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Efficacy of oncolytic virus in the treatment of intermediate-to-advanced solid tumors: a systematic review and meta-analysis.

This meta-analysis assessed oncolytic virus therapy's efficacy for intermediate-to-advanced solid tumors. We systematically searched PubMed, Cochrane Library, and Embase databases until March 6, 2025. Our review included 87 studies, involving 5,385 individuals, encompassing 75 clinical trials and 12 retrospective studies. Patient response rates were as follows: complete response (CR) 11%, partial response (PR) 18%, stable disease (SD) 32%, and progressive disease (PD) 32%. The overall response rate (ORR) was 29%, and the durable response rate (DRR) was 39%. Comparing oncolytic virus therapy to

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… Qi-Dong Xia, Email: qidongxia_md@163.com. Koenraad van Doorslaer, College of Agriculture & Life Sciences, University of Arizona, Tucson, Arizona, USA. DATA AVAILABILITY All the original data were collected from online databases. … Liu XY, Qiu SB, Zou WG, Pei ZF, Gu JF, Luo CX, Ruan HM, Chen Y, Qi YP, Qian C. 2005. Effective gene-virotherapy for complete eradication of tumor mediated by the combination of hTRAIL (TNFSF10) and plasminogen k5. Mol Ther 11:531–541. doi: 10.1016/j.ymthe.2004.12.003 111. …

An Overview of Advances in Rare Cancer Diagnosis and Treatment.

Cancer stands as the leading global cause of mortality, with rare cancer comprising 230 distinct subtypes characterized by infrequent incidence. Despite the inherent challenges in addressing the diagnosis and treatment of rare cancers due to their low occurrence rates, several biomedical breakthroughs have led to significant advancement in both areas. This review provides a comprehensive overview of state-of-the-art diagnostic techniques that encompass new-generation sequencing and multi-omics, coupled with the integration of artificial intelligence and machine learning, that have revolutioniz

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… Qi Z. Barrett T. Parikh A.S. Tirosh I. Puram S.V. Single-cell sequencing and its applications in head and neck cancer Oral. Oncol. 2019 99 104441 10.1016/j.oraloncology.2019.104441 31689639 PMC6981283 35. Huang D. Ma N. Li X. Gou Y. Duan Y. Liu B. Xia J. Zhao X. Wang X. Li Q. …

Immunotherapy in Acute Myeloid Leukemia: A Literature Review of Emerging Strategies.

In the last twenty years, we have witnessed a paradigm shift in the treatment and prognosis of acute myeloid leukemia (AML), thanks to the introduction of new efficient drugs or approaches to refine old therapies, such as Gemtuzumab Ozogamicin, CPX 3-5-1, hypomethylating agents, and Venetoclax, the optimization of conditioning regimens in allogeneic hematopoietic stem cell transplantation and the improvement of supportive care. However, the long-term survival of non-M3 and non-core binding factor-AML is still dismal. For this reason, the expectations for the recently developed immunotherapies,

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… Qi Y. Zhao W. Huang Y. Xu Y. Qian C. Bispecific Antibodies: From Research to Clinical Application Front. Immunol. 2021 12 626616 10.3389/fimmu.2021.626616 34025638 PMC8131538 36. Sivori S. Pende D. Quatrini L. Pietra G. Della Chiesa M. Vacca P. Tumino N. Moretta F. Mingari M.C. Locatelli F. … Qi J. Li J. Jiang B. Jiang B. Liu H. Cao X. Zhang M. Meng Y. Xiaoyu M.A. Jia Y. …

Therapeutic targeting in pediatric acute myeloid leukemia with aberrant HOX/MEIS1 expression.

Despite advances in the clinical management of childhood acute myeloid leukemia (AML) during the last decades, outcome remains fatal in approximately one third of patients. Primary chemoresistance, relapse and acute and long-term toxicities to conventional myelosuppressive therapies still constitute significant challenges and emphasize the unmet need for effective targeted therapies. Years of scientific efforts have translated into extensive insights on the heterogeneous spectrum of genetics and oncogenic signaling pathways of AML and identified a subset of patients characterized by upregulati

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… Fiskus W, Boettcher S, Daver N, Mill CP, Sasaki K, Birdwell CE, Davis JA, Takahashi K, Kadia TM, DiNardo CD, Jin Q, Qi Y, Su X, McGeehan GM, Khoury JD, Ebert BL, Bhalla KN, 2022a. Effective Menin inhibitor-based combinations against AML with MLL rearrangement or NPM1 mutation (NPM1c). … Zuber J, Shi J, Wang E, Rappaport AR, Herrmann H, Sison EA, Magoon D, Qi J, Blatt K, Wunderlich M, Taylor MJ, Johns C, Chicas A, Mulloy JC, Kogan SC, Brown P, Valent P, Bradner JE, Lowe SW, Vakoc CR, 2011. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia. …

Advances and Hurdles in CAR T Cell Immune Therapy for Solid Tumors.

