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Влияние ПГПР на структуру микробиологической сообщества ризосферы и урожайность солончаковых зерновых культур.

Растворяющиеся в почве бактерии, способствующие росту растений (PGPR), могут защищать растения от почвенных заболеваний и абиотических стрессовых условий. Основная цель данного исследования заключалась в оценке влияния различных PGPR (TF1, TF2, TF3 и TF4) на микробную сообщество ризосферы зерна для корма в солончаково-щелочной поле с использованием высокопроизводительной технологии последовательного секвенирования Illumina MiSeq. Результаты показали, что различные PGPRs значительно увеличили плотность уборки (на 21,31–45,16%), высоту растения (на 9,12–19,98%), диаметр стебля (на 30,07–45,78%)

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… Bacillus halophilus BH-8 combined with coal gangue as a composite microbial agent for the rehabilitation of saline-alkali land Microorganisms 2025 13 532 10.3390/microorganisms13030532 40142425 PMC11945998 19. Parida A.K. Das A.B. Salt tolerance and salinity effects on plants: A review Ecotox. …

Cancer burden and risk in the Chinese population aged 55 years and above: A systematic analysis and comparison with the USA and Western Europe.

BackgroundWe analysed the cancer burden among elderly Chinese people over the age of 55 years and compared them to USA and Western Europe to explore the cancer model in China.MethodsWe retrieved data on 29 cancers with 34 risk factors from the 2019 Global Burden of Disease database to evaluate the cancer burden in Chinese elderly individuals aged 55 years and older. We then used the age-standardised incidence rate (ASIR), age-standardised death rate (ASDR), age-standardised disability-adjusted life year (DALY) rate, and average annual percentage change (AAPC) to compare the characteristics and

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… However, the significant use of coal, the production of industrial waste, the increase in the use of motor vehicles, and the rapid development of cities all added to the ambient air pollution in China, making it one of the countries with the highest air pollution in the world [ 24 , 25 ]. …

Does childhood obesity foreshadow a future time-bomb of early and more aggressive cancers?

There has been a global explosion in the prevalence of childhood obesity with 20% of children worldwide now growing up with excess weight an … m to which children are particularly vulnerable. Protecting children will require broad multisector coalitions to enable sets of mutually reinforcing policies such as front-of-pack food labelling, restrictions on the ubiquitous marketing, food taxes, subsidies and mandated healthy school meal programs.

The disease burden attributable to 18 occupational risks in China: an analysis for the global burden of disease study 2017.

BackgroundChina has more than 18% of the global population and over 770 million workers. However, the burden of disease attributable to occupational risks is unavailable in China. We aimed to estimate the burden of disease attributable to occupational exposures at provincial levels from 1990 to 2017.MethodsWe estimated the summary exposure values (SEVs), deaths and disability-adjusted life years (DALYs) attributable to occupational risk factors in China from 1990 to 2017, based on Global Burden of Disease Study (GBD) 2017. There were 18 occupational risks, 22 related causes, and 35 risk-outcom

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… Meanwhile, China is a top producer of cement, coal, iron, steel with rich mineral reserves and resources. Rapid industrialization in China in recent years also brings more categories of jobs and occupational hazards. …

Воздействие иммунотерапии рака на рождаемость: уделение особого внимания гематологическим заболеваниям.

В последние годы лечению раковых заболеваний способствовали новые эффективные методы лечения, включая иммунную терапию. Хотя эта терапия повышает показатели выживаемости рака, она может изменять иммунную реакцию и вызывать долгосрочные побочные эффекты, гонадотоксичные последствия и потенциальное воздействие на фертильность мужчин и женщин вызывают все большую озабоченность. Иммунотерапии, такие, как ингибиторы иммунной системы, иммуномодуляторы, моноклонные антитела и CAR-T, могут привести к повышению уровней проинфламмации цитокинов и связанных с иммунным иммунитетом неблагоприятных явлений,

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… The role of macrophage polarization and related key molecules in pulmonary inflammation and fibrosis induced by coal dust dynamic inhalation exposure in Sprague-Dawley rats. Cytokine. 2024;173:156419. doi: 10.1016/j.cyto.2023.156419. 111. …

Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats.

The COVID-19 pandemic exposed a global deficiency of systematic, data-driven guidance to identify high-risk individuals. Here, we illustrate the utility of routinely recorded medical history to predict the risk for 1741 diseases across clinical specialties and support the rapid response to emerging health threats such as COVID-19. We developed a neural network to learn from health records of 502,489 UK Biobank participants. Importantly, we observed discriminative improvements over basic demographic predictors for 1546 (88.8%) endpoints. After transferring the unmodified risk models to the All

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… The training of a single model on an NVIDIA A100 GPU node for 18 epochs required approximately 11 h, equating to the emission of approximately 1.08 kg CO2 eq, 4.36 km driven by an average ICE car or 0.54 kgs of coal burned as calculated by the mlco2 calculator 70 . …

Global health burdens of plastics: a lifecycle assessment model from 2016 to 2040.

