Результаты поиска

Окисляющий стресс и воспаление в патогенезе неврологических расстройств: механизмы и последствия.

Нейрозащита — это активный подход к защите нервной системы, включая мозг, спинной мозг и периферийные нервы, путем предотвращения или ограничения повреждения нервных клеток и других компонентов. Она защищает центральную нервную систему от повреждений от острых и прогрессивных нейродегенеративных расстройств. Окисляющий стресс, дисбаланс между естественными механизмами защиты тела и образованием реактивных видов кислорода, имеет решающее значение для развития неврологических расстройств. Из-за высокой скорости метаболизма и потребления кислорода мозг особенно уязвим к окисляющему стрессу. Чрезм

Совпадение в полном тексте источника
… The attention of scholars in academia and industry has been captivated by the antioxidant capacity found in natural products to prevent age-related diseases. Mitochondria-targeted antioxidants have great potential against the damage caused by ROS generation. …

Development and application of decatungstate catalyzed C-H 18F- and 19F-fluorination, fluoroalkylation and beyond.

Over the past few decades, photocatalytic C-H functionalization reactions have received increasing attention due to the often mild reaction conditions and complementary selectivities to conventional functionalization processes. Now, photocatalytic C-H functionalization is a widely employed tool, supporting activities ranging from complex molecule synthesis to late-stage structure-activity relationship studies. In this perspective, we will discuss our efforts in developing a photocatalytic decatungstate catalyzed C-H fluorination reaction as well as its practical application realized through co

Совпадение в полном тексте источника
… We hope our experiences in developing both practical and scalable processes will inspire wider uptake and highlight the benefits of industry-academia collaborations to support basic reaction discovery that can often translate in unexpected ways. …

Use of Real-World Evidence to Drive Drug Development Strategy and Inform Clinical Trial Design.

Interest in real-world data (RWD) and real-world evidence (RWE) to expedite and enrich the development of new biopharmaceutical products has proliferated in recent years, spurred by the 21st Century Cures Act in the United States and similar policy efforts in other countries, willingness by regulators to consider RWE in their decisions, demands from third-party payers, and growing concerns about the limitations of traditional clinical trials. Although much of the recent literature on RWE has focused on potential regulatory uses (e.g., product approvals in oncology or rare diseases based on sin

Совпадение в полном тексте источника
… TrendyGenes, a computational pipeline for the detection of literature trends in academia and drug discovery. Sci. Rep. 11, 15747 (2021). 82. Ochsner, S.A. et al . The Signaling Pathways Project, an integrated ‘omics knowledgebase for mammalian cellular signaling pathways. Sci. …

An exploration of person-centred approach in end-of-life care policies in England and Japan.

BackgroundIncreasing evidence has suggested that a person-centred approach (PCA) is beneficial not only for improving care outcomes but also for mitigating the pressure on public health systems. However, policy implementation gaps have prevented the translation of this complex framework into useful practical, ethical and moral stances for end-of-life care (EOLC). This article aims to explore the meaning and implications of person-centredness in EOLC policy discourses.MethodsBy perceiving policy documents as a medium embodied with socio-political and cultural norms, we analysed how PCA in EOLC

Совпадение в полном тексте источника
… Taking a critical approach, we drew upon evidence from academia and wider society to further question these policy constructs of PCA within the complex structural and individual circumstances of EOLC (where the policies are made and implemented). …

Emerging Strategies Targeting Catabolic Muscle Stress Relief.

Skeletal muscle wasting represents a common trait in many conditions, including aging, cancer, heart failure, immobilization, and critical illness. Loss of muscle mass leads to impaired functional mobility and severely impedes the quality of life. At present, exercise training remains the only proven treatment for muscle atrophy, yet many patients are too ill, frail, bedridden, or neurologically impaired to perform physical exertion. The development of novel therapeutic strategies that can be applied to an in vivo context and attenuate secondary myopathies represents an unmet medical need. Thi

Совпадение в полном тексте источника
… Protacs: Great Opportunities for Academia and Industry Signal Transduct. Targeted Ther. 2019 4 10.1038/s41392-019-0101-6 PMC6927964 31885879 125. Polge C. Cabantous S. Deval C. Claustre A. Hauvette A. Bouchenot C. Aniort J. Béchet D. Combaret L. Attaix D. …

Chemical Patterns of Proteasome Inhibitors: Lessons Learned from Two Decades of Drug Design.

Drug discovery now faces a new challenge, where the availability of experimental data is no longer the limiting step, and instead, making sense of the data has gained a new level of importance, propelled by the extensive incorporation of cheminformatics and bioinformatics methodologies into the drug discovery and development pipeline. These enable, for example, the inference of structure-activity relationships that can be useful in the discovery of new drug candidates. One of the therapeutic applications that could benefit from this type of data mining is proteasome inhibition, given that mult

Совпадение в полном тексте источника
… However, despite some advances from academia and the pharmaceutical industry, more than fifteen years have passed since United States Food and Drug Administration (FDA) approval of the first proteasome inhibitor to treat MM and MCL. …

The management of type 2 inflammatory respiratory diseases: a Chinese expert consensus [2024].

