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Regulation of immunogenic cell death and potential applications in cancer therapy.

Immunogenic cell death (ICD), a type of regulatory cell death, plays an important role in activating the adaptive immune response. Activation of the tumor-specific immune response is accompanied by the cell surface exposure of calreticulin and heat-shock proteins, the secretion of adenosine triphosphate, and the release of high mobility group box-1. In this review, we summarize and classify the latest types of ICD inducers and their molecular mechanisms, and discuss the effects and potential applications of inducing ICD by chemotherapy drugs, targeted drugs, and oncolytic viruses in clinical r

A Novel Approach to Prognostic Factors and Risk Stratification in Pediatric AML: Case Report and Literature Review.

Acute myeloid leukemia (AML), the second most common type of leukemia in children, is a heterogeneous disease known to be caused by genetic, epigenetic, and transcriptional changes, predominantly somatic and germline abnormalities. Despite significant improvement of overall survival rates, the prognosis of pediatric AML remains unfavorable in comparison with acute lymphoblastic leukemia (ALL), especially in relapsed or refractory settings. The current status and future directions are focused on establishing an accurate diagnosis and treatment strategies based on the genomic background. Next-ge

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… Qi B.-Q. Zhang L. Zou Y. Chen Y.-M. Prognostic Stratification of Molecularly and Clinically Distinct Subgroup in Children with Acute Monocytic Leukemia Cancer Med. 2020 9 3647 3655 10.1002/cam4.3023 32216042 PMC7286455 31. Conneely S.E. McAtee C.L. Gupta R. Lubega J. Scheurer M.E. Rau R.E. …

The role of tumor types in immune-related adverse events.

Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block inhibitors of T cell activation and function. With the widespread use of ICIs in cancer therapy, immune-related adverse events (irAEs) have gradually emerged as urgent clinical issues. Tumors not only exhibit high heterogeneity, and their response to ICIs varies, with "hot" tumors showing better anti-tumor effects but also a higher susceptibility to irAEs. The manifestation of irAEs displays a tumor-heterogeneous pattern, correlating with the tumor type in terms of the affected organs, incidence, median onset time, and se

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… Wang Y Zhou S Yang F Qi X Wang X Guan X Shen C Duma N Aguilera JV Chintakuntlawar A Treatment-related adverse events of pd-1 and pd-l1 inhibitors in clinical trials: a systematic review and meta-analysis JAMA Oncol 2019 5 7 1008 1019 31021376 10.1001/jamaoncol.2019.0393 PMC6487913 Wang Y, Zhou S, Yang … F, Qi X, Wang X, Guan X, Shen C, Duma N, Aguilera JV, Chintakuntlawar A, et al. …

Research advances in peptide‒drug conjugates.

Peptide‒drug conjugates (PDCs) are drug delivery systems consisting of a drug covalently coupled to a multifunctional peptide via a cleavable linker. As an emerging prodrug strategy, PDCs not only preserve the function and bioactivity of the peptides but also release the drugs responsively with the cleavable property of the linkers. Given the ability to significantly improve the circulation stability and targeting of drugs in vivo and reduce the toxic side effects of drugs, PDCs have already been extensively applied in drug delivery. Herein, we review the types and mechanisms of peptides, link

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… Qi J. Oral delivery of proteins and peptides: challenges, status quo and future perspectives Acta Pharm Sin B 11 2021 2416 2448 34522593 10.1016/j.apsb.2021.04.001 PMC8424290 9 Pooja D. Gunukula A. Gupta N. Adams D.J. Kulhari H. … Qi X. Li S. Liu G. Siddhanta S. Furin-mediated intracellular self-assembly of olsalazine nanoparticles for enhanced magnetic resonance imaging and tumour therapy Nat Mater 18 2019 1376 1383 31636420 10.1038/s41563-019-0503-4 PMC6872935 27 Kamei N. Takeda-Morishita M. …

Recent Advances in Nanoparticle-Based Co-Delivery Systems for Cancer Therapy.

