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The JAK/STAT signaling pathway: from bench to clinic.

The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation. Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases. In this review, we discuss the current knowledge about the composition, activation, and regulation of the JAK/STAT pat

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… including 312 adults with active psoriatic arthritis (PsA) show that ustekinumab (45/90 mg q12 weeks) led to significant and long-term improvement of symptoms/signs, including in patients who had previously received anti-TNF treatment. 345 Pegvisomant, a competitive GH receptor antagonist, is used to treat acromegaly … Pegvisomant is generally used as a second-line therapy and has a high curative effect but the high cost in the treatment of acromegaly. 346 More cytokine/receptor antibodies are being studied, such as anti-IL-4, anti-IL-4R, anti-IL-5R, anti-IL-6R, anti-IL-9, and anti-IL-13. 6 JAK inhibitors JAK inhibitors …

Whole body vibration training during allogeneic hematopoietic cell transplantation-the effects on patients' physical capacity.

Patients undergoing allogeneic hematopoietic cell transplantation (alloHCT) experience a considerable decline in physical and psycho-social capacity. Since whole body vibration (WBV) is known to efficiently stimulate the neuromuscular system and enhance cardiorespiratory fitness and muscle strength in frail individuals, we hypothesized that WBV would maintain various physical and psychological capacities in patients during alloHCT. Seventy-one patients were randomly allocated to either an intervention group (IG) doing WBV or an active control group (CG) doing mobilization exercises five times

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… Pirlich M Schütz T Ockenga J Biering H Gerl H Schmidt B Improved assessment of body cell mass by segmental bioimpedance analysis in malnourished subjects and acromegaly Clin Nutr Edinb Scotl 2003 22 167 174 10.1054/clnu.2002.0617 12706134 56. …

Smart Targeting To Improve Cancer Therapeutics.

Cancer is the second largest cause of death worldwide with the number of new cancer cases predicted to grow significantly in the next decades. Biotechnology and medicine can and should work hand-in-hand to improve cancer diagnosis and treatment efficacy. However, success has been frequently limited, in particular when treating late-stage solid tumors. There still is the need to develop smart and synergistic therapeutic approaches to achieve the synthesis of strong and effective drugs and delivery systems. Much interest has been paid to the development of smart drug delivery systems (drug-loade

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… PEG-Intron ® | Interferon-α2b | 12 | Hepatitis C | 2000 | Schering-Plough/Enzon PEGinterferon-α2a | Pegasys ® | Interferon-α2a | 20 | Hepatitis C | 2001 | Hoffmann-La Roche PEGfilgrastim | Neulasta ® | filgrastim | 20 | Neutropenia | 2002 | Amgen PEGvisomant | Somavert ® | Growth hormone antagonist | 5 | Acromegaly …

Всемирный конгресс по болезням остеопороза, остеоартрита и мускулоскелета 2025).

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Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence.

Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation. Their crucial biological roles dictate the significance of PPAR-targeting synthetic ligands in medical research and drug discovery. Clinical implications of PPAR agonists span across a wide range of health conditions, including metabolic diseases, chronic inflammatory diseases, infections, autoimmune diseases, neurological and psychiatric disorders, and malignancies. In this review we aim to consolidate exist

Целевые стратегии лечения рака цвета кожи: изучение использования аптемеров и золотых нанопчастей.

Рак цвета кожи (КЗК) является второй ведущей причиной смертности от рака и является причиной ~10% из всех случаев рака. По оценкам, во всем мире случаи, связанные с КПР 1.9 million и 930,000 смертями в 2022. Несмотря на расширение доступа к обследованиям и лечению в рамках КПР, ожидается, что показатели смертности резко возрастут в районах с низким уровнем ресурсов, что подчеркивает настоятельную необходимость принятия новаторских мер по лечению в рамках КПР. Текущая химиотерапия создает проблемы, такие, как плохая биодоступность, резистентность к многочисленным лекарствам и негативные побочны

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… Risk factors for CRC include those stipulated for cancer in general, and they are exacerbated by obesity, diabetes mellitus, insulin resistance, acromegaly, and immunosuppression [ 40 ]. …

Primary hyperhidrosis: an updated review.

