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Novel Strategies for Cancer Combat: Drug Combination Using Repurposed Drugs Induces Synergistic Growth Inhibition of MCF-7 Breast and HT-29 Colon Cancer Cells.

Our group developed a new model of drug combination consisting of the use of antineoplastic drugs and different repurposed drugs, having demonstrated that antimalarial and central nervous system (CNS) drugs have a promising anticancer profile as standalone agents, as well as in combined regimens. Here, we evaluated the anticancer profiles of two different CNS drugs (edaravone and quetiapine), both alone and in combination with antineoplastic agents for breast and colon cancer, to explore whether these repurposed drugs could synergistically enhance the anticancer potential of chemotherapeutic d

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… Old Wine in New Bottles: Drug Repurposing in Oncology. Eur. J. Pharmacol. 2020;866:172784. doi: 10.1016/j.ejphar.2019.172784. 10. Verbaanderd C., Meheus L., Huys I., Pantziarka P. Repurposing Drugs in Oncology: Next Steps. Trends Cancer. 2017;3:543–546. doi: 10.1016/j.trecan.2017.06.007. 11. …

An Integrated Health-System Specialty Pharmacy Model for Coordinating Transitions of Care: Specialty Medication Challenges and Specialty Pharmacist Opportunities.

Adherence and persistence to specialty medications are necessary to achieve successful outcomes of costly therapies. The increasing use of specialty medications has exposed several unique barriers to certain specialty treatments' continuation. Integrated specialty pharmacy teams facilitate transitions in sites of care, between different provider types, among prescribed specialty medications, and during financial coverage changes. We review obstacles encountered within these types of transitions and the role of the specialty pharmacist in overcoming these obstacles. Case examples for each type

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… Viswanathan M., Golin C.E., Jones C.D., Ashok M., Blalock S.J., Wines R.C., Coker-Schwimmer E.J., Rosen D.L., Sista P., Lohr K.N. Interventions to improve adherence to self-administered medications for chronic diseases in the United States: A systematic review. Ann. Intern. …

Целые пищевые рационы на основе растений являются практически осуществимыми при автоматическом воздействии на организм человека и связаны с модификацией микробиома в зависимости от дозы.

Целые пищевые рационы, основанные на кратком планете, могут представлять собой целенаправленный подход к смягчению последствий нарушения микробиома и улучшению последствий для пациентов, проходящих аутологическую трансплантацию гематопоиетических клеток (auto-HCT) в случае множественной миеломы, в которой кишечный дисбиоз связан с более низким уровнем выживаемости. Мы провели одностороннее клиническое испытание в нашем центре, в ходе которого участники прошли автоHCT (n = 22) получили свежее, заранее подготовленное, растительное питание 5 Недели, охватывающие кондиционирование, нейтрализацию и

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… Importantly, dietary records show that alcohol intake in this cohort was largely derived from condiments within the study meals (eg, wine vinegars, vanilla), not from beverage consumption, as no alcoholic beverages were reported. …

Неинфекционные заболевания на юго-западе Ирана: профиль и базовые данные из исследования < < Шахрекорд ПЕРСИАН Корт > > .

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Критические межпровинциальные различия в структуре неинфекционных заболеваний (НИЗ) в Иране и трудности, связанные с определением методов профилактики для сокращения смертности от НИЗ, поставили под угрозу осуществление провинциального плана в области здравоохранения. Исследование < < Шахрекорд кохорт > > (СКС) было предназначено для устранения этих пробелов в Чахармахале и Бахтиари, провинции с высокой высотой на юго-западе Ирана, характеризующейся большим населением Бахтиари, а также этническими группами Фарса и Турка. МЕТОДЫ: Эта текущая группа, перспектив

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… Alcohol use was assessed as standard drinks (one standard drink =100ml wine, 285ml beer or 30ml spirit/toddy/arrack). A consumption of at least six and four standard drinks for men and women, respectively, on at least one occasion during the last 30 days, was considered harmful alcohol use. …

The sirtuin family in health and disease.

Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions. Notably, this protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, etc., thus, it is considered a

Large-Scale Plasma Proteomics and Genetic Integration Uncover Novel Biological Pathways in Male Pattern Baldness.

