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Primary Care Considerations for Elderly U.S. Veterans of World War II and the Korean War: A Narrative Review.

Many of the United States' more than 18 million veterans obtain healthcare through the Department of Veterans Affairs' (VA) Veterans Health Administration system; however, recent legislative changes have expanded veterans' access to non-VA care in their communities, particularly for those who do not live near VA medical centers. Veterans are seen by physicians in outpatient practice across the United States and are admitted to non-VA hospitals; this is particularly salient for older veterans, who may require a more frequent and high level of care. We present a review of characteristics of U.S.

Cultural adaptation and validation of the Sinhala version of the spiritual needs assessment for patients (S-SNAP) questionnaire.

BackgroundSpiritual support for patients and caregivers of critically ill patients is associated with improved quality of life. This aspect, however, is not incorporated into the current care pathways in Sri Lanka. The Spiritual Needs Assessment for Patients (SNAP) questionnaire, comprised of 3 domains: psychosocial, spiritual and religious, gives a platform for clinicians to assess the spiritual needs of those patients. This study presents the results of validation of the Sinhala version of the SNAP (S-SNAP) questionnaire.MethodsThe SNAP was translated from English to Sinhala using the standa

Cardiac Amyloidosis in Older Adults With a Focus on Frailty: JACC: Advances Expert Consensus.

Amyloidosis, which is caused by misfolded proteins that form amyloid fibrils, is predominantly diagnosed in older adults. Although previously considered a rare disease, increased awareness and noninvasive diagnostic methods have resulted in a rise in diagnoses. As a multisystem disease that affects multiple organ systems (cardiac, gastrointestinal, renal, and neurological), there is significant overlap with both geriatric conditions and common conditions in heart failure. Frailty is recognized as a distinct biological syndrome of declines across multiple physiological systems, which prevents m

Clinical and Demographic Factors Associated With Follow-Up in a Hospital-Based Exercise Oncology Program.

OBJECTIVE: Despite the numerous benefits of regular exercise participation for cancer survivors, nearly 60% of survivors do not meet current guidelines. Hospital-based exercise oncology programs may be one strategy to promote exercise engagement as survivors have expressed a preference for exercise programs associated with a cancer hospital. However, follow-up rates in hospital-based exercise oncology programs can be low. Follow-up assessments are a critical component of exercise oncology programs as they determine survivor progress, allow for revision of exercise prescriptions, and demonstrat

Risk factors associated with suicidal ideation among cancer patients: a systematic review and meta-analysis.

ObjectiveThe objective of this review was to provide a comprehensive summary and analysis of the risk factors associated with suicidal ideation among cancer patients.MethodsThis review adhered to the PICO/S framework and guidelines outlined in the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) framework (PROSPERO CRD42023433639). We searched Web of Science, PubMed, Embase, Scopus, PsycINFO, and Cochrane Library from the establishment date of the databases until June 9, 2023 for observational studies that reveal risk factors associated with suicidal ideation among ca

Гематологические болезни у пожилых пациентов: уделение особого внимания потенциальной роли управления гериатрической оценкой.

Управление гериатрической оценкой представляет собой многомерный инструмент, используемый для оценки прогнозов в отношении клинических результатов и целевых показателей в отношении мероприятий для пожилых людей, в которых рак проходит химиотерапию. В ходе этого обзора мы провели оценку возможного применения методов управления гериатрической оценкой (GAM) в гематологических паразитах. У пожилых пациентов с диффузной клеточной лимфомой B GAM может быть полезным как в прогнозировании запланированных госпитализаций, так и в улучшении качества жизни. В хронической миелоидной лейкемии индекс коморби

Patient Perspectives on Social and Identity Factors Affecting Multiple Myeloma Care: Barriers and Opportunities.

Patients living with multiple myeloma (MM) have a substantial disease burden and face multiple barriers to care. Building upon our previous research using mixed methods, this focus group research aimed to identify patients' priorities regarding specific social and identity-related needs, map these prioritized needs to the disease journey, and describe patient-generated ideas to improve patient support. Participants noted that patients with MM need a range of emotional, social, and financial support throughout the disease journey. They identified initial MM diagnosis and treatment adherence as

Longevity leap: mind the healthspan gap.