BackgroundQuantifying human health impacts throughout plastics lifecycles can inform global action against pollution that promotes sustainability across environmental, economic, and health concerns.MethodsWe combined material flow analysis, using the Plastics-to-Ocean model, with lifecycle assessment (LCA) to quantitatively compare disability-adjusted life-years (DALYs) associated with plastics lifecycles, under different global consumption and waste management scenarios between 2016 and 2040. We estimated global health effects of greenhouse gases, particulate matter, and specific chemical emi

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… Growing environmental footprint of plastics driven by coal combustion. Nat Sustain. 2022;5:139–148. 41. Karali N, Khanna N, Shah N. Climate impact of primary plastic production. April, 2024. https://eta.lbl.gov/publications/climate-impact-primary-plastic 42. …

Cancer prevalence, incidence, and mortality rates in Afghanistan in 2020: A review study.

BackgroundAfghanistan is in an epidemiological transition, as cancer is the second leading cause of mortality due to non-communicable diseases. This study is the first to provide a comprehensive perspective on the overall cancer situation in Afghanistan by discussing the top five most common cancers, their incidence variations, risk factors, and preventive measures. The limited number of cancer studies conducted in Afghanistan highlights the importance of the present review.Recent findingsThis article provides an overview of cancer burden in Afghanistan in 2020. It utilizes IARC-generated GLOB

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… increase in LC burden shortly. 60 Unfortunately, tobacco products are widely available in Afghanistan, and smoking is socially accepted. 61 Outdoor and occupational exposure to asbestos, radon, polycyclic aromatic hydrocarbons, and arsenic, and indoor air pollution from secondhand smoking, unventilated coal‐fueled …

Infectious Complications of Cancer Therapy

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… Hospital wards spreading vancomycin-resistant enterococci to intensive care units: returning coals to Newcastle. Crit Care Med. 1998;26:1942–1943. doi: 10.1097/00003246-199812000-00008. 253. Walsh T.J., Vlahov D., Hansen S.L., et al. …

Chest and Mediastinum

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The Italian Society of Andrology and Sexual Medicine (SIAMS), along with ten other Italian Scientific Societies, guidelines on the diagnosis and management of erectile dysfunction.

PURPOSE: Erectile dysfunction (ED) is one of the most prevalent male sexual dysfunctions. ED has been in the past mistakenly considered a purely psycho-sexological symptom by patients and doctors. However, an ever-growing body of evidence supporting the role of several organic factors in the pathophysiological mechanisms underlying ED has been recognized. METHODS: The Italian Society of Andrology and Sexual Medicine (SIAMS) commissioned an expert task force involving several other National Societies to provide an updated guideline on the diagnosis and management of ED. Derived recommendations

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… In particular, erectile function could be considered as the classical ‘canary in the coal mine’, thanks to its particular ability to occur earlier, as a consequence of lifestyle mistakes, with respect to the other NCDs [ 10 ]. …

The cGAS-STING pathway in senescence and aging-related diseases: mechanisms and therapeutic opportunities.

The cGAS-STING pathway acts as a critical molecular hub connecting genomic instability with cellular senescence. Functioning as a key regulator of the innate immune system, this pathway detects aberrant cytoplasmic DNA to activate downstream inflammatory responses, thereby playing a pivotal role in aging-related diseases. This review systematically explores the core mechanisms by which the cGAS-STING pathway regulates cellular senescence, emphasizing its role in triggering senescence through the recognition of DNA damage signals (e.g., oxidative stress, telomere dysfunction) and promoting para

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… alternatives | [ 314 ] Nano-targeted delivery systems | Scavenges excess cerebral Cu 2 ⁺ to inhibit ROS generation, activates nanozyme activity to catalyze NAD⁺ production and degrade H₂O₂ | TP@PB-COF@NADH | Suppresses cGAS-STING pathway and neuroinflammation | [ 315 ] Binds damaged DNA, delivers inhibitor | CoAl-LDH …

Интеграция нанотехнологий в онкологию для передовых стратегий наночастиц в целевую диагностику и лечение рака.

Рак остается одной из основных глобальных проблем в области здравоохранения. Обычная терапия часто ограничивается низкой избирательностью опухолей, системной токсичностью, резистентностью к многочисленным лекарствам и неоптимальными фармакокинетиками. Нанотехнология предлагает преобразующий подход в онкологии. Она позволяет осуществлять целенаправленные поставки наркотиков, контролировать или стимулировать их высвобождение и использовать многофункциональные платформы, сочетающие в себе терапию и диагностику. Нанопчасти повышают растворимость наркотиков, продлевают циркуляцию и повышают внутрик

Радиум - с момента открытия и до настоящего времени - обзор событий.

