Результаты поиска

Risk factors for prolonged hospitalization and disease course in osteomyelitis: a single-centre cohort study.

OBJECTIVE: To investigate pathogen epidemiology and clinical characteristics in osteomyelitis patients for optimizing clinical management strategies. METHODS: Confirmed osteomyelitis cases required pathogen isolation with radiological correlation. The cohort included both confirmed (culture-positive) and probable (culture-negative but meeting clinical and radiological criteria) cases, Radiation-induced osteomyelitis, sclerosing osteomyelitis and drug-associated osteomyelitis. Clinical specimens underwent standardized culture and VITEK Compact II or MALDI-TOF MS identification. SPSS 22.0 analy

Rare Diseases of the Orbit.

This article provides an overview of rare orbital diseases. Congenital malformations, inflammatory diseases, benign and malignant neoplasias are described. Although it represents a relatively small area of the body the orbit contains multiple different tissues. Therefore, a great variety of diseases can be found within the orbital space. That is the reason, why both the completeness and the level of detail in the description of particular diseases must be somewhat limited. Nevertheless, clinical manifestations, important aspects of diagnosis, treatment strategies, and, when specific data are a

Резюме книги: Тема: 13th Международный симпозиум на тему " Ходжкин лимфома " ; октябрь 2024

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Ocular effects caused by viral infections and corresponding vaccines: An overview of varicella zoster virus, measles virus, influenza viruses, hepatitis B virus, and SARS-CoV-2.

Many viral infections can affect vision and the visual system. Vaccination to prevent diseases is commonplace today, acting by stimulating an immune response without developing the pathology. It involves the production of persisting antibodies against the pathogen and the activation of T cells. Certain diseases have already been eradicated by rigorous vaccination campaigns, while others are hoped to be eliminated soon. Vaccines currently available on the market are largely safe, even if they can rarely cause some adverse effects, such as ocular complications. Analyzing existing literature, we

Совпадение в полном тексте источника
… Reyes-Capo et al. reported that a patient was diagnosed with right abducens nerve palsy ( 160 ), while Helmchen et al. reported female with a history of relapsing-remittent multiple sclerosis (MS) who was diagnosed with Optic neuritis with AQP4-antibody negative neuromyelitis optica spectrum disorders-like … Acute bilateral optic/chiasm neuritis with longitudinal extensive transverse myelitis in longstanding stable multiple sclerosis following vector-based vaccination against the SARS-CoV-2. J Neurol. (2021) 15:1–6. 10.1007/s00415-021-10647-x 162. Maleki A, Look-Why S, Manhapra A, Foster CS. …

Virtual music therapy during the COVID-19 pandemic: an updated scoping review.

ObjectiveThe objective of this update to a previously published scoping review was to map how music therapists used virtual music therapy during the COVID-19 pandemic.IntroductionVirtual music therapy underwent significant development during the COVID-19 pandemic. Consequently, the number of publications increased dramatically compared to early 2021, when only 10 records were available. An update to the previous scoping review was necessary to explore the current state of this emerging music therapy discipline and provide important information for health care practitioners, scholars, and resea

Advances in preclinical hematopoietic stem cell models and possible implications for improving therapeutic transplantation.

Hematopoietic stem cell transplantation (HSCT) is a treatment for many malignant, congenital, and acquired hematologic diseases. Some outstanding challenges in the HSCT field include the paucity of immunologically-matched donors, our inability to effectively expand hematopoeitic stem cells (HSCs) ex vivo, and the high infection risk during engraftment. Scientists are striving to develop protocols to generate, expand, and maintain HSCs ex vivo, however these are not yet ready for clinical application. Given these problems, advancing our understanding of HSC specification, regulation, and differ

Педиатрическое ожирение - долгосрочные последствия и последствия потери веса.

