Результаты поиска

Разработка и проверка новой хрупкой модели для пациентов с недавно поставленным диагнозом множественной миэломы.

Преобладание старения у пациентов с множественной миеломой (ММ) приводит по крайней мере к тому, что 30% пациентов, отнесенных к категории слабых при диагностике. По сравнению со здоровыми людьми слабые люди демонстрируют снижение терпимости к лечению и более низкое качество жизни, что связано со снижением показателей выживаемости. Несмотря на то, что были разработаны различные модели слабостей для MM, по-прежнему сохраняются проблемы с их широким применением и своевременной корректировкой лечения на основе оценок слабых мест в различных группах пациентов. МЕТОДЫ: В настоящем ретроспективном и

Совпадение в полном тексте источника
… Liang F, Dong XY, Tang GF, Qi KM, Chen W, Sang W, et al. Influence of prognostic nutritional index and controlling nutritional status on the prognosis of patients with multiple myeloma. Zhonghua Xue Ye Xue Za Zhi. 2021;42(4):332–7. 10.3760/cma.j.issn.0253-2727.2021.04.011. 42. …

Effect of counseling intervention on symptoms, pain acceptance and psychological wellbeing among patients with fibromyalgia.

BACKGROUND: Nurses to assist patients make the best choices in challenging circumstances, counseling is crucial. Patients' health and quality of life can be enhanced by healthcare providers, particularly nurses, through counseling and educational initiatives. Fibromyalgia is characterized by widespread pain that negatively impacts an individual's ability to work. People may be able to improve their physical and mental health and accept suffering with the use of nursing counseling methods. AIM: This study aimed to investigate the effect of counselling intervention on symptoms, pain acceptance,

Совпадение в полном тексте источника
… Exercise, including aerobic and anaerobic exercise, aquatic therapies, Qi Gong therapy, and Tai Chi, has demonstrated promise in lowering pain and enhancing function, however the long-term consequences are still being studied. …

Health-related quality of life and associated factors among family caregivers of patients with cancer in oncologic centers of Northwest Ethiopia.

BackgroundProviding care for individuals dealing with long-term illnesses like cancer demands significant amounts of time, energy, and emotional investment, potentially resulting in a challenging and overwhelming quality of life for those providing the care.ObjectiveThe purpose of this study was to assess the level of health-related quality of life (HRQoL) and associated factors among family caregivers of patients with cancer in oncologic centers of Northwest Ethiopia.MethodA cross-sectional study was conducted among 412 family caregivers of patients with cancer who were following treatment at

Совпадение в полном тексте источника
… It creates a profile with four domain scores: physical health (7 items), psychological health (6 items), social relationships (3 items), and environmental domain (8 items) as well as two individually scored items concerning the individuals’ impression of their quality of life (QI) and health (Q2). …

Decoding Cancer Risk: Understanding Gene-Environment Interactions in Cancer Development.

While lifestyle choices or behavioral patterns remain the most significant factors influencing cancer risk, environmental exposure to certain chemicals, both manufactured and natural, may also contribute to an individual's likelihood of developing cancer. This interplay of factors, coupled with an aging demographic and shifting lifestyle patterns, has led to an increasing prevalence of cancer in recent years. This study examines the environmental and behavioral factors that contribute to anomalies in the immune system and increase the risk of developing cancer. Significant environmental and oc

Совпадение в полном тексте источника
… Qi Q, Chu AY, Kang JH, et al. BMJ. 2014;348:0. doi: 10.1136/bmj.g1610. 41. Fried potato consumption is associated with elevated mortality: an 8-y longitudinal cohort study. Veronese N, Stubbs B, Noale M, et al. Am J Clin Nutr. 2017;106:162–167. doi: 10.3945/ajcn.117.154872. 42. …

Early prognosis prediction in acute myeloid and acute lymphoid leukemia patients using cell-free DNA concentration ratios.

Background: Cell-free DNA (cfDNA) is a promising biomarker for disease prediction in many cancers, including acute leukemia (acute myeloid leukemia [AML] and acute lymphoblastic leukemia [ALL]). This study investigated the role of cfDNA in predicting relapse or unfavorable outcomes in acute leukemia patients upon initial diagnosis. Methods: Paired peripheral blood samples of 25 patients with ALL and AML were compared at baseline and induction/follow-up and clinically correlated with clinicopathological and outcome variables according to the risk category. cfDNA was isolated using commercial cf

Совпадение в полном тексте источника
… Qi B. Chen X. Chang L. Zhang A. ( 2021 ). Targeted next-generation sequencing of circulating tumor DNA, bone marrow, and peripheral blood mononuclear cells in pediatric AML . Front. Oncol. 11 , 666470 . 10.3389/fonc.2021.666470 34422630 PMC8377768 Schwarzenbach H. Hoon D. S. Pantel K. ( 2011 ). …

Proteome analysis of urinary biomarkers in a cigarette smoke-induced COPD rat model.

