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Spine surgery for metastatic spine cancer in the era of advanced radiation therapy.

Metastatic spine cancer (MSC), a common complication of advanced malignancies, poses significant challenges due to pain, neurological deficits, and mechanical instability. While radiation therapy is a cornerstone of treatment, the role of spine surgery is evolving, fueled by advances in surgical techniques and radiation modalities such as stereotactic body radiation therapy (SBRT). This review examines the evolving role of spine surgery in MSC management, focusing on separation surgery, surgical innovations, and future directions. The treatment paradigm for MSC shifted with the advent of SBRT,

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… Minimally invasive approach, enhanced recovery after surgery protocols, and strategies to reduce bleeding and wound complications can improve patient outcomes. Decision-making frameworks and prognostic tools can guide individualized treatment plans for surgery or radiation. … recovery after surgery for fusion in degenerative spine surgery: impact on outcome, length of stay, and patient satisfaction Neurosurg Focus 2019 46 E6 10.3171/2019.1.FOCUS18669 30933923 86 Choi JU Kee TH Lee DH Enhanced recovery after surgery protocols in one- or two-level posterior lumbar fusion: …

A Comprehensive Review of the Role of the Latest Minimally Invasive Neurosurgery Techniques and Outcomes for Brain and Spinal Surgeries.

Minimally invasive neurosurgical techniques offer reduced surgical trauma, lower complication rates, and faster recovery compared to traditional open procedures. Approaches such as keyhole craniotomy, endoscopic skull base surgery, endovascular neurosurgery, and percutaneous spinal techniques have advanced the management of cranial and spinal pathologies. These methods aim to minimize tissue disruption, blood loss, and hospital stay while maintaining surgical efficacy. This narrative review explores their evolution, applications, and advantages in modern neurosurgery.

Integrating Academic and Community Cancer Care and Research through Multidisciplinary Oncology Pathways for Value-Based Care: A Review and the City of Hope Experience.

As the US transitions from volume- to value-based cancer care, many cancer centers and community groups have joined to share resources to deliver measurable, high-quality cancer care and clinical research with the associated high patient satisfaction, provider satisfaction, and practice health at optimal costs that are the hallmarks of value-based care. Multidisciplinary oncology care pathways are essential components of value-based care and their payment metrics. Oncology pathways are evidence-based, standardized but personalizable care plans to guide cancer care. Pathways have been developed

Электронные постеры

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Transpedicular Corpectomy in Minimally Invasive Surgery for Metastatic Spinal Cord Compression: A Single-Center Series.

Introduction The role of separation surgery in managing symptomatic spinal metastases has been increasing in recent years, and it represents a crucial part of the definitive management of this condition. Methods We report on a series of seven patients treated at the National Cancer Institute in Mexico using minimally invasive approaches to perform transpedicular corpectomy. The goal was to obtain a margin of tumor-free tissue, enabling the completion of oncological treatment with radiotherapy. Results We collected data from six cases. The mean age was 61.2 years. Surgical outcomes were good in

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… Patient outcomes following implementation of an enhanced recovery after surgery pathway for patients with metastatic spine tumors. Chakravarthy VB, Laufer I, Amin AG, et al. Cancer. 2022;128:4109–4118. doi: 10.1002/cncr.34484. 18. …

Oral Presentations

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Intramedullary Nailing Versus Modular Megaprosthesis in Pathological Humeral Fractures: A 10-Year Retrospective Comparative Study.