Согласно ВОЗ, детский ожирение - это one наиболее серьезных проблем, с которыми сталкивается 21st Столетие. Более 100 million Сегодня у детей ожирение. Уже в детстве почти все органы подвергаются риску ожирения. В этом обзоре мы представляем текущие знания о болезнях, связанных с детским ожирением, и о том, как они влияют на потерю веса. One Основным побудительным фактором является вызванное ожирением низкосортное хроническое воспаление, которое уже наблюдается у детей дошкольного возраста. Это воспаление в сочетании с эндокринным, паракринным и метаболическим воздействием ожирения повышает до

Совпадение в аннотации оригинала
Childhood obesity is, according to the WHO, one of the most serious challenges of the 21st century. More than 100 million children have obes … type 1 diabetes. Childhood obesity also increases the risk for several autoimmune diseases such as multiple sclerosis, Crohn's disease, arthritis, and type 1 diabetes and it is well established that childhood obesity also increases the risk for cardiovascular disease. Consequently, childhood obesity increases the risk for premature mortality, and the mortality rate …

What is the impact of metabolic dysfunction-associated steatotic liver disease (MASLD) on outcomes in people living with chronic hepatitis B (CHB)? An umbrella review protocol.

IntroductionAn estimated 254 million people are living with chronic hepatitis B virus (CHB) and 1.6 billion with metabolic dysfunction-associated steatotic liver disease (MASLD) worldwide. CHB remains a major global health challenge, despite a robust vaccine and suppressive antiviral treatment, and MASLD prevalence is increasing in line with a rise in cardiometabolic risk factors, such as obesity and type 2 diabetes. Thus, understanding the impact of concurrent CHB and MASLD on liver health is important to inform clinical practice and population surveillance. Current literature, including over

Совпадение в полном тексте источника
… Alzheimers Dement. 2017 ; 13 : 406 – 418 . 10.1016/j.jalz.2016.07.152 27599208 38 Belbasis L Bellou V Evangelou E : Environmental risk factors and multiple sclerosis: an umbrella review of systematic reviews and meta-analyses. …

Residential green spaces and neurodegenerative diseases in middle-aged and older adults: a systematic review and dose-response meta-analysis.

BackgroundThe potential protective role of residential green space against neurodegenerative diseases (NDs) is a topic of growing interest, yet evidence remains inconsistent. This systematic review and meta-analysis aimed to synthesize the current evidence on this association in middle-aged and older adults.MethodsWe searched PubMed, Embase, Web of Science, and the Cochrane Library through March 15, 2025, for observational studies that evaluated the association between objectively measured residential green space and the incidence of NDs in middle-aged and older adults. Risk of bias was assess

Совпадение в полном тексте источника
… Additionally, one study [ 49 ] investigated the relationship between residential green space and multiple sclerosis risk. Furthermore, one study [ 48 ] evaluated the association between residential green space and overall neurodegenerative disease risk. …

Создание нового банка тканей нервной системы человека: Дебресенский университет по введению банка тканей и ретроспективному анализу данных.

Ткани головного мозга человека, полученные в результате вскрытия, а также образцы мышц и нерва, полученные в результате биопсии, являются необходимыми ресурсами для изучения патомеханизма нервно-психических расстройств. В этом исследовании мы представляем " Нервусовый системный тканевый банк " Университета Дебрецена, который содержит формализованные и формализованные образцы головного мозга с парафинами (FFPE), а также образцы замороженного нерва и мышечной биопсии. Была создана база данных, содержащая клинические и патологические параметры. В случае вскрытия были зарегистрированы сл

Glial Fibrilar Acidic Protein как знак болезни в повторном многоразовом склерозе: постспециальный анализ испытаний этапа 3 Ozanimod.

