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Danshenol B alleviates central post-stroke pain by regulating the PIK3CG/NLRP3 signaling pathway.

BACKGROUND: Central post-stroke pain (CPSP) is a debilitating neuropathic condition that significantly impairs quality of life and is challenging to manage. Salvia miltiorrhiza (Danshen), a traditional Chinese herb, has demonstrated efficacy against neuropathic pain, but its active analgesic components and underlying mechanisms remain unclear. This study investigated the therapeutic potential of Danshenol B, an active component of Danshen, in a CPSP mouse model, focusing on its mechanism of action via the phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform (PIK3CG)/N

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… Shi ZM Jing JJ Xue ZJ Chen WJ Tang YB Chen DJ Qi XY Huang L Zou YQ Wu XZ Yang F Stellate ganglion block ameliorated central post-stroke pain with comorbid anxiety and depression through inhibiting HIF-1alpha/NLRP3 signaling following thalamic hemorrhagic stroke J Neuroinflammation 2023 20 82 10.1186/ … s12974-023-02765-2 36944982 PMC10031944 Shi ZM, Jing JJ, Xue ZJ, Chen WJ, Tang YB, Chen DJ, Qi XY, Huang L, Zou YQ, Wu XZ, Yang F. …

Towards a New Dawn for Neuro-Oncology: Nanomedicine at the Service of Drug Delivery for Primary and Secondary Brain Tumours.

(1) Background/Objectives: Primary and secondary brain tumours often hold devastating prognoses and low survival rates despite the application of maximal neurosurgical resection, and state-of-the-art radiotherapy and chemotherapy. One limiting factor in their management is that several antineoplastic agents are unable to cross the blood-brain barrier (BBB) to reach the tumour microenvironment. Nanomedicine could hold the potential to become an effective means of drug delivery to overcome previous hurdles towards effective neuro-oncological treatments. (2) Methods: A scoping review following th

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… Qi J., Fan J., You Y., Du Y., Liu D., Xu X., Wang J., Zhu L., Chen M., Gao S., et al. Synergistic Effect of Tumor Chemo-Immunotherapy Induced by Leukocyte-Hitchhiking Thermal-Sensitive Micelles. Nat. Commun. 2021;12:4755. doi: 10.1038/s41467-021-24902-2. 83. …

Update on preclinical models of cancer therapy-related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio-Oncology, and the ESC Working Group on Cellular Biology of the Heart.

New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the implementation of effective treatments. Therefore, there is a crucial need for appropriate preclinical models to understand the biological basis of their cardiotoxicity. This scientific statement summarizes the preclinical models hitherto used, from in

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… B‐cell malignancies 15 (8.0) | 155 (82.9) | 12 (10.3% of 116 pts with echo) LVSD, of which 6 AHF events | 10 (5.3), unspecified | 3 (1.6) Goldman et al . 51 | n = 2657 NHL 1777 (83.7), ALL 306 (14.4), other 39 (1.8) | 1457 (54.8) | Cardiomyopathy 69 (2.6) | 74 (2.8), of which 55 AF, 10 VT, 4 VF | NA Qi … J Am Coll Cardiol 2021 ; 78 : 1800 – 1813 . 10.1016/j.jacc.2021.08.044 34711339 PMC8562317 52 Qi K , Yan Z , Cheng H , Chen W , Wang Y , Wang X , et al . An analysis of cardiac disorders associated with chimeric antigen receptor T cell therapy in 126 patients: A single‐centre retrospective study . …

Systemic Consequences of Inflammatory Bowel Disease Beyond Immune-Mediated Manifestations.

Inflammatory bowel disease (IBD) management traditionally focuses on intestinal inflammation, yet extraintestinal manifestations can substantially impair patient quality of life. In this perspective, we emphasize the broad systemic impact of IBD-from highly prevalent conditions such as anemia, metabolic dysfunction-associated steatotic liver disease, or fatigue to rare but severe complications like interstitial lung disease and drug-induced glomerulonephritis. We review underlying mechanisms linking gut inflammation to distant organs, including immune dysregulation, microbial translocation, an

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… Marahleh A., Kitaura H., Ohori F., Kishikawa A., Ogawa S., Shen W.R., Qi J., Noguchi T., Nara Y., Mizoguchi I. TNF-α Directly Enhances Osteocyte RANKL Expression and Promotes Osteoclast Formation. Front. Immunol. 2019;10:2925. doi: 10.3389/fimmu.2019.02925. 66. … Ge X., Xia J., Wu Y., Ye L., Liu W., Qi W., Cao Q., Bai R., Zhou W. Sarcopenia assessed by computed tomography is associated with colectomy in patients with acute severe ulcerative colitis. Eur. J. Clin. Nutr. 2022;76:410–418. doi: 10.1038/s41430-021-00953-y. 86. …

The role of mesenchymal stem cells in attenuating inflammatory bowel disease through ubiquitination.

