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Варианты лечения под воздействием болезней при очень раннем многоразовом склерозе - какие варианты имеются для включения под действием 5 Годы? Систематический обзор.

Фон/задачи: Очень ранний педиатрический множественный склероз (POMS) встречается редко; клинические исследования с использованием методов коррекции заболеваний (DMT) не проводились. Клинические работники полагаются на исследования, проводимые в пожилом возрасте. Этот обзор стал результатом трудностей, с которыми сталкиваются врачи, и несанкционированного использования ДМТ в этом возрасте. Методы: Обзор литературы исследований, проведенных в период между 1982 и 2025 на очень раннем этапе ПОМС, особенно с наступлением до достижения возраста 5, был выполнен в поисках результатов без DMT или без D

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… Qi Z. Caillier S.J. Gourraud P.A. Yu J. Nathanson L. Belman A.L. Copy number variation in pediatric multiple sclerosis Mult. Scler. 2013 19 1014 1021 10.1177/1352458512469696 23239789 PMC5507577 35. Chou I.J. Wang H.S. Whitehouse W.P. Constantinescu C.S. …

Targeting the ubiquitin-proteasome system: a novel therapeutic strategy for neuroblastoma.

Neuroblastoma (NB) stands as a common and formidable malignant tumor among children, characterized by marked tumor heterogeneity and resistance to conventional treatments. Central to the regulation of protein stability, localization, and function is the process of ubiquitination-a critical protein modification. The therapeutic potential of drugs that target deubiquitination, demonstrated in the treatment of refractory multiple myeloma, warrants investigation in the context of NB. This review endeavors to demystify the intricate biological implications of ubiquitination within NB pathology, syn

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… Nat Rev Cancer . ( 2013 ) 13 : 83 – 96 . doi: 10.1038/nrc3430 23303139 PMC4161369 15 Qi SM Cheng G Cheng XD Xu Z Xu B Zhang WD . Targeting USP7-mediated deubiquitination of MDM2/MDMX-p53 pathway for cancer therapy: are we there yet ? …

Prevalence and risk factors for anxiety in patients with early- and middle-stage lung cancer: a cross-sectional study.

ObjectiveLung cancer is a leading cause of cancer-related morbidity and mortality worldwide, with patients frequently experiencing significant psychological distress, particularly anxiety. Despite the high prevalence of anxiety in patients with cancer, there is limited comprehensive research focusing on the specific factors influencing anxiety in patients with early- and middle-stage lung cancer within the context of Chinese medicine hospitals. Therefore, we aimed to investigate the epidemiology and factors influencing anxiety disorders in patients with early- and middle-stage primary bronchia

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… Oncol. 14, 69–80. doi: 10.5306/wjco.v14.i2.69, PMID: Gong J., Chen G., Qi Z., Zhong S., Su T., Pan Y., et al. (2021). Psychological effects of people isolated in Hubei due to COVID-19 epidemic. Front. Psych. 12:597894. doi: 10.3389/fpsyt.2021.597894, PMID: Gontijo Garcia G. S., Meira K. …

Centella Asiatica поощряет антиоксидантное гениевые экспрессии и митохондриальное окисляющее дыхание в экспериментальном аутоиммунном энцефаломелите.

Справочная информация/задачи: Centella asiatica (L.) — традиционная ботаническая медицина, применяемая при старении и слабоумии. Водные выдержки из C. asiatica (CAW) использовались для лечения нейропсихиатрических симптомов в соответствующих моделях животных и связаны с увеличением генов антиоксидантов (ARE) и улучшением митохондриальной дыхательной функции и нейронного здоровья. Поскольку множественный склероз (MS) разделяет ее нейрогенеративную патологию окислительного стресса и митохондриальной дисфункции со старением и слабоумием, нейропсихиатрические симптомы в MS могут также выиграть от

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… Qi Z. Ci X. Huang J. Liu Q. Yu Q. Zhou J. Deng X. Asiatic acid enhances Nrf2 signaling to protect HepG2 cells from oxidative damage through Akt and ERK activation Biomed. Pharmacother. 2017 88 252 259 10.1016/j.biopha.2017.01.067 28110191 27. Paemanee A. Rattanabunyong S. Ketngamkum Y. …

CAR T cell therapy in solid tumors: A review of current clinical trials.

