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The Power of Phytochemicals Combination in Cancer Chemoprevention.

Conventional therapies for cancer treatment have posed many challenges, including toxicity, multidrug resistance and economic expenses. In contrast, complementary alternative medicine (CAM), employing phytochemicals have recently received increased attention owing to their capability to modulate a myriad of molecular mechanisms with a less toxic effect. Increasing evidence from preclinical and clinical studies suggest that phytochemicals can favorably modulate several signaling pathways involved in cancer development and progression. Combinations of phytochemicals promote cell death, inhibit c

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… Resveratrol Resveratrol, a phytoalexin extracted from grapes, red wine, peanuts and berries with highest concentrations is found in Japanese knotweed ( Polygonum cuspidatum ) is a powerful antioxidant. …

Isolated Lesser Trochanter Fractures in Adults: A Systematic Review of Malignant, Infectious, and Benign Etiologies.

Isolated lesser trochanter (LT) fractures are uncommon in adults and may be the first clue to an underlying pathologic process. In contrast to adolescent apophyseal avulsions, the same finding in a skeletally mature patient has been linked to metastatic disease, primary bone tumors, hematologic malignancy, infection, and, less often, benign traumatic, stress-related, osteoporotic, or metabolic causes. This review examined the malignant, infectious, and benign etiologies, diagnostic pathways, treatments, and outcomes that have been reported in adults aged 18 years or older presenting with a rad

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… Outcome: NR Gradwohl and Mailliard, 1987 [ 27 ] | 61/M | Severe cough after aspiration while drinking wine. …

Immunogenicity to biological drugs in psoriasis and psoriatic arthritis.

Monoclonal antibodies or fusion proteins, defined as biological drugs, have modified the natural history of numerous immune-mediated disorders, allowing the development of therapies aimed at blocking the pathophysiological pathways of the disease, providing greater efficacy and safety than conventional treatment strategies. Virtually all therapeutic proteins elicit an immune response, producing anti-drug antibodies (ADAs) against hypervariable regions of immunoglobulins. Immunogenicity against biological drugs can alter their pharmacokinetic and pharmacodynamic properties, thereby reducing the

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… Vaisman-Mentesh A, Gutierrez-Gonzalez M, DeKosky BJ, Wine Y. The Molecular Mechanisms That Underlie the Immune Biology of Anti-drug Antibody Formation Following Treatment with Monoclonal Antibodies. Front Immunol. 2020;11:1951. doi: 10.3389/fimmu.2020.01951. 2. Kamata M, Tada Y. …

Potential Therapeutic Targets of Resveratrol, a Plant Polyphenol, and Its Role in the Therapy of Various Types of Cancer.

Cancer is among the most prominent causes of mortality worldwide. Different cancer therapy modes employed, including chemotherapy and radiotherapy, have been reported to be significant in cancer management, but the side effects associated with these treatment strategies are still a health problem. Therefore, alternative anticancer drugs based on medicinal plants or their active compounds have been generating attention because of their less serious side effects. Medicinal plants are an excellent source of phytochemicals that have been recognized to have health-prompting effects through modulati

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… Moreover, it is a well-known component of grapes and wines that contain it in modest concentration [ 5 , 6 ]. It is a member of the stilbene family [ 7 ], with two phenol rings that are joined by an ethylene bridge. …

Targeting Histone Deacetylases: Opportunities for Cancer Treatment and Chemoprevention.

The dysregulation of gene expression is a critical event involved in all steps of tumorigenesis. Aberrant histone and non-histone acetylation modifications of gene expression due to the abnormal activation of histone deacetylases (HDAC) have been reported in hematologic and solid types of cancer. In this sense, the cancer-associated epigenetic alterations are promising targets for anticancer therapy and chemoprevention. HDAC inhibitors (HDACi) induce histone hyperacetylation within target proteins, altering cell cycle and proliferation, cell differentiation, and the regulation of cell death pr

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… Chrysin (5,7-dihydroxyflavone) is a naturally occurring flavone belonging to a group of polyphenolic compounds found in mushrooms, olive oil, tea, red wine, and passion fruit flowers, as well as Thai propolis and honey, which exerts antitumor activities on various cancer cell types [ 48 , 179 , 180 ] … Resveratrol (3,5,4′-trihydroxytrans-stilbene) is a naturally occurring nonflavonoid stilbene polyphenol compound in grapes and wine, with cancer chemoprevention properties, because of its multitargeting activities on cancer initiation, promotion, and progression [ 182 , 193 , 194 ]. …

Educational Case: Atypical presentation of primary hyperparathyroidism with brown tumor.

