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Определение сексуальных потребностей и потребностей в интимности у пациентов с множественной миеломой: межсекторальное обследование.

ВВЕДЕНИЕ: Сексуальная дисфункция и интимная связь широко распространены в раке, однако они недооценены в гематологическая недостаточность, включая множественные миеломы (ММ). Бремя болезней MM может усугублять связанную с возрастом половую дисфункцию, однако структурированные данные по этой группе населения ограничены. Мы провели наблюдение, перекрестное, анонимное обследование среди взрослых, набранных из ММ 3 Израильские центры гематологии и израильская ассоциация пациентов ММ. В вопроснике на иврите были проанализированы области сексуальной дисфункции (до диагностирования ММ или по завершен

Совпадение в аннотации оригинала
INTRODUCTION: Sexual dysfunction and intimacy concerns are common in cancer but under-assessed in hematologic malignancies, including multip … o domains reached nominal statistical significance: low/no desire in women (21%-71%; p = 0.016) and erectile dysfunction in men (16%-53%; p = 0.016). The most common reasons for sexual inactivity were decreased desire, absence of a partner, and erectile dysfunction. Interest in supportive services was substantial: complementary medicine (27/53), hematologist consultat …

The effect of nebivolol on erectile function in the cases with coronary artery bypass surgery: A protocol for a systematic review and meta-analysis of randomized controlled trials.

BACKGROUND: Erectile dysfunction is a common disease. It affects the quality of life of both husband and wife and its prevalence is higher in patients with overt cardiovascular disease or cardiovascular risk factors. In recent years, multiple studies confirm that nebivolol exerts protective effects on erectile function against the disruptive effects of cardiopulmonary bypass in patients undergoing coronary artery bypass grafting, but its quality and efficacy have not been systematically evaluated. Therefore, it is necessary to carry out a systematic review and meta-analysis to fully evaluate t…

Mucuna pruriens var. pruriens Ethanolic Seed Extract Enhances Erectile Function-Related Mechanisms: Integrated In Vitro and In Vivo Evidence.

Mucuna pruriens (Linn.) DC. var. pruriens is used as a traditional medication to enhance male sexual function, yet integrated evidence linki … n models of erectile response. MPSE nevertheless represents a promising plant-derived candidate for erectile dysfunction.

S-nitrosylation of endothelial nitric oxide synthase impacts erectile function.

Neuronal and endothelial nitric oxide synthases (nNOS and eNOS respectively) play major roles in generating the nitric oxide bioactivity nec … tions in the balance of S-nitrosylation/denitrosylation either directly or indirectly contribute to erectile dysfunction.

Erectile function is improved in aged rats by PnTx2-6, a toxin from Phoneutria nigriventer spider venom.

INTRODUCTION: Age-associated erectile dysfunction (ED) involves a decrease in nitric oxide (NO) availability and impaired relaxation. PnTx2-6, a toxin from the Phoneutria nigriventer spider, has been demonstrated to improve erectile function via NO/cyclic guanosine monophosphate (cGMP) pathway. This spider's venom is characterized by several symptoms, including erection. PnTx2-6 has been implicated in this phenomenon. Animal venoms have been postulated as potential drugs to treat ED. AIM: PnTx2-6 toxin improves erectile function in aged rats via NO/cGMP. We investigated the effect of PnTx2-6 …

[Contribution of psychosexual approach to assessment and treatment of sexual dysfunction: a working model].

INTRODUCTION: Increasing awareness and medical studies of sexual dysfunction (SD) unveil the multi-dimensional nature of SD and the need for … tive sexual desire disorder (HSDD] (29.7%), sexual pain (28.5%) and anorgasmia (20.9%); and in men: erectile dysfunction (44.2%), premature ejaculation (24.5%) and HSDD (17.5%). Co-morbid relationship distress was found in 217 of the cases (26.5%). CONCLUSIONS: Subjects, referred by a physician or on their own initiation, present a variety of SDs, stemming from a com …

The progression of the penile vein: could it be recurrent?