Chimeric antigen receptor (CAR) T cell therapy has made tremendous strides in the arena of hematological malignancies with approved therapies in certain leukemias, lymphomas, and recently myeloma with overall highly favorable response rates. While numerous clinical studies are still ongoing for hematological malignancies, research is developing to translate the feasibility of CAR T therapy in solid organ malignancies. Unfortunately, the majority of diagnosed cancers are primarily solid tumors. Thus, a highly unmet clinical need for further research and development exists in this field. This re

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… Shi D, Shi Y, Kaseb AO, Qi X, Zhang Y, Chi J, et al. Chimeric Antigen Receptor‐Glypican‐3 T‐Cell Therapy for Advanced Hepatocellular Carcinoma: Results of Phase I Trials. Clin Cancer Res. 2020;26(15):3979‐89. 23. Guo J, Tang Q. …

CD13 downregulation mediated by ubenimex inhibits autophagy to overcome 5-FU resistance by disturbing the EMP3/FAK/NF-κB pathway in gastric cancer cells.

BackgroundGastric cancer (GC) is one of the most common malignant tumours in China, but the efficacy of chemotherapy on GC is significantly reduced due to the occurrence of drug resistance. Some studies have shown that the expression level of CD13 is associated with tumour resistance, but whether ubenimex, as a CD13 inhibitor, reverses GC drug resistance and the underlying mechanism remain unclear.MethodsHerein, resistance to 5-fluorouracil (5-FU) was reversed in GC by ubenimex, and the underlying mechanism was determined using Cell Counting Kit-8 (CCK-8) assays, gene chip analysis, high conte

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… Oncogene 2010 ; 29 : 1717 - 9 . 10.1038/onc.2009.519 20101204 38 Huang X Qi Q Hua X Beclin 1, an autophagy-related gene, augments apoptosis in U87 glioblastoma cells. …

JMJD3 suppresses tumor progression in oral tongue squamous cell carcinoma patients receiving surgical resection.

BackgroundJumonji domain-containing-3 (JMJD3) is reported to be a histone H3 lysine 27 (H3K27) demethylase and a tumor suppressor gene. The present study designed to investigate the crucial role of JMJD3 in oral tongue squamous cell carcinoma (OTSCC) patients who received surgical resection.MethodsWe enrolled a total of 156 OTSCC patients receiving surgical resection, including 73 patients (47%) with high expression of JMJD3 and 83 patients (53%) harboring low expression of JMJD3. Two OTSCC cell lines, SAS and Cal 27, were used to explore the modulation of cancer. GSK-J4, a potent inhibitor of

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… Tang et al. (2016) Tang B, Qi G, Tang F, Yuan S, Wang Z, Liang X, Li B, Yu S, Liu J, Huang Q, Wei Y, Zhai R, Lei B, Yu H, Tomlinson S, He S. Aberrant JMJD3 expression upregulates slug to promote migration, invasion, and stem cell-like behaviors in hepatocellular carcinoma. …

IgE-expressing long-lived plasma cells in persistent sensitization.

Persistent allergies affect the quality of life of patients and increase economic burdens. Many clinical observations indicate the presence of IgE+ long-lived plasma cells (LLPCs), which account for the persistent secretion of specific IgE; however, the characteristics of the IgE+ LLPCs have yet to be identified clearly. In this review, we summarized the generation of IgE+ PCs, discussed the prosurvival factors in the microenvironment, and reviewed the unique IgE-BCR signaling, which may bring insights into understanding the survival mechanisms of IgE+ LLPCs.