После его открытия радий первоначально пропагандировался в качестве терапевтического агента для широкого круга заболеваний, включая расстройства кожи, аллергию, проблемы зрения, боль в суставах и общее средство для укрепления здоровья. Однако последующие исследования продемонстрировали ее значительную радиологическую токсичность и вредное воздействие на здоровье человека. Несмотря на эти риски, более чем через сто лет после его открытия, некоторые радиевые изотопы по-прежнему имеют ограниченное применение в медицинских целях, особенно при лечении конкретных раковых заболеваний. После поглощени

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… Low levels have been observed in soil, water, rocks, plants, coal, and food, with no change in their content over time [ 2 , 56 , 72 ] . Radon exposure depends on the occupational source (e.g., uranium mining, caves, mines) or environmental source (e.g., home, offices). …

A review of spontaneous bone metastases in domestic and laboratory animals.

Bone metastases cause significant morbidity and ultimately death in some human cancer patients. Although experimental animal models of skeletal metastases have been invaluable for investigating the molecular mechanisms of cancer progression and growth in bones, few of these models recapitulate the heterogeneous nature of bone metastases observed in humans. Animals with naturally occurring cancers have been proposed as ideal and unique models for human cancer research. From this, understanding the incidence, histologic features, clinical presentation, and response to therapy of spontaneous bone

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… Canine on the couch: the new canary in the coal mine for environmental health research. Environ. Health. 2024;2:517–529. doi: 10.1021/envhealth.4c00029. 32. Ostrander E.A., Kruglyak L. Unleashing the canine genome. Genome Res. 2000;10:1271–1274. doi: 10.1101/gr.155900. 33. …

Malignant mesothelioma tumours: molecular pathogenesis, diagnosis, and therapies accompanying clinical studies.

The pathetic malignant mesothelioma (MM) is a extremely uncommon and confrontational tumor that evolves in the mesothelium layer of the pleural cavities (inner lining- visceral pleura and outer lining- parietal pleura), peritoneum, pericardium, and tunica vaginalis and is highly resistant to standard treatments. In mesothelioma, the predominant pattern of lesions is a loss of genes that limit tumour growth. Despite the worldwide ban on the manufacture and supply of asbestos, the prevalence of mesothelioma continues to increase. Mesothelioma presents and behaves in a variety of ways, making dia

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… Understanding the pathogenesis of occupational coal and silica dust-associated lung disease. Eur Respir Rev (2022) 31:1–17. doi: 10.1183/16000617.0250-2021 67. Sorolla MA, Sorolla A, Parisi E, Salud A, Porcel JM. …

Воздействие нефтеперерабатывающих и биотопливных заводов на здоровье человека: карта систематических доказательств и обзор скопирования.

ЦЕЛЬ ОБЗОРА: Нефтеперерабатывающие заводы являются важными источниками выбросов токсичных загрязнителей во всем мире, которые угрожают здоровью работников нефтеперерабатывающих предприятий и близлежащего населения. Мы провели обзор эпидемиологических данных об остром и хроническом воздействии нефтеперерабатывающих и биотопливных заводов на здоровье окружающих общин. Мы провели оценку доказательств с использованием оценок риска предубеждений и зафиксировали полученные результаты на карте доказательств для выявления пробелов в литературе. Мы систематически искали исследования, опубликованные к а

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… Excluded studies typically consisted of health risk assessments, occupational health studies, did not contain quantitative associations, or estimates attributable to refineries were not available for populations co-exposed to unrelated industries (e.g. coal, power plant, or metal). …

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[SENTIERI - Epidemiological Study of Residents in National Priority Contaminated Sites. Sixth Report].

INTRODUCTION ADN OBJECTIVES: The Sixth Report presents the results of the "SENTIERI Project: implementation of the permanent epidemiological … ndiscovered, between certain diseases and residence near petrochemical and steel plants, landfills, coal mines and asbestos sources. CONCLUSIONS AND PERSPECTIVES: Despite the fact that this is an ecological study, and the excesses of pathologies with multifactorial aetiology can never be mechanically attributed solely to the environmental pressure fac …

Analgesic Alkaloids Derived From Traditional Chinese Medicine in Pain Management.

Chronic pain is one of the most prevalent health problems. The establishment of chronic pain is complex. Current medication for chronic pain mainly dependent on anticonvulsants, tricyclic antidepressants and opioidergic drugs. However, they have limited therapeutic efficacy, and some even with severe side effects. We turned our interest into alkaloids separated from traditional Chinese medicine (TCM), that usually act on multiple drug targets. In this article, we introduced the best-studied analgesic alkaloids derived from TCM, including tetrahydropalmatine, aloperine, oxysophocarpine, matrine

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… Funding This study was supported by National Key Technologies R & D Program of China (2018YFA0108602), Open fund of the state key laboratory coal resources and safe mining (SKLCRSM21KFA11), CAMS Innovation Fund for Medical Sciences (2017-I2M-B&R-07, 2019-I2M-5-055), Fundamental Research Funds for the …