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- сайентометрическое исследование исследовательских тенденций и характеристик связанного с лекарственными препаратами остеонекроза челюсти.

Остеонекроз челюсти (MRONJ) - это изнурительное состояние, характеризующееся постепенным некрозом челюстной кости у пациентов, которые получали антирепрессивные или антиангиогенные лекарства. Цель этого исследования заключалась в анализе сайентометрических характеристик и исследовательских тенденций МРОНЖ. Все документы по ДРОНЖ были полностью извлечены из базы данных Scopus. РЕЗУЛЬТАТЫ: Среди всех 2857 документы о МИРОНЕ, 2251 (В тыс.78.8 %) были опубликованы стоматологами. Наиболее распространенными лекарствами, вызывающими MRONJ, были дифосфонаты, золедронная кислота и деносумаб. Болезни, с

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… Conventional surgery combined with the liquid nitrogen cryosurgery: an innovative treatment approach for the medication-related osteonecrosis of the jaw (MRONJ) J Dent Sci. 2025;20:1375–6. doi: 10.1016/j.jds.2024.11.023. 8. Lin Y, Wang J, Lai Y, et al. …

Diagnostic Delays for Non-melanoma Skin Cancers in Renal Transplant Recipients during the COVID-19 Pandemic: What is Hiding Behind the Mask?

Dear Editor, The ongoing pandemic of coronavirus disease 2019 (COVID-19) was declared by the World Health Organization on March 11, 2020, an … atosis for the zygomatic lesion. SCC in situ has been excised, and actinic keratosis was treated by cryosurgery. Patient 2 A 66-year-old woman received a renal allograft from a deceased donor in 2010 due to chronic glomerulonephritis without biopsy. The immunosuppressive protocol included basiliximab induction with tacrolimus, mycophenolate mofetil, and stero …

Bone marrow transplantation for therapy-related acute myeloid leukemia in congenital retinoblastoma associated with 13q deletion syndrome.

Children with constitutional deletion of the long arm of chromosome 13 are at risk for retinoblastoma (RB) due to loss of the RB tumor suppressor gene. The prognosis is poor since the tumors are often bilateral, aggressive, and recurrent and the patients often harbor other congenital abnormalities. One further complication is that of therapy-related malignancies later in life. We report a case of allogeneic stem cell transplantation for therapy-related acute myeloid leukemia in an 8-year-old girl after multimodality treatment for refractory bilateral relapsing RB, with excellent outcome in bot

Image-Guided Percutaneous Ablation for Primary and Metastatic Tumors.

Image-guided percutaneous ablation methods have been further developed during the recent two decades and have transformed the minimally invasive and precision features of treatment options targeting primary and metastatic tumors. They work by percutaneously introducing applicators to precisely destroy a tumor and offer much lower risks than conventional methods. There are usually shorter recovery periods, less bleeding, and more preservation of organ parenchyma, expanding the treatment options of patients with cancer who may not be eligible for resection. Image-guided ablation techniques are c

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… The process of freezing and the mechanism of damage during hepatic cryosurgery. Cryobiology. 1990;27:85–97. doi: 10.1016/0011-2240(90)90055-9. 30. Abtin F., Suh R.D., Nasehi L., Han S.X., Hsu W., Quirk M., Genshaft S., Gutierrez A.J., Cameron R.B. … Cryosurgery of breast cancer. Arch. Surg. 1997;132:28–34. doi: 10.1001/archsurg.1997.01430250030005. 34. Golberg A., Yarmush M.L. Nonthermal irreversible electroporation: Fundamentals, applications, and challenges. IEEE Trans. Biomed. Eng. 2013;60:707–714. doi: 10.1109/TBME.2013.2238672. 35. …

The Role of Natural Killer Cells in Soft Tissue Sarcoma: Prospects for Immunotherapy.

Soft-tissue sarcomas (STS) represent about 80% of sarcomas, and are a heterogeneous group of rare and malignant tumors. STS arise from mesenchymal tissues and can grow into structures such as adipose tissue, muscles, nervous tissue and blood vessels. Morphological evaluation has been the standard model for the diagnosis of sarcomas, and even in samples with similar characteristics, they present a diversity in cytogenetic and genetic sequence alterations, which further increases the diversity of sarcomas. This variety is one of the main challenges for the classification and understanding of STS

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… Condition/Disease | Study/Title | Therapy | Phase | Trial ID Completed | | | | Recurrent adult STS Others | Combination of cryosurgery and NK immunotherapy for recurrent sarcoma | Cryosurgery Multiple NK immunotherapies | I/II | NCT02849366 Rhabdomyosarcoma Others | NK DLI in Patients After Human …

Long-Term Outcome of WHIM Syndrome in 18 Patients: High Risk of Lung Disease and HPV-Related Malignancies.