Male pattern baldness (MPB) is a highly prevalent condition with a complex, poorly understood molecular basis that limits therapeutic innovation. This study aimed to bridge the gap between statistical genetic associations and biological function by identifying and prioritizing causal proteins and pathways involved in MPB. Using data from 24,069 men in the UK Biobank, we performed a proteome-wide association study of 2911 plasma proteins with self-reported MPB severity via multivariable ordinal logistic regression, adjusting for age, Body Mass Index (BMI), ethnicity, lifestyle, socioeconomic fa

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… Standard units of alcohol were assigned as follows: 2 units (16 g) per pint of beer/cider, 1.5 units (12 g) per glass of wine or other alcoholic beverages, and 1 unit (8 g) per measure of spirits. …

Fatty acid synthase in chemoresistance: mechanisms and therapeutic opportunities.

Chemoresistance has been a major obstacle to the efficient treatment of cancer. Recently, targeting lipid metabolism has gained significant attention because of its roles not only in promoting cancer progression but also in inducing chemotherapy resistance. Fatty acid synthase (FAS) is the sole enzyme that is in charge of catalyzing the synthesis of palmitate, a long-chain lipid that is essential for membrane construction and post-translational modification in cell biology. Both FAS and its product, palmitate, have been validated as critical players in mediating or causing chemoresistance in c

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… Resveratrol is a natural polyphenol found in grapes, red wine, peanuts, and several berries, known for its antioxidant, anti-inflammatory, and chemopreventive properties and has been identified as an FAS inhibitor ( Pandey et al., 2011 ; Wang et al., 2019 ). …

От профилактики к управлению: изучение воздействия рациона питания на множественный склероз.

Множественный склероз (MS) — хроническое имунное заболевание центральной нервной системы, характеризующееся нейроинфламмацией и прогрессивным нейродегенерацией. Растущие данные свидетельствуют о том, что диетическое вмешательство может влиять на прогресс и управление симптомами MS, изменяя воспаление, окислительный стресс и кишечный микробиотический состав. В настоящем описательном обзоре рассматриваются последствия средиземноморского, растительного, кетогенного, вальса, сванка, периодического постирования и без глютена наряду с такими ключевыми питательными веществами, как жирные кислоты омег

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… RSV, a polyphenol primarily found in grapes and red wine, exerts neuroprotective effects by reducing ROS production via NADPH oxidase inhibition, thereby mitigating oxidative stress and inflammation [ 81 ], as shown in Figure 2 . …

UMIB Summit 2015

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Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits.

Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with improved bioavailability. Polydatin possesses potential biological activities predominantly through the modulation of pivotal signaling pathways involved in inflammation, oxidative stress, and apoptosis. Various imperative biological activities have been suggested for polydatin towards promising therapeutic effects, including anticancer, cardioprotective, anti-diabetic, gastroprotective, hepatoprotective, neuroprotective, anti-microbial, as well as health-promoting roles on the renal system, the respiratory s

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… This phytochemical is also found in other plant sources such as red wine [ 9 ], nuts, vegetables, fruits [ 5 ], hop cones/pellets, and cocoa- and chocolate-containing products [ 10 ]. Polydatin is a glucoside derivative of resveratrol. … Determination of stilbenes (trans-astringin, cis-and trans-piceid, and cis-and trans-resveratrol) in Portuguese wines J. Agric. Food Chem. 1999 47 2666 2670 10.1021/jf9900884 10552542 18. Wang D.-G. Liu W.-Y. Chen G.-T. …

Novel Investigations of Flavonoids as Chemopreventive Agents for Hepatocellular Carcinoma.

We would like to highlight the application of natural products to hepatocellular carcinoma (HCC). We will focus on the natural products known as flavonoids, which target this disease at different stages of hepatocarcinogenesis. In spite of the use of chemotherapy and radiotherapy in treating HCC, patients with HCC still face poor prognosis because of the nature of multidrug resistance and toxicity derived from chemotherapy and radiotherapy. Flavonoids can be found in many vegetables, fruits, and herbal medicines that exert their different anticancer effects via different intracellular signalin

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… The flavonoids are a group of plant secondary metabolites that comprise diverse classes of polyphenolic compounds found in fruits, vegetables, roots, stems, flowers, and beans, as well as beverages such as tea and wine, which can be ingested daily. … It can be used as an ingredient in supplements and beverages (tea, wine, and beer) that have been shown to prevent a variety of human diseases due to their antihypertensive [ 203 ], anti-inflammatory [ 204 ], antioxidant [ 205 ], antimicrobial [ 206 ], antiviral [ 59 ], antiallergic [ 57 ], and antidiabetic …

The Role of Plant-Derived Natural Products as a Regulator of the Tyrosine Kinase Pathway in the Management of Lung Cancer.

