and ambulatory orthopedic surgeons in routine care on follow up consultations, sick leave, health service utilization and costs for acute LBP compared to matched patients not receiving manual therapy. This is a propensity score matched cohort study based on health claims data. We identified a total of 113.652 adult patients with acute LBP and no coded red flags of whom 21.021 (18%) received SMT by physicians.…

Which patients do not return to work after total knee arthroplasty?

Total knee arthroplasty (TKA) is increasingly being performed among working patients suffering from knee osteoarthritis. Two out of ten patients do not return to work (RTW) after TKA. Little evidence is available about these patients to guide clinicians. Therefore, this study investigates patients' characteristics associated with no RTW. A multicenter retrospective cohort study was performed among working patients having undergone a primary TKA during 2005-2010. The following preoperative characteristics were assessed: age at surgery, sex, comorbidity, body mass index (BMI), preoperative sick-

Severe to profound hearing impairment: quality of life, psychosocial consequences and audiological rehabilitation.

PURPOSE: To study the quality of life (QoL) and psychosocial consequences in terms of sick leave and audiological rehabilitation given to patients with severe to profound hearing impairment. METHOD: A retrospective study of data on 2319 patients with severe to profound hearing impairment in The Swedish Quality Register of Otorhinolaryngology, followed by a posted questionnaire including The Hospital Anxiety and Depression Scale (HADS). RESULTS: The results indicate greater levels of anxiety and depression among patients with severe or profound hearing impairment than in the general populatio…

An integrated model for the assessment of stress-related risk factors in health care professionals.

To assess the risk from exposure to occupational stress and burnout in health care workers (HCW), a cross-sectional study was planned to com … udy: a) working understaffed; b) ratio number of patients/HCW on service; c) ratio number of HCW on sick leave/ HCW on service; d) number of skipped days off after night shifts; e) days of sick leave; f) number of deceased patients; g) number of accidents at work. A total group of 230 HCW were examined, employed in six different sub-units of the Medical ward …

Epidemiology of musculoskeletal injuries among Norwegian conscripts undergoing basic military training.

Compulsory military service entails a change in the patterns of physical activity of many conscripts, and an accompanying risk of musculoskeletal injury. The present study was carried out to determine the incidence and types of musculoskeletal injury among Norwegian conscripts, and their consequences in the form of sick leave and discharge from the service. The study population consisted of 6488 conscripts in all, drawn from the Army, the Air Force and the Navy. They were monitored through an initial 6-10-week period of basic military and physical training. Every injury for which a conscript h…

Employment during pregnancy in relation to risk factors and pregnancy outcome.

OBJECTIVE: To describe the relation of employment status during pregnancy to potential demographic, behavioural and obstetrical risk factors … pregnancy, (2) women working in the first, but unemployed during the second trimester, (3) women on sick leave in the first and second trimester, (4) women unemployed throughout pregnancy, and (5) students. The association between employment status and having a small for gestational age infant and preterm delivery was evaluated, accounting for other risk fac …

Developing and testing a case-management intervention to support the return to work of health care workers with common mental health disorders.

BACKGROUND: To assess the feasibility and acceptability of conducting a trial of the clinical effectiveness and cost-effectiveness of a new case-management intervention to facilitate the return to work of health care workers, on sick leave, having a common mental disorder (CMD). METHODS: A mixed methods feasibility study. RESULTS: Systematic review examined 40 articles and 2 guidelines. Forty-nine National Health Service Occupational Health (OH) providers completed a usual care survey. We trained six OH nurses as case managers and established six recruitment sites. Forty-two out of 1938 staf…

Functional Status, Pain and Shoulder Mobility in Frozen Shoulder A Prospective Study.

The aim of our study was to assess the clinical course, disease duration, functional status dynamics and prevalence of elevated blood sugar values in patients with frozen shoulder (FS). We also tested two other hypotheses: a) Duration of symptoms before the beginning of therapy affects rehabilitation outcome and duration of symptoms. b) Postponed initiation of therapy affects the duration of sick leave.Our prospective study took place at the University Rehabilitation Institute-Republic of Slovenia (URI-RS) between April 2017 and March 2021. The sample comprised 26 patients with FS. We evaluate…

Risk of very serious injuries in Swedish scaffolders - What is an acceptable risk?

