Результаты поиска

Internal-locking intramedullary nails (talons, claws, wings, wedge-locks, endopins): a mechanics-guided scoping review of designs, failure signatures, and technique imperatives.

BACKGROUND: "Internal-locking" concepts-deployable talons/claws and tanged anchors, winged/wedge-wing head elements, blade-expandable and wedge-locked distal modules, inside-to-out internal distal locking pins (endopins), and shape-memory (nitinol) wings-aim to streamline intramedullary (IM) fixation by reducing reliance on freehand distal interlocking screws while maintaining stability. METHODS: A scoping, mechanics-informed review was conducted using PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar (January 1980-October 2025; last search October 25, 2025). Studies evaluating intra

2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines.

UNLABELLED: Since 1980, the American College of Cardiology (ACC) and American Heart Association (AHA) have translated scientific evidence in … time constraints on busy clinicians and facilitates easier access to recommendations via electronic search engines and other evolving technology. EVIDENCE REVIEW: Writing committee members review the literature; weigh the quality of evidence for or against particular tests, treatments, or procedures; and estimate expected health outcomes. In developing recomme …

Nanotechnology: an evidence-based analysis.

OBJECTIVE: Due to continuing advances in the development of structures, devices, and systems with a length of about 1 to 100 nanometres (nm) (1 nm is one billionth of a metre), the Medical Advisory Secretariat conducted a horizon scanning appraisal of nanotechnologies as new and emerging technologies, including an assessment of the possibly disruptive impact of future nanotechnologies. The National Cancer Institute (NCI) in the United States proclaimed a 2015 challenge goal of eliminating suffering and death from cancer. To help meet this goal, the NCI is engaged in a concerted effort to intro

The Experience and Effectiveness of Nurse Practitioners in Orthopaedic Settings: A Comprehensive Systematic Review.

REVIEW QUESTION/OBJECTIVE: This review asks "What is the experience and effectiveness of nurse practitioners in orthopaedic settings"?The objective of the quantitative component of this review is to synthesise the best available evidence on effectiveness of orthopaedic nurse practitioner specific care on patient outcomes and process indicators.The objective of the qualitative component of this review is to synthesise the best available evidence on the experience of becoming or being an orthopaedic nurse practitioner in relation to role development, role implementation and (ongoing) role evalua

Management of chronic pressure ulcers: an evidence-based analysis.

UNLABELLED: In April 2008, the Medical Advisory Secretariat began an evidence-based review of the literature concerning pressure ulcers.Please visit the Medical Advisory Secretariat Web site, http://www.health.gov.on.ca/english/providers/program/mas/tech/tech_mn.html to review these titles that are currently available within the Pressure Ulcers series.PRESSURE ULCER PREVENTION: an evidence based analysisThe cost-effectiveness of prevention strategies for pressure ulcers in long-term care homes in Ontario: projections of the Ontario Pressure Ulcer Model (field evaluation)MANAGEMENT OF CHRONIC P

Prospects for Development and Commercialisation of Allogeneic CAR-Based Therapies for Autoimmune Disease.

Chimeric antigen receptor (CAR)-T cell therapies represent a promising therapeutic approach for refractory autoimmune diseases. Although autologous CAR-T cells have achieved success thus far, they require expensive, individualised manufacturing, limiting their commercialisation potential. Allogeneic alternatives could overcome these scalability barriers, providing 'off-the-shelf' treatments, although they raise the issues of graft-vs-host reactions and host-mediated rejection. To mitigate such risks, gene-edited αβ T cells or non-alloreactive host cells (e.g., NK cells, γδ T cells) may be used

Продольные меры в качестве прогностических биомаркеров при многоразовом склерозе: систематический обзор и мета-анализ.

СПРАВОЧНАЯ ИНФОРМАЦИЯ И ЦЕЛИ: В качестве ценного маркера для оценки воспаления и нейроаксонального дегенерации при множестве склерозов (MS) появилась томография оптической согласованности (OCT). Хотя такие традиционные маркеры, как атрофия мозга и потеря аксона, имеют решающее значение для мониторинга движения MS, их клиническое применение может быть ограничено различными факторами. Цель этого метаанализа продольных исследований заключается в оценке прогнозируемого значения пороговых значений толщины сетчатого слоя на основе OCT для мониторинга и прогнозирования развития и когнитивного сокраще

Gaucher: A Systematic Review on Oral and Radiological Aspects.