В ходе этого постспециального анализа были изучены взаимосвязи между исходным плазменным фиброзным кислотным белоком (GFAP), потенциальным биомаркером множественного склероза (MS) и базовыми характеристиками и результатами обработки у участников с повторной пощечиной MS (RMS) в ходе двух испытаний этапа 3, в ходе которых случайным образом был присвоен озанимод 0,46 мг или 0,92 мг или интерферон β-1a 30 мкг. МЕТОДЫ: На этапе 3 судебных процессов (SUNBEAM [Clinical Processures.gov: NCT02294058; EudraCT: 2014-002320-27] продолжительность: ≥ 12 месяцев; и RADIANS [Clinical Processors.gov: NCT02047

Совпадение в аннотации оригинала
BACKGROUND: This post hoc analysis investigated relationships between baseline plasma glial fibrillary acidic protein (GFAP), a potential biomarker for multiple sclerosis (MS), and baseline characteristics and on-treatment outcomes in participants with relapsing MS (RMS) from two Phase 3 trials that randomly assigned ozanimod 0.46 mg or 0.92 mg or interferon…

Kidney Disease and Hematopoietic Stem Cell Transplantation.

Hematopoietic stem cell transplantation (HSCT) is a potentially curative therapy for patients with hematologic malignancies and certain solid tumors and nonmalignant hematologic conditions. Both AKI and CKD occur commonly after HSCT and are associated with significant morbidity and mortality. AKI and CKD in this setting may result from direct effects of the transplant or be caused by pretransplant bone marrow conditioning regimens and/or nephrotoxic agents administered in the post-transplant period. In this article, we review the epidemiology, risk factors, etiologies, pathophysiology, diagnos

Совпадение в полном тексте источника
… *Particularly for breast cancer, lymphomas other than Hodgkin lymphoma, POEMs, multiple sclerosis. ^TBI-based and busulfan-based. **Systemic, BK virus, CMV, parvovirus B19, adenovirus. …

Оказываешь новую клиническую услугу - что у тебя в лифте?

Люди с множественным склерозом (PwMS) определяют эмоциональное благополучие как одну из ключевых неудовлетворенных потребностей в уходе. Меры, основанные на заботливости, могут повысить эмоциональное благосостояние в ПВМС; вместе с тем отсутствует информация о том, как они применяются в рамках обычного ухода. Лица, оказывающие влияние на политику в области здравоохранения, могут получить критическую информацию о процессе осуществления. Цель этого исследования заключалась в изучении потребностей и приоритетов тех, кто оказывает влияние на политику в области здравоохранения, в деле внедрения МБМ

Совпадение в аннотации оригинала
BACKGROUND: People with multiple sclerosis (PwMS) identify emotional well-being as a key unmet care need. Mindfulness-based interventions (MBI) can improve emotional well-being in PwMS; however, there is a lack of information on their implementation in routine care. Healthcare policy influencers may provide critical insight as to the implementation process. …

Реституция CXCR3+CCR6+T17.1-Like Клетки в ответ на офатумумабскую терапию у пациентов с множественным склерозом.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛИ: Офатумумаб, полностью человек anti-CD20 Моноклональная антитела эффективна в сокращении рецидивов и развития инвалидности у пациентов с множественным склерозом. Цель этого исследования состояла в изучении изменений иммунных характеристик, связанных с атумумабами, у будущей группы китайских пациентов с повторно излучающимся множественным склерозом (RRMS). МЕТОДЫ: Seventeen Пациенты РУМС были зачислены в это неконтролируемое, перспективное когортное исследование наблюдений (ОМНИСКЕННОЕ исследование) и получали регулярное подкожное лечение от атумумаба. Подмножества

Совпадение в аннотации оригинала
BACKGROUND AND OBJECTIVES: Ofatumumab, a fully human anti-CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing-remitting multiple sclerosis (RRMS). MET…

Мелатонин улучшает астроглиоз и микроглиоз в мышечной модели купризоны.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛЬ: В ряде исследований сообщалось, что мелатонин участвует в совершенствовании подстрекательского процесса, совершенствовании функции миелина и регенерации центральной нервной системы (ЦНС). Нынешнее исследование направлено на оценку защитного воздействия мелатонина в кустарной зоне (КХЗ) в результате повреждения миелина в корпусе каллосум (КЦ) и изучение вероятных основополагающих механизмов способности к ремиелинации и/или нейрозащиты.Мы управляли кухонной зоной в чау в одиночестве каждый день. 6 Мы изучали демиэлизацию с помощью пятна LFB, пятна олигодендроцита с

Совпадение в полном тексте источника
… Introduction Multiple sclerosis (MS) is defined as a chronic demyelinating autoimmune disease of the central nervous system (CNS). During this neurodegenerative disorder, aberrant immune responses in the CNS lead to damage to the axon-oligodendrocyte-myelin unit [ 1 ]. …

The regulatory networks and mechanisms of bone microenvironment in tumorigenesis and metastasis.