Life expectancy has increased by three decades since the mid-twentieth century. Parallel healthspan expansion has however not followed, largely impeded by the pandemic of chronic diseases afflicting a growing older population. The lag in quality of life is a recognized challenge that calls for prioritization of disease-free longevity. Contemporary communal, clinical and research trends aspiring to extend the health horizon are here outlined in the context of an evolving epidemiology. A shared action integrating public and societal endeavors with emerging interventions that target age-related m

Prehabilitation Exercise Training to Target Improved Muscle Strength in Pretransplant Patients Diagnosed With Multiple Myeloma: Protocol for a Pilot Randomized Controlled Trial.

BACKGROUND: Muscle mass and strength are severely compromised in patients diagnosed with multiple myeloma, such that the risk of poor overall survival increases as the prevalence of low muscle mass, also known as sarcopenia, increases. Additionally, at the time of autologous stem cell transplant (ASCT), 51% of patients experience low muscle mass and strength, which can prolong hospitalization and lead to increased risk of obesity, insulin resistance, lowered physical function, and poor quality of life. OBJECTIVE: The PROTECT (Prehabilitation Exercise Training in Multiple Myeloma Patients Unde

A Practical Approach to Managing Patients With Myasthenia Gravis-Opinions and a Review of the Literature.

When the diagnosis of myasthenia gravis (MG) has been secured, the aim of management should be prompt symptom control and the induction of remission or minimal manifestations. Symptom control, with acetylcholinesterase inhibitors such as pyridostigmine, is commonly employed. This may be sufficient in mild disease. There is no single universally accepted treatment regimen. Corticosteroids are the mainstay of immunosuppressive treatment in patients with more than mild MG to induce remission. Immunosuppressive therapies, such as azathioprine are prescribed in addition to but sometimes instead of

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… In a small study ( 149 ), 12 MG patients underwent long-term respiratory muscle endurance training, which resulted in a change in their breathing pattern with prolonged expiration. … Effects of long-term respiratory muscle endurance training on respiratory and functional outcomes in patients with myasthenia gravis. Respir Med. (2018) 144:7–15. 10.1016/j.rmed.2018.09.001 150. Grob D, Brunner N, Namba T, Pagala M. Lifetime course of myasthenia gravis. …

Профессиональная реабилитация лиц с множественным склерозом в национальной системе здравоохранения Соединенного Королевства: оценка реального положения.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Имеются ограниченные данные о том, каким образом профессиональная реабилитация лиц с множественным склерозом (МС) может осуществляться через Национальную службу здравоохранения (НСЗ) Соединенного Королевства (Соединенное Королевство) и как она работает. AIM: Уяснить механизмы и контекст осуществления VR-терапии для лиц, имеющих MS в ГСЗ, и разработать теорию пояснительных программ. МЕТОДЫ: Реалистичная оценка, включая обзор доказательств, а затем полуструктурированные собеседования. Был проведен реалистический обзор VR для лиц, имеющих MS в НСЗ six Электронные базы данны

A case report on the treatment of autoimmune hemolytic anemia after CBT by daratumumab in a mucopolysaccharidosis type III patient.

RATIONALE: Mucopolysaccharidosis type III, also referred to as Sanfilippo disease, is a rare hereditary lysosomal storage illness and one of the more common variants. The illness can affect all tissues and organs of the body, with the central nervous system being the most profoundly impacted. Autoimmune hemolytic anemia (AIHA) is a rare, diverse, antibody-mediated disorder characterized by the production of antibodies that target and destroy red blood cells, leading to their rapid destruction. AIHA is a prevalent and notable complication in recipients following umbilical cord blood stem cell t

IMPROVE-BMT: a protocol for a pilot randomised controlled trial of prehabilitation exercise for adult haematopoietic stem cell transplant recipients.

IntroductionHaematopoietic stem cell transplant (HSCT) in adults is an intensive medical procedure for a variety of haematological malignancies. Although there is a large body of evidence demonstrating the negative effects of HSCT on physical function and psychosocial parameters, there is limited evidence on the impact of HSCT on body composition and bone health. Further, aerobic and resistance-training exercise interventions aimed at improving physical function and patient-reported outcomes largely take place during the peritransplant and post-transplant period. Prehabilitative exercise, or e

The influence of telehealth-based cancer rehabilitation interventions on disability: a systematic review.