Chimeric antigen receptor (CAR) T cells in solid tumors have so far yielded limited results, in terms of therapeutic effects, as compared to the dramatic results observed for hematological malignancies. Many factors involve both the tumor cells and the microenvironment. The lack of specific target antigens and severe, potentially fatal, toxicities caused by on-target off-tumor toxicities constitute major hurdles. Furthermore, the tumor microenvironment is usually characterized by chronic inflammation, the presence of immunosuppressive molecules, and immune cells that can reduce CAR T cell effi

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… Qi X. Zhang Y. Chi J. Lu Q. Gao H. Jiang H. Wang H. Chimeric Antigen Receptor-Glypican-3 T-Cell Therapy for Advanced Hepatocellular Carcinoma: Results of Phase I Trials Clin. Cancer Res. 2020 26 3979 3989 10.1158/1078-0432.CCR-19-3259 32371538 110. Junghans R.P. Ma Q. Rathore R. Gomes E.M. … Qi Y. Wilkerson M.D. Miller C.R. Ding L. Golub T. Mesirov J.P. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1 Cancer Cell 2010 17 98 110 10.1016/j.ccr.2009.12.020 20129251 PMC2818769 120. …

Role of Exosomal Non-Coding RNAs in Bone-Related Diseases.

Bone-related diseases seriously affect the lives of patients and carry a heavy economic burden on society. Treatment methods cannot meet the diverse clinical needs of affected patients. Exosomes participate in the occurrence and development of many diseases through intercellular communication, including bone-related diseases. Studies have shown that exosomes can take-up and "package" non-coding RNAs and "deliver" them to recipient cells, thereby regulating the function of recipient cells. The exosomal non-coding RNAs secreted by osteoblasts, osteoclasts, chondrocytes, and other cells are invol

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… Qi S. ( 2020a ). Exosomal miR-9-5p Secreted by Bone Marrow-Derived Mesenchymal Stem Cells Alleviates Osteoarthritis by Inhibiting Syndecan-1 . Cell Tissue Res 381 ( 1 ), 99 – 114 . 10.1007/s00441-020-03193-x 32377874 Jin Z. Ren J. Qi S. ( 2020b ). …

Emergence of immunotherapy as a novel way to treat hepatocellular carcinoma.

Tumor immunity proceeds through multiple processes, which consist of antigen presentation by antigen presenting cells (APCs) to educate effector cells and destruction by the effector cytotoxic cells. However, tumor immunity is frequently repressed at tumor sites. Malignantly transformed cells rarely survive the attack by the immune system, but cells that do survive change their phenotypes to reduce their immunogenicity. The resultant cells evade the attack by the immune system and form clinically discernible tumors. Tumor microenvironments simultaneously contain a wide variety of immune suppre

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… 40 Circelli L Petrizzo A Tagliamonte M Heidenreich R Tornesello ML Buonaguro FM Buonaguro L Immunological effects of a novel RNA-based adjuvant in liver cancer patients Cancer Immunol Immunother 2017 66 103 112 27832318 10.1007/s00262-016-1923-5 PMC11028778 41 Lu Z Zuo B Jing R Gao X Rao Q Liu Z Qi … 2017 66 545 551 27816492 10.1016/j.jhep.2016.10.029 PMC5316490 100 Bardhan K Anagnostou T Boussiotis VA The PD1:PD-L1/2 Pathway from Discovery to Clinical Implementation Front Immunol 2016 7 550 28018338 10.3389/fimmu.2016.00550 PMC5149523 101 Wang BJ Bao JJ Wang JZ Wang Y Jiang M Xing MY Zhang WG Qi …

Abstracts of the 36th Annual Meeting of the Society of General Internal Medicine. April 24-27, 2013. Denver, Colorado, USA.

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The role of hypoxic microenvironment in autoimmune diseases.