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… Liu X, Yao J, Zhao Y, Wang J, Qi H. Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota. Nat Immunol. (2022) 23:1564–76. 10.1038/s41590-022-01345-5 23. Nguyen DC, Duan M, Ali M, Ley A, Sanz I, Lee FE. …

Chimeric Antigen Receptor T-Cell Therapy: What We Expect Soon.

The treatment landscape for hematologic malignancies has changed since the recent approval of highly effective chimeric antigen receptor T-cell therapies (CAR-T). Moreover, more than 600 active trials are currently ongoing. However, early enthusiasm should be tempered since several issues are still unsolved and represent the challenges for the coming years. The lack of initial responses and early relapse are some hurdles to be tackled. Moreover, new strategies are needed to increase the safety profile or shorten the manufacturing process during CAR-T cells therapy production. Nowadays, most cl

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… -A., Zhang X., Xiong M., Zhang J., Zhou X., Qi F., Yang J., He T. Which is better in CD19 CAR-T treatment of r/r B-ALL, CD28 or 4-1BB? A parallel trial under the same manufacturing process. J. Clin. Oncol. 2018;36:3041. doi: 10.1200/JCO.2018.36.15_suppl.3041. 44. …

Cyclic Polypeptide D7 Protects Bone Marrow Mesenchymal Cells and Promotes Chondrogenesis during Osteonecrosis of the Femoral Head via Growth Differentiation Factor 15-Mediated Redox Signaling.

Osteonecrosis of the femoral head (ONFH) is a debilitating disease that is closely associated with the clinical application of high-dose glucocorticoids. Elevated oxidative stress contributes to the pathophysiological changes observed in ONFH. The lack of effective treatments besides surgical intervention highlights the importance of finding novel therapeutics. Our previous studies demonstrated that D7, a cyclic polypeptide, enhances the adhesion, expansion, and proliferation of bone marrow mesenchymal stem cells (BMSCs). Therefore, in this study, we investigated the therapeutic effects of D7

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… Steroid induced osteonecrosis: an analysis of steroid dosing risk Autoimmunity reviews 2010 9 11 721 743 10.1016/j.autrev.2010.06.007 2-s2.0-77956190013 20621176 PMC7105235 2 Qi Y. Zhu Y. Cao Y. …

Corneal nerve fiber loss relates to cognitive impairment in patients with Parkinson's disease.

Cognitive impairment in Parkinson's disease (PD) adversely influences quality of life. There is currently no available biomarker to predict cognitive decline in PD. Corneal confocal microscopy (CCM) has been used as a non-invasive tool for quantifying small nerve damage in PD. The present study investigated whether corneal nerve measures were associated with cognitive function in PD. Patients with PD were classified into those with normal cognitive function (PD-CN), mild cognitive impairment (PD-MCI), and dementia (PDD). Corneal nerve fiber density (CNFD), corneal nerve branch density (CNBD),

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… Hong-Qi Yang, Email: ericyng@163.com. Supplementary information The online version contains supplementary material available at 10.1038/s41531-021-00225-3. References 1. Morris R, et al. Cognitive function in people with and without freezing of gait in Parkinson’s disease. …

Elotuzumab for the treatment of extramedullary myeloma: a retrospective analysis of clinical efficacy and SLAMF7 expression patterns.

Extramedullary disease (EMD) represents a high-risk state of multiple myeloma (MM) associated with poor prognosis. While most anti-myeloma therapeutics demonstrate limited efficacy in this setting, some studies exploring the utility of chimeric antigen receptor (CAR)-modified T cells reported promising results. We have recently designed SLAMF7-directed CAR T cells for the treatment of MM. SLAMF7 is a transmembrane receptor expressed on myeloma cells that plays a role in myeloma cell homing to the bone marrow. Currently, the only approved anti-SLAMF7 therapeutic is the monoclonal antibody elotu

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… Deng S, Xu Y, An G, Sui W, Zou D, Zhao Y, Qi J, Li F, Hao M, Qiu L. Features of extramedullary disease of multiple myeloma: high frequency of p53 deletion and poor survival: a retrospective single-center study of 834 cases. …

MicroRNA‑145 promotes the apoptosis of leukemic stem cells and enhances drug‑resistant K562/ADM cell sensitivity to adriamycin via the regulation of ABCE1.