BackgroundChronic obstructive pulmonary disease (COPD) is a chronic inflammatory airway disease caused by inhalation of cigarette smoke (CS) and other harmful gases and particles.MethodsThis study aimed to explore potential urinary biomarkers for CS-induced COPD based on LC-MS/MS analysis.ResultsA total of 340 urinary proteins were identified, of which 79 were significantly changed (30, 31, and 37 at week 2, 4 and 8, respectively). GO annotation of the differential urinary proteins revealed that acute-phase response, response to organic cyclic compounds, complement activation classical pathway

Совпадение в полном тексте источника
… Acknowledgements The authors would like to thank Yanyan Sui and Lixin Sun for pulmonary function test support and Xuefei Qi for lung histopathology analysis. Statement on ARRIVE guidelines We declared that this study was carried out in compliance with the ARRIVE guidelines. …

A Phase II Study of the Efficacy and Safety of Oral Selinexor in Recurrent Glioblastoma.

PURPOSE: Selinexor is an oral selective inhibitor of exportin-1 (XPO1) with efficacy in various solid and hematologic tumors. We assessed intratumoral penetration, safety, and efficacy of selinexor monotherapy for recurrent glioblastoma. PATIENTS AND METHODS: Seventy-six adults with Karnofsky Performance Status ≥ 60 were enrolled. Patients undergoing cytoreductive surgery received up to three selinexor doses (twice weekly) preoperatively (Arm A; n = 8 patients). Patients not undergoing surgery received 50 mg/m2 (Arm B, n = 24), or 60 mg (Arm C, n = 14) twice weekly, or 80 mg once weekly (Arm

Совпадение в полном тексте источника
… Liu X, Chong Y, Tu Y, Liu N, Yue C, Qi Z, et al. CRM1/XPO1 is associated with clinical outcome in glioma and represents a therapeutic target by perturbing multiple core pathways. J Hematol Oncol 2016;9:108. 6. Wu S, Qiao Q, Li G. …

Pharmacological Interventions for the Management of Cancer-Related Fatigue Among Cancer Survivors: Systematic Review and Meta-Analysis.

ObjectiveCurrent guidelines have different recommendations on applying pharmacological interventions for managing cancer-related fatigue (CRF) among cancer survivors. This systematic review aims to synthesize clinical evidence on pharmacological interventions for managing CRF.MethodsFive databases were searched for potential randomized controlled trials (RCTs) from their inception until October 2020. RCTs assessing the effect of pharmacological treatments for CRF among cancer survivors were considered eligible. Clinical significance was determined by comparing the estimated effect with that of

Совпадение в полном тексте источника
… On the other hand, results from small sample size RCTs (n ≤ 40) indicated that American ginseng and Bojungikki-tang (also known as Bu-Zhong-Yi-Qi-Tang or Hochu-ekki-to) did not offer statistically significant alleviation in CRF when compared to control, although point estimation on the effect of Bojungikki-tang …

LncRNA OIP5‑AS1 aggravates house dust mite‑induced inflammatory responses in human bronchial epithelial cells via the miR‑143‑3p/HMGB1 axis.

Bronchial asthma poses a serious threat to human health. Previous studies have documented the role of long non‑coding RNAs (lncRNAs) in asthma. However, the molecular mechanism underlying bronchial asthma remains unclear. The aim of the present study was to evaluate the role of the lncRNA Opa‑interacting protein 5 antisense RNA1 (OIP5‑AS1) in the house dust mite‑induced inflammatory response in human bronchial epithelial cells. BEAS‑2B cells were treated with Dermatophagoides pteronyssinus peptidase 1 (Der p1) to establish an in vitro model of asthma. OIP5‑AS1 expression levels increased in BE

Совпадение в полном тексте источника
… Pu Y, Liu YQ, Zhou Y, Qi YF, Liao SP, Miao SK, Zhou LM, Wan LH. Dual role of RACK1 in airway epithelial mesenchymal transition and apoptosis. J Cell Mol Med. 2020;24:3656–3668. doi: 10.1111/jcmm.15061. 17. Lee HS, Park DE, Song WJ, Park HW, Sohn SW. …

Sorcin: a novel potential target in therapies of cancers.