Cancer therapies have advanced tremendously throughout the last decade, yet multiple factors still hinder the success of the different cancer therapeutics. The traditional therapeutic approach has been proven insufficient and lacking in the suppression of tumor growth. The simultaneous delivery of multiple small-molecule chemotherapeutic drugs and genes improves the effectiveness of each treatment, thus optimizing efficacy and improving synergistic effects. Nanomedicines integrating inorganic, lipid, and polymeric-based nanoparticles have been designed to regulate the spatiotemporal release of

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… Qi S.-S., Sun J.-H., Yu H.-H., Yu S.-Q. Co-delivery nanoparticles of anti-cancer drugs for improving chemotherapy efficacy. Drug Deliv. 2017;24:1909–1926. doi: 10.1080/10717544.2017.1410256. 14. Carvalho B.G., Vit F.F., Carvalho H.F., Han S.W., de la Torre L.G. …

Clinical Applications and Anticancer Effects of Antimicrobial Peptides: From Bench to Bedside.

Cancer is a multifaceted global health issue and one of the leading causes of death worldwide. In recent years, medical science has achieved great advances in the diagnosis and treatment of cancer. Despite the numerous advantages of conventional cancer therapies, there are major drawbacks including severe side effects, toxicities, and drug resistance. Therefore, the urgency of developing new drugs with low cytotoxicity and treatment resistance is increasing. Antimicrobial peptides (AMPs) have attracted attention as a novel therapeutic strategy for the treatment of various cancers, targeting tu

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… Peptides ( 2014 ) 59 : 14–9 . doi: 10.1016/j.peptides.2014.06.007 24972300 19 Wu D Gao Y Qi Y Chen L Ma Y Li Y . Peptide-Based Cancer Therapy: Opportunity and Challenge . Cancer Lett ( 2014 ) 351 ( 1 ): 13 – 22 . doi: 10.1016/j.canlet.2014.05.002 24836189 20 Lei J Sun L Huang S Zhu C Li P He J . … Mol Cell Biochem ( 2020 ) 464 ( 1 ): 1 – 9 . doi: 10.1007/s11010-019-03643-3 31673920 145 Ma L Liu J Zhang X Qi J Yu W Gu Y . P38 MAPK-Dependent Nrf2 Induction Enhances the Resistance of Glioma Cells Against TMZ . …

Novel agents in the treatment of multiple myeloma: a review about the future.

Multiple myeloma (MM) is a disease that affects plasma cells and can lead to devastating clinical features such as anemia, lytic bone lesions, hypercalcemia, and renal disease. An enhanced understanding of MM disease mechanisms has led to new more targeted treatments. There is now a plethora of treatments available for MM. In this review article, our aim is to discuss many of the novel agents that are being studied or have recently been approved for the treatment of MM. These agents include the following: immunomodulators (pomalidomide), proteasome inhibitors (carfilzomib, marizomib, ixazomib,

Кислотная терапия и риск излечения в случае воспламенительной болезни лопатки: сравнительное исследование в целях информирования о личностном лечении в мире.

Предыстория/цели: Известно, что ингибиторы протонных насосов (ИПЦ) изменяют состав кишечника микробиота; однако их связь с курсами заболеваний и результатами у пациентов с воспалительным кишечным заболеванием (ИБД) остается неопределенной. Наши цели заключались в оценке связи между использованием ИЦП и эскалацией лечения, диффицией Клостридиодов и использованием медицинских услуг в ИБД. Методы: Мы провели ретроспективное когортное исследование на платформе TriNetX. Пациенты IBD с ИЦП или histamine-2 Совпадали антагонисты рецептора (H2RA) one- чтобы...one с помощью баллов склонности. Итогом это

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… Zhang M., Liu W., Liu Y., Cheng Q., Zhang X., Qian N., Qi J., Chen T., Yu Y. Proton pump inhibitor increases intestinal epithelial paracellular permeability via the p38-MAPK/NF-kappaB signaling pathway. Mol. Biol. Rep. 2025;53:170. doi: 10.1007/s11033-025-11336-y. 31. …

Acupuncture for post-chemoradiotherapy complications in lung cancer with bone metastasis: a case report and literature review.

