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Effect of tea polyphenols on growth of oral squamous carcinoma cells in vitro.

Epidemiologic evidence indicates that both black and green tea is a rich source of flavonoids and other polyphenolic antioxidants which protects against heart disease and cancer. In the current investigation, utilizing human oral squamous carcinoma cell line SCC-25, we have evaluated the effect of three major tea constituents, (-)-epigallocatechin-3-gallate (EGCG), (-)-epicatechin-3-gallate (ECG) and (-)-epigallocatechin (EGC) on cell growth and DNA synthesis. Test agents in concentrations of 50, 80, 100 and 200 microM were incubated in triplicates in DMEM-HAM's F-12 (50: 50) supplemented with

Occurrence and concentration variability of pharmaceuticals, pesticides, and polyphenols in Nyabugogo River, Rwanda.

Pharmaceuticals, pesticides, and polyphenols are increasingly detected in aquatic environments, impacting water quality and aquatic life. This study screened these contaminants in Rwanda's Nyabugogo River, analysing 45 water samples from rural, peri-urban, and urban areas using solid-phase extraction and LC-MS/MS. Fifty-seven pharmaceuticals, five pesticides, and four polyphenols were quantified, with the highest average concentrations of albendazole (960 ng/L), metalaxyl (70 ng/L), and caffeic acid (49 ng/L). Pharmaceutical levels were significantly higher in urban areas, reflecting inadequat…

Extraction, characterization and antioxidant activity of free and bound polyphenols from Undaria pinnatifida.

Free polyphenols (FP) and bound polyphenols (BP) were extracted from Undaria pinnatifida, with processes optimized by response surface methodology. BP accounted for approximately 65% of total polyphenols. UHPLC-QTOF-MS/MS tentatively identified 28 phenolic compounds in BP and 3 in FP, with characteristic brown algal polyphenols, such as eckol-type phlorotannin derivatives and highly oxidized phlorotannin dimers, exclusively detected in BP. They showed stronger DPPH radical scavenging capacity than FP, even surpassing tea polyphenols at 3.5 mg/mL. These findings demonstrate that alkaline extrac…

Encapsulation of Pomegranate Polyphenols in Plant-Based Proteins and Bioactivity of Resulting Microparticles.

The main objective of this study was to generate protein-polyphenol microparticles on the basis of pea and rice proteins in combination with pomegranate juice. Protein microparticles were prepared as a freeze-dried powder and evaluated for total polyphenols and proanthocyanidins using spectrophotometric methods, and for individual polyphenols using the HPLC method. In addition, they were assessed for antioxidant activity, and IR spectra were recorded to establish structural changes in proteins upon adsorption of pomegranate polyphenols. The potential of the formulated microparticles to inhibit…

Plant-Based Approaches for Inhibition of Advanced Glycation End Products Formation: Dietary Polyphenols.

Advanced glycation end products arise during thermal processing and endogenous metabolism, contributing to oxidative stress, inflammation, and the progression of chronic diseases. Dietary polyphenols have emerged as promising advanced glycation end product (AGE) inhibitors through antioxidant activity, carbonyl trapping, metal chelation, and modulation of inflammatory pathways. This review summarizes current evidence on the effects of polyphenols in food systems and highlights how different polyphenol subclasses vary in their antiglycation potential depending on chemical structure, food matrix…

Therapeutic Effects of Tea Polyphenols on Renal Damage Induced by High Uric Acid.

BACKGROUND: Hyperuricemia (HUA) is a condition characterized by excessive uric acid production and/or inadequate uric acid excretion due to … hod. RESULTS: Hyperuricemia markedly worsens renal damage in rats following nephrectomy, while tea polyphenols demonstrate the ability to reduce levels of blood uric acid, urea nitrogen, creatinine, and urinary protein. Additionally, tea polyphenols enhance smooth muscle proliferation in renal glomerular arterioles, prevent the loss of interstitial capillari …

Chokeberry Pomace as a Source of Polyphenols for Complexation with Plant-Based Proteins.

