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Dental implants in immunocompromised patients: a systematic review and meta-analysis.

ObjectiveImpaired health conditions and related lack of adequate host healing are among the most important conditions that account for dental implant failure. Today clinicians face an increasing number of immunocompromised patients requesting implant-based rehabilitation. To provide clinical evidence for prospective decision-making, the aim of this systematic review and meta-analysis was to analyse the influence of immunodeficiency on dental implant survival.MethodsThe study was conducted according to the PRISMA Statement and the principles of the Cochrane Collaboration. MEDLINE and Web of Sci

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… All patients received prednisone or cortisone therapy and no effect on implant survival of either the medication or the underlying autoimmune disease was detected. … In the analysed studies, the predominant medication in patients suffering from autoimmune disorders is prednisone or cortisone therapy. In neither of the studies, a direct effect on implant survival of either the medication was detected. …

Питание пациентов с множественным склерозом, корреляция с качеством жизни и инвалидность - перспективное и квази-экспериментальное исследование.

Множественный склероз (MS) является многофакторным заболеванием, при этом питание и образ жизни играют важную роль в его развитии. Средиземноморское питание считается особенно полезным для пациентов с инфекциями. Цель настоящего исследования заключалась в изучении взаимосвязи между рационом питания и СУ, а также в оценке воздействия средиземноморского рациона питания на качество жизни и уровень инвалидности пациентов. Шестимесячное исследование охватывало 130 пациентов, которые были разделены на группу контроля и вмешательства. Инструменты сбора данных использовались для сбора данных о демогра

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… Patients receiving cortisone, patients who were recently diagnosed with multiple sclerosis, those who had participated in a pharmaceutical clinical trial, those who had recently changed their medication, or those who suffered from psychiatric diseases, intellectual disability, or comorbidities were excluded … In addition, data regarding years of illness, medication, cortisone administration, other health issues, exercise, smoking, and use of vitamins or nutritional supplements were obtained. …

Совпадение с Такаясу Артеритом и множественным склерозом: обзор скрипта и доклад по делу.

ВВЕДЕНИЕ: Такайасу-артерит (ТА) и множественный склероз (МС) являются как иммунизированными заболеваниями, которые могут сосуществовать, при этом ТА вызывает сосудистое воспаление, а MS - обезвоживание, вызванное аберрантной активностью Т-клеток. Совпадение этих условий подчеркивает наличие общих иммунных механизмов, таких, как регулирование " Т-клеток " и высвобождение цитокина, что подчеркивает необходимость нюансированного понимания их взаимодействия, которое изучается в ходе описательного обзора зарегистрированных случаев. Мы рассказываем обо всех зарегистрированных случаях насил

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… Multiple severe aortic arch stenoses (TA), extensive white matter disease with enhancing lesion (MS) 1 year of prednisone Chest discomfort improved with prednisone MS at age 34: blurred vision, diplopia, confusion, left hemiparesis and hemihypesthesia, episodic dystonia Relapses also improved with cortisone …

[Polycystic ovary syndrome of extra-ovarian origin. Review].

An established fact in the polycystic ovarian syndrome (POS) is an abnormal ovarian steroidogenesis. Though this suggest an intrinsic ovarian defect, the syndrome could also be influenced by factors outside the ovaries. Although of unknown etiology, the POS is one of the most frequent endocrine disorders in the gynecologic practice. The disorder is characterized by ultrasound findings of enlarged polycystic ovaries, hyperandrogenism, menstrual disorders, obesity and including the appearance of infertility. There are a series of mechanisms involved in the extraovarian androgen increase in patie

Clinical features and pathological analysis of primary rib Langerhans cell histiocytosis: case series and literature review.

BackgroundLangerhans cell histiocytosis (LCH) is a rare histiocytic neoplasm characterized by the abnormal proliferation of Langerhans cells, which can infiltrate various tissues throughout the body, leading to a spectrum of organ damage. This study aims to explore the clinical characteristics, imaging manifestations, and pathological features of the disease to enhance clinical diagnosis and understanding of such conditions.Case descriptionThis study reviews the clinical data of four patients diagnosed with LCH at The First Affiliated Hospital of Hunan University of Traditional Chinese Medicin

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… In addition to surgery, chemotherapy and targeted therapy, there are also the options of waiting after bioptic confirmation with or without cortisone instillation or ( 10 ), in the case of multifocal osseous involvement, the supportive administration of bisphosphonates ( 11 ). …

Glucocorticoid-induced osteonecrosis in systemic lupus erythematosus patients.