Inflammatory bowel disease (IBD), a condition of the digestive tract and one of the autoimmune diseases, is becoming a disease of significant global public health concern and substantial clinical burden. Various signaling pathways have been documented to modulate IBD, but the exact activation and regulatory mechanisms have not been fully clarified; thus, a need for constant exploration of the molecules and pathways that play key roles in the development of IBD. In recent years, several protein post-translational modification pathways, such as ubiquitination, phosphorylation, methylation, acety

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… In addition, Qi et al. showed that serum-preconditioned adipose-derived MSCs (CM-AcMSC) significantly prevent the phosphorylation of p65 and IκB in colon cells of DSS-induced colitis model in rats, up-regulate the expression of MUC2 and tight-junction proteins such as ZO-1, claudin-1, and occludin, and … Qi LL, Fan ZY, Mao HG, Wang JB. The Therapeutic Efficacy of Adipose Tissue-Derived Mesenchymal Stem Cell Conditioned Medium on Experimental Colitis Was Improved by the Serum From Colitis Rats [published correction appears in Front Bioeng Biotechnol. …

Traditional and Complementary Medicine Use among Cancer Patients in Asian Countries: A Systematic Review and Meta-Analysis.

Globally, cancer patients frequently use T&CM during their treatment for various reasons. The primary concerns regarding the use of T&CM among cancer patients are the potential risks associated with interactions between pharmaceuticals and T&CM, as well as the risk of noncompliance with conventional cancer treatments. Despite the higher prevalence of T&CM use in Asia, driven by cultural, historical, and resource-related factors, no prior review has tried to estimate the prevalence and influencing factors of T&CM use and disclosure among cancer patients in this region. This study aims to examin

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… at the university cancer center June 2005 | 248 (50.9) | NR | M: 100 (40.3) F: 148 (59.7) | Br: 78 (31.4) GI: 57 (22.9) HM: 29 (11.7) HN: 27 (10.8) Lu: 25 (9.9) O: 33 (13.5) | 207 (83.5) | NR (63.5) | Tonics/supplements (50.4) Food therapy (41.5) Herbal decoctions (47.6) Patent medicines (31.8) Tai Qi … Oncology of the National University Cancer Institute January 2007 | 316 (77.1) | 55 (18–99) | M: 97 (30.7) F: 217 (68.7) Missing: 2 | Br: 100 (31.6) HM: 48 (15.2) Col: 43 (13.6) Lu: 25 (7.9) O: 100 (31.6) | 173 (54.7) | 88 (50.9) | Traditional Chinese medicine: (68.8) Health supplements: (52.6) Taiji/Qi …

Melatonin and Its Role in the Epithelial-to-Mesenchymal Transition (EMT) in Cancer.

The epithelial-to-mesenchymal transition (EMT) is a cell-biological program that occurs during the progression of several physiological processes and that can also take place during pathological situations such as carcinogenesis. The EMT program consists of the sequential activation of a number of intracellular signaling pathways aimed at driving epithelial cells toward the acquisition of a series of intermediate phenotypic states arrayed along the epithelial-mesenchymal axis. These phenotypic features include changes in the motility, conformation, polarity and functionality of cancer cells, u

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… Qi W. Cui Y. Xuan Y. GLI1 promotes cancer stemness through intracellular signaling pathway PI3K/Akt/NFκB in colorectal adenocarcinoma Exp. Cell Res. 2018 373 145 154 10.1016/j.yexcr.2018.10.006 30321514 86. Abou-Fayçal C. Hatat A.S. Gazzeri S. Eymin B. …

Cytokine release syndrome and cancer immunotherapies - historical challenges and promising futures.

