Результаты поиска

Postoperative changes of erythrocyte sedimentation rate, plasma viscosity and C-reactive protein levels after hip surgery.

We measured the behavior of the erythrocyte sedimentation rate (ESR), plasma viscosity (PV), and C-reactive protein (CRP) in 66 patients who underwent hip implant operations, from day 0 to day 21 postoperation. We analyzed the behavior of these parameters after the trauma of the operation. We identified a subset of patients with evidence of superficial clinical infection/inflammation, where the magnitude and duration of the response to surgery was different from the main group. PV and CRP show less variability between patients and consequently are better indicators of the acute phase response

Blood and urine biomarkers associated with long-term respiratory dysfunction following neonatal hyperoxia exposure: Implications for prematurity and risk of SIDS.

Former preterm infants, many of whom required supplemental O2 support, exhibit sleep disordered breathing and attenuated ventilatory responses to acute hypoxia (HVR) beyond their NICU stay. There is an increasing awareness that early detection of biomarkers in biological fluids may be useful predictors/identifiers of short- and long-term morbidities. In the present study, we identified serotonin (5-HT), dopamine (DA) and hyaluronan (HA) as three potential biomarkers that may be increased by neonatal hyperoxia and tested whether they would be associated with an impaired HVR in a rat model of su

Baroreflex sensitivity assessed with the sequence method is associated with ventricular arrhythmias in patients implanted with a defibrillator for the primary prevention of sudden cardiac death.

BACKGROUND: Left ventricular ejection fraction lacks accuracy in predicting sudden cardiac death, resulting in unnecessary implantation of cardioverter defibrillators for the primary prevention of sudden cardiac death. Baroreflex sensitivity could help to stratify patients at risk of ventricular arrhythmia. AIM: To assess the association between cardiac baroreflex sensitivity and ventricular arrhythmias in patients implanted with an implantable cardioverter defibrillator for the primary prevention of sudden cardiac death after myocardial infarction. METHODS: This case-control single-centre s

The type of the functional cardiovascular response to upright posture is associated with arterial stiffness: a cross-sectional study in 470 volunteers.

BACKGROUND: In a cross-sectional study we examined whether the haemodynamic response to upright posture could be divided into different functional phenotypes, and whether the observed phenotypes were associated with known determinants of cardiovascular risk. METHODS: Volunteers (n = 470) without medication with cardiovascular effects were examined using radial pulse wave analysis, whole-body impedance cardiography, and heart rate variability analysis. Based on the passive head-up tilt induced changes in systemic vascular resistance and cardiac output, the principal determinants of blood press

Evaluation of the therapeutic effects of nebulized inhalation of hydrogen-rich water on primary blast lung injury in C57BL/6 mice.

BACKGROUND: Primary blast lung injury is a common and severe consequence of explosion events, characterized by immediate and delayed effects … ations were made at 6, 12, 24, and 48 hours postinjury. Lung function was assessed using whole-body plethysmography, and arterial blood gases were analyzed. Lung tissue was examined histologically and biochemically for markers of inflammation and oxidative stress. RESULTS: The survival rates at different time points postinjury in the nebulized hydrogen-rich wate …

[A comparative study of biological indicators of phlegm-heat syndrome and phlegm-dampness syndrome model with acute exacerbation of chronic obstructive pulmonary disease].

OBJECTIVE: To compare phlegm-heat syndrome with phlegm-dampness syndrome of acute exacerbation of chronic obstructive pulmonary disease (AEC … ar lavage fluid (BALF) were determined with radioimmunology. Lung function was tested by whole-body plethysmography. RESULTS: (1)The count of WBC and neutrophil ratio in PDs group were higher than in PHs group, AECOPD group and normal group, there was significant difference in multiple comparison. The levels of inflammatory mediators in serum and BALF in three m …

Effect of elexacaftor-tezacaftor-ivacaftor on bronchial dilatations in adolescents with cystic fibrosis: a multicentre prospective observational study.

