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Alignment of preferences in the treatment of multiple myeloma - a discrete choice experiment of patient, carer, physician, and nurse preferences.

BACKGROUND: Multiple Myeloma (MM) is a cancer characterised by the proliferation of malignant plasma cells in the bone marrow. This study examined the treatment preferences of people living with MM compared to the treatment preferences of other groups involved in treatment decision making, including carers, as well as physicians and nurses who treat people living with MM in Australia. METHODS: Data were collected using discrete choice experiments (DCEs) through an online survey. The DCEs presented participants with a traditional treatment generic choice experiment (e.g., treatment A vs treatm

Towards contrast-agnostic soft segmentation of the spinal cord.

Spinal cord segmentation is clinically relevant and is notably used to compute spinal cord cross-sectional area (CSA) for the diagnosis and monitoring of cord compression or neurodegenerative diseases such as multiple sclerosis. While several semi and automatic methods exist, one key limitation remains: the segmentation depends on the MRI contrast, resulting in different CSA across contrasts. This is partly due to the varying appearance of the boundary between the spinal cord and the cerebrospinal fluid that depends on the sequence and acquisition parameters. This contrast-sensitive CSA adds v

MSLesSeg: исходные и контрольные параметры нового набора данных о спектрации множественных склерозов.

В настоящем документе представлен новый общедоступный набор данных МРТ MSLesSeg, предназначенный для проведения исследований в области сегментации множественных склерозов (MS). Этот набор данных включает 115 обследований 75 пациентов, включая последовательности T1, T2 и FLAIR, а также дополнительные клинические данные, собранные из различных источников. В утверждаемых экспертами аннотациях содержатся высококачественные знаки сегментации повреждений, в результате чего для целей сопоставления создается надежный набор данных, помеченных на человека. Часть набора данных была передана экспертам-исс

Искусственный интеллект в педиатрической нейрорадиологии: текущий ландшафт, проблемы и будущие направления.

В настоящем обзоре содержится информация о нынешнем ландшафте искусственного интеллекта (АИ) в области педиатрической и эмбриональной нейрорадиологии, критическая оценка текущей практики, барьеров на пути к клиническому усыновлению и будущего потенциала. Мы искали рецензированные исследования за последнее десятилетие, сфокусировавшись на сегментации изображений, обнаружении повреждений, классификации, прогнозировании и поддержке клинического решения при педиатрической съемке мозга. Особое внимание было уделено уникальным педиатрическим факторам, таким, как развитие мозга и нехватка данных. Мет

Взаимосвязь между моторными и когнитивными характеристиками и кортикальной активностью у пациентов с множественным склерозом: систематический обзор функциональных почти инфракрасных спектроскопических исследований.

Цель настоящего обзора заключалась в изучении взаимосвязи между характеристиками двигателя/когнитива и корковой активностью у лиц с множественным склерозом (МС) в условиях одноразового и двойного назначения с использованием функциональной почти инфракрасной спектроскопии (FNIRS). МЕТОДЫ: Обзор был предварительно зарегистрирован в рамках ПРОСПЕРО (CRD420261402862) и проводился в соответствии с протоколом PRISMA. На систематической основе проводились обыски в библиотеке " Пубмед " , " Кокрейн " и " Web of Science " ; 18 для решения проблем, связанных с four ключевые

The contributions of family care-givers at end of life: A national post-bereavement census survey of cancer carers' hours of care and expenditures.

BackgroundFamily members provide vital care at end of life, enabling patients to remain at home. Such informal care contributes significantly to the economy while supporting patients' preferences and government policy. However, the value of care-givers' contributions is often underestimated or overlooked in evaluations. Without information on the activities and expenditures involved in informal care-giving, it is impossible to provide an accurate assessment of carers' contribution to end-of-life care.AimThe aim of this study was to investigate the contributions and expenditure of informal, fam

Assessing the Therapeutic Role of Rehabilitation Programs in Chemotherapy-Induced Peripheral Neuropathy (CIPN)-A Scoping Review.

Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a common, debilitating side effect of cancer treatment. Characterized by symptoms like pain, numbness, and muscle weakness, CIPN significantly impacts patients' quality of life. Current management strategies vary, with limited consensus on effective treatments. This scoping review aims to explore comprehensive rehabilitation interventions for CIPN, focusing on enhancing patient well-being and functional abilities. Methods: A scoping review, guided by Arksey and O'Malley's framework and Levac et al.'s refinements, was conducted to

Oncology Nursing During a Pandemic: Critical Reflections in the Context of COVID-19.

