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Male breast cancer with mandibular metastasis. A case report.

Female breast cancer is one of the major causes of death among women while male breast cancer is relatively uncommon and accounts for about 1% of all breast cancers in both sexes. Influencing factors are: gynecomasty, familiarity for male breast cancer, Jewish and African-American male population. From the histological point of view, it is not different from the female breast cancer, except for the infiltrant ductal carcinoma, but with a much severe prognosis. Breast cancer metastases to the jaws are rare, only 1%; the most common sites of metastases are: lungs(59-69%), liver (58-65%), bone (4

The chemosensitivity to therapy of childhood early B acute lymphoblastic leukemia could be determined by the combined expression of CD34, SPI-B and BCR genes.

We have identified genes differentially expressed in childhood early B acute lymphoblastic leukemia at diagnosis, according to chemosensitivity. Chemosensitive (M1) and chemoresistant (M3) patients present <5% and >25% of residual leukemic blasts at 21 days of treatment, respectively. The expression profiles of 4205 genes for 32 patients included in the FRALLE93 protocol have been determined using microarray. From differential analysis, CD34, SPI-B and BCR distinguished M1 from M3 patients using microarray and RT-PCR data. Linear discriminant analysis (LDA) and cross-validation show that the c

Effects of glucocorticoid replacement therapy in patients with pituitary disease: A new perspective for personalized replacement therapy.

Secondary adrenal insufficiency (SAI) is an endocrine disorder due to impaired secretion of ACTH resulting from any disease affecting the pituitary gland. Glucocorticoid replacement therapy is mandatory to ensure patient survival, haemodynamic stability, and quality of life. In fact, a correct dose adjustement is mandatory due to the fact that inappropriately low doses expose patients to hypoadrenal crisis, while inappropriately high doses contribute to glucose metabolic and cardiovascular deterioration. This review analyses the current evidence from available publications on the epidemiology

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… Hydrocortisone is the already active cortisol analogue, whereas cortisone acetate requires hepatic activation by the 11b-HSD1 enzyme. … A recently introduced approach is the use of epigenetics in the long-term evaluation of exposure to cortisone. DNA methylation in NR3C1, SLC6A4 and KITLG genes resulted in HPA axis dysregulation in non-tumoral hypercortisolism [ 46 – 49 ]. …

Akathisia induced by concurrent use of mirogabalin and sulfamethoxazole-trimethoprim: a case report.

BACKGROUND: Mirogabalin and trimethoprim-sulfamethoxazole (TMP/SMX) are frequently used as supportive purpose during and/or after chemotherapy. Mirogabalin is used to treat neuropathic pain, whereas TMP/SMX is used to prevent pneumocystis pneumonia (PCP) in patients who are immunocompromised. The interaction between mirogabalin and TMP/SMX has not been reported. Here, we report a case of akathisia that developed after concurrent administration of mirogabalin and TMP/SMX. CASE PRESENTATION: We report the case of a 69-year-old male patient who experienced akathisia twice. The patient was diagnos

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… Brain Circ. 2020;6(2):96–106. 10.4103/bc.bc_57_19. 33033779 10.4103/bc.bc_57_19 PMC7511912 21. 21) Bräunig P Cortisone-induced psychoses Nervenarzt 1988 59 10 596 602 3237266 21), Bräunig P, et al. Cortisone-induced psychoses. Nervenarzt. 1988;59(10):596–602. 3237266 22. …

Отсутствие взаимодействия между 5α-сокращенные ингибиторы и глюкокортикоиды при инфаркте миокарда у людей с типом 2 Диабет.

Цели людей с типом 2 диабет сталкивается с повышенным кардиометаболическим риском, и как синтетические глюкокортикоиды, так и использование 5Ингибиторы α-редукции в индивидуальном порядке связаны с повышенным риском инфаркта миокарда. Мы проверили, не усугубляется ли рост риска в результате совместного назначения обоих лекарственных средств. Пациенты с типом 2 диабет в возрасте ≥ 40 годы получения 5α-редукционные ингибиторы или тамсулосин, которые пользовались системными глюкокортикоидами во время 2006-2021 были включены. Мы смоделировали совместный эффект 5Ингибиторы α-редуктазы и кумулятивно

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… Synthetic glucocorticoids including budesonide [ 14 ], cortisone [ 15 ], hydrocortisone [ 15 ], prednisolone [ 16 ] and prednisone [ 16 ], are also substrates of 5α‐reductases. … This was converted to prednisolone‐equivalent doses using the conversion factor where prednisolone 5 mg = betamethasone 0.75 mg = cortisone 25 mg = deflazacort 6 mg = dexamethasone 0.75 mg = hydrocortisone 20 mg = methylprednisolone 4 mg = prednisone 5 mg = triamcinolone 4 mg [ 22 ]. …

Наркотики, основанные на сходстве генных экспрессионных сигнатур, чтобы исследовать потенциальные признаки кексетина: тематическое исследование множественных склерозов.