Cancer is the leading cause of death worldwide. Cancer immunotherapy involves reinvigorating the patient's own immune system to fight against cancer. While novel approaches like Chimeric Antigen Receptor (CAR) T cells, bispecific T cell engagers, and immune checkpoint inhibitors have shown promising efficacy, Cytokine Release Syndrome (CRS) is a serious adverse effect and remains a major concern. CRS is a phenomenon of immune hyperactivation that results in excessive cytokine secretion, and if left unchecked, it may lead to multi-organ failure and death. Here we review the pathophysiology of C

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… Zhang H, Li F, Cao J, Wang X, Cheng H, Qi K, et al. A chimeric antigen receptor with antigen-independent OX40 signaling mediates potent antitumor activity. Sci Transl Med (2021) 13(578):1–16. doi: 10.1126/scitranslmed.aba7308 31. Ramos CA, Rouce R, Robertson CS, Reyna A, Narala N, Vyas G, et al. … Ma J, Mo Y, Tang M, Shen J, Qi Y, Zhao W, et al. Bispecific antibodies: from research to clinical application. Front Immunol (2021) 12:626616. doi: 10.3389/fimmu.2021.626616 95. Kontermann RE, Brinkmann U. Bispecific antibodies. …

Research progress on the clinical application and mechanism of iguratimod in the treatment of autoimmune diseases and rheumatic diseases.

Autoimmune diseases are affected by complex pathophysiology involving multiple cell types, cytokines, antibodies and mimicking factors. Different drugs are used to improve these autoimmune responses, including nonsteroidal anti-inflammatory drugs (NSAIDs), corticosteroids, antibodies, and small molecule drugs (DMARDs), which are prevalent clinically in the treatment of rheumatoid arthritis (RA), etc. However, low cost-effectiveness, reduced efficacy, adverse effects, and patient non-response are unattractive factors driving the development of new drugs such as iguratimod. As a new disease-modi

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… Qi et al. found that Iguratimod can effectively improve the dry symptoms of NOD mice and reduce the pathological damage of submandibular gland ( 104 ); they speculated that Iguratimod may inhibit the inflammatory response of submandibular gland in Sjogren ‘s syndrome mice by inhibiting the activation … J Pract Med ( 2018 ) 34 ( 22 ): 3700–4 . doi: 10.3969/j.issn.1006-5725.2018.22.009 104 Qi J Tian Y Sun C Gao L Guo H . Effects of iguratimod on submandibular gland inflammation and NF-κB signaling pathway in Sjogren's syndrome mice . …

JAK/STAT Signaling: Molecular Targets, Therapeutic Opportunities, and Limitations of Targeted Inhibitions in Solid Malignancies.

JAK/STAT signaling pathway is one of the important regulatory signaling cascades for the myriad of cellular processes initiated by various types of ligands such as growth factors, hormones, and cytokines. The physiological processes regulated by JAK/STAT signaling are immune regulation, cell proliferation, cell survival, apoptosis and hematopoiesis of myeloid and non-myeloid cells. Dysregulation of JAK/STAT signaling is reported in various immunological disorders, hematological and other solid malignancies through various oncogenic activation mutations in receptors, downstream mediators, and a

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… Hyperactivation of STAT3 was found in a number of GC cell lines and its elevated expression in histological sections of GC patients was strongly associated with angiogenic factors such as VEGF and microvessel density formation thereby contributing to GC progression ( Qi et al., 2020 ). … Hepatol. 7 , 1054 – 1063 . 10.4254/wjh.v7.i8.1054 26052394 PMC4450182 Qi H. Yang Z. Dai C. Wang R. Ke X. Zhang S. ( 2020 ). STAT3 Activates MSK1-Mediated Histone H3 Phosphorylation to Promote NFAT Signaling in Gastric Carcinogenesis . …

IL-6 in the Ecosystem of Head and Neck Cancer: Possible Therapeutic Perspectives.

Interleukin-6 (IL-6) is a highly potent cytokine involved in multiple biological processes. It was previously reported to play a distinct role in inflammation, autoimmune and psychiatric disorders, ageing and various types of cancer. Furthermore, it is understood that IL-6 and its signaling pathways are substantial players in orchestrating the cancer microenvironment. Thus, they appear to be potential targets in anti-tumor therapy. The aim of this article is to elucidate the role of IL-6 in the tumor ecosystem and to review the possible therapeutic approaches in head and neck cancer.

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… Qi F. Wu B. Sinha U. Interleukin 6 and Interleukin 8 as Potential Biomarkers for Oral Cavity and Oropharyngeal Squamous Cell Carcinoma Arch. Otolaryngol.-Head Neck Surg. 2004 130 929 935 10.1001/archotol.130.8.929 15313862 110. Duffy S.A. Teknos T. Taylor J.M.G. Fowler K.E. Islam M. Wolf G.T. … Qi M. Siltuximab, a Novel Anti-Interleukin-6 Monoclonal Antibody, for Castleman’s Disease J. Clin. Oncol. 2010 28 10.1200/JCO.2009.27.2377 20625121 152. Choy E.H. de Benedetti F. Takeuchi T. Hashizume M. John M.R. Kishimoto T. Translating IL-6 Biology into Effective Treatments Nat. Rev. …

Circulating biomarkers in osteosarcoma: new translational tools for diagnosis and treatment.