BACKGROUND: Pathological fractures of the humerus secondary to metastatic disease represent a significant cause of pain, disability, and reduced quality of life in oncologic patients. Surgical management aims to restore stability, reduce pain, and allow early mobilization. However, the optimal strategy between intramedullary nailing and modular megaprosthesis remains debated, particularly in relation to functional outcomes and long-term results. METHODS: A retrospective observational study was conducted on 48 patients treated for pathological or impending humeral fractures between January 201

Oral Presentations

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… ID: AGS26/2950 A008: Implementation of a multi-institutional enhanced recovery after surgery (ERAS) for elective spine surgery: two-year Michigan Spine Surgery Improvement Collaborative (MSSIC) experience Anisse Chaker 1 , Kylie Springer 1 , Kari Jarabek 1 , Michael Melhem 1 , Heegook Yeo 1 , Jian-hui … Recovery After Surgery (ERAS) protocols have been introduced to several surgical specialties with the intention to reduce peri-operative adverse events and improve various health-system quality metrics including length of stay and patient satisfaction. …

Indian Society of Periodontology Good Clinical Practice Recommendations for dental pain management and use of analgesics.

Pain is one of the most frequent reasons for seeking dental care and significantly influences patient comfort, treatment acceptance, and clinical outcomes. Effective management of dental pain requires accurate diagnosis, timely intervention, and the rational use of analgesics supported by evidence-based clinical decision-making. Recognizing the need for structured guidance for everyday dental practice, the Indian Society of Periodontology has developed Good Clinical Practice Recommendations on Pain Management and the Use of Analgesics in Dental Clinics. These recommendations were formulated by

Advancements in metastatic spinal cord compression treatment: a narrative review of innovations, challenges, and future directions.

ObjectiveTo synthesize recent advancements in metastatic spinal cord compression (MSCC) treatment, evaluating their efficacy in improving neurological function, pain relief, survival, and quality of life.BackgroundMSCC is an oncologic emergency caused by the progression of cancer to the spine and is prevalent in approximately 3-5% of all cancer patients, with a relatively higher incidence of breast, prostate, and lung cancers. MSCC can lead to irreversible paralysis due to loss of vital sensory and motor functions, thus requiring an immediate diagnosis and treatment.MethodsA systematic PubMed

E-Posters

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Current Advancements in the Diagnosis and Treatment of Metastatic Spinal Cord Compression and Its Postintervention Care: A Comprehensive Review.

Malignant spinal cord compression (MSCC) is a serious oncological emergency that can result in neurological impairment and significant pain. It is associated with high morbidity, mortality, and a decrease in quality of life. This review reviews the current literature concerning diagnosis, guidelines, timely intervention, and management options in oncology patients with MSCC. A literature search of PubMed using relevant keywords and MeSH terms yielded 604 articles. Of these, 31 studies met the predefined inclusion criteria and were selected for detailed data extraction and synthesis into a narr

Sequential bortezomib and temozolomide treatment promotes immunological responses in glioblastoma patients with positive clinical outcomes: A phase 1B study.

BackgroundGlioblastoma (GBM) is an aggressive malignant brain tumor where median survival is approximately 15 months after best available multimodal treatment. Recurrence is inevitable, largely due to O6 methylguanine DNA methyltransferase (MGMT) that renders the tumors resistant to temozolomide (TMZ). We hypothesized that pretreatment with bortezomib (BTZ) 48 hours prior to TMZ to deplete MGMT levels would be safe and tolerated by patients with recurrent GBM harboring unmethylated MGMT promoter. The secondary objective was to investigate whether 26S proteasome blockade may enhance differentia

Регулирующие расстройства и качество жизни у пациентов с травматологической и трахеотической каннулой: обзор.

ВВЕДЕНИЕ: Операция по Трахеостомии (TCT) и последующее включение трахеиальной каннулы (TC) сопряжены с рядом физических, коммуникативных и психологических изменений для пациента. В этих клинических ситуациях часто наблюдаются такие расстройства настроения и расстройства, как болезненное беспокойство, депрессия и стресс, что сказывается на качестве жизни (QoL) и процессе реабилитации. Цель этого обзора состоит в изучении исследований, содержащихся в литературе по расстройствам регулирования (АЖД) у пациентов с ТХТ или ТЦ, и того, как это влияет на их QOL в ходе процесса реабилитации. МЕТОДЫ: Ис

Neurosurgical management of brain metastases in the elderly: a prospective study on adverse event prevalence and predictors.