Soluble resistance-related calcium-binding protein (sorcin) is a member of the penta-EF-hand protein family. Sorcin is widely distributed in normal human tissues, such as the brain, heart, lymphocytes, kidneys, breast and skin. Findings suggest that sorcin is associated with the regulation of calcium homeostasis, cell cycle and vesicle trafficking. It has been reported that many types of non-neoplastic diseases such as diabetes, viral infection, infertility, and nervous system diseases were affected by the expression of sorcin. One of the main issues is the role of sorcin in neoplastic disease

Совпадение в полном тексте источника
… Tan Y, Qi J, Liu WJ, et al. Preliminary studies on the mechanisms of a new anti-tumor agent PH Ⅱ-7 with special preference to multidrug resistant tumor cells. Acta Academiae Medicinae Sinicae . 2002;(02):134–139. 82. Xing CL, Li GY, Wang J, et al. …

Calpastatin phosphorylation regulates radiation-induced calpain activity in glioblastoma.

Glioblastoma (GBM) is an aggressive, malignant brain tumor that inevitably develops resistance to conventional chemotherapy and radiation treatments. In order to identify signaling pathways involved in the development of radiation resistance, we performed mass spectrometry-based phospho-proteomic profiling of GBM cell lines and normal human astrocytes before and after radiation treatment. We found radiation induced phosphorylation of a number of proteins including calpastatin, specifically in GBM stem cells (GSCs). Herein, we focused on calpastatin, an endogenous inhibitor of calpain proteases

Совпадение в полном тексте источника
… Arch Biochem Biophys 2014 564 26 36 25305531 10.1016/j.abb.2014.09.018 16 Cai JJ Qi ZX Hua W Zhu JJ Zhang X Yao Y Mao Y Increased expression of Capn4 is associated with the malignancy of human glioma CNS Neurosci Ther 2014 20 521 527 24628706 10.1111/cns.12248 PMC6492991 17 Braun C Engel M Seifert …

Latest developments in MUC1 immunotherapy.

Currently, there is renewed interest in attempting to recruit the host immune system to eliminate cancers, and within this renewed activity, MUC1 continues to arouse interest. MUC1 has been considered a possible therapeutic target for the past 30 years as it is up-regulated, aberrantly glycosylated and its polarization is lost in many adenocarcinomas. Moreover, MUC1 is expressed by some haematopoietic cancers, including acute myeloid leukaemia and myeloma. Although multiple clinical trials have been initiated and immune responses have been documented, effective clinical benefit worthy of appro

Совпадение в полном тексте источника
… U.S.A. 84 , 6060 – 6064 10.1073/pnas.84.17.6060 2888110 PMC299007 2 Lan M.S. , Batra S.K. , Qi W.N. , Metzgar R.S. and Hollingsworth M.A. ( 1990 ) Cloning and sequencing of a human pancreatic tumor mucin cDNA . J. Biol. …

Tripchlorolide induces autophagy in lung cancer cells by inhibiting the PI3K/AKT/mTOR pathway and improves cisplatin sensitivity in A549/DDP cells.

Tripchlorolide (T4) has been shown to induce A549 lung cancer cell death predominantly by activating an autophagy pathway. However, the underlying mechanism remains unclear. Herein, we demonstrated that compared with T4 treatment alone, pretreatment with wortmannin (an inhibitor of phosphatidylinositol 3-kinase), perifosine (an inhibitor of AKT) or rapamycin (an inhibitor of mTOR) combined with a subsequent T4 treatment significantly impaired the cell viability of A549 and A549/DDP lung cancer cells. We found that either treatment scheme markedly reduced the activity of P13K and AKT. Expressio

Совпадение в полном тексте источника
… e995008 27308476 10.4161/23723556.2014.995008 PMC4905313 28 Guan H Zhao P Dai Z Liu X Wang X SH3GL1 inhibition reverses multidrug resistance in colorectal cancer cells by downregulation of MDR1/P-glycoprotein via EGFR/ERK/AP-1 pathway Tumour Biol 2016 37 12153 60 27220321 10.1007/s13277-016-5092-0 29 Qi …

The next new target in leukemia: The embryonic stem cell gene SALL4.

The embryonic stem (ES) cell gene SALL4 has recently been identified as a new target for cancer therapy, including leukemia. SALL4 is expressed in ES cells and during embryonic development, but is absent in most adult tissues. It is, however, aberrantly expressed in various solid tumors and hematologic malignancies such as myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Aberrant expression of SALL4 is frequently associated with a more aggressive cancer phenotype, which includes high-risk MDS and its progression to AML. SALL4 contributes to leukemogenesis through multiple path

Совпадение в полном тексте источника
… Delmore JE , Issa GC , Lemieux ME , Rahl PB , Shi J , Jacobs HM , Kastritis E , Gilpatrick T , Paranal RM , Qi J , et al. BET bromodomain inhibition as a therapeutic strategy to target c-Myc . …

The DAC system and associations with multiple myeloma.