Despite significant advances in oncologic therapeutics, chemoradiotherapy-induced complications, including chemotherapy-induced peripheral neuropathy (CIPN) and hip dysfunction, remain clinically challenging to manage with pharmacological interventions alone. This report presents the case of a 52-year-old male with a history of right-sided lung cancer resection performed more than three years previously and confirmed bone metastasis for over two years. Following metastasis to the right ilium and acetabulum, the patient developed pain, numbness, gait disturbance, and impaired mobility in the ri

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… Xie S, Wu Z, Qi Y, Wu B, Zhu X. The metastasizing mechanisms of lung cancer: Recent advances and therapeutic challenges. BioMed Pharmacother. (2021) 138:111450. doi: 10.1016/j.biopha.2021.111450. PMID: 3. Coleman RE. Skeletal complications of Malignancy. …

Талкетамаб у японских пациентов с рецидивной/рефрактной множественной миеломой MonumenTAL-1 Учёба.

Talquetamab — первая группа рецепторов с протеиновым сцеплением G. 5 Член D (GPRC5D) × CD3 biod антитела, официально утвержденного для повторной/охлажденной множественной миеломы (RRMMM). Мы сообщаем о первых результатах эффективности и безопасности талькетамаба у японских пациентов, зарегистрированных в качестве отдельной группы в глобальном масштабе MonumenTAL-1 Учёба. С июля 2022 и декабрь 2023, 36 пациенты были зачислены и приняты 0.4 Мг/кг талькетамаба еженедельно. Медианная последующая деятельность 13.4 месяцев. Общий показатель ответов: 77.8% (В тыс.55.6% обеспечение полного или более э

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… Ye JC, Biran N, Nair S, Lin X, Qi K, Londhe A, et al. Talquetamab versus real-world physician’s choice treatment: comparative effectiveness in patients with triple-class exposed relapsed/refractory multiple myeloma. Clin Lymphoma Myeloma Leuk. 2025;25(2):124-34.e5. 10.1016/j.clml.2024.08.003. 29. …

Case Report: Primed dendritic cell immunotherapy for multiple solid tumors.

Many patients with advanced solid tumors ultimately develop resistance to conventional therapies, with especially limited options for those experiencing rapid progression or poor performance status, highlighting the need for personalized immunotherapies capable of inducing durable responses. In this retrospective case series, we describe the clinical course and outcomes of five adults (4 male, 1 female; median age 51 years [range, 39-62]) with metastatic solid tumors who achieved complete and durable remission following doubly loaded autologous dendritic cell therapy after failure of standard

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… Qi C, Liu C, Peng Z, Zhang Y, Wei J, Qiu W, et al. Claudin-18 isoform 2-specific CAR T-cell therapy (satri-cel) versus treatment of physician's choice for previously treated advanced gastric or gastro-oesophageal junction cancer (CT041-ST-01): a randomised, open-label, phase 2 trial. …

Ассоциация между респираторными вакцинами и риском когнитивного расстройства, слабоумия и болезни Альцгеймера: обзор.