Osteosarcoma (OS) is a rare primary malignant bone tumour arising from primitive bone-forming mesenchymal cells, with high incidence in children and young adults, accounting for approximately 60% of all malignant bone tumours. Currently, long-term disease-free survival can be achieved by surgical treatment plus chemotherapy in approximately 60% of patients with localized extremity disease, and in 20-30% of patients with metastatic lung or bone disease. Diagnosis of primary lesions and recurrences is achieved by using radiological investigations and standard tissue biopsy, the latter being cost

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… Yang Z, Zhang Y, Zhang X, Zhang M, Liu H, Zhang S, Qi B, Sun X. Serum microRNA-221 functions as a potential diagnostic and prognostic marker for patients with osteosarcoma. Biomed Pharmacother. 2015;75:153–8. doi: 10.1016/j.biopha.2015.07.018. 87. Guttilla IK, White BA. … Qi P, Du X. The long non-coding RNAs, a new cancer diagnostic and therapeutic gold mine. Mod Pathol. 2013;26:155–65. doi: 10.1038/modpathol.2012.160. 106. Zhu KP, Zhang CL, Shen GQ, Zhu ZS. …

Endoplasmic reticulum stress in disease pathogenesis: its implications for therapy.

Endoplasmic reticulum (ER) stress is a key cellular mechanism that is important in the development of many diseases, including cancer. Since the discovery of the unfolded protein response (UPR), research has greatly improved our understanding of how ER stress affects cellular functions, especially protein folding and adaptation to stress. The UPR consists of three main branches: IRE1, ATF6, and PERK, each of which is crucial for regulating stress responses, protein homeostasis, and apoptosis. These pathways normally help cells handle stress effectively; however, excessive or prolonged activati

Выявляется высокий уровень использования медицинских услуг после операции на шейном позвоночнике с использованием комплексных методов прогнозирования.

Расходы на медицинское обслуживание пациентов с хроническими заболеваниями позвоночника и пациентов, проходящих хирургическую операцию, продолжают расти заметными темпами. Таким образом, выявление пациентов, подверженных риску в плане более широкого использования послеоперационного медицинского обслуживания, имеет решающее значение для оптимизации результатов медицинского обслуживания и распределения ресурсов. Цель нашего исследования заключается в использовании целого ряда предоперабельных характеристик пациентов, включая всеобъемлющую медицинскую, хирургическую и социальную историю, для разр

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… Qi W, Mei Z, Mao X, Zhu L, Shao Y, Ge G, et al. Causal associations between sarcopenia-related traits and intervertebral disc degeneration: A two-sample Mendelian randomization analysis. Eur Spine J. 2024;33:2430–8. doi: 10.1007/s00586-024-08291-w. 26. …

Longitudinal studies on financial toxicity in cancer patients: a scoping review.

ObjectiveThis scoping review focuses on financial toxicity in cancer patients, aiming to identify its measurement time points, assessment tools, developmental trends, and influencing factors. Based on existing evidence, this review reveals the occurrence trajectory and long-term impacts of financial toxicity among cancer patients. It can provide a reference for improving patients' financial well-being in clinical practice and optimizing the medical security system at the health policy level and also points out key directions for future related research.MethodsThis study strictly followed the m

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… Kuang Y, Qi X, Qiu JJ, Qiu J, Liu Y, Guo S, et al. Unraveling the vicious cycle: longitudinal analysis between financial toxicity and symptom burden in women with breast cancer. Support Care Cancer. (2025) 33:829. doi: 10.1007/s00520-025-09873-0, Associated Data Supplementary Materials …

Scleroderma-Specific Autoantibodies and Disease Trajectories in Early Systemic Sclerosis: Insights From a Single-Center Prospective Registry.