BACKGROUND: In the warts, hypogammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, variable phenotypic expression may delay diagnosis. Panleukopenia, malignancy, and chronic lung disease all affect morbidity and mortality risks. Routinely used treatments include immunoglobulins, granulocyte-colony stimulating factor (G-CSF), and antibiotics; recent trials with a target C-X-C chemokine receptor type 4 (CXCR4) antagonist show promising results. OBJECTIVE: We sought to characterize the largest cohort of patients with WHIM and evaluate their diagnostic and therapeutic management. ME

Percutaneous lumbopelvic fixation for pathologic sacral fractures and spinopelvic dissociation: patient series.

BackgroundBecause patients with advanced cancer live longer, the number of patients with the sequelae of metastatic spine disease has increased. Pathologic instability of the mobile spine has been classified, and minimally invasive surgery has been well described. However, pathologic sacral instability is uncommon and often underdiagnosed. Although most sacral fractures are stable, patients with unstable U- or H-type fractures have spinopelvic dissociation and can experience progressive pain, sacral kyphosis, and neurological injury. Open lumbopelvic fusion carries a high perioperative risk fo

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… 22729363 10.1007/s00586-012-2394-9 PMC3463705 11 Thiagarajan A Pan L Zatcky J Krol G Boland PJ Yamada Y Insufficiency fractures of the sacrum following stereotactic body radiotherapy for sacral tumors J Radiosurg SBRT 2014 3 1 59 65 29296386 PMC5725331 12 Kollender Y Meller I Bickels J Role of adjuvant cryosurgery …

Progression of Femoral Osteolytic Metastases after Intramedullary Nailing and Subsequent Salvage Techniques.

Intramedullary nailing insertion from the proximal-to-distal femur is frequently performed for impending and complete pathological femur fractures due to osteolytic metastases. After nailing through cancer-laden bone, residual chemotherapy- and/or radiation-resistant tumor may progress. Progression of osteolysis risks future nail failure or pathological fractures. This study assesses the incidence of cancer progression following intramedullary nailing in a femur-only cohort and describes a percutaneous rod-retaining salvage technique. A single-institution, retrospective study was conducted to

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… Cryosurgery in the treatment of giant cell tumors of bone. A report of 52 consecutive cases Cancer 1978 41 957 969 10.1002/1097-0142(197803)41:3<957::AID-CNCR2820410325>3.0.CO;2-Y 638982 28. Zhao W. Peng Z.-H. Chen J.-Z. Hu J.-H. Huang J.-Q. Jiang Y.-N. Luo G. Yi G.-F. Wang H. Jin S. …

Минимально инвазивное плазменное устройство для борьбы с множественным раком кожи Бенигена, связанное с сериями Rare Gendermatoses-Cases, и обзор терапевтических методов.

Фон: Немеланоцитические доброкачественные опухоли кожи включают в себя разнообразную группу повреждений, классифицированных по признаку их клеточного происхождения, таких, как эпидермальные, сосудистые, волокнистые, нейронные, мышечные и аднексальные опухоли. Хотя они часто обнаруживают повреждения в одиночестве, многочисленные опухоли кожи сосредотачиваются на генодерматозах. Каждый синдром обладает различными клиническими характеристиками и потенциальными осложнениями, включая категорические и внекачественные недуги, некоторые из которых могут представлять опасность для жизни. Диагнозные ген

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… Alternative therapies comprise electrocautery, cryosurgery, dermabrasion, topic retinoids, interferon 2 alpha, and bleomycin chemotherapy [ 1 , 2 , 3 , 65 , 66 , 67 , 68 , 69 , 70 ]. Only 50% of patients with CS have facial lesions with features typical of trichilemmomas. … Cryosurgery updated J. Am. Acad. Dermatol. 1994 31 925 946 10.1016/S0190-9622(94)70261-6 7962774 102. Chaudhary S. Dayal S. Radiofrequency ablation: A safe and economical modality in treatment of Brooke-Spiegler syndrome Dermatol. Online J. 2012 18 7 10.5070/D32TF564DM 22948057 103. …

Application of dendritic cell extracellular vesicles as a valid nanoparticle platform for cancer therapies: a narrative review.