BACKGROUND: This case study estimates the risk of injuries causing death or at least one year's sick leave due to fall from height among Swedish scaffolders. FINDINGS: Cases occurring in 2020 to 2023 were identified from national statistics of accidents at work and statistics from an insurance company. The number of scaffolders in Sweden were estimated through national statistics. Their risk was compared to what is considered an unacceptable risk for exposure to carcinogens. Between 2020 and 2023 there were 10 accidents due to fall from height causing death or at least one years' sick leave a…

Workplace Phobic Anxiety as a Mental Health Phenomenon in the Job Demands-Resources Model.

PURPOSE: Anxiety-related problems at work are a serious problem in the occupational context, as they come along with sick leave and problems in work participation. The aim of this study is to analyse workplace phobic anxiety in nonclinical context using the Job Demands-Resources model. METHODS: The study involved a sample of 739 workers from a retail company, mostly with permanent contracts. Structural equation modelling analyses were performed using AMOS software. RESULTS: Both the health impairment and motivational variables in the JD-R model were significantly related to workplace phobic …

[Recurrent respiratory infections in patients with chronic obstructive bronchitis: medical treatment and costs].

The objective of this study is to describe usual medical management and costs associated with recurrent respiratory infections in subjects with chronic obstructive bronchitis in France. A prospective survey was performed in Autumn 1994 on a national sample of private practice pulmonologists (N = 71). Two hundred forty-four patients, presenting at least one infection of the lower respiratory tract, were included. Bronchitis was the most frequent acute exacerbation observed (94%). Pneumonia concerned 9% of the patients. Biological tests, X-rays and pulmonary function tests were prescribed for, r

Subgroup analyses on return to work in sick-listed employees with low back pain in a randomised trial comparing brief and multidisciplinary intervention.

BackgroundMultidisciplinary intervention is recommended for rehabilitation of employees sick-listed for 4-12 weeks due to low back pain (LBP … in the first year after the intervention. At the first interview in the clinic, it was ensured that sick leave was primarily due to low back problems.Questionnaires were used to obtain data on health, disability, demographic and workplace-related factors. Cox hazard regression analyses were used with RTW as outcome measure and hazard rate ratios (HRR = HRmul …

Treatment of acute ankle sprain. Comparison of a semi-rigid ankle brace and compression bandage in 73 patients.

We randomized 73 patients with grades II and III ankle sprain to treatment with an Air-Stirrup ankle brace or a compression bandage. All patients were instructed to attempt early motion and weight bearing when comfortable. Ankle function was evaluated after 3-5 days and 2, 4, and 10 weeks with a clinical examination, the Sickness Impact Profile questionnaire, Karlsson's scoring scale and recording of sick leaves. The group treated with the Air-Stirrup ankle brace was more mobile in the initial phase of rehabilitation and had a shorter sick leave. Ankle brace treatment resulted in socioeconomic…

Costs of ulcerative colitis from a societal perspective in a regional health care area in Spain: A database study.

OBJECTIVES: To estimate the management of UC associated costs from the societal perspective in Spain. METHODS: Observational, longitudinal study with retrospective data collection based on reviews of outpatient health records. Socio-demographic, clinical and sick leave information was gathered. Patients diagnosed of UC between 2002 and 2012, older than 18 years, followed-up by a minimum of 12 months post diagnosis, with at least two clinical and use of resources data recorded, were included. RESULTS: 285 UC patients [51.2% men; 44.5 (SD: 15.6) years old; 88.4% without family history of UC; 3…

Multidisciplinary intensive treatment for chronic low back pain: a randomized, prospective study.

BACKGROUND: Americans with low back pain have been helped to return to work by multidisciplinary intensive treatment programs. Whether this … ork, compared with 14 of 49 (29%) in the control group. The treated patients had used fewer days of sick leave (P < .02), had contacted health care. professionals fewer times (P < .001), and had lower pain and disability scores. CONCLUSIONS: Although such programs are expensive, they can reduce pension expenditures, sick leave days, health care contacts, an …