The management of brain metastases (BM) in geriatric patients poses significant challenges in the context of an aging population and advances in systemic cancer treatment. This study provides insights into the prevalence and nature of adverse events (AEs) following intracranial surgery in patients aged 65 years and older. It highlights the complexities and implications of treating this demographic patient population and identifies risk factors associated with AEs. This prospective study includes patients aged 65 years and older with BM who underwent surgery between January 2022 and December 20

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… These roles might vary according to the phase and setting of care and the patient’s condition. hese findings underscore the importance of developing robust databases as well as implementing prehabilitation and Enhanced Recovery After Surgery (ERAS) protocols. …

Резюме МКАРЕ 2023 77th Национальный конгресс " СИААРТИ "

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… CONCLUSIONS Based on our experience, we can argue that an adequate perioperative ventilation strategy is useful in patients with OHS/OSA candidates for bariatric surgery [4], also for ERAS (Enhanced Recovery After Surgery) protocol applicability [5]. … The opioid sparing effect of systemic i.v. lidocaine could be a significant criterion to better investigate its efficacy for the applicability of ERAS (Enhanced Recovery After Surgery) protocols [7]. …

Construction for the predictive model of quality of life in patients after robot-assisted radical prostatectomy: a cohort study.

Background: Urinary incontinence (UI) and erectile dysfunction (ED) often arise as frequent postoperative complications following robotic-assisted radical prostatectomy (RARP) for prostate cancer (PCa). These issues can significantly diminish patients' quality of life (QoL). The assessment of QoL is even more important because treatment decisions may be influenced by the expected QoL. Few studies have integrated the clinical profiles of patients with magnetic resonance imaging (MRI) metrics to assess postoperative UI and ED. Methods: PCa patients treated with RARP between January 2018 and Sept

Complication avoidance, rehabilitation, pain therapy and palliative care for patients with metastatic spine tumors: WFNS spine committee recommendations.

ObjectiveThis review aims to formulate the most current, evidence-based recommendations regarding complication avoidance, rehabilitation, pain therapy and palliative care for patients with metastatic spine tumors.MethodsA systematic literature search in PubMed and MEDLINE, and was performed from 2013 to 2023 using the search terms "complications" + "spine metastases", "spine metastases" + + "rehabilitation", "spine metastases" + "pain therapy" + "palliative care". Screening criteria resulted in 35, 15 and 56 studies respectively that were analyzed. Using the Delphi method and two rounds of vot

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… Chakravarthy VB, Laufer I, Amin AG, Cohen MA, Reiner AS, Vuong C, Persaud PS, Ruppert LM, Puttanniah VG, Afonso AM et al (2022) Patient outcomes following implementation of an enhanced recovery after surgery pathway for patients with metastatic spine tumors. … , Manlapaz MR, Krishnaney AA (2019) Development and implementation of a comprehensive spine surgery enhanced recovery after surgery protocol: the Cleveland Clinic experience. …

Patient-specific risk factors for adverse outcomes following geriatric proximal femur fractures.

BACKGROUND: Proximal femur fractures (PFFs) occur frequently among geriatric patients due to diverse risk factors, such as a lower bone mineral density and the increased risk of falls. METHODS: In this review, we focus on recent literature of patient-specific risk factors and their impact on common complications and outcome parameters in patients with PFF. RESULTS: Patient- and treatment related factors have a significant impact on outcome and are associated with an increased risk of mortality, impairments in functional rehabilitation and complicative courses. CONCLUSION: Geriatric patients

Favorable neurological recovery for MESCC-induced paralysis with median 9-day duration before surgery.

PurposeThis study aimed to evaluate the neurological outcomes of Metastatic epidural spinal cord compression (MESCC) patients who underwent decompressive surgery after experiencing over 48 h of paralysis.MethodsThis retrospective study hypothesizes that, unlike in cases of trauma and degenerative disorders where delayed decompression surgery often leads to poor outcomes, delayed decompression surgery for MESCC-induced paralysis yields relatively favorable results. This study included MESCC patients who had been paralyzed for more than 48 h and underwent decompressive surgery between January 20