BACKGROUND: Elexacaftor-tezacaftor-ivacaftor (ETI) is a cystic fibrosis transmembrane conductance regulator (CFTR) modulator that improves c … 0001, n=306). From month 0 to month 12, there were significant reductions in lung hyperinflation on plethysmography, and in mucus plugs, bronchial wall thickening, and bronchial dilatation on chest CT. Significant improvements were also observed in sweat chloride, weight Z score, LCI2.5, quality of life, and sputum and blood proinflammatory biomarkers. In 188 par …

Twenty-one years of experience with minimally invasive repair of pectus excavatum by the Nuss procedure in 1215 patients.

OBJECTIVE: To review the technical improvements and changes in management that have occurred over 21 years, which have made the minimally in … computed tomography (CT) scans of the chest, resting pulmonary function studies (spirometry and/or plethysmography), and a cardiology evaluation which included echocardiogram and electrocardiogram. Surgery was indicated if the patients were symptomatic, had a severe pectus excavatum on a clinical basis and fulfilled two or more of the following: CT index greater …

Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice.

We have used a mouse model of allergen-induced airway hyperresponsiveness to demonstrate that immunostimulatory DNA sequences (ISS) containing a CpG DNA motif significantly inhibit airway eosinophilia and reduce responsiveness to inhaled methacholine. ISS not only inhibited eosinophilia of the airway (by 93%) and lung parenchyma (91%), but also significantly inhibited blood eosinophilia (86%), suggesting that ISS was exerting a significant effect on the bone marrow production of eosinophils. The inhibition of the bone marrow production of eosinophils by 58% was associated with a significant in

Exposure to mycotoxins increases the allergic immune response in a murine asthma model.

RATIONALE: Epidemiological studies have shown that indoor molds are associated with increased prevalence and exacerbation of respiratory symptoms and asthma. Mycotoxins, secondary metabolites of molds, may contribute to these effects. OBJECTIVES: To investigate the adjuvant activity of mycotoxins on allergic airway inflammation. METHODS: Balb/c mice were exposed via the airways to gliotoxin and via the intestine to patulin, sensitized with ovalbumin (OVA), and then analyzed in acute and chronic murine asthma models. In addition, the effect of mycotoxin exposure on dendritic cell (DC) functio

Nicotine activates the chemosensory cation channel TRPA1.

Topical application of nicotine, as used in nicotine replacement therapies, causes irritation of the mucosa and skin. This reaction has been attributed to activation of nicotinic acetylcholine receptors (nAChRs) in chemosensory neurons. In contrast with this view, we found that the chemosensory cation channel transient receptor potential A1 (TRPA1) is crucially involved in nicotine-induced irritation. We found that micromolar concentrations of nicotine activated heterologously expressed mouse and human TRPA1. Nicotine acted in a membrane-delimited manner, stabilizing the open state(s) and dest

Brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor are required simultaneously for survival of dopaminergic primary sensory neurons in vivo.

Null mutations affecting members of the transforming growth factor-beta and neurotrophin families result in overlapping patterns of neuronal cell death. This is particularly striking in the cranial sensory nodose-petrosal ganglion complex (NPG), in which loss of either glial cell line-derived neurotrophic factor (GDNF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), or neurotrophin-4 (NT-4) results in a 30-50% reduction in neuronal survival. It is unknown, however, whether GDNF and any single neurotrophin support survival of the same cells, and if so, whether they are require

Elevated serum Activin A in chronic obstructive pulmonary disease with skeletal muscle wasting.

OBJECTIVE: Muscle wasting contributes to the reduced quality of life and increased mortality in chronic obstructive pulmonary disease (COPD). Muscle atrophy in mice with cachexia was caused by Activin A binding to ActRIIB. The role of circulating Activin A leading to muscle atrophy in COPD remains elusive. METHODS: In the present study, we evaluated the relationship between serum levels of Activin A and skeletal muscle wasting in COPD patients. The expression levels of serum Activin A were measured in 78 stable COPD patients and in 60 healthy controls via ELISA, which was also used to determi

Совпадение в полном тексте источника
… Pulmonary function and inflammatory testing According to well-established methods 12 , effective pulmonary function tests, including spirometry, lung volume with body plethysmography, and diffusion carbon monoxide diffusion capacity were used in all patients and controls during the initial evaluation …

Early termination of cardiovascular trials as a consequence of poor accrual: analysis of ClinicalTrials.gov 2006-2015.