Quercetin (QR) — природный флавонол, широко распространенный в королевстве растений с обширными фармакологическими последствиями. Чтобы найти потенциальные клинические показатели QR, 156 Дифференциально выраженные гены (DEG), регулируемые QR, были получены из базы данных Gene Express Omnibus, и новые потенциальные фармакологические эффекты и клинические показатели QR были перенаправлены путем интегрирования соединений с аналогичными генными сигнатурами возмущения и соответствующими сигнатурами болезни QR на основе карты связи и платформ Coexedia. Предлагаемые результаты QR оказывают главным об

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… Osteoarthritis Almezgagi et al. (2020) interleukin inhibitor; anti-inflammation methylprednisolone 1.47 corticosteroids allergic and autoimmune inflammatory diseases [including multiple sclerosis ( MS * )] Wang et al. (2020b) glucocorticoid receptor agonist; anti-inflammation and immunosuppression cortisone … Among the drugs screened by CMap, corticosteroids (methylprednisolone, cortisone acetate, betamethasone) mainly treat allergic and autoimmune inflammatory diseases (including MS) through anti-inflammatory and immunosuppressive effects ( Fischer et al., 2019 ). …

Different states of clinical control are associated with changes in IGF-I and IGFBPs in children with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

OBJECTIVE: Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) is characterized by high androgen levels, ambiguous genitalia or premature pubarche, increased height velocity and skeletal maturation. Considering the possibility of changes in the IGF system components depending on the state of clinical control, the objective of the present study was to analyse serum IGF-I, IGF-II and IGFBP levels in children with 21-OHD under two states of clinical control. PATIENTS AND DESIGN: We studied 12 prepubertal children with 21-OHD CAH aged 4.0 +/- 0.7 years. They were classi

Intensive care for seriously ill patients affected by novel coronavirus sars - CoV - 2: Experience of the Crema Hospital, Italy.

AIMS: In this work, the survival and mortality data of 54 consecutive patients admitted to the Intensive Care Unit (ICU) and suffering from … s was subjected to the off - label protocol with antivirals and hydroxychloroquine therapy, we used cortisone support therapy under surveillance and in 3 cases the protocol with anti - IL6 monoclonal antibody (Tolicizumab). In a simplified classification of the tomographic examination of the chest, mostly 3D and 2C lesions were found in the deceased patient …

No Short-term Clinical Benefit to Bovine Collagen Implant Augmentation in Primary Rotator Cuff Repair: A Matched Retrospective Study.

BACKGROUND: Bovine bioinductive collagen implants (herein, "bovine collagen implant") can be used to augment rotator cuff repair. Concern ex … ncluding physical therapy, NSAIDs, at least one course of oral methylprednisolone, and at least one cortisone injection (reoperations for traumatic retears were excluded). Secondary outcomes were patient-reported outcomes (SSV, ASES score, and VAS score for pain), receipt of methylprednisolone prescriptions, and receipt of corticosteroid injections. Chi-squ …

Ранняя потеря "Macular Ganglion Cell" в Leber Hereditary Optic Neurophy — биомаркер оптической совместимости для дифференцирования оптического неврита.

Фон/цели: Наследственная оптическая нейропатия Лебера (LHON) часто неправильно диагностируется на ранних этапах как идиопатический единичный оптический неуриит (SION) или многоклерозовый оптический неврал (MS-ON) из-за раннего возраста пациентов, потери субакутного зрения и нарушения центрального визуального поля. Цель этого ретроспективного исследования состояла в том, чтобы оценить изменения в перипиллярном RNFL и GCLT с течением времени у пациентов с ранним LHON, MS-ON и SION, с тем чтобы провести различие между наследственной нейропатией (LHON) и оптическим неуриитом (ON) на ранних стадиях

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… Eight out of the nine patients had received systemic therapy with cortisone for suspected ON at the time of initial presentation. Two patients were female, and seven were male. All but one patient developed visual loss in the other eye within one year of initial symptoms. … Conclusions In summary, a common way to differentiate LHON from MS-ON/idiopathic SION is still the response of MS-ON/idiopathic SION patients to high-dose cortisone treatment (“ex juvantibus”) and the unalterable progressive vision loss in LHON patients. …

The Treatment Gap in Osteoporosis.