The hypoxic microenvironment, characterized by significantly reduced oxygen levels within tissues, has emerged as a critical factor in the pathogenesis and progression of various autoimmune diseases (AIDs). Central to this process is the hypoxia-inducible factor-1 (HIF-1), which orchestrates a wide array of cellular responses under low oxygen conditions. This review delves into the multifaceted roles of the hypoxic microenvironment in modulating immune cell function, particularly highlighting its impact on immune activation, metabolic reprogramming, and angiogenesis. Specific focus is given to

The Confluence of Nanotechnology and Heat Shock Protein 70 in Pioneering Glioblastoma Multiforme Therapy: Forging Pathways Towards Precision Targeting and Transformation.

Heat-shock protein 70 (HSP70) and nanotechnology have emerged as promising avenues in glioblastoma multiforme (GBM) therapy, addressing the critical challenges posed by its aggressive nature and therapeutic resistance. HSP70's dual role in cellular stress response and tumour survival emphasises its potential as both a biomarker and therapeutic target. This review explores the innovative integration of HSP70 with nanotechnology, emphasising advancements in imaging, drug delivery and combination therapies. Nanoparticles, including SPIONs, liposomes, gold nanoparticles and metal-organic framework

Применение методов извлечения дискриминирующих и глубоких элементов для полного анализа слайдов: обследование.

Цифровые патологические технологии, включая целые слайды, значительно улучшили современные клинические методы, облегчая хранение, просмотр, обработку и совместное цифровое сканирование стеклянных слайдов. Исследователи предложили различные решения в области искусственного интеллекта (АИ) для применения в цифровой патологии, такие, как автоматизированный анализ изображений, для извлечения диагностической информации из WSI в целях повышения производительности, точности и воспроизводимости патологии. Методы экстракции особей играют решающую роль в преобразовании первичных данных об образе в значи

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… Finally, color histograms can be used for image retrieval: Qi et al. 147 propose a content-based image retrieval (CBIR) framework based on a hierarchical searching algorithm. …

"Smart" drug delivery: A window to future of translational medicine.

Chemotherapy is the mainstay of cancer treatment today. Chemotherapeutic drugs are non-selective and can harm both cancer and healthy cells, causing a variety of adverse effects such as lack of specificity, cytotoxicity, short half-life, poor solubility, multidrug resistance, and acquiring cancer stem-like characteristics. There is a paradigm shift in drug delivery systems (DDS) with the advent of smarter ways of targeted cancer treatment. Smart Drug Delivery Systems (SDDSs) are stimuli responsive and can be modified in chemical structure in response to light, pH, redox, magnetic fields, and e

Antioxidants in brain tumors: current therapeutic significance and future prospects.

Brain cancer is regarded among the deadliest forms of cancer worldwide. The distinct tumor microenvironment and inherent characteristics of brain tumor cells virtually render them resistant to the majority of conventional and advanced therapies. Oxidative stress (OS) is a key disruptor of normal brain homeostasis and is involved in carcinogenesis of different forms of brain cancers. Thus, antioxidants may inhibit tumorigenesis by preventing OS induced by various oncogenic factors. Antioxidants are hypothesized to inhibit cancer initiation by endorsing DNA repair and suppressing cancer progress

Analysis of risk factors for PICC-related venous thrombosis in patients with hematological malignancies and establishment of a nomogram prediction model.

ObjectiveTo analyze the independent risk factors for PICC-related venous thrombosis in patients with hematologic malignancies, and to construct and validate a risk prediction model.MethodsThis retrospective study analyzed data from 264 hematologic malignancy patients who received PICC chemotherapy at the Affiliated Hospital of Qingdao University between January 2022 and December 2024. Patients were randomly divided into training and validation sets (7:3), and the incidence of CRT was calculated. In the training set, LASSO regression and multivariable logistic regression identified independent …

Challenges in the management of bone metastases: focus on differentiated thyroid cancer and neuroendocrine tumors.

Bone metastases represent an uncommon but clinically significant complication in endocrine malignancies including differentiated thyroid cancer and neuroendocrine tumors. Although these malignancies typically follow an indolent course, the development of bone metastases is associated with a worse prognosis and increased risk of skeletal-related events. The optimal strategies for the prevention and management of bone metastases in these patients remain unclear and are largely extrapolated from studies in other solid tumors. This presents a unique clinical challenge as treatment decisions need t

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… J Clin Oncol . 2019 ; 37 ( 15_suppl ): e17578 ‐ e17578 . 41 Qi W-X , Tang L-N , He A-N , Yao Y , Shen Z . Risk of osteonecrosis of the jaw in cancer patients receiving denosumab: a meta-analysis of seven randomized controlled trials . …

Watchful waiting in children with unifocal osseous Langerhans cell histiocytosis.