BACKGROUND: Hyperhidrosis (HH) is a condition characterized by excessive sweating beyond the physiological needs of thermoregulation. HH can be classified as primary (idiopathic) hyperhidrosis (PHH) or secondary hyperhidrosis (SHH), which is associated with underlying medical conditions, medications or systemic disorders. This narrative review provides an updated overview of PHH, with a focus on epidemiology, aetiopathogenesis, clinical manifestations, diagnostic approaches and current management strategies, particularly highlighting pharmacological and procedural treatment options. METHODS:

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… autoimmune/autoinflammatory conditions, malignant disease or medications. 27 These categories and corresponding conditions are summarized in Table 1 . 15 , 28 – 54 , 55 – 83 Table 1 A list of categories and causes of secondary HH. 15 , 28 – 54 , 55 – 83 Category | Conditions Endocrine | Hyperthyroidism, acromegaly …

Oxidative Stress Linking Obesity and Cancer: Is Obesity a 'Radical Trigger' to Cancer?

Obesity is on the rise worldwide, and consequently, obesity-related non-communicable diseases are as well. Nutritional overload induces metabolic adaptations in an attempt to restore the disturbed balance, and the byproducts of the mechanisms at hand include an increased generation of reactive species. Obesity-related oxidative stress causes damage to vulnerable systems and ultimately contributes to neoplastic transformation. Dysfunctional obese adipose tissue releases cytokines and induces changes in the cell microenvironment, promoting cell survival and progression of the transformed cancer

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… Acromegaly and colorectal cancer: A comprehensive review of epidemiology, biological mechanisms, and clinical implications Horm. Metab. Res. 2003 35 712 725 10.1055/s-2004-814150 14710350 65. Caldon C.E. Sutherland R.L. Musgrove E. …

Landscape of small nucleic acid therapeutics: moving from the bench to the clinic as next-generation medicines.

The ability of small nucleic acids to modulate gene expression via a range of processes has been widely explored. Compared with conventional treatments, small nucleic acid therapeutics have the potential to achieve long-lasting or even curative effects via gene editing. As a result of recent technological advances, efficient small nucleic acid delivery for therapeutic and biomedical applications has been achieved, accelerating their clinical translation. Here, we review the increasing number of small nucleic acid therapeutic classes and the most common chemical modifications and delivery platf

2018 ACVIM Forum Research Report Program. Seattle, Washington, June 14 - 16, 2018.

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… Octreotide for Managing Insulin Dysregulation in Horses Nicholas Frank Tufts University, North Grafton, MA, USA Canagliflozin is a sodium‐glucose co‐transporter 2 (SGLT2) inhibitor used to control diabetes mellitus in humans and octreotide is a somatostatin analog prescribed for the treatment of acromegaly …

Advances in Radionuclides and Radiolabelled Peptides for Cancer Therapeutics.

Radiopharmaceutical therapy, which can detect and treat tumours simultaneously, was introduced more than 80 years ago, and it has changed medical strategies with respect to cancer. Many radioactive radionuclides have been developed, and functional, molecularly modified radiolabelled peptides have been used to produce biomolecules and therapeutics that are vastly utilised in the field of radio medicine. Since the 1990s, they have smoothly transitioned into clinical application, and as of today, a wide variety of radiolabelled radionuclide derivatives have been examined and evaluated in various

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… Acromegaly: Molecular Expression of Somatostatin Receptor Subtypes and Treatment Outcome; pp. 129–134. 130. de Herder W.W., Rehfeld J.F., Kidd M., Modlin I.M. A Short History of Neuroendocrine Tumours and Their Peptide Hormones. Best Pract. Res. Clin. Endocrinol. …

CSI position statement on management of heart failure in India.

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Прогресс в развитии лекарственных средств на основе пептида: платформы для доставки, терапевтические средства и вакцины.

