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Feasibility and effects of the telerehabilitation program during hematopoietic stem cell transplantation.

This study aims to identify the feasibility and effects of the telerehabilitation program for patients with hematologic cancer who underwent hematopoietic stem cell transplantation (HSCT). In this single-arm prospective study, a telerehabilitation program was administered to patients who underwent HSCT. The program utilized a camera and video conferencing system, delivering 30-minute exercise sessions based on the Otago exercise. Baseline, immediate follow-up, and 3-month follow-up examinations were performed using the European Organization for Research and Treatment of Cancer Quality of Life

Combined Topography-Guided Trans-Epithelial PRK and PTK for Treatment of Calcific Band Keratopathy Unresponsive to EDTA Chelation Therapy.

Patients with indolent B-cell non-Hodgkin lymphoma (iNHL) generally require treatment but experience normal survival, emphasizing the need for simpler, safer therapies. Proteasome inhibitors target aberrant signaling pathways within iNHL and have manageable toxicities. We evaluated the oral proteasome inhibitor ixazomib as initial monotherapy, and combined with rituximab, for first-line treatment of iNHL. Treatment-naïve patients with iNHL needing therapy received oral ixazomib 4 mg weekly until progressive disease or unacceptable adverse events. A 4-week course of rituximab was added during m

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… Outcomes following watchful waiting for stage II-IV follicular lymphoma patients in the modern era. Br J Haematol. 2016;172(5):724–734. doi: 10.1111/bjh.13895. 3. Morschhauser F, Fowler NH, Feugier P, et al. Rituximab plus lenalidomide in advanced untreated follicular lymphoma. …

Psychological distress, chronic conditions and quality of life in elderly hematologic cancer patients: study protocol of a prospective study.

BackgroundSimilar to most solid tumors, the incidence of hematologic malignancies has been rising. Although the median age at diagnosis is about 70 years, little is known about psychosocial aspects and comorbid conditions in elderly patients with hematologic cancers. The main objectives of our study are to assess the prevalence of psychological distress, chronic conditions, functional disabilities, and quality of life in both elderly hematologic cancer patients aged ≥70 years and an age-matched comparison sample of the general population.MethodsWe conduct a prospective study with three measuri

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… More chronic forms of hematologic cancer (e.g. chronic lymphoid leukemia, myelodysplastic syndromes) may require ongoing maintenance therapy or life-long follow-up (“watchful waiting”) [ 4 , 5 ]. …

Predictive value of serial measurements of quality of life on all-cause mortality in prostate cancer patients: data from CaPSURE (cancer of the prostate strategic urologic research endeavor) database.

IntroductionHealth-related quality of life (HRQOL) is a legitimate construct for evaluating treatment and its side effects. Recently, predictive value of HRQOL on survival also has been of interest. In light of the longer survival in patients with prostate cancer and importance of quality of life, we seek to evaluate the association between HRQOL and survival using traditional and novel techniques.MethodsPatients from CaPSURE (Cancer of the Prostate Strategic Urologic Research Endeavor) who were treated within 6 months of diagnosis and had pre-treatment and sufficient post-treatment follow-up

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… Watchful waiting patients were not included in study population due to small sample size and insufficient follow-up data. Demographic and clinical characteristics of the study population such as race/ethnicity, BMI, and marital status were evaluated in initial analysis. …

Differences between physician and patient preferences for cancer treatments: a systematic review.

BackgroundShared decision-making is useful to facilitate cancer treatment decisions. However, it is difficult to make treatment decisions when physician and patient preferences are different. This review aimed to summarize and compare the preferences for cancer treatments between physicians and patients.MethodsA systematic literature search was conducted on PubMed, Embase, PsycINFO, CINAHL and Scopus. Studies elicited and compared preferences for cancer treatments between physicians and patients were included. Information about the study design and preference measuring attributes or questions

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… Chapple A Is ‘watchful waiting’ a real choice for men with Prostate cancer? A qualitative study BJU Int 2015 90 3 257 64 10.1046/j.1464-410X.2002.02846.x 12133062 47. Charles C, et al. …

Monoclonal Gammopathies and the Bone Marrow Microenvironment: From Bench to Bedside and Then Back Again.

Multiple myeloma (MM) is an incurable hematologic malignancy characterized by a multistep evolutionary pathway, with an initial phase called monoclonal gammopathy of undetermined significance (MGUS), potentially evolving into the symptomatic disease, often preceded by an intermediate phase called "smoldering" MM (sMM). From a biological point of view, genomic alterations (translocations/deletions/mutations) are already present at the MGUS phase, thus rendering their role in disease evolution questionable. On the other hand, we currently know that changes in the bone marrow microenvironment (TM

Oncologists' Perspectives on Oncology Stewardship: A Focus Group Exploration in a Statewide Quality Improvement Consortium.