PurposeTo characterize delivery features and explore effectiveness of telehealth-based cancer rehabilitation interventions that address disability in adult cancer survivors.MethodsA systematic review of electronic databases (CINAHL Plus, Cochrane Library: Database of Systematic Reviews, Embase, National Health Service's Health Technology Assessment, PubMed, Scopus, Web of Science) was conducted in December 2019 and updated in April 2021.ResultsSearches identified 3,499 unique studies. Sixty-eight studies met inclusion criteria. There were 81 unique interventions across included studies. Interv

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… Physical Therapy | Oncology rehabilitation of exercise and education Djuric (2011) [ 44 ] | Motivational interviewing; Education and counseling | Telephone calls | Individual | 52 weeks Variable | Dietetics | Education, pedometer, log, newsletters Dong (2019) [ 45 ] | Remotely-guided muscle training, endurance … training, and education | Video Conferencing; Instant Messaging or Texting; Mobile Application; Activity Tracker | Individual | 12 weeks Fixed Interactions: 84 | Physical Therapy | Usual care (traditional rehabilitation) Dong (2020) [ 46 ] | Remotely-guided muscle training, endurance training, and education …

Физические упражнения низкой интенсивности связаны с улучшением мелиорации и сокращением микрогранной активации в модели обезвоживания Cuprizone.

Уничтожение таких болезней, как множественный склероз, приводит к повреждению милиновой оболочки, что приводит к неврологическим проблемам. Хотя точные причины НР неясны, известно, что подстрекательские процессы и плохое воспоминание способствуют прогрессированию заболеваний. Упражнения показали, что они являются ненаркотической терапией для MS, и, согласно сообщениям, выгоды для мобильности, настроения и потенциальной нейрозащиты. Однако не в полной мере понимаются конкретные способы воздействия физических упражнений на воспоминание и нейронное воспаление в условиях демиелина. В рамках этого

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes-7.

Breakthroughs in Medicinal Chemistry [...].

Feasibility of whole body vibration during intensive chemotherapy in patients with hematological malignancies - a randomized controlled pilot study.

BackgroundHospitalized cancer patients undergoing intensive or high-dose chemotherapy often experience a considerable decline in functional performance associated with the increased risk of adverse health events. Exercises, particularly resistance-based exercises that may counteract this decline are restricted by therapy-related side effects. Since whole body vibration (WBV) is known to efficiently stimulate the neuromuscular system without significantly raising blood pressure, we hypothesize that especially WBV is particularly feasible even during intensive or high-dose chemotherapy (primary

Predictors of adherence to exercise interventions during and after cancer treatment: A systematic review.

ObjectiveExercise interventions benefit cancer patients. However, only low numbers of patients adhere to these interventions. This review aimed to identify predictors of exercise intervention adherence in patients with cancer, during and after multimodality cancer treatment.MethodsA literature search was performed using electronic databases (PubMed, Embase, and Cochrane) to identify relevant papers published before February 1, 2017. Papers reporting randomized controlled trials, conducted in adult cancer patients who participated in an exercise intervention during and/or after multimodality ca

Patient Navigation in Cancer Treatment: A Systematic Review.

Purpose of reviewPatient navigation promotes access to timely treatment of chronic diseases by eliminating barriers to care. Patient navigation programs have been well-established in improving screening rates and diagnostic resolution. This systematic review aimed to characterize the multifaceted role of patient navigators within the realm of cancer treatment.Recent findingsA comprehensive electronic literature review of PubMed and Embase databases was conducted to identify relevant studies investigating the role of patient navigators in cancer treatment from August 1, 2009 to March 27, 2023.

Therapeutic strategies against cancer cachexia.

Cancer cachexia has two main components: anorexia and metabolic alterations. The main changes associated with the development of this multi-organic syndrome are glucose intolerance, fat depletion and muscle protein hypercatabolism. The aim of this paper is to review the more recent therapeutic approaches designed to counteract the wasting suffered by the cancer patient with cachexia. Among the most promising approaches we can include the use of ghrelin agonists, beta-blockers, beta-adrenergic agonists, androgen receptor agonists and anti-myostatin peptides. The multi-targeted approach seems es