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Pre- and post-diagnosis physical activity, television viewing, and mortality among hematologic cancer survivors.

PurposeThe associations of physical activity and television (TV) viewing with mortality risk among individuals with hematologic malignancies remain unclear.MethodsWe examined the relations of physical activity and TV viewing time before and after diagnosis with mortality among 5182 U.S. adults aged 50-71 years from the NIH-AARP Diet and Health Study cohort who survived a first primary hematologic cancer between 1995-1996 and 2011.ResultsFor the pre- and post-diagnosis analyses, we confirmed 2606 and 613 deaths respectively. In multivariable-adjusted Cox proportional hazard regression models, c

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… Vital status was identified by annual linkage of the cohort to the Social Security Administration Death Master File [ 28 ] and verified by the National Death Index (NDI) Plus [ 29 ]. We used ICD-9 and ICD-10 codes to classify mortality from hematologic cancer. … The Social Security Administration's Death Master File: the completeness of death reporting at older ages . Soc Secur Bull 2001 ; 64 : 45 – 51 . 12428517 29 Rich-Edwards JW , Corsano KA , Stampfer MJ . Test of the National Death Index and Equifax Nationwide Death Search . …

Пациенты испытывают на себе воздействие множественных склерозов и корректирующих болезни терапии.

ЦЕЛЬ: Для регулирования множественных склерозов (MS) жизненно важное значение имеют методы лечения, корректирующие заболевания (DMT), однако исследования, проводимые с использованием административных данных, часто исключают предпочтения пациентов и факторы, которые врачи учитывают при принятии решений о лечении. Данные об опыте пациентов имеют важнейшее значение для понимания и улучшения инициирования, соблюдения и результатов лечения НР. МЕТОДЫ: С декабря в Интернете было проведено перекрестное обследование взрослых в США, имеющих MS или клинически изолированный синдром. 2022 по январь 2023 К

Do non-responders of a geriatric screening questionnaire face lower one-year survival compared to responders? A retrospective cohort study.

PURPOSE: A geriatric screening questionnaire was implemented in 2020 at the Department of Oncology, Gødstrup Hospital, Denmark, to identify frailty and individualize cancer care for all patients aged ≥ 60 years. However, not all patients answered. The primary aim of this study was to investigate the association between response status to the geriatric screening questionnaire and one-year survival. A secondary aim was to compare one-year survival according to the responders’ frailty status. METHODS: We conducted a retrospective cohort study including all patients with cancer aged ≥ 60 who were

Ethics of overtreatment and undertreatment in older adults with cancer.

BackgroundOver-/undertreatment are pervasive in older adults with cancer, and challenges arise in applying the principles of bioethics: beneficence, nonmaleficence, justice, and patient autonomy. The objective of this study was to determine whether these ethical principles relate to over-/undertreatment for older adults, and how tensions among the principles may contribute.MethodsWe conducted a modified Delphi study with 13 experts in biomedical ethics for iterative rounds of data collection. In the first round, we presented via electronic questionnaire our previously published definitions of

Financial toxicity in female patients with breast cancer: a national cross-sectional study in China.

PurposeTo quantify financial toxicity of female patients with breast cancer in China and investigate its factors and patients' coping strategies.MethodsThe Comprehensive Score for Financial Toxicity (COST) is defined by using a structured questionnaire containing 12 items measuring perceived affordability of healthcare services, with the range of scoring of which being from 0 to 44 (higher score indicates lower financial toxicity). From January to March 2021, a total of 664 female patients diagnosed with stage 0-IV breast cancer were recruited from 33 public tertiary cancer hospitals located i

Healthcare Resource Utilization and Cost of Patients with Multiple Myeloma in Germany: A Retrospective Claims Data Analysis.

ObjectiveThis study aimed to analyze the healthcare resource use (HCRU) and associated costs of multiple myeloma (MM) using German claims data.MethodsAnonymized claims data from one of the largest sickness funds in Germany were analyzed. Costs and HCRU were calculated from the perspective of the statutory health insurance. To analyze MM-associated incremental costs in a most recent calendar period for an overall MM population (31 March 2018-31 March 2019), a prevalent cohort of MM patients (continuously insured during 01 January 2010 until 31 March 2019 or death; two or more outpatient and/or

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… The work on the dataset conformed to all social security data protection requirements. Results Patient Characteristics As shown in panels a and b of Fig. 2 , 5711 patients were continuously insured for the entire study period and had a diagnosis of MM based on the considered diagnostic criteria. … The work on the dataset conformed to all social security data protection requirements. Consent to participate As the study addressed a retrospective anonymized dataset, no informed consent of patients was needed. …

"Catch-Up Vaccinations Post-Stem Cell Transplant: A case series and review of the literature".

