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Implementation planning for community-based point-of-care HIV testing for infants: Recommendations from community leaders in Kenya.

BACKGROUND: Early infant diagnosis (EID) establishes the presence of HIV infection in HIV-exposed infants and children younger than 18 month … results, improved reach) of community-based testing. CONCLUSION: Community members felt that with strategic planning and engagement, community-based POC HIV testing could be a feasible and acceptable strategy to overcome the existing barriers of hospital-based EID.

Where Are All the Clinical Trials for Chronic Rejection?

Chronic rejection is arguably the main obstacle to long-term graft survival. Yet, clinical trials focusing on this condition are disappointingly scarce. Significant advances in treating chronic rejection cannot happen if there is no conduit for testing novel therapies. Here, we identified the main hurdles holding back clinical trials for chronic rejection and outlined a series of actions to address these roadblocks. We suggest that a new strategic plan combining expertise in basic and clinical research and leveraging complementary resources be launched to specifically target chronic rejection

Advancing Medication Safety: Establishing a National Action Plan for Adverse Drug Event Prevention.

BACKGROUND: Adverse drug events (ADEs) are important contributors to preventable morbidity and mortality, comprising one third of all hospital adverse events. In response to growing evidence detailing the high prevalence of ADEs, particularly among vulnerable older adults, Congress requested that the Secretary of the Department of Health and Human Services (HHS) convene a Federal Interagency Steering Committee to establish a National Action Plan to focus on ADE prevention. In August 2014, the Office of Disease Prevention and Health Promotion released the final version of the National Action Pl

Interdisciplinary management of a skeletal class II, hyperdivergent patient accompanied by multiple missing teeth and severe overeruption with orthodontic assisted space redistribution and implant restoration.

Long-term absence of posterior teeth often leads to significant overeruption of the antagonists, posing a substantial challenge for restorative treatment planning. This case report presents an interdisciplinary approach for a skeletal class II, hyperdivergent patient accompanied by missing maxillary second premolars (15,25), left maxillary second molar (27), mandibular first and second molars (36,37,46,47) and severe overeruption of maxillary first molars (16,17). The maxillary first molars were intruded using both buccal and palatal miniscrews while the existing maxillary spaces were closed.

COVID-19 pandemic, dengue epidemic, and climate change vulnerability in Bangladesh: Scenario assessment for strategic management and policy implications.

Bangladesh is one of the most vulnerable countries to climate change impacts also struck by the COVID-19 pandemic. The lockdown measures were ineffective with no sign of flattening the curve. Therefore, the high risk of transmission is evident with an increasing number of affected people. Under this circumstance, a multiple hazards scenario can be developed in this country due to climatic hazards such as cyclones, floods, landslides, heat waves, and the outbreak of infectious diseases such as dengue, cholera, and diarrhoea. The country experiences simultaneously the global pandemic, exceptiona

The Multicriteria Decision Analysis for Extended Reality (MCDA-XR) Governance Framework for Health Care Adoption: Mixed Methods Development Study.

BACKGROUND: Health services increasingly face decisions about how to integrate immersive technologies into routine practice. International guidance highlights the need for structured governance in digital health, yet extended reality (XR) initiatives are often launched through isolated pilots without a clear assessment of organizational readiness or implementation risk. Although factors influencing XR adoption are well documented, health care organizations and system-level decision-makers still lack practical, governance-oriented tools to translate these determinants into structured strategic

Readiness assessment as a strategy, not an afterthought: leveraging implementation science to integrate tuberculosis comorbidity care in Pakistan's health system.

Health facility readiness assessment is a foundational element in designing and implementing integrated tuberculosis (TB) and comorbidity interventions, particularly in low- and middle-income countries (LMICs) like Pakistan. The integration of TB care with management of comorbid conditions like diabetes mellitus, depression, and tobacco use is complicated and challenged by diverse, multifaceted barriers at the health system, organizational, and individual levels. Evidence-based frameworks, such as Consolidated Framework for Implementation Research (CFIR), Reach, Effectiveness, Adoption, Implem

Staged surgical management of advanced leg lymphedema: A successful Charles procedure in a resource-limited setting, case report.

INTRODUCTION: Lymphedema, marked by localized tissue swelling, poses a worldwide challenge. In sub-Saharan Africa, where patients often present in advanced stages, resectional techniques such as the Charles procedure become the sole option. This case report illustrate the staged surgical approach to address extensive lower limb lymphedema through the utilization of the Charles procedure. CASE PRESENTATION: A 38-year-old female with a 20-year history of right leg lymphedema underwent a three-stage surgical plan. The first stage involved partial excision of lymphedema mass, the second stage foc

Urban flooding: Coping with Weija Dam spillage by downstream communities in Ghana.

UNLABELLED: This study adds to knowledge by specifically focusing on the dam spillage-induced floods within a fast-urbanising city with weak law enforcement in a developing country. Employing a sequential mixed-method approach, we first selected and analysed data from 120 respondents through a survey and complemented it with key informants residing in the communities affected by flooding. The findings revealed that dramatic ramifications of dam spillage-induced floods disrupt the livelihoods of many individuals in the form of disruption to income-generating activities and substantial property

Road criticality assessment to improve commutes during floods.

Flooding undermines the functionality of road links, leading to commute disruption, such as increased commuting time and immobility. Therefore, identifying the critical roads under different flood scenarios is of great significance for transportation planning to minimize flood risk. Previous studies on the road criticality under pluvial floods have focused on mostly structural characteristics of the roads, lacking the quantification of the flood impact on traffic. We employed an integrated framework coupling pluvial flood modeling with commute simulation to assess the criticality of flooded ro

Identifying intangible assets in interprofessional healthcare organizations: feasibility of an asset inventory.