BackgroundMultiple resource utilization challenges impact hematology-oncology practices including the expanding number of novel cancer-directed therapies, increasing costs of care, and imbalances in access to care. Oncology stewardship is a comprehensive approach to addressing these challenges while focusing on improving patient outcomes, enhancing quality of life, and optimizing resource utilization.ObjectiveThe purpose of this project was to explore oncologists' perceptions of oncology stewardship and a potential statewide oncology stewardship program through the Michigan Oncology Quality Co

Smoldering Multiple Myeloma: Early Intervention or Structured Surveillance? A Comprehensive Review of Evidence for and Against Early Therapy.

Smoldering multiple myeloma (SMM) is an asymptomatic plasma cell disorder characterized by a heterogeneous risk of progression to overt multiple myeloma (MM). Historically managed with active surveillance, advances in risk stratification and the development of novel therapeutics have renewed debate regarding early intervention, particularly in patients with high-risk disease. We conducted a narrative review of clinical trials and observational studies evaluating early treatment versus observation in SMM. Outcomes assessed included progression-free survival (PFS), time to progression (TTP), ove

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… These results establish daratumumab as the first agent to demonstrate an improvement in overall survival with a favorable trend in high-risk SMM, supporting a paradigm shift away from watchful waiting toward early intervention in this patient population. …

Характеристики и клинический курс пациентов с мелоидозом и раком.

У пациентов с активным раком больше шансов на развитие мелиоидоза, однако характеристики и клинический курс мелиоидоз у больных с раком не были подробно изучены. Профилактика триметоприма/сульфаметоксазола (TMP-SMX) предписывается для предотвращения мелоидоза у пациентов, получающих в некоторых юрисдикциях иммунную антираковую терапию, и рекомендуется в национальных австралийских руководящих принципах, хотя риски и выгоды этой стратегии определены не полностью. МЕТОДЫ: Исследование проводилось в Дальнем Северном Квинсленде (ФНК) в тропической Австралии. Характеристики и клинический курс пациен

Survival in hematological malignancies in the Nordic countries through a half century with correlation to treatment.

Studies of survival in hematological malignancies (HMs) have generally shown an improvement over time, although most of these studies are limited by a short follow-up period. Using the NORDCAN database with data from Denmark, Finland, Norway and Sweden, we follow periodic increases in relative survival in seven HMs through half a century up to 2015-2019. Five-year survival improved in all seven HMs, reaching 90% for Hodgkin lymphoma (HL), myeloproliferative neoplasias and chronic lymphocytic leukemia (CLL), 60% for multiple myeloma (MM) and chronic myeloid leukemias (CMLs), 50% for the myelody

Oral-Health-Related Quality of Life in Patients with Medication-Related Osteonecrosis of the Jaw: A Prospective Clinical Study.

Medication-related osteonecrosis of the jaw (MRONJ) represents an adverse side effect of antiresorptive and antiangiogenic medications. It is associated with impaired quality of life, oral health, and oral function and can be classified into various stages. The purpose of this prospective clinical study is to evaluate the impact of stages I and II MRONJ on oral-health-related quality of life (OHRQoL) and related parameters. Patients' OHRQoL, satisfaction with life, oral discomfort, and oral health were assessed using the German version of the Oral Health Impact Profile (OHIP-G49), visual analo

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… During the last decade, there was a drift towards a more aggressive surgical approach since watchful waiting strategies oftentimes failed [ 17 ]. Table 1 MRONJ classification according to the American Association of Oral and Maxillofacial Surgeons. …

Recent Advances in the Management of Smoldering Multiple Myeloma.

There is remarkable progress in the treatment of multiple myeloma (MM) with significant improvement in survival in the past 10 years. Monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) can evolve into symptomatic multiple myeloma (sy-MM) with organ involvement. SMM has associated with a much higher progression to MM compared to MGUS. In 2014, International Myeloma Working Group (IMWG) reclassified ultra-high-risk smoldering myeloma patients with bone marrow plasma cells > 60% or serum-free light chain ratio (FLCr) > 100 or > 1 focal bone lesion on t

Нетуберкулезные микобактерные инфекции в Центре комплексного рака Национального института рака во Флориде.

Нетуберкулезная микобактерия (НТМ) - это экологические организмы, которые становятся оппортунистическими патогенами в некоторых популяциях. Показатель распространенности НТМ возрос во всем мире, что, вероятно, объясняется расширением диагностических тестов и наличием демографических исследований. Нынешняя литература по онкологическим пациентам минимальна и представляет собой уникальную область исследований. Здесь мы представляем эпидемиологию и лечение случаев заражения НТМ в созданном Национальным институтом раковых заболеваний Центре комплексного лечения раковых заболеваний. Мы провели ретро

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… It is an important takeaway that sometimes, even in patients with an active NTM infection, watchful waiting may be the best approach when considering the entirety of these. …

Предсказатели высоко- и низкоинтенсивного лечения склероза первой линии.