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… Her social history is noncontributory as she has never smoked, enjoys one glass of red wine weekly, and does not use marijuana or other recreational drugs. …

Targeting the Endocannabinoidome in Pancreatic Cancer.

Pancreatic Ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, is an aggressive and lethal form of cancer with a very high mortality rate. High heterogeneity, asymptomatic initial stages and a lack of specific diagnostic markers result in an end-stage diagnosis when the tumour has locally advanced or metastasised. PDAC is resistant to most of the available chemotherapy and radiation therapy treatments, making surgery the most potent curative treatment. The desmoplastic tumour microenvironment contributes to determining PDAC pathophysiology, immune response and therapeutic

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… Lysophosphatidylinositol signalling: New wine from an old bottle. Biochim. et Biophys. Acta (BBA)-Mol. Cell Biol. Lipids. 2012;1821:694–705. doi: 10.1016/j.bbalip.2012.01.009. 40. Ueda N., Tsuboi K., Uyama T. …

Lifestyle considerations in multiple myeloma.

As the prognosis for multiple myeloma (MM) has significantly improved and patients remain on therapy longer, there is a need for supportive care interventions to optimize patient quality of life (QOL) and functional status over the course of cancer treatment. MM is characterized by a significant symptom burden and a relatively lower QOL compared to other cancers. This review evaluates the role of healthy lifestyle behaviors in improving both the physical functioning and psychological well-being of the MM population. We (1) describe the current literature on physical activity, weight management

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… This association was seen across different alcoholic beverages such as beer, wine, and liquor and did not differ when adjusted for smoking status, BMI, or education. …

Стратегии охраны мозга у лиц среднего возраста с незначительным нейрокогнитивным расстройством: аналитическая оценка.

Здравоохранение мозга означает оптимальное функционирование и целостность мозга, определяемые сложными когнитивными, психологическими и социальными детерминантами. Лица с легким нейрокогнитивным расстройством (mNCD) подвергаются повышенному риску развития слабоумия. Первостепенное состояние мозга имеет важное значение на протяжении всей жизни, особенно в период среднего возраста, когда риск для здоровья часто возникает наряду с тяжелыми жизненными обязанностями. В международных рамочных программах особое внимание уделяется изменению факторов риска на протяжении всей жизни в целях снижения риск

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… Cultural specificity was largely inferred and adapted through local adaptation, such as the Chinese-adapted MIND diet, which accounts for the traditional consumption of freshwater fish [ 42 ], in contrast to Western staples such as wine, dairy, and olive oil [ 50 ]. …

Computational study of SENP1 in cancer by novel natural compounds and ZINC database screening.

Introduction: Sentrin-specific protease 1 (SENP1) is a protein whose main function is deSUMOylation. SENP1 inhibits apoptosis, and increases angiogenesis, estrogen and androgen receptor transcription and c-Jun transcription factor, proliferation, growth, cell migration, and invasion of cancer. The in vivo and in vitro studies also demonstrated which natural compounds, especially phytochemicals, minerals, and vitamins, prevent cancer. More than 3,000 plant species have been reported in modern medicine. Natural compounds have many anti-cancerous andanti-turmeric properties such as antioxidative,

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… In addition, resveratrol is a popular part of grapes and wines ( Poulsen et al., 2015 ). It has been reported that resveratrol has cytotoxic effects against several tumor cells such as myeloid, lymphoid, breast, colon, cervix, skin, stomach, ovary, prostate, liver, and thyroid carcinoma cells. …

Targeting the proteasome in cancer therapy: development and future opportunities in natural products.