ObjectivesTo provide a critical reflection of COVID-19 in the context of oncology nursing and provide recommendations for caring for people affected by cancer during this pandemic.Data sourcesElectronic databases, including CINAHL, MEDLINE, PsychINFO, Scopus, professional web sites, and grey literature were searched using Google Scholar.ConclusionNurses are key stakeholders in developing and implementing policies regarding standards of care during the COVID-19 pandemic. This pandemic poses several challenges for oncology services. Oncology nurses are providing a pivotal role in the care and ma

Design for a digital twin in clinical patient care.

Digital Twins hold great potential to personalize clinical patient care, provided the concept is translated to meet specific requirements emerging from established clinical workflows. We present a general and unspecialized Digital Twin design combining knowledge graphs and ensemble learning to reflect the entire patient's clinical journey and assist clinicians in their decision-making. Such a design is predictive, modular, evolving, informed, interpretable and explainable, thus opening broad clinical applications.

Patient and Physician Preferences for Acute Myeloid Leukemia Maintenance Treatments Following Hematopoietic Stem Cell Transplantation.

PurposeThis study assessed and compared preferences for treatment attributes of maintenance therapies post-hematopoietic stem cell transplantation (HSCT) in patients with acute myeloid leukemia (AML) and in physicians who treat these patients.Patients and methodsPatients with AML post HSCT and physicians from the United States, United Kingdom, Canada, and Australia (physicians only) completed a web-based discrete choice experiment (DCE). The DCE used inputs identified via a targeted literature review and qualitative interviews to ascertain relevant treatment attributes and associated levels. S

"Let him die. He caused it": A qualitative study on cancer stigma in Tanzania.

Cancer stigma presents a critical barrier to care seeking, contributing to delayed presentation and poor cancer outcomes worldwide. The burden of cancer in Tanzania is on the rise, with cancer being the third-leading cause of death in the country. Despite rising incidence and poor outcomes of cancer, cancer-related stigma interventions have received low prioritization. There is a need for sound research that focuses on understanding attitudes driving stigma, its impact on care-seeking and treatment adherence, and intervention models to reduce stigma. We used a cross-sectional qualitative study

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… Task-shifting to train community health workers to provide counseling support and screening could improve care for cancer patients, as has been done in child healthcare [ 41 , 42 ] and malarial campaigns [ 43 ]. … Task shifting and task sharing in the health sector in sub-Saharan Africa: evidence, success indicators, challenges, and opportunities. Pan Afr Med J. 2023. Sep 11;46:11. doi: 10.11604/pamj.2023.46.11.40984 42. Gibson E, Zameer M, Alban R, Kouwanou LM. …

The PRO-CAR-T™ study: achieving excellence in patient and public involvement and engagement.

BackgroundPatient and Public Involvement and Engagement (PPIE) is advocated in Patient Reported Outcome (PRO) research, but implementation remains inconsistent and often suboptimal. Many barriers exist, including a lack of understanding about how to apply the principles of PPIE in practice. This paper offers an example of how PPIE can be meaningfully integrated into the development of a digital PRO system within the complex and rapidly evolving field of advanced therapies. The aims are to offer practical insights about how PPIE was conceptualised and operationalised in the context of this stud

Воздействие совместных мероприятий на популяризацию пожилых людей: систематический обзор и метаанализ.

Справочная информация/задачи: Сочетание учений с когнитивной подготовкой (комбинированное вмешательство) является стратегией борьбы с обусловленным возрастом когнитивным упадком; однако по-прежнему не ясно, какой из наиболее оптимальных видов упражнений необходим для максимального повышения нейрозащитного воздействия комбинированного вмешательства. Таким образом, цель этого систематического обзора и метаанализа (СРПД) состояла в том, чтобы сопоставить воздействие комбинированных мероприятий (активизация плюс когнитивная подготовка) с воздействием только физических упражнений на когнитивную фун

Прогнозирование неблагоприятных явлений для стратификации риска химиотерапии на основе мобилизации стволовых клеток в множестве миеломы.

