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[Pathological fractures of the femoral neck in hemodialyzed patients. Apropos of 26 cases].

PURPOSE OF THE STUDY: This study is based on a retrospective analysis of 26 pathological fractures of the femoral neck in 19 chronic haemodialysis patients. The purpose of this study is to analyze the epidemiological and etiological factors of these fractures in relation to osteo-arthropathy of the dialyzed patient, as well as the results of various treatments, both curative and preventive. MATERIAL AND METHODS: 26 pathological fractures of the femoral neck appeared in 19 chronic haemodialysis patients, 11 men and 8 women, 6 patients presented bilateral fractures. The patient's average age at

Цереброспинная жидкость и сывороточные биомаркеры в идиопатической внутричерепной гипертонии: систематический обзор.

ЦЕЛЬ: Это исследование было направлено на систематический анализ литературы по растворимым биомаркерам у взрослых с идиопатической внутричерепной гипертонией (МИГ). КОЛИЧЕСТВО: Идиопатическая внутричерепная гипертония представляет собой многофакторное расстройство, характеризующееся повышенным внутричерепным давлением без какой-либо явной причины. Хотя она в первую очередь затрагивает женщин репродуктивного возраста с избыточным весом, ее патогенез по-прежнему не до конца изучен. Симптомы включают головную боль и визуальные нарушения, вызванные папилледомой. Все большее внимание уделяется раст

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… , tetrahydrocortisol, 5α‐tetrahydrocortisol, tetrahydrocortisone, total cortisol metabolites, total cortisone metabolites, androsterone, etiocholanolone | CSF glucocorticoids: no change after therapeutic weight loss | Cortisol, cortisone, cortisol/cortisone ratio: no change Tetrahydrocortisol +5α‐tetrahydrocortisol … /tetrahydrocortisone, total cortisol/cortisone metabolites, androsterone, androsterone/etiocholanolone ratio: ↓ | Weight loss led to ↓ in 11β‐HSD1 activity, correlated with ↓ in intracranial pressure; ↓ in CSF cortisone correlated with ↓ weight | Gas chromatography/mass spectrometry and liquid chromatography …

Насколько общим является гиперкортизолизм у пациентов с гипертензией? Факторы риска, эпидемиология и диагностика.

Эндогенный гиперкортизолизм (ЭГК) является недооцененным и клинически значительным фактором гипертонии, особенно резистентной гипертонии. После того, как EHC считается редким субъектом, он теперь воспринимается как спектр избытка кортизола, связанного с неблагоприятными кардиометаболическими результатами и ущербом, причиненным мишени. Недавно проведенные широкомасштабные исследования свидетельствуют о значительном увеличении распространенности ЭГК среди пациентов с устойчивой гипертонией и трудноконтролируемым диабетом, зачастую в отсутствие классических особенностей кушингоида. В настоящем об

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… Farther downstream, cortisol may overwhelm the protective capacity of 11β‐HSD2, which ordinarily renders cortisol inactive by converting it to cortisone in the distal nephron [ 12 ]. … Ongoing work in this area includes investigation of late‐night salivary cortisone and emerging wearable technologies designed to monitor circadian cortisol dynamics. The next step is to measure plasma ACTH. …

PreB1 (CD10-) acute lymphoblastic leukemia: immunophenotypic and genomic characteristics, clinical features and outcome in 38 adults and 26 children. The Groupe dEtude Immunologique des Leucémies.

The less differentiated stage (CD10-) of B-lineage acute lymphoblastic leukaemia (ALL) described as preB1-ALL in the GEIL nomenclature, accounts for less than 10% of ALL. It is classically considered to be associated with translocation (4;11)(q21;q23), and to have a poor prognosis. We report an extensive immunophenotypic, genomic and clinical study of a series of 64 preB-1 ALL patients, representing 6.3% of a cohort of consecutive ALLs. The engagement of preB1-ALL cells in the B-lineage was confirmed by their B-lineage score, equal to or higher than 2. In addition, more than 90% of the cases t

Predicting posttraumatic stress symptoms from pretraumatic risk factors: a 2-year prospective follow-up study in firefighters.

OBJECTIVE: Most studies focusing on risk factors for posttraumatic stress disorder (PTSD) have used retrospective study designs. Only a small number of studies have prospectively examined risk factors in the immediate aftermath of trauma exposure in predicting PTSD symptoms. The purpose of this study was to identify predictive risk factors for posttraumatic stress symptoms and comorbid psychopathological symptoms present during the time before exposure to traumatic stress in a high-risk population. METHOD: Forty-three professional firefighters were assessed immediately after basic training (b

Intratracheal interferon-gamma augments pulmonary defenses in experimental legionellosis.