Worldwide, there are millions of people who have been diagnosed with osteoporosis, a bone disease that increases the risk of fracture due to low bone mineral density and deterioration of bone architecture. In the US alone, there are approximately ten million men and women diagnosed with osteoporosis and this number is still growing. Diagnosis is made by measuring bone mineral density. Medications used for the treatment of osteoporosis are bisphosphonates, denosumab, raloxifene, and teriparatide. Recently, romosozumab has been added as well. In recent years, a number of advances have been made

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… Pathological fractures in patients with rheumatoid arthritis treated with cortisone. JAMA. 1952;149:750–752. doi: 10.1001/jama.1952.02930250032011. 65. Teicher R., Nelson C.T. Osteoporosis and Pathological Fractures Following Treatment with Acth and Cortisone. J. Investig. … Vertebral fractures resulting from prolonged cortisone and corticotropin therapy. J. Am. Med. Assoc. 1954;156:467–469. doi: 10.1001/jama.1954.02950050007002. 67. Compston J. Glucocorticoid-induced osteoporosis: An update. Endocrine. 2018;61:7–16. doi: 10.1007/s12020-018-1588-2. 68. …

Does Therapeutic Repurposing in Cancer Meet the Expectations of Having Drugs at a Lower Price?

Therapeutic repurposing emerged as an alternative to the traditional drug discovery and development model (DDD) of new molecular entities (NMEs). It was anticipated that by being faster, safer, and cheaper, the development would result in lower-cost drugs. As defined in this work, a repurposed cancer drug is one approved by a health regulatory authority against a non-cancer indication that then gains new approval for cancer. With this definition, only three drugs are repurposed for cancer: Bacillus Calmette-Guerin (BCG) vaccine (superficial bladder cancer, thalidomide [multiple myeloma], and p

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… In 1948, the first patient with rheumatoid arthritis was treated with cortisone, and soon after that, other rheumatologic patients were treated [ 25 ]. … In 1944, it was shown that cortisone caused tumor regression in transplantable mouse lymphosarcoma, a finding that soon extended to various murine lymphatic tumors. The effects of corticosteroids were also evaluated on many non-endocrine and non-lymphoid transplantable rodent tumors. …

The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity.

Glucocorticoids exert pleiotropic effects on all tissues to regulate cellular and metabolic homeostasis. Synthetic forms are used therapeutically in a wide range of conditions for their anti-inflammatory benefits, at the cost of dose and duration-dependent side effects. Significant variability occurs between tissues, disease states, and individuals with regard to both the beneficial and deleterious effects. The glucocorticoid receptor (GR) is the site of action for these hormones and a vast body of work has been conducted understanding its function. Traditionally, it was thought that the anti-

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… Cortisone acetate and prednisone are inactive precursors that require conversion by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) to the active hydrocortisone and prednisolone respectively ( 128 ). Table 1 lists common glucocorticoids used in clinical practice. Table 1. … Medication | Equivalent dosage (mg) | Anti-inflammatory potency (relative) | HPA axis suppression potency (relative) | Mineralocorticoid potency (relative) | Duration of action (h) Hydrocortisone | 20 | 1 | 1 | 1 | 8-12 Cortisone acetate | 25 | 0.8 | 0.8 | 0.8 | 8-12 Prednis(ol)one | 5 | 3 | 4 | 0.75 …

Экстракорпоральное обнаружение биомаркеров и патогенов в слюне: всеобъемлющий, панорамный обзор.

Человеческая слюна представляет собой разнородную жидкость с сложным составом, которая содержит антитела, белки и вирусы, что делает ее применимой в клинической диагностике. Анализ проб слюны имеет несколько преимуществ по сравнению с другими биофильтрами, включая неинвазивную и простую процедуру сбора для эксторального обнаружения. Диагностика биомаркеров или патогенов в слюне может осуществляться различными методами: масс-спектрометрией, ПЦР, ЭЛИСА, электрохимическими и оптическими методами, такими, как флуоресцентная, SPR и SERS. Раннее обнаружение раковых и других биомаркеров заболеваний,

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… Grau et al. developed a new methodology using LC-MS/MS to measure cortisol and cortisone in the M-SA-DSPE extract. The insight is to use M-SA-DSPE, a magnetic sorbent like in M-DSPE, and a disperser solvent like in SA-DSPE. … This approach enables quick and non-invasive detection of cortisol and cortisone, utilizing only small quantities of sample, organic solvent, and sorbent. The sample preparation requirements are minimal, as the method does not require supporting equipment [ 229 ]. …