Stem cell transplantation (SCT), including autologous and allogeneic approaches, is a potentially curative therapy for various hematologic malignancies and selected non-malignant disorders. Autologous stem cell transplantation (ASCT) is an established curative treatment for hematologic malignancies, including Hodgkin lymphoma (HL). Non-Hodgkin Lymphoma (NHL), and Multiple Myeloma (MM), but infectious complications remain a major challenge. Vaccination is an essential strategy to reduce the risk of vaccine-preventable infections following transplant. This case series describes immunocompromised

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… No personal or identifying information such as names, initials, hospital or social security numbers, or dates of birth were included. All efforts were made to ensure the privacy and confidentiality of the patient and research subjects. …

Development of a quality indicator set for day hospices in Germany - a multi-stage, quality-assured review of German guidelines and quality indicator sets.

BackgroundDay hospices are an emerging component of outpatient palliative care in Germany. However, a standardized quality management system utilizing defined quality indicators has not yet been implemented. This study aimed to develop a new set of quality indicators for day hospices.MethodsThrough a multi-phase, quality-assured review, we screened validated quality indicators from German-language S3 guidelines and established quality indicator sets, including the Quality Indicator System for Outpatient Care (QISA) and Outpatient Quality Indicators and Key Figures (AQUIK) based on defined crit

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… A comparison of the new quality indicator set with the contractual requirements for day hospices in Germany (the contract cannot be published due to data protection laws; see also Sect. 113, Social Security Code (SGB) XI [ 27 ]) revealed that most of the required objectives and quality assurance criteria … Abbreviations General Local Health Insurance Fund Outpatient Quality Indicators and Key Figures Association of Scientific Medical Societies in Germany National Association of Statutory Health Insurance Physicians Quality Indicator System for Outpatient Care Social Security Code Publisher’s Note …

Потенциал транскраниального прямого течения (tDCS) в повышении качества жизни пациентов с множественным склерозом: обзор и обсуждение механизмов действий.

Фон/цели: Множественный склероз (MS) является наиболее распространенным неизлечимым нетравматическим расстройством у молодых людей. Она вызывает многочисленные симптомы, включая покалывание, усталость, мышечные спазмы, когнитивные расстройства и нервно - психические расстройства. Это заболевание значительно ухудшает качество жизни (QoL), и этот аспект общего функционирования обеспечивает ценную информацию об эффективности лечения и благосостояния. Существует психологическая помощь, которая может улучшить QoL, но ее количество ограничено. Поэтому поиск новых методов, которые были бы как можно б

Chronic Non-cancer Pain Management and Addiction: A Review.

The use of opioids in chronic non-cancer pain (CNCP) has been a fast-rising treatment phenomenon in the last two decades. Though opioids are advocated in various chronic pain management guidelines, their use in chronic non-cancer pain still remains controversial as evidence of this approach is still weak. This paper highlights potential adverse effects associated with opioid use in pain management, including an increase in tolerance, dependence, and addiction outcomes. Nonetheless, opioids have an important place in contemporary CNCP management for selected patients. However, pain management m

A Rebalancing of Financial Valuations and Expectations Moving Forward in the Telehealth Sector as the United States Moves Toward a Post-COVID-19 Reality.

The telehealth sector of health care delivery experienced significant growth at the start of the pandemic as web-based care quickly became essential for the ongoing safety of patients and health care providers, such as clinicians and other health care professionals. After vaccines were introduced, however, telehealth companies lost value as the need for web-based care appeared to lessen. Presently, both existing telehealth companies and new entrants to the space are seeking ways to innovate, gain investor and customer buy-in, and overcome competitors. New companies are hoping to be seen not as

Chemotherapy-based versus chemotherapy-free stem cell mobilization (± plerixafor) in multiple myeloma patients: an Italian cost-effectiveness analysis.

Given the availability and efficacy of the mobilizing agent plerixafor in augmenting hematopoietic progenitor cell mobilization with granulocyte colony-stimulating factor (G-CSF), there is a strong case for comparing the cost-effectiveness of mobilization with G-CSF + cyclophosphamide versus G-CSF alone. This study investigated the cost and effectiveness (i.e., successful 4 million-CD34+ collection) of G-CSF alone versus high-dose cyclophosphamide (4 g/m2) + G-CSF mobilization (± on-demand plerixafor) in patients with multiple myeloma (MM) eligible for autograft in Italy. A decision tree-suppo

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… The loss of working hours was valued using the gross wage rate (i.e., net wage + income taxes + social security contributions; Table S13 ) [ 39 – 41 ]. … National Institute for Social Security. Channel Information. Minima daily wages (in Italian). In. 41. Posnett J, Jan S. Indirect cost in economic evaluation: the opportunity cost of unpaid inputs. Health Econ. 1996;5:13–23. doi: 10.1002/(SICI)1099-1050(199601)5:1<13::AID-HEC182>3.0.CO;2-J. 42. …

Effect of electronic patient record use on mortality in End Stage Renal Disease, a model chronic disease: retrospective analysis of 9 years of prospectively collected data.

