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Target-Specific Dermatological Adverse Event Reporting With T-Cell-Engaging Bispecific Antibodies: A Pharmacovigilance Analysis of FAERS and Canada Vigilance, 2016-2026.

BACKGROUND: T-cell-engaging bispecific antibodies are increasingly utilised in haematological malignancies and are beginning to be adopted in solid-tumour treatment protocols. Cytokine release syndrome and neurotoxicity are well recognised, but target-specific dermatological adverse event reporting patterns remain poorly defined. METHODS: We analysed 12,333,305 deduplicated FAERS reports from 2016Q1 to 2026Q1, including 23,386 reports exposed to ten T-cell-engaging bispecific antibodies grouped by target: CD19, CD20, BCMA, GPRC5D and DLL3. A disease-matched haematologic-oncology comparator co

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… .: bullous dermatoses, eczematous, psoriasiform, rash, severe cutaneous eruptions, toxic eruptions, urticaria/angioedema, hair changes, hyperhidrosis, pruritus, skin lesions, vascular cutaneous, wound/ulcer and other skin changes [ 11 , 19 ]. …

Реальная эффективность, стойкость, терпимость и безопасность атумумаба в клинической практике.

АИСЮ: Описание 12-month :: эффективность, стойкость, терпимость и безопасность атумумаба (ОМБ) -- высокоэффективной терапии для борьбы с заболеваниями (ДМТ) для повторного склероза (МС) в реальном мире. & МЕТОДЫ: Электронные медицинские записи пациентов, начинающих OMB с октября 2020 по август 2022 на two Был проведен обзор комплексных центров НР. Демографические показатели и характеристики болезней и 6- и 12-month Были проанализированы клинические, описанные пациентами и радиоологические показатели. РЕЗУЛЬТАТЫ: Всего 175 пациенты начали ОМБ со средним возрастом 44.9 (СД) 10.4) и продолжительн

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… Fever 3 (1.7%) 0 (0%) 3 (1.7%) Rhinorrhea 1 (0.6%) 0 (0%) 1 (0.6%) GI Symptoms 6 (3.4%) 1 (0.6%) 7 (4.0%) Nausea 5 (2.9%) 0 (0%) 5 (2.9%) Abdominal Pain 1 (0.6%) 0 (0%) 1 (0.6%) Unspecified GI 0 (0%) 1 (0.6%) 1 (0.6%) Dermatological Symptoms 3 (1.7%) 0 (0%) 3 (1.7%) Flushed 2 (1.1%) 0 (0%) 2 (1.1%) Angioedema …

Эффективность и безопасность иммуноадсорбции как спасательной терапии подстрекательских миопатий: доклад three - обзор дел и литературы.

Идиопатическая воспалительная миопатия (МИМ) резюмирует редкие, системные аутоиммунные условия, характеризующиеся главным образом провокационным повреждением скелетной мышцы. Несмотря на то, что мышечные мышцы повреждены в первую очередь, эти заболевания, связанные с IIM, связаны с другими органами, включая кожу, легкие, верхний желудочно-кишечный тракт, суставы и сердце. Несмотря на то, что многие пациенты адекватно реагируют на иммунодепрессивное лечение, некоторые пациенты развивают быстро прогрессивные и устойчивые к лечению жизнестойкие курсы. Для лечащего врача ИИМ является сложным делом

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… Characteristic | | Patient 1 | Patient 2 | Patient 3 Sex | Female | Female | Female Age (at the time of IA) | 74 | 55 | 55 Diagnosis | DM (06/2017) | DM (04/2020) | IMNM (2010) Clinical presentation | | Skin • Gottron papules • Erythema of face and décolleté | Skin • Angioedema of the face • Heliotrope …

Rituximab-Associated Flare of Cryoglobulinemic Vasculitis.