BACKGROUND: The ubiquitin-proteasome pathway is a critical therapeutic target in malignancies, particularly multiple myeloma. The development of proteasome inhibitors (PIs) has marked a milestone in multiple myeloma therapy and now constitutes the backbone of frontline treatment regimens. However, primary and acquired resistance remain a major challenge, underscoring the need to identify new PIs as well as agents that can resensitize resistant cells. METHOD: This review provides an overview of the current clinical applications of PIs and offers a comprehensive summary of natural products that

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… (G) Structure of resveratrol, a polyphenolic stilbene found in grapes ( Vitis vinifera L.) and red wine, was demonstrated. (H) Structure of curcumin, isolated from Curcuma longa L., was demonstrated. (I) Structure of caffeic acid, a constituent of propolis extracts, was demonstrated. … Resveratrol ( Figure 11G ), a polyphenolic stilbene found in grapes ( Vitis vinifera L.) and red wine, exhibited biphasic effects: at low concentrations, it protected against MG132-, PSI-, lactacystin-, and epoxomicin-induced cytotoxicity ( Niu et al., 2011 ), whereas at high concentrations, it synergized …

Cancer Chemoprevention: A Strategic Approach Using Phytochemicals.

Cancer chemoprevention approaches are aimed at preventing, delaying, or suppressing tumor incidence using synthetic or natural bioactive agents. Mechanistically, chemopreventive agents also aid in mitigating cancer development, either by impeding DNA damage or by blocking the division of premalignant cells with DNA damage. Several pre-clinical studies have substantiated the benefits of using various dietary components as chemopreventives in cancer therapy. The incessant rise in the number of cancer cases globally is an issue of major concern. The excessive toxicity and chemoresistance associat

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… Resveratrol Resveratrol (3, 4′, 5-trihydroxystilbene), is a natural polyphenolic stilbene and common phytoalexin which is present mainly in grape skin, red wine, mulberries, blueberries, pistachio and peanuts. … Bioactive Compounds and Metabolites from Grapes and Red Wine in Breast Cancer Chemoprevention and Therapy. Molecules 25 (15), 3531. 10.3390/molecules25153531 Fiedler M. A., Wernke-Dollries K., Stark J. M. (1998). …

Regulation of microRNAs by natural agents: new strategies in cancer therapies.

MicroRNAs (miRNAs) are short noncoding RNA which regulate gene expression by messenger RNA (mRNA) degradation or translation repression. The plethora of published reports in recent years demonstrated that they play fundamental roles in many biological processes, such as carcinogenesis, angiogenesis, programmed cell death, cell proliferation, invasion, migration, and differentiation by acting as tumour suppressor or oncogene, and aberrations in their expressions have been linked to onset and progression of various cancers. Furthermore, each miRNA is capable of regulating the expression of many

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… Quercetin, a flavonoid found in onions, apples, tea, and red wine, upregulated miR-142-3p in pancreatic ductal adenocarcinoma cells (MIA PaCa-2, Capan-1, and S2-013). Overexpression of miR-142-3p inhibited cell proliferation and reduced the expression of its target, heat-shock protein 70 (HSP7). …

Минимально инвазивное плазменное устройство для борьбы с множественным раком кожи Бенигена, связанное с сериями Rare Gendermatoses-Cases, и обзор терапевтических методов.

Фон: Немеланоцитические доброкачественные опухоли кожи включают в себя разнообразную группу повреждений, классифицированных по признаку их клеточного происхождения, таких, как эпидермальные, сосудистые, волокнистые, нейронные, мышечные и аднексальные опухоли. Хотя они часто обнаруживают повреждения в одиночестве, многочисленные опухоли кожи сосредотачиваются на генодерматозах. Каждый синдром обладает различными клиническими характеристиками и потенциальными осложнениями, включая категорические и внекачественные недуги, некоторые из которых могут представлять опасность для жизни. Диагнозные ген

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… Wine Lee L. Phacomatosis Pigmentokeratotica: A Mosaic RASopathy with Malignant Potential Pediatr. Dermatol. 2017 34 352 355 10.1111/pde.13119 28523882 16. Shah R.R. Allman P. Schwartz R.A. Muir–Torre Syndrome: A Cutaneous Finding Amidst Broader Malignancies Am. J. Clin. …

Cardiotoxicity of Novel Targeted Hematological Therapies.