КОЛИЧЕСТВО: Лекарства для лечения различных склерозов (MS) могут быть либо с высокой, либо с низкой интенсивностью. Цель этого исследования заключается в изучении прогнозов, связанных с высокоинтенсивными стратегиями обработки MS с использованием данных о коммерческих претензиях. Мы использовали коммерческие и дополнительные базы данных " Merative MarketScan " для обследования пациентов с помощью: амбулаторного диагноза MS ( " Merative MarketScan " )ICD-9/-10:: 340xx, G35.xx); заполнение ДМТ; отсутствие ДМТ 1 год, предшествующий диагностике MS с помощью DMT; и 6 Непрерывная

The Relationship Between Illness Uncertainty and Social Support Among Cancer Patients: A Meta-analysis.

BackgroundAs a common psychological problem in cancer patients, illness uncertainty has attracted wide attention from scholars. Some studies have pointed out that the level of social support may affect illness uncertainty in patients with cancer, but the results of these studies remain controversial.ObjectiveThe aim of this study was to evaluate the correlation between illness uncertainty and social support in patients with cancer using meta-analysis.MethodsPubMed, Web of Science, EMBASE, EBSCO, Cochrane Library, China National Knowledge Infrastructure, Wanfang Data Knowledge Service Platform,

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… Illness uncertainty and quality of life of patients with small renal tumors undergoing watchful waiting: a 2-year prospective study. Eur Urol . 2013;63(6):1122–1127. 75. Christman NJ McConnell EA Pfeiffer C, et al. …

Financial challenges of being on long-term, high-cost medications.

The isocitrate dehydrogenase (IDH) inhibitor, vorasidenib, may offer a promising new treatment option for patients with IDH-mutant gliomas. However, the indefinite nature of this targeted therapy raises significant financial concerns. High costs of targeted cancer therapies, often exceeding $150 000 annually, contribute to financial toxicity, characterized by medical debt, income loss, and psychological stress, and place stress on health systems. This review analyzes the drug approval and pricing mechanisms in various countries and their impact on healthcare costs and patient access, focusing

Physical Activity, Symptoms, Quality of Life and Exercise Program Preferences in People With Chronic Lymphocytic Leukaemia.

BackgroundChronic lymphocytic leukaemia (CLL) has a heterogeneous lifelong course. While some patients never require treatment, most experience intermittent periods of active monitoring with other time points in active treatment. Most patients experience significant symptoms which negatively impact their quality of life (QoL). Although physical activity and exercise may help manage symptoms, it is unclear what disease-related factors drive the physical inactivity observed in people with CLL.MethodsThis study explored physical activity among people with CLL and assessed differences and relation

Autoimmune Hemolytic Anemias: Challenges in Diagnosis and Therapy.

BackgroundAutoimmune hemolytic anemia (AIHA) is a rare disease due to increased destruction of erythrocytes by autoantibodies, with or without complement activation.SummaryAIHA is usually classified in warm AIHA (wAIHA) and cold agglutinin disease (CAD), based on isotype and thermal amplitude of the autoantibody. The direct antiglobulin test (DAT) or Coombs test is the cornerstone of AIHA diagnosis, as it is positive with anti-IgG in wAIHA, and with anti-C3d/IgM antisera plus high titer cold agglutinins in CAD. Therapy is quite different, as steroids and rituximab are effective in the former,

Real-world patient-reported outcomes and concordance between patient and physician reporting of side effects across lines of therapy in multiple myeloma within the USA.

PURPOSE: We aimed to explore patient-reported outcomes (PROs) and patient and physician concordance of side effects perception across lines of therapy (LOT) in multiple myeloma (MM) within the United States of America (USA). METHODS: Data were drawn from the Adelphi Real World MM III Disease Specific Programme™, a point-in-time survey of hemato-oncologists/hematologists and their patients with MM conducted in the USA between August 2020 and July 2021. Physicians reported patient characteristics and side effects. Patients reported side-effect bother and health-related quality of life (HRQoL) u

Development, acceptability and uptake of an on-line communication skills education program targeting challenging conversations for oncology health professionals related to identifying and responding to anxiety and depression.

BackgroundAnxiety and depression screening and management in cancer settings occurs inconsistently in Australia. We developed a clinical pathway (ADAPT CP) to promote standardized assessment and response to affected patients and enhance uptake of psychosocial interventions. Health professional education is a common strategy utilised to support implementation of practice change interventions. We developed an interactive on-line education program to support staff communication and confidence with anxiety/depression screening and referral prior to the ADAPT CP being implemented in 12 oncology ser