The prevalence of cancers has actually increased during the last few decades, affecting almost all human societies. Despite progress in therapeutic protocols, cancer is still the main cause of global human mortality. Although the advancement of modern immunotherapeutic approaches can increase the survival rate of cancer patients, new modalities are essential for improved therapeutic outcomes. Extracellular vesicles (EVs) are nanosized particles and are used for cell-free approaches instead of direct whole cell-based administration. It has been thought that EVs can reduce the risks and side eff

Translational progress on tumor biomarkers.

There is an urgent need to apply basic research achievements to the clinic. In particular, mechanistic studies should be developed by bench researchers, depending upon clinical demands, in order to improve the survival and quality of life of cancer patients. To date, translational medicine has been addressed in cancer biology, particularly in the identification and characterization of novel tumor biomarkers. This review focuses on the recent achievements and clinical application prospects in tumor biomarkers based on translational medicine.

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… Changes in the expression of serum markers CA242, CA199, CA125, CEA, TNF-alpha and TSGF after cryosurgery in pancreatic cancer patients. Biotechnol Lett. 2012;34:1235–1241. doi: 10.1007/s10529-012-0908-5. Jing JX, Wang Y, Xu XQ, et al. …

Field-Deployable Treatments For Leishmaniasis: Intrinsic Challenges, Recent Developments and Next Steps.

Leishmaniasis is a neglected tropical disease endemic primarily to low- and middle-income countries, for which there has been inadequate development of affordable, safe, and efficacious therapies. Clinical manifestations of leishmaniasis range from self-healing skin lesions to lethal visceral infection with chances of relapse. Although treatments are available, secondary effects limit their use outside the clinic and negatively impact the quality of life of patients in endemic areas. Other non-medicinal treatments, such as thermotherapies, are limited to use in patients with cutaneous leishman

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… Treatment of cutaneous leishmaniasis with cryosurgery. Int J Dermatol . 2005;44(9):749–752. doi: 10.1111/j.1365-4632.2005.02628.x 36. Al-Qubati Y, Janniger EJ, Schwartz RA. Cutaneous leishmaniasis: cryosurgery using carbon dioxide slush in a resource-poor country. …

Percutaneous Vertebral Reconstruction (PVR) Technique of Pathological Compression Fractures: An Innovative Combined Treatment of Microwave Ablation, Bilateral Expandable Titanium SpineJack Implants Followed by Vertebroplasty.

(1) Background: to retrospectively evaluate safety and efficacy of combined microwave ablation (MWA) and bilateral expandable titanium SpineJack (SJ) implants followed by vertebroplasty (VP) for the treatment of painful thoracolumbar pathological vertebral compression fracture. (2) Methods: from July 2017 to October 2022, twenty-eight patients (13 women and 15 men; mean age 68 ± 11 years) with a history of primary neoplasm and thirty-six painful vertebral metastases with vertebral compression fracture underwent combined MWA and bilateral expandable titanium SpineJack implants with vertebroplas

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… Percutaneous MRI guided cryosurgery of bone tumors. Radiology. 2002;225:514. 9. Callstrom M.R., Atwell T.D., Charboneau J.W., Farrell M.A., Goetz M.P., Rubin J., Sloan J.A., Novotny P.J., Welch T.J., Maus T.P., et al. …

Watchful waiting in children with unifocal osseous Langerhans cell histiocytosis.

BackgroundLangerhans cell histiocytosis (LCH) is a rare inflammatory neoplasm most commonly involving bone. However, data on single-system, single-site LCH (SS-s-LCH), particularly with unifocal bone disease, remain limited. Management strategies for unifocal osseous LCH vary globally, and the safety of a watchful-waiting approach is not well-defined. This study aimed to evaluate whether patients with osseous SS-s-LCH can be managed with observation alone without compromising long-term outcomes.MethodsIn this retrospective, multicenter study, we enrolled children with biopsy-proven osseous SS-

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… Eosinophilic granuloma of bone: results of treatment with curettage, cryosurgery, and bone grafting. J Pediatr Orthop B. 1998;7:253-256. 23. Sessa S, Sommelet D, Lascombes P, Prévot J. Treatment of Langerhans-cell histiocytosis in children. Experience at the Children’s Hospital of Nancy. …

Predictive value of serial measurements of quality of life on all-cause mortality in prostate cancer patients: data from CaPSURE (cancer of the prostate strategic urologic research endeavor) database.