Background and Objectives: Gaucher disease (GD) is a lysosomal storage disorder with the genetic autosomal recessive transmission. Bone involvement is a prevalent finding in Gaucher disease. It causes deformity and limits daily activities and the quality of life. In 75% of patients, there is bone involvement. This review aims to evaluate the principal findings in the jaw by a Cone-beam computed tomography (CBTC) and X-ray orthopantomography; Materials and Methods: PubMed, Web of Science, Lilacs and Scopus were systematically searched until 31 December 2022. In addition, a manual search was per

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… The keywords used in the search engine using MeSh are as follows: (“Gaucher disease” [MeSH Terms] OR (“gaucher” [All Fields] AND “disease” [All Fields] OR “gaucher disease” [All Fields] AND (“bone and bones” [MeSH Terms] OR (“bone” [All Fields] AND “bones” [All Fields] OR “bone and bones” [All Fields … A fourth search engine on Scopus was used, given the specificity of the topic. In addition, 1226 articles were eliminated as duplicates. …

Инфодемиология и инфовелленс множественных склерозов в Италии

Множественный склероз (MS) является хроническим изнурительным заболеванием вероятной аутоиммунной провокационной природы, аэтология которого не в полной мере понята, несмотря на многочисленные усилия и исследования. В этой рукописи мы пересматриваем концепцию < < мультипликаторного склероза 2.0 > > , т.е. использование Интернета пациентами, страдающими MS, для поиска медицинских и связанных с болезнями материалов для целей самообслуживания и саморегулирования, и внедряем основанный на Google Trends подход к мониторингу связанных с MS запросов и поисков в Google, который называется

Совпадение в полном тексте источника
… SARS was discovered through monitoring search engines, since Larry Brilliant discovered a “viral” search of anti-influenza drugs in China [ 34 ]. Scholars have stressed the correlations between Internet search and the triage data, the hospital access, and the need of drugs [ 35 , 36 ]. … Gunn III and Lester surveyed suicides using search engines [ 39 ], and other scholars have replicated these findings [ 40 , 41 ], while Deluca and collaborators exploited the Web for studying the epidemiology of drug addiction [ 42 ]. …

Efficacy and safety of chimeric antigen receptor T-cell (CAR-T) therapy in hematologic malignancies: a living systematic review (protocol).

ObjectiveTo determine the efficacy and safety of CAR-T therapy in the treatment of patients with hematologic malignancies, in comparison with other current therapies.DesignA living systematic review.MethodsWe will include randomized trials evaluating the effect of CAR-T therapy versus other active treatments, hematopoietic stem cell transplantation, best supportive care or any other intervention in patients with hematologic malignancies. Non-randomized primary studies will be searched in case we found no direct evidence from randomized controlled trials. Two reviewers will independently screen

Потребности и предпочтения в поддержке людей с множественным склерозом: протокол быстрого обзора.

ВВЕДЕНИЕ: Люди с множественным склерозом (МС) живут в прогрессивном состоянии, которое может привести к возникновению сложных потребностей в поддержке инвалидов. Следовательно, они могут нуждаться в специализированном уходе и ассистивных технологиях для поддержания своей независимости дома. Важно обеспечить понимание потребностей и предпочтений людей, имеющих НР, с целью сохранения независимости и повышения качества их жизни. МЕТОДЫ И АНАЛИЗ: Принципы системы систематического обзора включены в наш быстрый обзор. Таким образом, с самого начала проекта была нанята целевая группа, которая определ

Совпадение в полном тексте источника
… Search terms will be refined to accommodate the limits of the search engine (see box 1 ). The inclusion and exclusion criteria will apply as per the initial search strategy. … As per Cullerton et al, 35 we will use just one search engine. Adopting further advice by Cullerton et al , 35 we will create parameters for the Advanced Google search, including a PDF format filter and prioritising the highest-ranking unsponsored results. …

BLAB2CancerKD: a knowledge graph database focusing on the association between lactic acid bacteria and cancer, but beyond.

In a broad sense, lactic acid bacteria (LAB) is a general term for Gram-positive bacteria that can produce lactic acid by utilizing fermentable carbohydrates. It is widely used in essential fields such as industry, agriculture, animal husbandry and medicine. At the same time, LAB are closely related to human health. They can regulate human intestinal flora and improve gastrointestinal function and body immunity. Cancer, a disease in which some cells grow out of control and spread to other body parts, is one of the leading causes of human death worldwide. In recent years, the potential of LAB i

From induced pluripotent stem cell (iPSC) to universal immune cells: literature review of advances in a new generation of tumor therapies.