Healthcare systems increasingly use business models that focus on tangible assets such as finances and facilities. Yet intangible assets, such as values, relationships and human capital, remain critical for understanding the worth of interprofessional healthcare education and collaboration. We implemented a novel interprofessional collaborative pilot exercise to explore the feasibility and usefulness of an Asset Inventory-using KJ methodology and an appreciative inquiry perspective-to identify and better understand intangible assets and their value in interprofessional healthcare education/tra

Barriers and facilitators to participant recruitment to randomised controlled trials: A qualitative perspective.

Low recruitment rates for randomised controlled trials (RCTs) are a common issue. Information on barriers and facilitators to recruitment fo … olidated Standards of Reporting Trials Statement to improve the quality of reporting and ensure the strategic planning of future RCTs.

Улучшение ухода за сепсисом в Африке: возможность перемен?

Сепсис является широко распространенным явлением и представляет собой серьезное бремя для здоровья населения, связанное со значительной заболеваемостью и смертностью. Однако, несмотря на значительный прогресс в признании сепсиса и управлении им в хорошо финансируемых системах здравоохранения, в Африке по-прежнему ощущается явная нехватка исследований в области сепсиса. Отсутствие данных сказывается на всех уровнях медицинского обслуживания, начиная с индивидуального ухода за пациентами и кончая стратегическим планированием на уровне системы здравоохранения. Это особенно актуально, поскольку аф

Совпадение в аннотации оригинала
Sepsis is common and represents a major public health burden with significant associated morbidity and mortality. However, despite substanti … he lack of evidence affects all levels of healthcare delivery from individual patient management to strategic planning at health-system level. This is particular pertinent as African countries experience some of the highest global burden of sepsis. The 2017 World Health Assembly resolution on sepsis and the creation of the Africa Sepsis Alliance provided an opportun …

Global characteristics of the rabies biologics market in 2017.

In 2017, the World Health Organization, the World Organisation for Animal Health, the Food and Agriculture Organization of the United Nations and the Global Alliance for Rabies control developed a strategic plan to end human rabies deaths by 2030. A survey for manufacturing capacity and product characteristics of rabies biologics was conducted to inform this process. Twenty-three of 42 manufacturers, responded, giving a market capacity for 2017 of 90 million vials for human vaccines, 2.5 million vials for rabies immunoglobulins, 2 million vials for monoclonal antibodies and 181 million vials f

Airway management of neonates with antenatally detected head and neck anomalies.

Five cases of prenatally detected neck masses that had a potential for airway obstruction at birth are described. The various options for management of the airway are discussed, including using maternal-fetal circulation until intubation, rigid bronchoscopy, tracheotomy, cyst aspiration, or extracorporeal membrane oxygen support. Congenital abnormalities involving the fetal face or neck are extremely rare. With technical advances in ultrasonography, these masses were first noted on prenatal ultrasound in the late 1970s. Before that period, they were detected at delivery. These masses are solid

Assessing current and future demand for PET-CT imaging in England: a comparative analysis of 2013 and 2022 Royal College of Radiologists Guidelines.

OBJECTIVES: This study aimed to provide a comprehensive analysis of the increasing demand for PET-CT imaging in England, driven by advancements in technology and updated clinical guidelines. By comparing the 2013 and 2022 guidelines issued by the Royal College of Radiologists, the analysis sought to quantify the gap between actual PET-CT provision and modeled requirements, benchmarked against international comparators, to inform strategic planning for equitable access to advanced imaging. METHODS: A detailed modeling approach was developed, mapping guideline-based PET-CT scan requirements to …

Community education program on autism spectrum disorder: a case study of an ecosystem intervention involving family, school, NGO, and community stakeholders.

BACKGROUND: This paper documents the JC A-Connect: Jockey Club Autism Support Network community education program, which was a decade-long, … of our strategies require multidisciplinary expertise and financial investment, and this calls for strategic planning, community-wide participation, and shared ownership.

Home care clients: a research protocol for studying their pathways.

BACKGROUND: Enhancing non-clinical home care supports and services for older adults to live well is a strategic priority in developed countr … s will help to contextualize these findings. The iKT model will ensure that findings are useful for strategic planning and decision-making, and supporting changes in care practice.

Defining workload components and activity standards for human resources professionals in Iranian public hospitals: A WISN-based framework for strengthening non-clinical workforce planning.

BACKGROUND: Defining valid workload components and activity standards is a prerequisite for workload-based workforce planning. This study aimed to develop and validate workload components and activity standards for human resources (HR) departments in Iranian public hospitals using a framework aligned with the Workload Indicators of Staffing Need (WISN) methodology. METHODS: A consensus-based mixed-method approach was used. An initial list of HR activities was developed through expert consultation and enriched through approximately 200 hours of field observation and staff interviews in a selec

Resilience at the crossroads: Strategic resilience in UK rail - responding to disruption, shaping the future.

The UK rail sector is undergoing structural, cultural and operational change, creating both opportunities and challenges for resilience. This paper examines how London North Eastern Railway (LNER) has adapted its business continuity and emergency planning practices in response to prolonged industrial action, climate-related disruption and sector-wide reform under the transition to Great British Railways. Drawing on practical examples, including the contingency planning model developed during 2022-24 strike activity and lessons learned from Storm Babet, it explores how structured planning cycle