Bone tumors, encompassing heterogeneous primary and metastatic lesions, are driven in their initiation, progression, and metastasis by dysregulation of the bone microenvironment (BME). Clinically manifested by localized pain, pathological fractures, and neurological deficits, these malignancies substantially threaten patient survival. Radiographic patterns (osteolytic, osteoblastic, mixed) directly reflect pathogenic BME-tumor interactions, particularly involving osteoblast-osteoclast imbalance. The BME-a specialized niche of bone-resident cells (osteocytes, osteoblasts, osteoclasts), immune c

Association between circulating inflammatory proteins and temporomandibular disorders: insight from a two-sample Mendelian randomization analysis.

BackgroundPast studies have indicated links between specific inflammatory proteins in the bloodstream and temporomandibular disorders (TMDs). Nonetheless, there remains the need for further solid research pinpointing the exact causes behind these associations. This Mendelian randomization (MR) study aims to examine the association between 91 circulating inflammatory proteins and TMDs.MethodologyThe most comprehensive genome-wide association studies available for circulating inflammatory proteins and TMDs was used in this two-sample MR analysis. The association between genetic predispositions t

Совпадение в полном тексте источника
… Beyond its involvement in metabolic diseases and cancers, CCL4 plays a role in the development of systemic lupus erythematosus, multiple sclerosis, multiple myeloma, psoriasis, cystic fibrosis, and sarcoidosis. …

Targeting autoimmune mechanisms by precision medicine in Myasthenia Gravis.

Myasthenia Gravis (MG) is a chronic disabling autoimmune disease caused by autoantibodies to the neuromuscular junction (NMJ), characterized clinically by fluctuating weakness and early fatigability of ocular, skeletal and bulbar muscles. Despite being commonly considered a prototypic autoimmune disorder, MG is a complex and heterogeneous condition, presenting with variable clinical phenotypes, likely due to distinct pathophysiological settings related with different immunoreactivities, symptoms' distribution, disease severity, age at onset, thymic histopathology and response to therapies. Cur

Совпадение в полном тексте источника
… Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain . J Exp Med . ( 2007 ) 204 : 2899–912 . doi: 10.1084/jem.20071030 PMC2118531 17984305 37 Croia C Serafini B Bombardieri M Kelly S Humby F Severa M . … Bruton tyrosine kinase inhibitors for multiple sclerosis . Nat Rev Neurol . ( 2023 ) 19 : 289 – 304 . doi: 10.1038/s41582-023-00800-7 37055617 PMC10100639 68 Gomez AM Willcox N Vrolix K Hummel J Nogales-Gadea G Saxena A . …

PROCEEDINGS 32nd Symposium ESVN-ECVN WROCLAW, POLAND 12th-14th September 2019. Selected research communications of the 32nd Symposium of the ESVN-ECVN Wroclaw, Poland 12th to 14th September 2019.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Pharmacological treatments of COVID-19.

The viral infection due to the new coronavirus or coronavirus disease 2019 (COVID-19), which was reported for the first time in December 2019, was named by the World Health Organization (WHO) as Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV2), because of the very similar genome and also its related symptoms to SARS-CoV1. The ongoing COVID-19 pandemic with significant mortality, morbidity, and socioeconomic impact is considered by the WHO as a global public health emergency. Since there is no specific treatment available for SARS-CoV2 infection, and or COVID-19, several clinical and

Совпадение в полном тексте источника
… Fingolimod is the first FDA approved oral drug for the treatment of relapsing–remitting multiple sclerosis (RRMS). S1P down-modulation slows the lymphocytes egress from lymph nodes and its recirculation can inhibit angiogenesis during inflammation. …