Background and objectiveTumor therapy is still a tough clinical challenge, and cancer immunotherapy has drawn increasing attention. T cells and natural killer (NK) cells play crucial roles in the immune response. Induced pluripotent stem cell (iPSC) technology opens up a new way to produce functionally improved universal iPSC-derived chimeric antigen receptor (CAR) T (CAR-iT) and iPSC-derived CAR-NK (CAR-iNK) cells. This study aims to comprehensively review the generation and clinical applications of iPSC-derived universal CAR-iT and CAR-iNK cells to explore their potential and future directio

Research trends and hotspots of CAR-T cell therapy for acute lymphoblastic leukemia: A bibliometric analysis.

This study aims to analyze the global research patterns and emerging trends in CAR-T cell therapy for ALL through a bibliometric analysis. Publications were retrieved from the Web of Science Core Collection database. The bibliometric analysis utilized VOSviewer, CiteSpace, and the R package "bibliometrix" to visualize collaborations, keyword co-occurrences, and emerging research trends. A total of 844 articles from 253 journals by 6,459 authors across 44 countries were analyzed, showing an annual growth rate of 40.08%. The USA (372 articles, 38,065 citations) and China (275 articles, 5,636 cit

CRISPR-Cas9-Mediated Gene Editing in Hematological Disorders: Advancing Translational and Clinical Applications.

Clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR-Cas9)-mediated gene editing has emerged as a pivotal advancement in hematological medicine, addressing genetic and regulatory abnormalities underlying inherited and acquired blood disorders. Conventional therapeutic strategies offer symptomatic control or partial disease modification, leaving substantial unmet clinical need for durable, mechanism-driven interventions. This narrative review aims to synthesize the translational and clinical progress of CRISPR-Cas9 applications in hematological disorders, with

The Role of Chimeric Antigen Receptor-T Cell Therapy in the Treatment of Hematological Malignancies: Advantages, Trials, and Tribulations, and the Road Ahead.

Immunotherapy is the upcoming trend in cancer treatment. Traditional cancer treatment methods include surgical resection, radiotherapy, chemotherapy, small molecule targeted drugs, monoclonal antibodies, and hematopoietic stem cell transplantation (HSCT). Surgical resection is useful for early-stage patients but not for metastatic cancer cells; radiotherapy and chemotherapy are more common but produce substantial damage to normal tissues and have poor selectivity. Targeted drugs, including monoclonal antibodies, have better comprehensive efficacy but can also encourage gene mutation of tumor c

Cell therapies in the clinic.

Cell therapies have emerged as a promising therapeutic modality with the potential to treat and even cure a diverse array of diseases. Cell therapies offer unique clinical and therapeutic advantages over conventional small molecules and the growing number of biologics. Particularly, living cells can simultaneously and dynamically perform complex biological functions in ways that conventional drugs cannot; cell therapies have expanded the spectrum of available therapeutic options to include key cellular functions and processes. As such, cell therapies are currently one of the most investigated

Machine Learning for Differentiating Essential Tremor: A Scoping Review.

BackgroundEssential tremor (ET) is the most common movement disorder, affecting ~6% of adults over 65 [1]. Differentiating ET from other tremors remains clinically challenging due to overlapping features and variable presentation. Artificial intelligence (AI), particularly machine learning (ML), has emerged a potential tool to support neurologists by enhancing pattern recognition and complementing traditional assessments in complex cases. This is the first scoping review examining ML's potential role in distinguishing essential tremor from other tremor types.MethodsA systematic, scoping search

The Role of Extracellular Vesicles in Bone Regeneration and Associated Bone Diseases.

Extracellular vesicles (EVs) are nanoscale particles with a lipid bilayer membrane structure secreted by various cell types. Nearly all human cells secrete EVs, primarily mediating intercellular communication. In recent years, scientists have discovered that EVs can carry multiple biological cargos, such as DNA, non-coding RNAs (ncRNAs), proteins, cytokines, and lipids, and mediate intercellular signal transduction. Bone is a connective tissue with a nerve supply and high vascularization. The repair process after injury is highly complex, involving interactions among multiple cell types and bi

CAR-Based Cell Therapy in Head and Neck Cancer: A Comprehensive Review on Clinical Applicability.

Background/Objectives: Chimeric antigen receptor T-cell (CAR-T) therapy is a novel form of adoptive cellular immunotherapy that involves modifying autologous T cells to recognize and target tumor-associated antigens (TAAs) on malignant cells, independent of major histocompatibility complex (MHC) restriction. Although CAR-T therapy has shown remarkable success in treating hematologic malignancies, its efficacy in solid tumors remains limited, largely due to the lack of tumor-specific antigens and the complexity of the tumor microenvironment. This review aims to explore the rationale for continu