One way to utilize by-products from fruit production is the extraction of bioactive compounds and their subsequent complexation with appropriate carriers. Consequently, we used chokeberry pomace extract for complexation with plant-based proteins, namely almond, rice, pea, and pumpkin-seed protein matrices, which differ in their composition and protein content. The obtained complexes, as well as the chokeberry pomace extract and protein matrices, were evaluated for the concentration of individual polyphenols, total polyphenols, procyanidins, and antioxidant activity. Color parameters and IR spe…

In silico analysis of selected polyphenols as potential multitarget rheumatoid arthritis modifying agents.

INTRODUCTION: Rheumatoid arthritis (RA) arises from a complex inflammatory network involving cytokines, kinases, and matrix degrading enzymes. Methotrexate is the clinical standard but is limited by poor pharmacokinetics and a narrow mechanism. METHODOLOGY: This study evaluates six polyphenols sinapic acid, catechin, galangin, piceatannol, umbelliferone, and pinocembrin against fifteen validated RA targets and benchmarks them against methotrexate.An integrated in silico framework assessed ADME properties, molecular docking, and network pharmacology. ADME screening included Lipinski compliance,…

Characterisation of Dandelion Polyphenols and Their In Vitro Neuroprotective Effects During Simulated Digestion.

Dandelion, a herb with medicinal and nutritional properties, was studied for the stability and neuroprotective effects of polyphenols from its flowers, roots, and leaves during in vitro simulated digestion. Using UPLC-QTOF-ESI-MS/MS, 84 phenolic metabolites were identified, with flavonoids being most abundant in flowers and phenolic acids in leaves and roots. In vitro neuroprotection assays revealed that leaf polyphenols exhibited the highest inhibition rates against acetylcholinesterase and lipoxygenase, while flower polyphenols showed the strongest scavenging activity against reactive nitrog…

Полифенолы и нейродегенеративные заболевания: понимание знаний, механистические свидетельства и новые виды применения в области питания.

Полифенолы представляют собой разнообразную группу биоактивных веществ растительного происхождения, которые были исследованы в качестве многоцелевых возможностей для потенциальной профилактики и лечения нейродегенеративных заболеваний (НДИ). Мы провели комплексный библиометрический и механистический обзор, охватывающий 12 классов полифенола и семь основных НИЗ, с использованием записей из PubMed, Embase, Cochrane Bibrary и Web of Science (1940-2024). Для картирования исследовательских ландшафтов и новых тем использовались ключевые слова, анализы по группам и модели BERTopic. Механистические до

Совпадение в аннотации оригинала
Polyphenols are a diverse group of plant-derived bioactives that have been investigated as multi-target candidates for the potential prevention and management of neurodegenerative diseases (NDDs). We conducted an integrated bibliometric and mechanistic scoping review covering 12 polyphenol classes and seven major NDDs using records from PubMed, Embase, the C…

Comparison of In Vitro Biotransformation of Olive Polyphenols Between Healthy Young and Elderly.

BACKGROUND: Olive leaves are a rich source of polyphenols, predominantly secoiridoids, flavonoids, and simple phenols, which exhibit various biological properties. Extracts prepared from olive leaves are associated with hypoglycemic, hypotensive, diuretic, and antiseptic properties. Upon ingestion, a substantial fraction of these polyphenols reaches the colon where they undergo extensive metabolism by the gut microbiota. Host characteristics, like age, can influence the composition of the gut microbiome, potentially affecting the biotransformation of these compounds. Therefore, it can be hypot…

Olive polyphenols as modulators of amyloid aggregation: mechanisms and implications for neurodegenerative diseases.

The Mediterranean diet is well known for its role in promoting healthy aging and reducing the risk of chronic diseases, with extra virgin ol … tion. This review summarizes current evidence on the anti-amyloidogenic properties of olive-derived polyphenols, emphasizing their mechanisms of action and therapeutic relevance in two major neurodegenerative diseases, Alzheimer's and Parkinson's. Additionally, insights from molecular modeling studies are discussed to elucidate the structural basis of interac …

Impact of gut microbiota in chronic kidney disease: natural polyphenols as beneficial regulators.

Chronic kidney disease (CKD) poses a severe health risk with high morbidity and mortality, profoundly affecting patient quality of life and survival. Despite advancements in research, the pathophysiology of CKD remains incompletely understood. Growing evidence links CKD with shifts in gut microbiota function and composition. Natural compounds, particularly polyphenols, have shown promise in CKD treatment due to their antioxidant and anti-inflammatory properties and their ability to modulate gut microbiota. This review discusses recent progress in uncovering the connections between gut microbio…

Ultrasound-Assisted Green Extraction and Hydrogel Encapsulation of Polyphenols from Bean Processing Waste.