Справочная информация/цели: Нейрокогнитивные расстройства представляют собой растущее бремя для пожилых людей. Хотя респираторные вакцины доказали свою эффективность и безопасность в предотвращении острых респираторных явлений, их потенциальное воздействие на развитие таких хронических нейрокогнитивных расстройств, как когнитивное расстройство, слабоумие и болезнь Альцгеймера (АБ), не было тщательно изучено. Цель этого аналитического обзора заключалась в обобщении и анализе имеющихся данных о взаимосвязи между вакцинацией органов дыхания и риском развития когнитивного расстройства, слабоумия и

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… Qi J. Wu X. Effects of Influenza Vaccination on Neurodegenerative and Demyelinating Disorders: A Systematic Review and Meta-Analysis J. Neurol. 2025 272 499 10.1007/s00415-025-13238-2 40637899 14. Censi S. Bisaccia G. Gallina S. Tomassini V. Uncini A. …

Кетогенные изменения в метаболизме печени с потенциальными последствиями для озанимодных фармакокинетических мышей.

Кетогенное питание (КД) все чаще рассматривается в качестве адъюнктивного терапевтического подхода к целому ряду заболеваний, однако его воздействие на фармакокинетику сопутствующих лекарств остается неясным. Такое взаимодействие может иметь особое значение в случае множественного склероза, когда КД изучается в качестве дополнительной стратегии наряду с лечением заболеваний, например, озанимодом. Поэтому мы изучили вопрос о том, влияет ли KD на озанимодный метаболизм и фармакокинетику, и изучили потенциальные факторы, которые могут способствовать такому воздействию. Женщинам, не содержащим пат

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… Xiao Y-L, Gong Y, Qi Y-J, Shao Z-M, Jiang Y-Z. Effects of dietary intervention on human diseases: molecular mechanisms and therapeutic potential. Signal Transduct Target Ther. 2024;9(1):59. doi: 10.1038/s41392-024-01771-x 47. Brunner LJ, Bai S. …

Development and application of machine learning models for hematological disease diagnosis using routine laboratory parameters: a user-friendly diagnostic platform.

AimIn recent years, with the change of social environment, the incidence and detection rate of hematological diseases have shown an increasing trend. Early diagnosis and detection of hematological diseases are very important to improve the quality of life and prognosis of patients.MethodsIn this study, we employed 54 clinical and conventional laboratory parameters. By optimally combining multiple feature selection methods and machine learning algorithms, we developed 7 machine learning models with varying feature set sizes. We comprehensively evaluated the performance of these models, analyzed

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… Qi Y Liu X Ding Z Yu Y Zhuang Z . A potential predictive model based on machine learning and CPD parameters in elderly patients with aplastic anemia and myelodysplastic neoplasms . BMC Med Inform Decis Mak . ( 2024 ) 24 : 379 . doi: 10.1186/s12911-024-02781-z , PMID: 39695587 PMC11654282 36. …

Ferroptosis: a new dawn in the treatment of acute lymphoblastic leukemia.

Acute lymphoblastic leukemia poses substantial challenges in therapeutic management. As a novel form of programmed cell death, ferroptosis has emerged as a promising research direction in cancer therapy. Studies have emphasized the pivotal role of ferroptosis in ALL, indicating that targeting this pathway could provide a novel therapeutic strategy. This article systematically reviews the molecular regulatory mechanisms of ferroptosis in ALL and explores its potential clinical applications in the treatment and prognostic evaluation of the disease.

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… Chen L, Fang W, Liu J, Qi X, Zhao L, Wang Y, et al. (PAA) inhibits T-cell acute lymphoblastic leukemia through inducing autophagic cell death and ferroptosis. Biochem Biophys Res Commun. (2022) 608:108–15. doi: 10.1016/j.bbrc.2022.03.105, PMID: 64. …

Network analysis used to investigate the symptoms of cancer patients during chemotherapy: a scoping review.

ObjectiveTo provide an overview of the symptom experience and interrelationships among symptoms during chemotherapy in cancer patients, as well as the state of symptom network research in this field.MethodsThis scoping review was conducted using the framework proposed by Arksey and O'Malley and the PRISMA guidelines. It included studies that focused on symptom network analysis of cancer patients currently undergoing chemotherapy treatment. A comprehensive search was conducted in both English and Chinese databases, including PubMed/MEDLINE, Cochrane, EMBASE, CINAHL (EBSCO), Web of Science, ProQ

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… Qi Y, Li H, Guo Y, et al. Symptom clusters in breast cancer patients receiving adjuvant chemotherapy: a systematic review. J Clin Nurs. 2024;33(12):4554–67. 10.1111/jocn.17479. 10. Cai Y, Li J, Bi L, et al. …

Hematological cancer patients' social support, coping strategies, anxiety, depression and posttraumatic growth: a structural equation model.