One of the most common malignant tumors worldwide is lung cancer, and it is associated with the highest death rate among all cancers. Traditional treatment options for lung cancer include radiation, chemotherapy, targeted therapy, and surgical resection. However, the survival rate is low, and the outlook is still dreadfully dire. The pursuit of a paradigm change in treatment approaches is, therefore, imperative. Tyrosine kinases (TKs), a subclass of protein kinases, regulate vital cellular function by phosphorylating tyrosine residues in proteins. Mutations, overexpression, and autocrine parac

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… The foods rich in apigenin include celery, parsley, artichokes, and oregano, as well as beverages like red wine and beer. The dried flowers of Matricaria recutita L. are used to make chamomile tea, which is a rich source of apigenin. The chamomile flower head contains around 16.8% apigenin [ 130 ]. … It can be found in drinks like coffee, wine, and tea as well as in common medications like propolis [ 189 ]. By increasing ROS levels and compromising mitochondrial function, caffeic acid can cause cancer cells to undergo apoptosis. …

Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation.

Cancer is one of the main causes of death globally and considered as a major challenge for the public health system. The high toxicity and the lack of selectivity of conventional anticancer therapies make the search for alternative treatments a priority. In this review, we describe the main plant-derived natural products used as anticancer agents. Natural sources, extraction methods, anticancer mechanisms, clinical studies, and pharmaceutical formulation are discussed in this review. Studies covered by this review should provide a solid foundation for researchers and physicians to enhance basi

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… Resveratrol in red wine was determined using the online solid-phase extraction HPLC method improved by exerting a novel nanofibrous sorbent [ 44 ]. …

Oxidative Stress in Multiple Myeloma: Pathogenic Mechanisms, Biomarkers, and Redox-Targeted Therapeutic Strategies.

Multiple myeloma (MM) is an incurable plasma cell malignancy characterized by high metabolic activity, chronic endoplasmic reticulum stress, and persistent redox imbalance. Excessive immunoglobulin synthesis and adaptation to the hypoxic bone marrow microenvironment lead to sustained production of reactive oxygen species (ROS). Their excessive accumulation promotes genomic instability, disease progression, osteolytic bone disease, and resistance to therapy. Paradoxically, MM cells adapt to oxidative stress by activating antioxidant and metabolic defense mechanisms, including Nuclear factor ery

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… Sources of this substance include bananas, strawberries, lemons, red wine, and green tea. It possesses strong antioxidant properties due to the presence of three hydroxyl groups attached to the aromatic ring in the ortho position [ 90 , 91 , 92 , 93 ]. …

Olive Leaf Extract (OLE) Anti-Tumor Activities Against Hematologic Tumors: Potential Therapeutic Implications for Pediatric Patients with B-Acute Lymphoblastic Leukemia.

Background/Objectives: Several studies reported that olive leaf extract (OLE) may exert potent anti-cancer activities against human solid and hematological tumors. Such effects are mostly related to the polyphenol oleuropein and its derivatives, which are highly concentrated in OLE. Here, we investigated the anti-tumor effects of OLE in vitro against human acute leukemia and lymphoma cells. Methods: Cell proliferation and apoptosis have been evaluated by flow cytometry (using CFSE and Annexin-V/7AAD, respectively) in the presence or absence of OLE at different concentrations and in combination

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… (Oleaceae) is a characteristic Mediterranean species used to produce olives and oils, representing key components of the traditional Mediterranean diet that includes a high intake of fruit, vegetables, fish, red wine, and extra virgin olive oil (EVOO). …

Hypothetical interventional effect of health behaviors for improving depression symptoms among patients diagnosed with cancer: a g-formula based study.