Pod is the major solid waste from bean processing, and its accumulation is expected to increase in the coming years due to the increases in pulse consumption. This study aimed to investigate (a) the efficacy ultrasound (US)-assisted extraction of polyphenols from bean pod; (b) their solubilization rate constants and effective diffusivities (De), which are relevant parameters for scaling-up the process; and (c) the encapsulation efficiencies of the recovered phenolic compounds in hydrogel microbeads. Extracts were obtained either in water with US assistance (50-350 W·L-1) at 30 °C; in water at …

Extraction, Phytochemical Analysis, and Bioactivity Evaluation of Polyphenols from Kunzea ericoides (Kanuka) Plant.

Kunzea ericoides (kanuka), a native plant of New Zealand, has a significant role in traditional medicine due to the presence of essential oils. Apart from these oils, this plant also is a source of many bioactive compounds, majority of which are polyphenols. However, there is lack of sufficient data supporting the extraction of polyphenols from kanuka plant leaves and investigating its bioactivity and phytochemical properties. The study aims to extract polyphenols from kanuka plant leaves with a conventional solvent-based method and determine the phytochemical analysis as well as bioactive pot…

Polyphenols from Inula oculus-christi L. Induced Cell-Specific Membrane and Cytoskeleton Reorganization.

Interrelations between the plasma membrane and cytoskeleton are of crucial importance for essential cellular processes such as endocytosis, formation of intercellular junctions, cell morphology, etc. Many studies validate the beneficial effects of polyphenols as antioxidant and protective agents, but a molecular mechanism of their interaction and transition through the plasma membranes of different cell lines is still missing. In this study, we examined the affinity of fractions enriched in flavonoid glycosides (FGs) and caffeoylquinic acids (CQAs), obtained from the methanol extract of the me…

[Preparation and physicochemical properties of double aldehyde starch microcapsules loaded with tea polyphenols].

OBJECTIVE: To achieve high-value and functional applications of Mongolian oak starch resources. METHODS: Dialdehyde Mongolian oak starch was prepared by modifying Mongolian oak starch with NaIO_4, using the degree of aldehyde substitution as an indicator to study the oxidation conditions. The dialdehyde Mongolian oak starch was then combined with gum arabic to create a composite wall material for encapsulating tea polyphenols, and the reaction conditions were optimized through PB tests and response surface analysis to investigate the encapsulation efficiency and sustained release properties o…

Multi-Target Modulation of Polyphenols in Diabetic Kidney Disease Therapeutics: A Comprehensive Review.

Diabetic kidney disease (DKD) is a severe complication of diabetes that presents as progressive kidney dysfunction and is the primary cause … used singly to target the disease's underlying pathophysiology or integrated into traditional care. Polyphenols possess biological properties capable of addressing these unmet needs by targeting multiple underlying mechanisms involved in DKD pathogenesis. The literature search occurred between September 2024 and April 2025, with most articles sourced from the …

[Effect of polyphenols on vascular dilation in rats receiving a high-fat diet].

UNLABELLED: Consumption of a high-fat diet (HFD) leads to the development of metabolic syndrome (MS), and the use of polyphenols can have a protective effect, reducing the severity of MS and preventing disorders of the cardiovascular system. The aim of the study was to test the hypothesis of a possible protective effect of polyphenol (resveratrol and quercetin) usage on the reactivity of the mesenteric arteries in Wistar rats fed an excessive amount of fat in the diet. MATERIAL AND METHODS: The study included 4 groups of Wistar rats: the HFD group (n=15) received HFD (50% fat by calories), gr…

Unraveling the Molecular Mechanisms of Osteoarthritis: The Potential of Polyphenols as Therapeutic Agents.

The complex nature of osteoarthritis (OA), driven by the intricate interplay of genetic, environmental, and lifestyle factors, necessitates … pro-inflammatory cytokines, with elevated MMP expression and decreased type II collagen synthesis. Polyphenols are nature's gifted magic molecules, which possess diverse biological properties like anti-oxidant, anti-bacterial, anti-inflammatory, estrogenic, and insulin-sensitizing effects, which can manage and treat all the multi-factorial contributing facto …