BackgroundPatients with cryoglobulinemic vasculitis (CV) can develop disease flare after rituximab administration. The objective of our study was to describe the prevalence, clinical characteristics, predisposing factors, and outcomes of patients with rituximab-associated flare of CV.MethodsWe conducted a retrospective study in a tertiary referral center until March 25, 2020.ResultsAmong 64 patients with CV who received rituximab therapy in our center, 14 (22%) developed disease flare. Median age was 67.5 years. Seven patients (50%) had type II CV and the other half had either type I (n = 6) o

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… Serum sickness and severe angioedema following rituximab therapy in RA. Int J Rheum Dis. 2012;15:e6–e7. doi: 10.1111/j.1756-185X.2011.01645.x. 23. Hellerstedt B., Ahmed A. Delayed-type hypersensitivity reaction or serum sickness after rituximab treatment. …

The Schnitzler syndrome.

The Schnitzler syndrome is a rare and underdiagnosed entity which is considered today as being a paradigm of an acquired/late onset auto-inflammatory disease. It associates a chronic urticarial skin rash, corresponding from the clinico-pathological viewpoint to a neutrophilic urticarial dermatosis, a monoclonal IgM component and at least 2 of the following signs: fever, joint and/or bone pain, enlarged lymph nodes, spleen and/or liver, increased ESR, increased neutrophil count, abnormal bone imaging findings. It is a chronic disease with only one known case of spontaneous remission. Except of

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… Edematous swelling of the face (angioedema) is very rare [ 3 , 10 , 11 ] and significant mucosal swelling with dyspnea and/or dysphonia is exceptional. Many patients report exacerbating factors including heat exposure, cold-exposure, alcohol consumption, some aliments, physical work, stress,... …

Complication from Desensitization

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… Adverse events can include urticaria, hypotension, angioedema, hypoxia, pulmonary infiltrates, acute respiratory distress syndrome, myocardial infarction, ventricular fibrillation, or cardiogenic shock. … CINRYZEâ (Shire ViroPharma Incorporated, Lexington, MA) is a human plasma-derived C1 INH that is approved for use in patients with hereditary angioedema. Up until now there is not a report on the prophylactic use of C1 esterase inhibitor in sensitized renal transplant recipients. …

Scientific Advancements in Gene Therapies: Opportunities for Global Regulatory Convergence.

On 4 September 2024, the Reagan-Udall Foundation for the FDA (FDA Foundation) in collaboration with the Food and Drug Administration (FDA) and the Gates Foundation hosted a workshop titled "Scientific Advancements in Gene Therapies: Opportunities for Global Regulatory Convergence". The event brought together a diverse group of experts, including international regulatory bodies, regulated industries, healthcare professionals, patients, academic researchers and global health advocates, to discuss the rapid advancements in gene therapy and the pressing need for equitable access in low-and middle-

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… Company | Phase | Ongoing Research Intellia Therapeutics | Phase 3 | Utilizing CRISPR-based gene editing to target ATTR amyloidosis by editing the TTR gene | Phase 2 | Utilizing CRISPR-based gene-editing therapy for hereditary angioedema (HAE) by targeting the KLKB1 gene Verve | Phase 1 | Utilizing …

The Effect of Family-Centered Supportive Program on Chemotherapy-Induced Symptoms in Patients with Acute Lymphoblastic Leukemia (ALL).

Background: Acute lymphoblastic leukemia is a disease of the hematopoietic system and chemotherapy is recommended as the primary treatment. As many chemotherapeutic agents have severe adverse effects, patients require to be supported by their family to deal with chemotherapy-related symptoms. This study attempted to investigate the effect of family-centered supportive programs on chemotherapy symptom control in patients with acute lymphoblastic leukemia. Materials and Methods: Sixty-six patients with acute lymphoblastic leukemia undergoing chemotherapy along with their caregivers participated

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… The complications or symptoms of chemotherapy may include chest pain, anorexia, nausea, vomiting, diarrhea, skin redness and rash, hair loss, angioedema, depression and anxiety, pancytopenia, anemia, neutropenia, leukopenia, lymphopenia, thrombocytopenia, infection and sepsis, stomatitis, oral and anal …

Blood Coagulation and Beyond: Position Paper from the Fourth Maastricht Consensus Conference on Thrombosis.