ObjectivesTo present a snapshot of experimental cardiovascular research with a focus on geographical and temporal patterns of early termination due to poor accrual.SettingThe Aggregate Analysis of ClinicalTrials.gov (AACT) database, reflecting ClinicalTrials.gov as of 27 March 2016.DesignThe AACT database was searched for all cardiovascular clinical trials that started from January 2006 up to December 2015.ResultsThirteen thousand and seven hundred twenty-nine cardiovascular trials were identified. Of these, 8900 (65%) were classified as closed studies. Globally, 11% of closed trials were term

Совпадение в полном тексте источника
… donors); E01.370.370 diagnostic techniques, cardiovascular (including angiography, angioscopy, blood circulation time, blood flow velocity, blood pressure/volume determination, capillary fragility, carotid intima-media thickness, heart function tests, laser Doppler flowmetry, microscopic angioscopy, plethysmography …

Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine.

The American Academy of Sleep Medicine (AASM) Sleep Apnea Definitions Task Force reviewed the current rules for scoring respiratory events i … o facilitate visualization of inspiratory flattening are also specified. The respiratory inductance plethysmography (RIP) signals to be used as alternative sensors for apnea and hypopnea detection are specified. The task force reached consensus on use of the same sensors for adult and pediatric patients except for the following: (1) the end-tidal PCO(2) signal ca …

Editorial: Cancer therapy: The challenge of handling a double-edged sword.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

Совпадение в полном тексте источника
… Insights into acute and delayed cisplatin-induced emesis from a microelectrode array, radiotelemetry and whole-body plethysmography study of suncus murinus (house musk shrew) . Front. Pharmacol. 12 , 746053 . 10.3389/fphar.2021.746053 34925008 PMC8678571 Wang B. C. Kuang B. H. Xiao B. Y. Lin G. …

Livedoid vasculopathy: A multidisciplinary clinical approach to diagnosis and management.

Livedoid vasculopathy (LV) is a rare, chronic, and occlusive disease of the veins supplying the upper parts of the skin. The pathogenesis of the disease is not precisely understood, and its attacks are often unpredictable but tend to worsen during the summer. LV affects women more often. This increased risk for LV in women might be related to sex-specific physiological conditions, such as pregnancy, or a higher incidence of LV-associated conditions, such as connective tissue diseases, hypercoagulable states, and venous stasis in women. The typical clinical appearance of LV consists of three ma

Совпадение в полном тексте источника
… enzyme-linked immunosorbent assay for HIV, COVID-19, swab wound culture, and tissue cultures Conditions associated with stasis (chronic venous hypertension of the limbs, varicose veins) Venous Doppler ultrasound, arterial Doppler ultrasound, ankle-brachial/toe-brachial pressure index, venous duplex imaging, plethysmography … enzyme-linked immunosorbent assay for HIV, COVID-19, swab wound culture, and tissue cultures Conditions associated with stasis (chronic venous hypertension of the limbs, varicose veins) | Venous Doppler ultrasound, arterial Doppler ultrasound, ankle-brachial/toe-brachial pressure index, venous duplex imaging, plethysmography …

Association between systemic immune-inflammation indexes and Nuodikang capsule's protection in LPS-induced acute lung injury in mice.

BACKGROUND: Acute lung injury (ALI) is a prevalent clinical syndrome characterized by respiratory distress and progressive hypoxemia, which … /kg). Respiratory function and the degree of lung injury in ALI mice were assessed using whole-body plethysmography (WBP). Additionally, complete blood counts in blood and bronchoalveolar lavage fluid (BALF) of mice were analysed by hematology analyzer. The water content in the lung tissue of mice was determined by calculating the ratio of dry weight to wet weigh …