BackgroundLangerhans cell histiocytosis (LCH) is a rare inflammatory neoplasm most commonly involving bone. However, data on single-system, single-site LCH (SS-s-LCH), particularly with unifocal bone disease, remain limited. Management strategies for unifocal osseous LCH vary globally, and the safety of a watchful-waiting approach is not well-defined. This study aimed to evaluate whether patients with osseous SS-s-LCH can be managed with observation alone without compromising long-term outcomes.MethodsIn this retrospective, multicenter study, we enrolled children with biopsy-proven osseous SS-

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… Luo ZH, Lu PX, Qi WL, Liao FX, Jin AF, Zen QY. Role of (18)F-FDG PET/CT in the diagnosis and management of patients with Langerhans cell histiocytosis. Quant Imaging Med Surg. 2022;12:3351-3363. 10.21037/qims-21-823 41. …

PTGS2 as a potential target for apigenin to promote spinal cord injury repair.

Spinal cord injury (SCI) is characterized by damage to the spinal cord caused by various reasons, and there is a lack of effective drug treatments. Apigenin, a well-known natural small molecule drug, may serve as a therapeutic agent for a variety of diseases. However, the potential mechanisms by which Apigenin exerts its effects in SCI remain unclear. By utilizing an integrative multiomics strategy that combines network pharmacology, Mendelian randomization, and single-cell transcriptomic profiling, we established a systems-level target identification framework. Mechanistic analysis revealed a

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… Nat Genet 53:1300–1310 Wu Y, Zeng J, Zhang F, Zhu Z, Qi T, Zheng Z et al (2018) Integrative analysis of omics summary data reveals putative mechanisms underlying complex traits. …

Extramedullary disease is associated with severe toxicities following B-cell maturation antigen CAR T-cell therapy in multiple myeloma.

Extramedullary disease (EMD) in multiple myeloma (MM) is associated with poor outcomes following B-cell maturation antigen (BCMA)-targeted chimeric antigen receptor (CAR) T therapy, yet its impact on treatment-related toxicity remains unclear. This study evaluates the impact of active EMD on toxicity, efficacy, and survival in patients with MM treated with idecabtagene vicleucel (ide-cel) or ciltacabtagene autoleucel (cilta-cel). We conducted a retrospective cohort study of all patients with MM who received ide-cel (N=32) or cilta-cel (N=76) as standard-of-care therapy at our institution from

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… Qi Y Qiao J Li Z Xu K. Efficacy and safety of BCMA-specific CAR T cell-based therapy in relapsed/refractory multiple myeloma patients with extramedullary disease . Blood . 2023 ; 142 ( Supplement 1 ): 4844 . 10. Li W Liu M Yuan T Yan L Cui R Deng Q. …

Psychological Resilience, Symptom Burden, and Supportive Care Needs in Chemotherapy Patients: A Path Analysis

ABSTRACT Introduction and Aim While chemotherapy contributes to the survival of cancer patients, it also leads to various psychological and physiological problems, increasing the need for supportive care. This study aimed to determine the relationship between psychological resilience, chemotherapy symptoms, and supportive care needs in patients undergoing chemotherapy. Method This is a descriptive and correlational study. Data were collected using the Descriptive Characteristics Form, the Psychological Resilience Scale (PRS), the Nightingale Symptom Assessment Scale (N‐SAS), and the Supportive

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… Hu, H. , Li H., Xu H., Liu J., and Qi Y.. 2024. “Effect of Personalized Nutrition Combined With Acceptance and Commitment Therapy on Psychological Resilience, Quality of Life and Side Effects of Chemotherapy in Patients With Advanced Gastric Cancer.” …

Trends in Kampo Medicine Usage as Supportive Care During Anticancer Drug Treatment in Japanese Patients: A Nationwide Cohort Analysis from Fiscal Years 2015 to 2021.

The adverse effects of anticancer drugs significantly impact the quality of life of patients undergoing chemotherapy, necessitating evidence-based supportive therapies. In Japan, Kampo medicines, traditional Japanese herbal therapies used for relief of various symptoms, have been widely used as complementary and alternative treatments for cancer, despite limited evidence regarding their efficacy and safety. Thus, we investigated the actual use of Kampo medicines as supportive care in patients undergoing anticancer drug treatment and evaluated the trends in prescription according to year. We an

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… Qi X. Wang X. He B. Zhang W. Zhao W. Deng M. Xiong X. Wang Y. Efficiency of protective interventions on irinotecan-induced diarrhea: A systematic review and meta-analysis Integr. Cancer Ther. 2024 23 15347354241242110 10.1177/15347354241242110 38567795 PMC10993684 56. Toffoli G. Cecchin E. …