BackgroundDepressive symptoms are frequently reported among patients undergoing treatment for malignancies and among cancer survivors. However, treatment options for depression in this population remain limited due to significant side effects and suboptimal efficacy. These challenges underscore the urgent need for safe, well-tolerated, and effective strategies to alleviate depressive symptoms in individuals affected by cancer. Therefore, we aimed to evaluate the hypothetical interventional effects of seven lifestyle factors on alleviating depressive symptoms in individuals currently or previou

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… The MED diet is characterized by plant-based foods (fruits, vegetables, legumes and grains), olive oil as the main cooking fat, moderate intake of fish, eggs, poultry and dairy products, low intake of red meat and moderate consumption of red wine [ 53 ]. …

Transplant oncology and anti-cancer immunosuppressants.

Organ transplantation is a life-saving intervention that enhances the quality of life for patients with end-stage organ failure. However, long-term immunosuppressive therapy is required to prevent allogeneic graft rejection, which inadvertently elevates the risk of post-transplant malignancies, especially for liver transplant recipients with a prior history of liver cancer. In response, the emerging field of transplant oncology integrates principles from oncology and immunology to improve outcomes for patients at high risk of tumor occurrence or recurrence following transplantation. Therefore,

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… Metronomic chemotherapy in cancer treatment: new wine in an old bottle. Theranostics. (2024) 14:3548–64. doi: 10.7150/thno.95619 143. Gassmann D, Weiler S, Mertens JC, Reiner CS, Vrugt B, Nageli M, et al. …

Redox Remodeling by Nutraceuticals for Prevention and Treatment of Acute and Chronic Inflammation.

Antioxidant-rich dietary regimens are considered the best practice to maintain health, control inflammation, and prevent inflammatory diseases. Yet, nutraceuticals as food supplements are self-prescribed and purchasable over the counter by healthy individuals for the purpose of beneficial effects on fitness and aging. Hence, the effectiveness, safety, and correct intake of these compounds need to be better explored. Since redox-modulating activity of these compounds appears to be involved in activation and or suppression of immune cells, the preventive use of nutraceuticals is very attractive

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… DAISY epidemiological study (longitudinal) NOD Hu tumor grafts in mice | ▼ T1D Incidence, severity (long-term assumption) | Antioxidant | NOT DESCRIBED | ▼ NF-κB ▼ IL-6, IL-8, TNF-α, IFN-γ ▼ PGE2 ▼ M1 ▼ Th1 EFF / Th17 EFF ▲ IL-10, IL-4 ▼ M2 ▲ Th2 EFF ▲ Treg | [ 40 , 52 , 53 ] Resveratrol | Grapes Red wine …

Antidepressant Drug Sertraline against Human Cancer Cells.

The use of FDA-approved drugs for new indications represents a faster and more economical way to find novel therapeutic agents for cancer therapy, compared to the development of new drugs. Repurposing drugs is advantageous in a pharmacological context since these drugs already have extensive data related to their pharmacokinetics, facilitating their approval process for different diseases. Several studies have reported the promising anticancer effects of sertraline, both alone and combined, in different types of cancer cell lines. Here, we performed a literature review on the anticancer potent

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… Old Wine in New Bottles: Drug Repurposing in Oncology Eur. J. Pharmacol. 2020 866 172784 10.1016/j.ejphar.2019.172784 31730760 4. Prasad V. Mailankody S. Research and Development Spending to Bring a Single Cancer Drug to Market and Revenues After Approval JAMA Intern. …

Resveratrol and Curcumin for Chagas Disease Treatment-A Systematic Review.

Chagas disease (CD) is a neglected protozoan infection caused by Trypanosoma cruzi, which affects about 7 million people worldwide. There are two available drugs in therapeutics, however, they lack effectiveness for the chronic stage-characterized mainly by cardiac (i.e., cardiomyopathy) and digestive manifestations (i.e., megaesophagus, megacolon). Due to the involvement of the immuno-inflammatory pathways in the disease's progress, compounds exhibiting antioxidant and anti-inflammatory activity seem to be effective for controlling some clinical manifestations, mainly in the chronic phase. Re

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… Study of Potential Anti-Inflammatory Effects of Red Wine Extract and Resveratrol through a Modulation of Interleukin-1-Beta in Macrophages. Nutrients. 2018;10:1856. doi: 10.3390/nu10121856. 38. Bononi I., Tedeschi P., Mantovani V., Maietti A., Mazzoni E., Pancaldi C., Brandolini V., Tognon M. …