The Fourth Maastricht Consensus Conference on Thrombosis included the following themes. Theme 1: The "coagulome" as a critical driver of cardiovascular disease. Blood coagulation proteins also play divergent roles in biology and pathophysiology, related to specific organs, including brain, heart, bone marrow, and kidney. Four investigators shared their views on these organ-specific topics. Theme 2: Novel mechanisms of thrombosis. Mechanisms linking factor XII to fibrin, including their structural and physical properties, contribute to thrombosis, which is also affected by variation in microbio

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… Interestingly, excess FXIIa levels are observed in a genetic disease called hereditary angioedema (HAE), characterized by recurrent episodes of severe edema due to extreme bradykinin release. 83 It is caused either by a FXII mutation causing increased autoactivation or a deficiency of its main inhibitor …

SARS-CoV-2 Вакцины и множественный склероз: обновление.

В высшей степени заразная зоонозная болезнь коронавируса 2019 (В тыс.COVID-19), вызванной острым острым респираторным синдромом коронавируса 2 (В тыс.SARS-CoV-2), была объявлена пандемией Всемирной организацией здравоохранения в марте 11, 2020, и это привело к глобальному кризису в области здравоохранения с почти 777 million подтвержденные инфекции и более 7 million к ноябрю 10, 2024.1-3 Со временем появились различные варианты, при этом Омикрон и его подлинии доминировали над миром в прошлом. 3 Годы.4 Кроме того, растет число свидетельств, касающихся иммунной реакции SARS-CoV-2 вакцины, особе

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… (odds ratio 0.41). e68 Similar observations had been reported earlier. e69 Moreover, the severity of the SARS-CoV-2 infections seems to heighten the risk of GBS. e70 In addition, the following other adverse events (AEs) have been reported in very small case numbers after SARS-CoV-2 vaccination: angioedema …

Real-practice management and treatment of idiopathic multicentric Castleman disease with siltuximab: a collection of clinical experiences.

Castleman disease (CD) is a group of lymphoproliferative disorders that share common histopathological features yet have widely different aetiologies, clinical features and grades of severity as well as treatments and outcomes. Siltuximab is currently the only therapy approved by the FDA and EMA for idiopathic multicentric CD and is recommended as first-line therapy in treatment guidelines. Despite the extensive characterization of siltuximab treatment in clinical trials, available evidence from real-world practice is still scant. This collection of clinical experiences focuses on patients tre

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… The patient also reported episodes of spontaneous eyelid angioedema and abdomen skin rash. Four years earlier, the patient had been diagnosed with Sjogren’s syndrome but required no therapy. …

MASTering systemic mastocytosis: Lessons learned from a large patient cohort.

BACKGROUND: Systemic mastocytosis (SM), a rare condition affecting about 32,000 individuals in the United States, is often misdiagnosed or underdiagnosed owing to its nonspecific symptoms and the need for invasive biopsies. OBJECTIVE: Our aim was to identify, classify, and characterize the natural history of patients with SM. METHODS: In a retrospective cohort study, administrative data from a large managed care organization was used to identify patients with confirmed SM, based on World Health Organization criteria. Demographic data, delay to diagnosis, disease progression, and health care

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… Symptoms included abdominal pain, allergic reaction, anaphylaxis, angioedema, diarrhea, hives, rash, and urticaria , and any “B” or “C” finding on laboratory test or imaging results. …

Medicine manipulation: An alternative to mitigate therapeutic gaps in the Brazilian Unified Health System?