Leukemia is a type of cancer which originates in blood‑forming tissues. MicroRNAs (miRNAs or miRs) have been shown to be involved leukemogenesis. In the present study, following the gain‑ and loss‑function of miR‑145 and ATP‑binding cassette sub‑family E member 1 (ABCE1) in K562 cells and K562 adriamycin‑resistant cells (K562/ADM cells), the levels of multidrug resistance protein 1 (MRP1) and P‑glycoprotein (P‑gp) were measured. The viability of the K562 cells and K562/ADM cells treated with various concentrations of ADM, and cell sensitivity to ADM were measured. The apoptosis of stem cells w

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… Gao JH Wang TY Episomal lentiviral vector-mediated miR-145 overexpression inhibits proliferation and induces apoptosis of human esopha-geal carcinomas cells Recent Pat Anticancer Drug Discov 11 453 460 2016 10.2174/1574892811666160822161157 27549139 30 Gao M Miao L Liu M Li C Yu C Yan H Yin Y Wang Y Qi …

Ixazomib Improves Bone Remodeling and Counteracts sonic Hedgehog signaling Inhibition Mediated by Myeloma Cells.

Multiple myeloma (MM) is a clonal B-cell malignancy characterized by an accumulation of plasma cells (PC) in the bone marrow (BM), leading to bone loss and BM failure. Osteolytic bone disease is a common manifestation observed in MM patients and represents the most severe cause of morbidity, leading to progressive skeletal damage and disabilities. Pathogenetic mechanisms of MM bone disease are closely linked to PCs and osteoclast (OCs) hyperactivity, coupled with defective osteoblasts (OBs) function that is unable to counteract bone resorption. The aim of the present study was to investigate t

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… Qi M. Chai T. Walsh J.P. Ratajczak T. Zheng M.H. Xu J. Proteasome inhibitors impair RANKL-induced NF-kappaB activity in osteoclast-like cells via disruption of p62, TRAF6, CYLD, and IkappaBalpha signaling cascades J. Cell Physiol. 2009 220 450 459 10.1002/jcp.21787 19365810 13. Von Metzler I. …

The Adiponectin-AdipoR1 Axis Mediates Tumor Progression and Tyrosine Kinase Inhibitor Resistance in Metastatic Renal Cell Carcinoma.

The survival of patients diagnosed with metastatic renal cell carcinoma (RCC) is still limited and the current targeted therapies are only partially effective. Herein, we investigated the clinical value and functions of adiponectin receptors (AdipoR1 and AdipoR2) in metastatic renal cell carcinoma (RCC) patients treated with tyrosine kinase inhibitors (TKIs). A total of 127 mRCC patients treated with first-line TKIs between 2008 and 2017 at a single institution were collected. AdipoR1 and AdipoR2 expression was assessed by immunohistochemistry. AdipoR1 was positively expressed in 87.4% (111/12

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… Guo H, German P, Bai S, Barnes S, Guo W, Qi X, Lou H, Liang J, Jonasch E, Mills GB. The PI3K/AKT pathway and renal Ccell carcinoma. J Genet Genomics. 2015;42:343–353. doi: 10.1016/j.jgg.2015.03.003. 22. Network CGAR. Comprehensive molecular characterization of clear cell renal cell carcinoma. …

MicroRNAs - novel biomarkers for malignant pleural effusions.