BackgroundType 2 (T2) inflammatory respiratory diseases encompass a range of conditions characterized by inflammation affecting the airways and lung parenchyma, with their pathogenesis rooted in T2 inflammation. Biological treatments that mitigate T2 inflammation revolutionize the therapeutic landscape for these respiratory diseases. However, there are decision-making difficulties in terms of the target population, timing of initiation, and type selection for biological targeted therapy.MethodsSearch strategies were focused on relevant issues related to T2 inflammatory respiratory diseases fro

Совпадение в полном тексте источника
… Acta Academiae Medicinae Sinicae 2018 ; 40 : 170 - 7 . 10.3881/j.issn.1000-503X.2018.02.006 29724306 152 Lin RY Santiago TP Patel NM . Favorable response to asthma-dosed subcutaneous mepolizumab in eosinophilic pneumonia. …

Next-Generation HDAC Inhibitors: Advancing Zinc-Binding Group Design for Enhanced Cancer Therapy.

Histone deacetylases (HDACs) are pivotal epigenetic regulators that control gene expression, cell proliferation, and differentiation, and their dysregulation is closely associated with the onset and progression of multiple cancers. The therapeutic importance of these enzymes is reflected by FDA approval of HDAC inhibitors for oncology indications. Despite this clinical success, most FDA-approved agents employ conventional zinc-binding groups (ZBGs) such as hydroxamic acid and 2-aminoanilide, which are frequently linked to metabolic instability, genotoxicity, and poor pharmacokinetic behavior.

Совпадение в полном тексте источника
… HDAC-Based Dual-Target Inhibitors Over the past five years, increasing attention from both academia and industry has been directed toward the development of isoform-selective HDACi and HDAC-based dual inhibitors (hydroximate and non-hydroximate-based scaffolds) that simultaneously modulate HDACs and …

An overview of randomized phase III clinical trials of cancer nanomedicines.

BackgroundCancer therapy has undergone significant advances in recent decades attributed to personalized medicine and targeted drug delivery. Among the promising approaches, the use of nano-based delivery systems has become a relevant approach capable of improving treatment by releasing antineoplastic drugs at the target site, improving therapeutic efficacy, minimizing cytotoxicity in healthy tissues, and ultimately, reducing the intensity of adverse effects of chemotherapy. This study prospectively evaluated the impact of formulating anti-neoplastic drugs as nanomedicines on clinical response

Совпадение в полном тексте источника
… The complex nature of nanomedicine formulations necessitates streamlined regulatory frameworks and robust manufacturing processes to ensure quality, safety, and consistency. 23 Collaboration between academia, industry, and regulatory bodies is essential to establish standardized guidelines and facilitate …

Beyond Formulation: Contributions of Nanotechnology for Translation of Anticancer Natural Products into New Drugs.

Nature is the largest pharmacy in the world. Doxorubicin (DOX) and paclitaxel (PTX) are two examples of natural-product-derived drugs employed as first-line treatment of various cancer types due to their broad mechanisms of action. These drugs are marketed as conventional and nanotechnology-based formulations, which is quite curious since the research and development (R&D) course of nanoformulations are even more expensive and prone to failure than the conventional ones. Nonetheless, nanosystems are cost-effective and represent both novel and safer dosage forms with fewer side effects due to m

Совпадение в полном тексте источника
… The clinical development of paclitaxel: A successful collaboration of academia, industry and the national cancer institute. Oncologist. 1996;1:240–243. doi: 10.1634/theoncologist.1-4-240. 13. Henry D.W. Cancer Chemotherapy. Volume 30. ACS Publications; Washington, DC, USA: 1976. …

[Conceptualization of Narrative Bioethics in Healthcare].

Ethical dilemmas in real-world medical settings expose the limitations of bioethics,represented by the "four-principle framework," in dynamic and personalized clinical decision-making.The development of narrative medicine provides more space for showcasing the unique context of life,alleviating the predicament of normative ethics.However,current ethical practices in narrative medicine have not responded to the theoretical problem of the lack of ontology,moral subject,and reflective process in principlism,calling for the further exploration of the moral issues inherent in the narrative process

Anatomical and Morphological Structure of the Lesser Occipital Nerve.

Objective To characterize the anatomical features of the lesser occipital nerve，thereby providing an applied anatomical basis for cervical neuralgia and local surgical procedures. Methods This study included both left and right sides of 40 adult formalin-fixed adult human specimens，totaling 80 sides.Routine incision was adopted in the dissection of lateral cervical region and the sternocleidomastoid region. Results The dissection rate of the lesser occipital nerve was 100%.Specifically，67.5%，25.0%，and 7.5% originated from the anterior branch of the third cervical nerve，the ansa cervicalis of t

Precursor B-Cell Acute Lymphoblastic Leukemia With PICALM∶∶MLLT10 Fusion Gene Positivity:Report of One Case and Literature Review.