Despite the various initiatives carried out in Brazil and in the world, the challenge of offering essential medicines in adequate presentations remains, especially to the public affected by diseases considered neglected and the pediatric population, for whom the therapeutic options remain limited. The main objective of this study was to evaluate the production of manipulated medicines as a strategy to mitigate therapeutic and access gaps to essential medicines within the Brazilian public health system, called the Unified Health System (SUS). The evaluation, carried out between 2020 and 2021, i

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… substances in pediatrics include benzyl alcohol due to neurotoxicity, metabolic acidosis and Gasping syndrome; polysorbate 20 and 80 can lead to liver and kidney failure; polyethylene glycol has the potential to cause metabolic acidosis, and azo compounds can cause urticaria, bronchoconstriction and angioedema …

Dermatologic Emergencies

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… Differential Diagnosis Significant facial edema occurs in approximately 25 % of cases, often in the mid-facial region, and can sometimes be mistaken for angioedema. …

The Crossroads of Geriatric Cardiology and Cardio-Oncology.

Cancer and cardiovascular disease (CVD) are two major causes of mortality in older adults. With improved survival and outcomes from cancer and CVD, the role of the geriatrician is evolving. Geriatricians provide key skills to facilitate patient-centered and value-based care in the growing older population of cancer patients (and survivors). Cancer treatment in older adults is particularly injurious with respect to complications stemming from cancer therapy and as well as to CVD related to cancer therapy in the context of physiologic aging. To best meet their natural potential as caregiving lea

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… inhibition Endothelial cell dysfunction | •Anti-hypertensives •Smooth muscle relaxants •Temporary interruption •Diuretics •Avoid other QT prolonging agents; termination if QTc >470 ms Cetuximab | Hypotension | Anaphylaxis and hypersensitivity reaction Electrolytes imbalance Rituximab | Hypotension, angioedema …

The prince and the pauper. A tale of anticancer targeted agents.

Cancer rates are set to increase at an alarming rate, from 10 million new cases globally in 2000 to 15 million in 2020. Regarding the pharmacological treatment of cancer, we currently are in the interphase of two treatment eras. The so-called pregenomic therapy which names the traditional cancer drugs, mainly cytotoxic drug types, and post-genomic era-type drugs referring to rationally-based designed. Although there are successful examples of this newer drug discovery approach, most target-specific agents only provide small gains in symptom control and/or survival, whereas others have consiste

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… A dry, irritating cough is the most common side effect, but angioedema is the most serious; if it affects the oropharynx, can be fatal. Angioedema is most frequently found among blacks and smokers. … Adverse-event incidence is low; angioedema occurs, but much less frequently than with ACE inhibitors. Precautions for angiotensin II receptor blocker use in patients with renovascular hypertension, hypovolemia, and severe heart failure are the same as those for ACE inhibitors. …

Pruritus: an overview. What drives people to scratch an itch?

Pruritus is a common complaint associated with many conditions. It negatively impacts sleep, quality of life, and mortality. Itch is transmitted along both histaminergic and non-histaminergic pathways with a complex interplay between keratinocytes, immune cells and cutaneous neurons. Individuals who present with pruritus should undergo a thorough assessment, especially those over 65 years old, to exclude underlying malignancy. Treatment no longer consists of antihistamines alone. Physicians now have an array of therapies in their armamentarium, to help alleviate this distressing symptom.

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… It has a prevalence of 0.5-1%. 30 Clinically, this manifests with wheals, angioedema or both, and usually lasts less than 24 hours. Urticaria is divided into acute (duration <6 weeks) or chronic (duration >6 weeks). …

Integumentary System

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CSI position statement on management of heart failure in India.

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Repurposing Drugs in Oncology (ReDO)-mebendazole as an anti-cancer agent.

Mebendazole, a well-known anti-helminthic drug in wide clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical studies across a number of different cancer types. Significantly, there are also two case reports of anti-cancer activity in humans. The data are summarised and discussed in relation to suggested mechanisms of action. Based on the evidence presented, it is proposed that mebendazole would synergise with a range of other drugs, including existing chemotherapeutics, and that further exploration of the potential of mebendazole as an anti-cancer

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… Hypersensitivity reactions, such as rash, urticaria, and angioedema, have been observed on rare occasions. MBZ is contraindicated during pregnancy. Caution is also recommended in treating infants below the age of 2, primarily due to a lack of data in such cases [ 3 ]. …