Despite the clear progress achieved in recent years in the treatment of MM, most patients eventually relapse and therefore novel therapeutic options are still necessary for these patients. In this regard, several drugs that target specific mechanisms of the tumor cells are currently being explored in the preclinical and clinical setting. This manuscripts offers a review of the rationale and current status of the antimyeloma activity of one of the most relevant examples of these targeted drugs: deacetylase inhibitors (DACi). Several studies have demonstrated the prooncogenic activity of deacety

Совпадение в полном тексте источника
… Chang H Qi C Yi QL Reece D Stewart AK p53 gene deletion detected by fluorescence in situ hybridization is an adverse prognostic factor for patients with multiple myeloma following autologous stem cell transplantation Blood 2005 105 358 360 10.1182/blood-2004-04-1363 15339849 38. …

Curcumin and Its Derivatives as Anticancer Agents in Head and Neck Cancer: Molecular Mechanisms and Preclinical Evidence

Head and neck cancer (HNC), particularly oral squamous cell carcinoma (OSCC), remains a major clinical challenge due to its aggressive behavior, high recurrence rates, and frequent resistance to conventional therapies. Natural compounds, especially curcumin and its derivatives, have gained increasing attention as potential anticancer agents due to their ability to target multiple molecular pathways involved in tumor progression. This review critically evaluates the current preclinical and translational evidence supporting curcumin and its derivatives as monotherapeutic agents in HNC, with part

Targeting LAG-3, TIM-3, and TIGIT for cancer immunotherapy.

In one decade, immunotherapy based on immune checkpoint blockades (ICBs) has become a new pillar of cancer treatment following surgery, radiation, chemotherapy, and targeted therapies. However, not all cancer patients benefit from single or combination therapy with anti-CTLA-4 and anti-PD-1/PD-L1 monoclonal antibodies. Thus, an increasing number of immune checkpoint proteins (ICPs) have been screened and their effectiveness evaluated in preclinical and clinical trials. Lymphocyte activation gene-3 (LAG-3), T cell immunoglobulin and mucin-domain-containing-3 (TIM-3), and T cell immunoreceptor w

Targeting epigenetic methylation: emerging diagnosis and therapeutic strategies in cancer.

Epigenetics shapes all aspects of cancer occurrence and progression. Among them, chromatin methylation is a particularly important regulator of oncogenic processes. The dynamic shifts in methylation can influence the development or death of tumor cells. In the therapeutic context, effectively targeting and modulating DNA, RNA, and histone methylation brings promise for the early detection, prognostic assessment, and treatment of cancer. In particular, novel methylation inhibitors or modulators powerfully kill tumor cells or improve existing therapeutic strategies through different signaling pa

The Potential and Prospects of Marine Drugs in Intervening Nerve-Tumor Crosstalk.

The bidirectional crosstalk between the nervous system and tumors has emerged as a transformative new frontier in both precision oncotherapy and mechanism-driven cancer pain management. Marine natural products with inherent neuroactive properties exhibit unparalleled intervention advantages for targeting this complex pathophysiological axis. Herein, we systematically and prospectively dissect the multi-layered bidirectional communication between the nervous system and malignancies, comprehensively summarize the pivotal contributions of marine-derived bioactive molecules to advances in neurosci

Совпадение в полном тексте источника
… Qi J.C., Xue W.Y., Zhang Y.P., Qu C.B., Lu B.S., Yin Y.W., Liu K.L., Wang D.B., Li W., Zhao Z.M. Cholinergic α5 nicotinic receptor is involved in the proliferation and invasion of human prostate cancer cells. Oncol. Rep. 2020;43:159–168. doi: 10.3892/or.2019.7411. 23. … Guo X., He L., Xu W., Wang W., Feng X., Fu Y., Zhang X., Ding R.B., Qi X., Bao J., et al. αO-Conotoxin GeXIVA[1,2] Suppresses In Vivo Tumor Growth of Triple-Negative Breast Cancer by Inhibiting AKT-mTOR, STAT3 and NF-κB Signaling Mediated Proliferation and Inducing Apoptosis. Mar. …

Research Progress on Chinese Herbal Medicine Components Targeting Ferroptosis for Cancer Therapy.

Recent studies indicate that ferroptosis shows unique advantages in oncotherapy, particularly in reversing multidrug resistance (MDR). Despite current therapeutic advancements, the treatment of high-incidence malignancies with dismal prognoses continues to face challenges, including limited clinical efficacy, significant side effects, and drug resistance. In recent years, Chinese herbal medicine (CHM) has gained increasing attention in anti-tumor therapy. CHM bioactive components are highly effective in inducing tumor cell ferroptosis, inhibiting tumor proliferation and migration, and reversin