IntroductionHealth-related quality of life (HRQOL) is a legitimate construct for evaluating treatment and its side effects. Recently, predictive value of HRQOL on survival also has been of interest. In light of the longer survival in patients with prostate cancer and importance of quality of life, we seek to evaluate the association between HRQOL and survival using traditional and novel techniques.MethodsPatients from CaPSURE (Cancer of the Prostate Strategic Urologic Research Endeavor) who were treated within 6 months of diagnosis and had pre-treatment and sufficient post-treatment follow-up

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… More than half of the patients underwent radical prostatectomy as an initial treatment (58%), with brachytherapy and external beam radiation constituting another third (22 and 11%, respectively), and the rest of treatments divided between cryosurgery and hormonal treatment. …

Grzybowski's Generalized Eruptive Keratoacanthomas in a Patient with Terminal Kidney Disease-An Unmet Medical Need Equally Ameliorated by Topical Imiquimod Cream and Lapacho Tea Wraps: A Case Report.

IntroductionDevelopment of singular keratoacanthoma (KA) is generally considered a benign condition as it has a tendency to regress spontaneously in spite of histological similarity to squamous cell carcinoma. Most KAs undergo excision to rule out differential diagnoses. Several alternative treatment modalities (keratinolytic, ablative, immunomodulating, antiproliferative, or targeted therapy) have been described in the past with varying success, underlining the therapeutic challenges associated with large or multiple lesions. Isomorphic response (Koebner phenomenon) may limit the efficacy of

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… Gaitanis G Bassukas ID Cryosurgery, intralesional methotrexate and imiquimod for keratoacanthoma: tuning the combination Case Rep Dermatol Med 2019 2019 3489748 10.1155/2019/3489748 31815022 PMC6877974 17. …

NK Cell-Based Immunotherapy in Renal Cell Carcinoma.

Natural killer (NK) cells are cytotoxic lymphocytes that are able to kill tumor cells without prior sensitization. It has been shown that NK cells play a pivotal role in a variety of cancers, highlighting their relevance in tumor immunosurveillance. NK cell infiltration has been reported in renal cell carcinoma (RCC), the most frequent kidney cancer in adults, and their presence has been associated with patients' survival. However, the role of NK cells in this disease is not yet fully understood. In this review, we summarize the biology of NK cells and the mechanisms through which they are abl

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… NCT number | Treatment | NK cell-related analysis | Title of the clinical trial NCT02843607 | Cryosurgery + NK cell infusion | Not specified | Combination of Cryosurgery and NK Immunotherapy for Advanced Kidney Cancer NCT00328861 | Chemotherapy + IL-2 (Aldesleukin) + NK cell infusion | Not specified …

Intramedullary Nailing with and without the Use of Bone Cement for Impending and Pathologic Fractures of the Humerus in Multiple Myeloma and Metastatic Disease.

Although intramedullary nailing (IMN) is considered the standard of care for the surgical management of most femur metastatic diseases, the optimal treatment of metastatic humeral impending and/or pathologic fractures is still debatable. Moreover, the use of cemented humeral nails has not been thoroughly studied, and only a few small series have compared their results with uncemented nails. The purpose of this study was to compare the (1) survivorship, (2) functional outcomes, and (3) perioperative complications in patients receiving cemented versus uncemented humerus IMN for impending or comp

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… Additionally, limited open or closed IMN techniques often leave behind the tumor burden and preclude the use of the local adjuvant options of radio-resistant tumors, such as cryosurgery, argon beam, and phenol therapy. …

Exploring versatile applications of a vacuum-assisted bone harvester in orthopedic surgery.

BACKGROUND: Orthopedic procedures often require removing bone or pathological tissue, with traditional methods involving instruments like curettes and rongeurs. However, these methods can be time-consuming and lead to increased blood loss. To mitigate these side effects, vacuum-assisted tools have been developed to aid in tissue removal. These devices enable surgeons to suction tissue without discarding it, potentially improving outcomes in conditions such as osteomyelitis or tumor removal while enabling collection of the material for downstream applications. Despite limited research, vacuum-a

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… Treatment of benign and low-grade malignant intramedullary chondroid tumours with curettage and cryosurgery. Eur J Surg Oncol. 1998;24(2):120–6. 10.1016/S0748-7983(98)91459-7 5. Steffner R. Benign bone tumors. Cancer Treat Res. 2014;162:31–63. 10.1007/978-3-319-07323-1_3 6. …

γδ T cells: origin and fate, subsets, diseases and immunotherapy.

The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and hyperactivation, highlights the potential of immune renormalization as a promising strategy in disease treatment. In recent years, our primary focus has centered on γδ T cell-based immunotherapy, particularly pioneering the use of allogeneic Vδ2+ γδ T cells for treating late-stage solid tumors and tuberculosis patients. However, we recognize untapped potential and optimization opportunities to fully harness γδ T cell effector functions in immunotherapy. This review aims to thoroughly examine γδ T cell im