Chemotherapy-related cardiac dysfunction, also known as cardiotoxicity, is a group of drug-related adverse events negatively affecting myocardial structure and functions in patients who received chemotherapy for cancer treatment. Clinical manifestations can vary from life-threatening arrythmias to chronic conditions, such as heart failure or hypertension, which dramatically reduce quality of life of cancer survivors. Standard chemotherapy exerts its toxic effect mainly by inducing oxidative stress and genomic instability, while new targeted therapies work by interfering with signaling pathways

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… Resveratrol, a red wine antioxidant, reduces atrial fibrillation susceptibility in the failing heart by PI3K/AKT/eNOS signaling pathway activation Heart Rhythm. 2015 12 1046 1056 10.1016/j.hrthm.2015.01.044 25640634 30. Li M. Sala V. De Santis M.C. Cimino J. Cappello P. Pianca N. Di Bona A. …

Resveratrol Nanoformulations for Cancer Management: A Comprehensive Review of Disease-Specific Strategies and Clinical Translational Barriers.

Cancer remains a leading cause of mortality worldwide, highlighting the need for therapeutic strategies that reduce systemic toxicity and drug resistance. Resveratrol (RES), a natural polyphenolic stilbenoid, possesses antioxidant, anti-inflammatory, pro-apoptotic, anti-metastatic, and chemosensitizing activities. However, its clinical translation is limited by poor aqueous solubility, chemical instability, rapid metabolic clearance, and consequently low systemic bioavailability. Nanotechnology-based drug delivery systems provide a promising strategy to address these limitations. This review s

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… In modern pharmacology, interest in RES was further stimulated by the “French Paradox” hypothesis, which proposed an association between moderate red wine consumption and reduced cardiovascular risk despite diets rich in saturated fat. 12 Structurally, RES contains two phenolic rings linked by a styrene …

Skin cancer: understanding the journey of transformation from conventional to advanced treatment approaches.

Skin cancer is a global threat to the healthcare system and is estimated to incline tremendously in the next 20 years, if not diagnosed at an early stage. Even though it is curable at an early stage, novel drug identification, clinical success, and drug resistance is another major challenge. To bridge the gap and bring effective treatment, it is important to understand the etiology of skin carcinoma, the mechanism of cell proliferation, factors affecting cell growth, and the mechanism of drug resistance. The current article focusses on understanding the structural diversity of skin cancers, tr

Histone modifications across cancers: mechanisms, therapy and clinical translation.

Cancer continues to be a major cause of death across the globe, and epigenetic dysregulation, including histone modifications, has been recognized as a major hallmark of cancer development, heterogeneity, and drug resistance. This review seeks to offer an overview of histone modifications in cancer, including the more studied histone modifications such as acetylation and methylation, as well as the less explored histone modifications such as phosphorylation, ubiquitination, and glycosylation. It also examines the role of histone modifications in the dysregulation of the three categories of enz

Leveraging Dietary Interventions to Benefit Patients with Hematologic Malignancies and Clonal Hematopoiesis.

Diet is a modifiable factor that influences multiple pathways relevant to hematologic malignancy, including systemic inflammation, immune cell activity, gut microbiota composition, and cancer cell metabolism. Translation of preclinical findings into clinical practice for hematologic malignancies remains nascent, although momentum is building to evaluate dietary interventions as a component of supportive and disease-modifying care. This review examines the mechanistic rationale for dietary interventions across the spectrum of clonal hematologic disorders and synthesizes current clinical evidenc

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… Distribution | Duration/Timing in Clinical Use | Proposed Mechanism in Heme Malignancy | Hematologic Application Mediterranean | Extra-virgin olive oil as principal fat; ≥3 servings fruit/day; ≥2 servings vegetables/day; ≥3 servings legumes/wk; ≥3 servings fish/wk; nuts ≥ 3 servings/wk; moderate red wine …

Systemic complications of rheumatoid arthritis: Focus on pathogenesis and treatment.

As a systemic autoimmune disease, rheumatoid arthritis (RA) usually causes damage not only to joints, but also to other tissues and organs including the heart, kidneys, lungs, digestive system, eyes, skin, and nervous system. Excessive complications are closely related to the prognosis of RA patients and even lead to increased mortality. This article summarizes the serious complications of RA, focusing on its incidence, pathogenesis, clinical features, and treatment methods, aiming to provide a reference for clinicians to better manage the complications of RA.

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… Some SIRT1 activators, such as resveratrol, a polyphenol found in wine, have been extensively studied as SIRT activators and they exhibit potent antioxidant, anti-inflammatory and anti-cancer properties ( 61 ). …