Автологическая трансплантация стволовых клеток является фундаментальной терапией для множественных миелом. Хотя стационарная химическая мобилизация стволовых клеток (КЦМ) является в Германии стандартной системой ухода, амбулаторные подходы могут облегчить проблемы, связанные с медицинским обслуживанием. Мы проанализировали 109 Пациенты миэломы проходят курс SCM и коллекционируются в медицинском центре Университета Геттингена на предмет безопасности. Затем мы подготовили модели машинного обучения для прогнозирования неблагоприятных явлений (АЭ), требующих госпитализации, и прогнозирования сроко

DANCE Rehabilitation EXperience (DANCEREX-DTx): Protocol for a randomized controlled trial on effectiveness of digital therapeutics in chronic neurological disabilities.

OBJECTIVE: Rehabilitation is an important player in preventing and reducing the high impact of disability on everyday functioning in chronic neurological diseases (CNDs), especially if timely, intensive, and multidimensional. However, to date, rehabilitation is often a service accessible only to a few people, and the issue of a progressive decrease in treatment adherence still remains to be addressed. This study protocol describes an RCT whose aim is to test the effectiveness in terms of adherence of DANCE Rehabilitation EXperience (DANCEREX-DTx), a new digital therapeutic solution which combi

Cancer Research in the Time of COVID-19: A Colombian Narrative.

Cancer research is deficient in Colombia and efforts and resources diverted due to the COVID-19 pandemic could worsen the situation. We explore the impact of the pandemic on cancer research funding, output, and conduct. We sought information at national level and used the experience of an academic reference center to contrast the impact at institutional level. We searched databases and official documents of national governmental institutions, trial registries, hospital registries, and the Web of Science. We interviewed principal investigators (PIs) to retrieve information on the conduct of can

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… One member of the research team carried out a manual classification regarding impact of workload and task shifting, development and approval of research proposals, difficulties in operational issues, and patient adherence and follow-up. …

Demographic shift disproportionately increases cancer burden in an aging nation: current and expected incidence and mortality in Hungary up to 2030.

BACKGROUND: Population aging is a common demographic pattern in developed countries, and aging increases the risk of cancer. The disproportionately high cancer burden, as a consequence, is especially pronounced in Central and Eastern European countries, including Hungary. METHODS: We summarized current and projected future cancer incidences and mortalities utilizing data from the last two decades. Predictions are based on cancer incidence and mortality collected between 1996 and 2015 in Hungary. In addition to the crude rates, data were age standardized to the European standard population (ES

Ensuring the Safety of Hospitalized Oncology Patients During a Pandemic.

Patients with hematologic malignancies present a unique set of circumstances during the COVID-19 pandemic; they are at increased risk of complications and death from COVID-19 infection, but the treatment of their cancer cannot be delayed. This article highlights some of the practice changes made by an inpatient hematology/oncology advanced practice provider team at a large academic institution in Philadelphia, Pennsylvania, at both a hospital-wide and service level. Practice changes have included restructuring the rounding process, imposing visitor restrictions, adjusting blood transfusion par

HERV Dys Regulation в деле Myalgic Encephalomyelitis и Multic Sclerosis Responsive to Rituximab.

В этой статье резюмируется случай, когда 30-летний мужчина диагностировал синдром мальгического энцефаломелита/хронического утомительного синдрома (ME/CFS) и его продольный слежение, в результате чего через восемь лет был диагностирован множественный склероз (MS). Наиболее ощутимым результатом стала его реакция на ритуксимаб после систематического отказа в предварительном лечении. Хотя выражение эндогенных ретровирусных белков ассоциируется с автоиммунитетом, пациент не продемонстрировал более широкое выражение токсичного белка HERV (человеческий ретровирус)-W ENV, который является целью текущ

Impact of integrated teaching-learning method on oncology clinical decision-making ability and cognitive learning of nursing students.

BackgroundInnovative and student-centered teaching methods are required to improve critical thinking and clinical reasoning skills. The objective of this study was to determine the impact of an oncology internship training on learning outcomes of nursing students using an integrated teaching-learning method.MethodsA pre- and post-test quasi-experimental study was conducted among 107 undergraduate nursing students in fourth year who were allocated to two groups (intervention group = 51 and control group = 55) to receive an integrated teaching-learning method and routine method respectively. Dat