Our aim was to study retrospectively the destiny of the deep dorsal vein of the penis in the event of its stripping surgery or its simple ligation in patients diagnosed with venoocclusive dysfunction 17 years ago. From June 1986 to May 1987, a total of 31 men were seen for erectile dysfunction due to venous leakage resulting from priapism, aging, or congenital or idiopathic factors. Of these, 23 men underwent venous stripping of the deep dorsal vein and are referred to as the stripping group. The remaining 8 patients received a simple ligation of the deep dorsal vein and are classified as the …

First Outcomes of the ZSI 475 FtM, a Specific Prosthesis Designed for Phalloplasty.

INTRODUCTION: The ZSI 475FtM is a new prosthesis that has recently been specifically designed for phalloplasty. It has several functions tha … o answer a satisfaction questionnaire that included the International Index of Erectile Function-5, Erectile Dysfunction Inventory of Treatment Satisfaction, and Self-Esteem and Relationship, as well as other non-validated questions. MAIN OUTCOME MEASURE: Complication rates and the scores of the different questionnaires were reviewed. RESULTS: 20 patients who had ge …

[Premature ejaculation].

Premature ejaculation is the more frequent sexological consultation in men along with the Erectile Dysfunction. In this article a revision will become of its definitions, its clinical manifestations that allow to an effective diagnosis and its therapeutic boarding with Sexual Therapies and, in certain cases, with drugs like PDE-5 Inhibitors, tricyclic antidepressants, IRSS, or dapoxetine.

Testosterone Deficiency and Sleep Apnea.

Obstructive sleep apnea (OSA) is a common condition among middle-aged men and is often associated with reduced testosterone (T) levels. OSA can contribute to fatigue and sexual dysfunction in men. There is suggestion that T supplementation alters ventilatory responses, possibly through effects on central chemoreceptors. Traditionally, it has been recommended that T replacement therapy (TRT) be avoided in the presence of untreated severe sleep apnea. With OSA treatment, however, TRT may not only improve hypogonadism, but may also alleviate erectile/sexual dysfunction.

Testosterone Deficiency and Sleep Apnea.

Obstructive sleep apnea (OSA) is a common condition among middle-aged men and is often associated with reduced testosterone (T) levels. OSA can contribute to fatigue and sexual dysfunction in men. There is suggestion that T supplementation alters ventilatory responses, possibly through effects on central chemoreceptors. Traditionally, it has been recommended that T replacement therapy (TRT) be avoided in the presence of untreated severe sleep apnea. With OSA treatment, however, TRT may not only improve hypogonadism, but may also alleviate erectile/sexual dysfunction.

Clinical approach to autonomic dysfunction.

Patients with autonomic dysfunction may present with a variety of seemingly unrelated symptoms, both generalised and involving specific systems, including fatigue, difficulty concentrating, orthostatic intolerance, palpitations, constipation or diarrhoea, early satiety, urinary retention or incontinence and erectile dysfunction. Failure to connect the diverse symptoms with a single underlying mechanism may lead to incorrect diagnoses, inappropriate interventions and frustration on the part of both doctors and patients. We describe recent developments in the understanding of the pathophysiology…

Aging effects in the extracellular matrix of the clitoris: A scanning electron microscopic analysis.

OBJECTIVE OF THE STUDY: The present work aims to observe the clitoris' extracellular matrix in young and old women with a scanning electron … d herein may alter the function of the organ and are similar to observations in studies of men with erectile dysfunction. CONCLUSION: Female sexual dysfunction is a condition prevalent in a significantly large portion of women and it is more common in elderly women. It is known that the tumescence mechanism requires integrity of the extracellular matrix. The changes …

[Sexual dysfunctions after traumatic brain injury: Systematic review of the literature].