OBJECTIVE: Early diffuse cutaneous systemic sclerosis (dcSSc) is associated with substantial disease-specific mortality.  Scleroderma-specific autoantibodies (SSc-Ab) may influence disease course, but their prognostic value in very early dcSSc remains unclear. We examined associations between autoantibody profiles and disease trajectories for clinical events in a prospective single-center cohort. METHODS: We retrospectively analyzed prospectively collected data from a subset of patients enrolled in an early SSc registry between October 2012 and July 2021, including those with early dcSSc or i

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… Qi X, Chen X, Dai X, et al. A retrospective analysis of clinical characteristics of systemic sclerosis‐associated interstitial lung disease. Medicine (Baltimore) 2026;105:e47876. 26. Burja B, Boubaya M, Bruni C, et al; EUSTAR collaborators. …

Внутриядерное периферальное перевыражение Pituitary-Tumor-transforming Gene 1:: Иммуногистохимическая биомаркировка лимфатического узла в яичной семиноме.

Фон/цели: Опухоли яичных микробных клеток, особенно полунома, являются основной причиной рака у мужчин в возрасте 15-40 Годы. Решение о адъютантной терапии основывается на гистологических особенностях с неопределенной перспективной ценностью. Ген Pituitary-Tumor-Transforming Gene 1 (PTTG1), который кодирует секуриновый протеин, имеет решающее значение для разделения сестринских хроматидов. Наши предыдущие исследования in vitro показали, что ядерное выражение PTTG1 поощряет инвазивность, дедифференцацию и неолимфангиогенез в яичниковой полуноме. Методы: Мы провели гипотетическое ретроспективное

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… Qi P. Weng W. Shen X. Ni S. Huang D. Tan C. Sheng W. Zhou X. Pituitary Tumor-Transforming Gene-1 Serves as an Independent Prognostic Biomarker for Gastric Cancer Gastric Cancer 2016 19 107 115 10.1007/s10120-015-0459-2 25627474 55. Noll J.E. Vandyke K. Hewett D.R. Mrozik K.M. Bala R.J. …

ZHX2 inhibits diabetes-induced liver injury and ferroptosis by epigenetic silence of YTHDF2.

ObjectiveMetabolic dysfunction-associated steatotic liver disease (MASLD) is a common complication of type 2 diabetes mellitus (DM). The transcription factor zinc fingers and homeoboxes 2 (ZHX2) has been implicated in the pathogenesis of chronic liver diseases, yet its precise role and underlying mechanism in DM-induced hepatic injury remain poorly elucidated.MethodsTo investigate this, we used a high-fat diet (HFD) and streptozotocin (STZ) administration to create a DM model in mice, while high glucose (HG) exposure was used to simulate DM in vitro. Through various experiments such as lucifer

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… Yang T, Qi F, Guo F, Shao M, Song Y, Ren G, et al. An update on chronic complications of diabetes mellitus: from molecular mechanisms to therapeutic strategies with a focus on metabolic memory. Mol Med. 2024;30:71. 36. Subramanian S, Khan F, Hirsch IB. New advances in type 1 diabetes. …

Does anxiety influence the use of complementary or alternative medicine among cancer patients?

PurposeThe aim of this study was to investigate the extent to which patients' anxiety due to their cancerous disease has an influence on the use of complementary and alternative medicine (CAM) methods.Methods230 patients completed an anonymous voluntary questionnaire that was sent to outpatient oncological facilities participating in the survey. This questionnaire included standardised tests such as the Allgemeine Selbstwirksamkeit Kurzskala (ASKU, self-efficacy short scale) and the State-Trait-Anxiety-Inventory (STAI) as well as socio-demographic information and a section on CAM use. Statisti

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… Furthermore, yoga, tai chi, qi gong (N = 31; 17.8%), special diets such as ketogenic, vegan, fasting (N = 20; 11.5%), homeopathy (N = 18; 10.3%), probiotics (N = 14; 8.0%), acupuncture, acupressure (N = 9; 5.2%), detoxifying procedures (N = 8; 4.6%), reiki, therapeutic touch and similar techniques (N …

Chidamide in Combination With DCAG With or Without Venetoclax for Relapsed/Refractory Acute Myeloid Leukemia.

INTRODUCTION: Currently, there are only a few avaailable treatment options for patients with relapsed and refractory acute myeloid leukemia (R/R AML). METHODS: We conducted a single-center, phase 1 prospective study (ChiCTR2200065634) to evaluate the efficacy and safety of chidamide, demethylating drugs (azacitidine), cytarabine, aclacinomycin, and G-CSF plus venetoclax (CDCAG-VEN) in patients with R/R AML. The previous CDCAG regimen was used as a historical control to compare its efficacy and safety. Thirty and 22 patients received one course of CDCAG with or without a 14-day course of venet

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… C., Qi L., Zhou Y. L., Yu M., Huang W. …