PICALM∶∶MLLT10 fusion gene-positive precursor B-cell acute lymphoblastic leukemia(pro-B-ALL)is clinically rare.This article reports the case of a 29-year-old female patient who presented a mediastinal mass.Diagnostic investigations confirmed PICALM∶∶MLLT10 fusion gene-positive pro-B-ALL.The patient sequentially received radiotherapy and multiple lines of chemotherapy but developed short-term drug resistance and lineage change,progressing to mixed-phenotype acute leukemia.A review of relevant literature was conducted to analyze its pathogenesis and molecular characteristics,aiming to provide re

Mitochondria and Liver Cancer.

The high incidence and mortality rates of liver cancer necessitate in-depth exploration of its pathogenesis and therapeutic strategies.Mitochondrial dysfunction and its mediated metabolic reprogramming play pivotal roles in liver cancer progression.Studies have indicated that mitochondrial proteins and key metabolic enzymes promote liver cancer progression by modulating reactive oxygen species levels,enhancing apoptosis resistance,and rewiring energy metabolism.Targeted therapies,metabolic interventions,and nanodrug delivery systems show promising efficacy in preclinical studies,though caution

Research Progress in Chemokine Ligand 13 as a Potential Therapeutic Target in the Tumor Microenvironment of Colorectal Cancer.

Colorectal cancer is one of the most common malignant tumors in the digestive system and the third leading cause of malignant tumor-related deaths globally.The lack of effective therapeutic drug targets and biomarkers has resulted in low survival rates of colorectal cancer patients.In recent years,increasing studies have shown that the expression of chemokine ligand 13 (CXCL13) in the tumor microenvironment is closely related to tumor progression,prognosis,and response to immunotherapy.Especially in colorectal cancer,CXCL13 exhibits great potential as a potential marker for immune checkpoint t

Role of Brain Insulin Resistance in the Pathogenesis of Alzheimer's Disease.

Alzheimer's disease (AD) is the most common type of dementia,in which brain insulin resistance (BIR) plays a key role.BIR affects the response of brain cells to insulin and is associated with cognitive decline and pathological features of AD.This study explores the role of BIR in the pathogenesis of AD and evaluates potential treatment strategies,aiming to provide new directions for the prevention and treatment of AD.

Progress in Adoptive Cell Therapy for Advanced Gastric Cancer.

Although great progress has been achieved in radiotherapy,chemotherapy,and molecular targeted therapy for gastric cancer in recent years,the clinical benefits for patients with gastric cancer are very limited due to the high heterogeneity of gastric cancer.As the research on the immune microenvironment and the progression mechanism of solid cancers keeps advancing,accumulating evidence indicates that adoptive cell transfer therapy (ACT),as a novel precision therapy,holds important potential clinical applications in solid tumors such as gastric cancer.Chimeric antigen receptor T cell (CAR-T) th

Expert Consensus on the Artificial Intelligence Proficiency Competency List and Assessment Framework for Medical Students (2025 Edition).

To cultivate composite medical professionals capable of adapting to the development of intelligent healthcare,this consensus is grounded in the competency-based medical education,integrating the competency model and Miller's pyramid of clinical competence. A two-round Delphi method involving a multidisciplinary expert panel was conducted,combined with a systematic literature review,to develop a 21-indicator artificial intelligence(AI) literacy competency list for medical students across three domains:knowledge (8 indicators),skills (8 indicators),and attitudes (5 indicators). Furthermore,the c

Pan-Cancer Landscape of Thymine DNA Glycosylase and Its Potential Role in Lung Adenocarcinoma.

Objective To examine the expression patterns,prognostic relevance,and immune regulatory functions of thymine DNA glycosylase (TDG) across a spectrum of cancer types,with a particular emphasis on its role in lung adenocarcinoma. Methods A comprehensive analysis was conducted using multiple bioinformatics databases to assess TDG expression levels in pan-cancer contexts,as well as its associations with prognosis and immune regulation.The expression and clinical relevance of TDG in lung adenocarcinoma were examined through online platforms such as UALCAN and BEST.Additionally,small interfering RNA

Research and Practice of Narrative Nursing in Traditional Chinese Medicine.

Narrative nursing is an important practical model for the implementation of humanistic nursing.This article reviews the origin and development of narrative nursing as well as its core concepts and theoretical connotations,and then elaborates on the conceptual definition and current development status of narrative nursing in traditional Chinese medicine (TCM).It summarizes the clinical applications of narrative nursing in the fields of disease management,health education,nurse-patient relationships,and nursing education,analyzes the existing problems in current practice,and makes an outlook on