BACKGROUND: Sexual dysfunction (SD) is common in the general population, up to 50% in women and with no clearly defined prevalence in men but up to 30% in erectile dysfunction. Sexual dysfunctions (SD) are common after a traumatic brain injury (TBI) but remain underrated in clinical practice, yet it is a crucial aspect of the person with consequences for the relationship with the other, psychological wellbeing and quality of life. OBJECTIVE: To determine, through a systematic literature review, the epidemiology, assessment tools and treatment of SD in the TBI population. SOURCES: (keywords, …

Does Transperineal Prostate Biopsy Affect Sexual Function? Results from a Prospective Cohort Study.

Objectives: Transperineal (TP) prostate biopsy is increasingly used because of its lower complication rates compared with the transrectal approach. However, prospective data regarding its effects on erectile and ejaculatory function remain limited. This study prospectively evaluated short-term sexual function outcomes after TP prostate biopsy in sexually active men. Methods: This single-center prospective observational cohort study included men undergoing TP prostate biopsy between 15 April 2025 and 1 September 2025. Indications for biopsy were prostate-specific antigen levels >4 ng/mL, abnorm

Heat Shock Protein 70 in Penile Neurovascular Regeneration Requires Cystathionine Gamma-Lyase.

PURPOSE: Diabetes mellitus, one of the major causes of erectile dysfunction, leads to a poor response to phosphodiesterase-5 inhibitors. Heat shock protein 70 (Hsp70), a ubiquitous molecular chaperone, is known to play a role in cell survival and neuroprotection. Here, we aimed to assess whether and how Hsp70 improves erectile function in diabetic mice. MATERIALS AND METHODS: Eight-week-old male C57BL/6 mice and Hsp70-Tg mice were used in this study. We injected Hsp70 protein into the penis of streptozotocin (STZ)-induced diabetic mice. Detailed mechanisms were evaluated in WT or Hsp70-Tg mic…

Cavernoplasty with oral mucosa graft for the surgical treatment of Peyronie's disease.

BACKGROUND: Peyronie's disease is a disorder of the tunica albuginea and causes penile curvature, requiring surgical correction when the def … operative and postoperative values were not statistically significant (P=ns). One patient developed erectile dysfunction. In all cases, the residual curvature was <20°. Nine patients (90%) stated that they would undergo the same operation. CONCLUSIONS: The short-term results suggest that cavernoplasty with oral mucosa graft can be an alternative to traditional grafts …

Impact of COVID-19 on Online Interest in Urologic Conditions: An Analysis of Google Trends.

Background With COVID-19 leading to several isolation measures for preventative care, health care utilization, especially within urology, de … top queries were often related to symptoms, treatments, and COVID-19. COVID showed higher SVIs for erectile dysfunction (p=0.04) and lower SVIs for bladder cancer (p<0.01), hematuria (p<0.01), kidney cancer (p<0.01), kidney stones (p=0.03), and prostate cancer (p<0.01). Correlations to COVID-19 searches were seen for bladder cancer (RS=-0.36, p<0.01), erectile dysfun …

Urinary symptoms and sexual dysfunction among Italian men: The results of the #Controllati survey.

OBJECTIVE: Prevention may improve the quality of life and sexual and reproductive health. To improve prevention require a comprehensive rese … CI 1.12-1.64)]. 27.2% (IC 95% overall 25.2% -29.3%) of the subjects had at least a sexual disorder (erectile dysfunction, premature ejaculation, hypoactive sexual desire). The erectile dysfunction and hypoactive sexual desire increased with age, but premature ejaculation tended to be higher among younger aged men aged 40 years or more. Current any urinary symptoms [OR …

Sexual Dysfunction in Infertile Men: A Systematic Review and Meta-Analysis.

BACKGROUND: According to previous studies of male infertility, we found that the association between sexual dysfunction and male infertility was reported rarely and controversially. AIM: We carried out this 1meta-analysis to evaluate the prevalence of sexual dysfunction and the International Index of Erectile Function (IIEF) score in infertile men. METHODS: A systematic search of the target literature was conducted using PubMed, EMBASE, and Cochrane Library. Data were analyzed using Review Manager 5.4 software. Standardized mean differences (SMD) with the corresponding 95% confidence interva