ObjectivePosttraumatic growth (PTG), defined as positive psychological changes following traumatic events, has been observed in some hematological cancer patients during their disease course. These changes, encompassing shifts in life perspective, interpersonal relationships, and self-perception, are critical for psychological recovery. However, the interplay of social support, coping strategies, anxiety, and depression in shaping PTG remains unclear. Therefore, the aim of this study was to explore these associations in hematological cancer patients using a hypothetical model.MethodsFrom Augus

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… Psychooncology . ( 2017 ) 26 ( 12 ): 2007–18 . doi: 10.1002/pon.4426 28317221 8 Cao W Qi X Cai DA Han X . Modeling posttraumatic growth among cancer patients: The roles of social support, appraisals, and adaptive coping . …

Immune mechanisms and immunomodulatory therapies in steroid-resistant nephrotic syndrome.

Steroid-resistant nephrotic syndrome (SRNS) is a complex and refractory kidney disease generally causing chronic kidney dysfunction, characterized by persistent proteinuria despite prolonged corticosteroid therapy. This review comprehensively explores the mechanisms of immunity driving SRNS, mainly focusing on the complex function network within immune cells, pro-inflammatory cytokines, and podocyte injury. Current immunosuppressive therapies show limited efficacy, prompting exploration of precision immunomodulatory strategies. Emerging approaches include IL-17 or low-dose IL-12 modulation, pr

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… Kidney Int . 2022 ; 102 ( 3 ): 604 – 612 . doi: 10.1016/j.kint.2022.04.029 . 35643375 76 Wang H , La Russa M , Qi LS. CRISPR/Cas9 in genome editing and beyond . …

Сопоставление эффективности различных методов тренировки для взрослых МСИ: сетевой мета-анализ.

Небольшие когнитивные расстройства (MCI) считаются доклинической или продромальной стадией болезни Альцгеймера (AD). Пациенты MCI имеют годовую вероятность развития к слабоумию 10%-15%, намного выше, чем нормальные престарелые1%-2%). Мы провели сетевой метаанализ (NMA) относительно эффективности различных способов упражнений для взрослых, охваченных MCI. Компьютерный поиск MethodsA был проведен в Эмбасе, Пубмеде, Кокранской библиотеке и Сети наук для RCT о последствиях тренировок для пациентов MCI с момента их создания по февраль. 22, 2025. Two Эксперты, проводящие обзор, несут независимую отв

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… Qi , et al. 2018 . “ Effects of a Specially Designed Aerobic Dance Routine on Mild Cognitive Impairment .” …

Bibliometric analysis of dendritic cell-based vaccines over the past 15 years.

Dendritic cells, which are crucial for inducing T-cell responses, are pivotal in current immunotherapy strategies aiming to replenish depleted T cells within the tumor microenvironment to combat tumors. Consequently, dendritic cell vaccine-based cancer therapies have garnered significant attention. Through bibliometric analysis, we examined research trends in this field. We searched the Web of Science core database and identified 16,476 articles on dendritic cell-based vaccines published from January 1, 2009, to December 30, 2023. The United States leads in this research domain, with Emory Uni

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… Yu X , Dai Y , Zhao Y , Qi S , Liu L , Lu L , Luo Q , Zhang Z . Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response . Nat Commun . [ 2020 Feb 28 ]. 11 ( 1 ): 1110 . doi: 10.1038/s41467-020-14906-9 . 32111828 PMC7048802 26. Zhu M . …