Успешное утверждение лекарств на основе пептида можно отнести на счет совместных усилий по целому ряду дисциплин. Интеграция новых методов разработки и синтеза лекарственных средств, отображение библиотечных технологий, систем доставки, достижений в области биоинженерии и искусственного интеллекта в значительной степени ускорила разработку новейших лекарств на основе пептида, эффективно устраняя препятствия, связанные с их характером, такие, как быстрое обезвреживание и деградация, необходимость субколичественной инъекции, ведущей к усилению дискомфорта пациентов, и в конечном итоге продвигая

C-Reactive Protein: Pathophysiology, Diagnosis, False Test Results and a Novel Diagnostic Algorithm for Clinicians.

The current literature provides a body of evidence on C-Reactive Protein (CRP) and its potential role in inflammation. However, most pieces of evidence are sparse and controversial. This critical state-of-the-art monography provides all the crucial data on the potential biochemical properties of the protein, along with further evidence on its potential pathobiology, both for its pentameric and monomeric forms, including information for its ligands as well as the possible function of autoantibodies against the protein. Furthermore, the current evidence on its potential utility as a biomarker of

Cancer status in the Occupied Palestinian Territories: types; incidence; mortality; sex, age, and geography distribution; and possible causes.

Cancer is a disease in which some cells of the body grow uncontrollably and occasionally spread to other parts of the body. With a group of more than 100 different types, cancer can start almost anywhere in the body. Defective cells may form a mass called a tumor which can be cancerous (malignant), which grows and spreads to other parts of the body, or benign that can grow but not spread throughout the body. In 2021, more than 10 million people died of cancer worldwide (1 out of 6 deaths). This paper has thoroughly investigated the cancer status in the Occupied Palestinian Territories (OPT), i

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… overactive) or hypothyroidism (underactive) thyroid; (ii) a family history of thyroid cancer, where the risk is higher if one of close relatives has it; (iii) childhood radiation’s exposure, such as radiation therapy (radiotherapy); (iv) a bowel condition called “Familial Adenomatous Polyposis” (FAP); (v) acromegaly …

Customer-centric product presentations for monoclonal antibodies.

Delivering customer-centric product presentations for biotherapeutics, such as monoclonal antibodies (mAbs), represents a long-standing and paramount area of engagement for pharmaceutical scientists. Activities include improving experience with the dosing procedure, reducing drug administration-related expenditures, and ultimately shifting parenteral treatments outside of a controlled healthcare institutional setting. In times of increasingly cost-constrained markets and reinforced with the coronavirus pandemic, this discipline of "Product Optimization" in healthcare has gained momentum and ch

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… Co-creation of a lanreotide autogel/depot syringe for the treatment of acromegaly and neuroendocrine tumours through collaborative human factor studies. Adv Ther. 2019;36(12):3409–3423. doi: 10.1007/s12325-019-01112-3. Ahmed M, Bankov G, Casey D, Perry ME. …

Transformative Impact of Nanocarrier-Mediated Drug Delivery: Overcoming Biological Barriers and Expanding Therapeutic Horizons.

Advancing therapeutic progress is centered on developing drug delivery systems (DDS) that control therapeutic molecule release, ensuring precise targeting and optimal concentrations. Targeted DDS enhances treatment efficacy and minimizes off-target effects, but struggles with drug degradation. Over the last three decades, nanopharmaceuticals have evolved from laboratory concepts into clinical products, highlighting the profound impact of nanotechnology in medicine. Despite advancements, the effective delivery of therapeutics remains challenging because of biological barriers. Nanocarriers offe

[Guidelines for the diagnosis and treatment of obstructive sleep apnea in adults (2025)].

Obstructive sleep apnea (OSA) is a highly prevalent sleep-related breathing disorder with a considerable healthcare burden. Previously, the … es mellitus, cardiovascular disease, metabolic syndrome, hypothyroidism, polycystic ovary syndrome, acromegaly, neuromuscular diseases, depression, and anxiety; (4) Specific populations, including middle-aged and older men, pregnant women, and postmenopausal women; (5) Individuals with a family history of OSA, particularly those with first-degree relatives a …

Более широкие соображения в отношении интеграции медицинских и стоматологических данных

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Irish Endocrine Society 44th Annual Meeting.

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… This retrospective study was carried out to determine the prevalence of increased IGF-1 levels in patients with prolactinoma/presumed prolactinoma (excluded if acromegaly was the presenting diagnosis). …