BackgroundIn chronic disease, health information technology promises but has yet to demonstrate improved outcomes and decreased costs. The main aim of the study was to determine the effects on mortality and cost of an electronic patient record used in daily patient care in a model chronic disease, End Stage Renal Disease, treated by chronic maintenance hemodialysis. Dialysis treatment is highly regulated, and near uniform in treatment modalities and drugs used.MethodsThe particular electronic patient record, patient-centered and extensively coded, was used first in patient care in 3 dialysis u

Factors Determining the Level of Acceptance of Illness and Satisfaction with Life in Patients with Cancer.

IntroductionCancer threatens life and brings about many negative emotions in patients, which influence their satisfaction with life and contribute to a low level of their acceptance of illness. This is why the acceptance of illness is a serious problem among patients with cancer; contributes to the intensification of symptoms; and influences the patient's physical, mental, emotional, social, and spiritual condition.AimThe purpose of this work is to assess the acceptance of illness and satisfaction with life in patients with cancer, as well as to identify social, demographical, and clinical fac

Financial toxicity and employment status in cancer survivors. A systematic literature review.

BackgroundFinancial toxicity has traditionally been attributed to the rising costs of cancer care. As ability to work impacts one's financial situation, limited employment and reduced income may also contribute to financial toxicity. We examined evidence of the association between financial toxicity and employment status in cancer survivors.MethodsA systematic literature review was performed via PubMed, Web of Science, CINAHL, and PsycINFO with search terms including "Cancer," "Financial toxicity," and "Employment" on September 25, 2019.ResultsThirty-one papers met eligibility criteria. Thirte

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… This suggests that the association of employment and financial toxicity is not only a function of health care insurance but of social security systems as well. … Return to work is influenced by social security systems, especially the length of paid sick leave. Furthermore, differences in legislation, incentives, and possibilities of an employer to provide employees with return to work programs differ among countries. …

Behaviors, perceptions, and impact of the COVID-19 pandemic and vaccination on oncology patients in New Mexico with substantial representation of racial minorities and rural residents.

IntroductionThe COVID-19 pandemic has affected all sectors of life. This study helps us better understand the perceptions and practices related to the COVID-19 pandemic in the oncology patient population of New Mexico. It also explores patient knowledge regarding safe practices and perceptions regarding vaccination.MethodsThe data for this cross-sectional survey study was collected from July 20, 2021 to September 6, 2021.ResultsThere were no significant differences noted in the incidence of COVID-19 infection based on race, comorbidities, or modality of treatment regardless of vaccination stat

Emergency department-initiated palliative care for advanced cancer patients: protocol for a pilot randomized controlled trial.

BackgroundFor patients with advanced cancer, visits to the emergency department (ED) are common. Such patients present to the ED with a specific profile of palliative care needs, including burdensome symptoms such as pain, dyspnea, or vomiting that cannot be controlled in other settings and a lack of well-defined goals of care. The goals of this study are: i) to test the feasibility of recruiting, enrolling, and randomizing patients with serious illness in the ED; and ii) to evaluate the impact of ED-initiated palliative care on health care utilization, quality of life, and survival.Methods/de

Social support score in patients with malignant diseases-with sociodemographic and medical characteristics.

IntroductionSocial support as a complex construct has a positive influence not only on a patient's condition but also on the process of the patient's emotional adjustment to cancer. The goal of this study is to investigate aspects of the level of social support in oncology patients and its interconnection with sociodemographic and medical variables.MethodThe study was conducted as a prospective observational study in 2020, including 250 patients aged 19 and over, both sexes, with a diagnosis of oncological disease. The research was conducted in the Department of General Medicine of the Health

The influence of caregiver type on isolation distress and care satisfaction in hematopoietic stem cell transplant patients: the mediating role of relationships.

BACKGROUND: Protective isolation is essential for preventing infection in patients undergoing hematopoietic stem cell transplantation (HSCT). However, it is associated with significant psychosocial morbidity. Understanding the factors influencing isolation perception and its impact on care satisfaction is crucial, particularly in resource-limited settings. METHODS: This cross-sectional observational study enrolled 47 adults who underwent autologous or allogeneic HSCT at a tertiary care center in India. Perceptions of isolation and satisfaction with care were measured using validated ISOLA and

Bone Pain in Multiple Myeloma (BPMM)-A Protocol for a Prospective, Longitudinal, Observational Study.

Multiple myeloma (MM) is a bone marrow neoplasia that causes bone pain in 70% patients. While preclinical models of MM have suggested that both nerve sprouting and nerve injury may be causative for the pain, there is a lack of clinical data. Thus, the primary aims of this clinical study are: (1) to provide a deep characterization of the subjective experience of pain and quality of life in MM patients; (2) to investigate disturbances in the bone innervation of MM patients. Secondary aims include exploring correlations between pain and serum inflammatory and bone turnover biomarkers. In a prospe