Lung cancer is one of the most common causes of cancer death. Its poor prognosis can be attributed to the patients' advanced or metastatic presentation at the time of diagnosis. To improve and accelerate the diagnosis, better therapeutic and diagnostic methods are constantly being sought. MicroRNAs (miRNAs) are short nucleotide sequences of single-stranded, non-coding RNA that function as critical post-transcriptional regulators of gene expression. They are identified not only intracellularly, but also in physiological and pathological body fluids. These molecules are responsible for the regul

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… Qi J, Yu JY, Shcherbata HR, et al. microRNAs regulate human embryonic stem cell division. Cell Cycle. 2009;8:3729–3741. doi: 10.4161/cc.8.22.10033. 37. Vasudevan S, Tong Y, Steitz JA. Cell-cycle control of microRNA-mediated translation regulation. …

Dental Implant Placement in Patients on Bisphosphonate Therapy: a Systematic Review.

OBJECTIVES: The review aims to study dental implant placement purposefulness for patients who have been treated or are on treatment with bisphosphonate medication. MATERIAL AND METHODS: Structured search strategy was applied on electronic databases: MEDLINE, PubMed, PubMed Central and ResearchGate. Scientific publications in English between 2006 and 2017 were identified in accordance with inclusion, exclusion criteria. Publication screening, data extraction, and quality assessment were performed. Outcome measures included implant failure or implant-related osteonecrosis of the jaw. RESULTS:

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… J Clin Periodontol. 2017 Sep;44(9):941-949. 10.1111/jcpe.12776 28703333 11 Li JP Li P Hu J Dong W Liao NN Qi MC Li JY Early healing of hydroxyapatite-coated implants in grafted bone of zoledronic acid-treated osteoporotic rabbits. …

Posttransplant maintenance therapy in multiple myeloma: the changing landscape.

Transplant-eligible patients with multiple myeloma (MM) now have extended survival after diagnosis owing to effective modern treatment strategies that include new agents in induction therapy, autologous stem cell transplant (ASCT), consolidation therapy and posttransplant maintenance therapy. Standard of care for newly diagnosed, fit patients includes ASCT and, often nowadays, posttransplant maintenance. Several large studies have shown the efficacy of maintenance with thalidomide, lenalidomide and bortezomib in the treatment scheme of MM with regards to prolonging progression-free survival an

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… Clin Lymphoma Myeloma Leuk 2012 ; 12 : 319 –324. 23040438 10.1016/j.clml.2012.07.007 Dimopoulos M, Siegel DS, Lonial S, Qi J, Hajek R, Facon T et al. …

From Selection to Use: Aptamers as Targeting Reagents in Hematology.

Aptamers are synthetic nucleic acid ligands that have been proposed as alternatives to antibodies for targeting molecules and cells. In hematology, most reviews have organized aptamer literature around diseases or technological platforms. This framing has obscured how unevenly different blood cell types have been covered. In this review, we present developed aptamers organized by blood cell lineages. Specifically, we examine aptamers for B cells, T cells, natural killer cells, and red blood cells. This organization revealed a strong concentration on a small set of canonical surface markers and

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… Qi J. Zeng Z. Iyer S.P. Lin P. Tung C.H. Zu Y. Oligonucleotide aptamer-drug conjugates for targeted therapy of acute myeloid leukemia Biomaterials 2015 67 42 51 10.1016/j.biomaterials.2015.07.025 26204224 PMC4550516 118. Li X. Dai J. Shi Y. Chen J. Zhou F. Qian X. Wang P. Fu X. Tan W. …

Marine Natural Products as Potent Anticancer Agents (2020-2024): Structural Diversity, SARs and Target Prediction.

In recent years, Marine Natural Products (MNPs) have emerged as a significant source for anticancer drug discovery, as many natural products can offer structural diversity, unique mechanisms of action, and relatively low toxicity. This article provides a systematic review of MNPs with reported anticancer activities from 2020 to 2024. These compounds are classified into seven major categories: terpenoids, alkaloids, sterols, polyketides, peptides and proteins, polysaccharides, and macrolides. For each category, we elaborate on the marine sources, structural identification, in vitro anticancer a