To study the effects of recombinant interferon-gamma (IFN-gamma) on pulmonary defenses in vivo, we measured Ia antigen expression by alveolar macrophages and whole-lung clearance of inhaled Legionella pneumophila in normal and corticosteroid-treated rats. We found that Ia antigen was expressed by 7, 29, 50, and 65% of alveolar macrophages harvested from normal rats 24 h after intratracheal administration of 0, 10(3), 10(4), or 10(5) U of IFN-gamma, respectively, and by 76% of alveolar macrophages harvested from corticosteroid-treated rats given 10(5) U of IFN-gamma. Corticosteroid-treated rats

Thymus cell migration: cells migrating from thymus to peripheral lymphoid organs have a "mature" phenotype.

To gain information on the lineage relationship of cells leaving the thymus, we studied the phenotype of thymus emigrants within hours of their exit. The migrants were identified in the peripheral lymphoid organs by their fluorescence, 3 to 4 hr after intrathymic injection of a solution of fluorescein isothiocyanate, a technique that initially only labels thymocytes. Migrants identified in this way were analyzed with rhodamine-anti-Thy-1 or rhodamine peanut agglutinin (PNA). They were found to express Thy-1 antigen and PNA binding sites at levels very similar to those found on the majority of

Genicular Nerve Radiofrequency Ablation for Painful Knee Arthritis: The Why and the How.

BACKGROUND: Genicular nerve radiofrequency ablation (GNRFA), including conventional, cooled, and pulsed techniques, has been used in the man … flammatory drugs in combination with a proton pump inhibitor, autologous blood-based therapies, and cortisone and hyaluronic acid injections1,2. Surgical treatment for symptomatic knee OA includes knee arthroscopy, high tibial osteotomy, total knee replacement, and unicompartmental knee replacement in patients without lateral compartment disease2. It should …

[Pharmacology of glucocorticoids and ENT pathology].

UNLABELLED: 1. NATURAL AND SYNTHETIC HORMONES: Glucocorticoids are indispensable circulating hormones implicated in carbohydrate and protein metabolism. They also have strong antiinflammatory effects used in therapy. This antiinflammatory activity has led to the development of synthetic compounds with an antiinflammatory action that is much greater than that of the natural hormones (cortisol, cortisone) with reduced mineralocorticoid activity. 2. ANTIINFLAMMATORY EFFICACY OF GLUCOCORTICOIDS: The action of glucocorticoids on the majority of the cells involved in inflammatory reactions, particul…

Systematic review of the clinical effect of glucocorticoids on nonhematologic malignancy.

BackgroundGlucocorticoids are often used in the treatment of nonhematologic malignancy. This review summarizes the clinical evidence of the effect of glucocorticoid therapy on nonhematologic malignancy.MethodsA systematic review of clinical studies of glucocorticoid therapy in patients with nonhematologic malignancy was undertaken. Only studies having endpoints of tumor response or tumor control or survival were included. PubMed, EMBASE, the Cochrane Register/Databases, conference proceedings (ASCO, AACR, ASTRO/ASTR, ESMO, ECCO) and other resources were used. Data was extracted using a standar

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… As causes of death, rates of pulmonary infection, hemorrhage, heart failure and perforated ulcer were very similar between the placebo and cortisone arms. The authors stated that they were unable to explain why the cortisone arm did worse [ 41 ]. … Although it is unclear how systematically this was studied, the authors did not observe a difference in the rate of cancer progression between the placebo and cortisone arms based on x-ray and autopsy information [ 42 ]. …

Воздействие лечения на стероидом у женщин с множественным склерозом.

Множественный склероз (MS) — хроническое воспалительное нейродегенеративное заболевание центральной нервной системы. Происхождение MS связано с стероидными изменениями во время менструального цикла и беременности. Поскольку данных о воздействии лечения противомоскитных препаратов на стероидом недостаточно, мы провели оценку стерейдомичных изменений (79 стероидов) у 61 женщины-психолога репродуктивного возраста 39 лет (29, 47 лет) после лечения с помощью антимиосных препаратов на платформе GC-MS/MS и иммуномассы (кортизол и эстрадиол). Эти изменения были оценены с использованием уровней стероид

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… Specifically, cortisol measured by both GC-MS/MS and radioimmunoassay (RIA) showed a significant decrease in FP, like cortisone and corticosterone. The changes in circulating cortisol, cortisone, and corticosterone are also illustrated in Figure 1 . 2.1.2. … The bioavailability of cortisol in target tissues depends on its interconversion to cortisone, which is inactive. The balance between bioactive cortisol and inactive cortisone is regulated by the reductive enzyme HSD11B1 and the oxidative enzyme HSD11B2. …

Donor Evaluation for Hematopoietic Stem and Progenitor Cell Collection

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… Long-term oral steroids (>3 months) such as prednisone, hydrocortisone, cortisone Antibiotic or antiviral, if treating current infection that is resolving or for treatment of acne Treatment of a condition requiring antiplatelet agents for TIA or unmanaged cardiac disease. … | Long-term oral steroids (>3 months) such as prednisone, hydrocortisone, cortisone Antibiotic or antiviral, if treating current infection that is resolving or for treatment of acne | | Treatment of a condition requiring antiplatelet agents for TIA or unmanaged cardiac disease. …