Osteonecrosis (ON) is a complex and multifactorial complication of systemic lupus erythematosus (SLE). ON is a devastating condition that causes severe pain and compromises the quality of life. The prevalence of ON in SLE patients is variable, ranging from 1.7% to 52%. However, the pathophysiology and risk factors for ON in patients with SLE have not yet been fully determined. Several mechanisms for SLE patients' propensity to develop ON have been proposed. Glucocorticoid is a widely used therapeutic option for SLE patients and high-dose glucocorticoid therapy in SLE patients is strongly assoc

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… Fat cell hypertrophy Fat cell hypertrophy and fat emboli have been detected in rabbits after the exposure to high‐dose cortisone for 5 months. 91 Fat emboli can activate the complement pathway, deposit immune complexes, and increase intravascular coagulation, 92 leading to ON. … Angiogenesis inhibition and tumor regression caused by heparin or a heparin fragment in the presence of cortisone . Science . 1983 ; 221 : 719 ‐ 725 . 6192498 10.1126/science.6192498 69 Kerachian MA , Harvey EJ , Cournoyer D , Chow TY , Seguin C . …

Oral Vitamin D supplementation impacts gene expression in granulosa cells in women undergoing IVF.

STUDY QUESTION: Does oral Vitamin D supplementation alter the hormonal milieu of follicular fluid (FF) and the transcriptomic profile of lut … ry was used to measure FF abundance of 25-hydroxyvitamin D, aldosterone, androstenedione, cortisol, cortisone, corticosterone, 11-deoxycorticosterone, 11-deoxycortisol, 21-deoxycortisol, dehydroepiandrosterone, dehydroepiandrosterone sulfate, dihydrotestosterone, oestradiol (E2), 17-OH-hydroxyprogesterone, progesterone (P4) and testosterone. GCs were isolat …

Uncommon Blepharitis.

Blepharitis is a common chronic inflammatory condition affecting the eyelid margins; the pathophysiology of blepharitis is complex and not fully understood. The disease is anatomically divided into anterior (inflammation of eyelashes) and posterior (meibomian gland dysfunction) types. Diagnosis relies on clinical examination, revealing characteristic features like scurf, vascular changes, and meibomian gland dysfunction. The main goals of blepharitis treatment are symptom relief, recurrence prevention, and complication risk minimization. Treatment options include lid hygiene, topical and syste

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… The management of toxicity from EGFR inhibitors involves the use of artificial tears for the treatment of related dry eyes; trichiasis must be treated with the removal of excess eyelashes by an ophthalmologist, for blepharitis, eyelid hygiene and topical cortisone are recommended, and in cases of severe …

Anti-carcinogenic and Anti-bacterial Properties of Selected Spices: Implications in Oral Health.

"Let food be thy medicine and medicine be thy food", as said by the father of medicine, Hippocrates in 431 B.C. Nature has provided us with a variety of treatment modalities in the form of food. For the first 5,000 years of civilization, humans relied on herbs and foods for medicine. Only in the past 60 years have we forgotten our medicinal "roots" in favor of patented medicines. While pharmaceutical ingredients have their value, we should not overlook the well-documented, non-toxic and inexpensive healing properties of food. As an individual we consume food several times a day without a compl

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… Anti-inflammatory properties Anti-inflammatory action of curcumin occurs by lowering histamine levels and increasing the production of natural cortisone [ 8 ]. It has an anticoagulant action by preventing platelets from clumping together [ 8 ]. …

TEL-AML1 fusion RNA as a new target to detect minimal residual disease in pediatric B-cell precursor acute lymphoblastic leukemia.

It has recently been shown that the t(12;21)(p13;q22) translocation fuses two genes, TEL on chromosome 12 and AML1 on chromosome 21. We have evaluated the frequency of this newly described translocation in acute lymphoblastic leukemia (ALL), and the feasibility of minimal residual disease (MRD) monitoring by polymerase chain reaction (PCR) amplification of TEL-AML1 transcripts. Thirty-nine adult- and 45 childhood-ALLs consecutively diagnosed in a single center were included in this study. TEL-AML1 fusion transcripts were searched for in the 39 adult- and 45 childhood-ALLs for which material wa

Economic Burden of Intravenous Decitabine Administration in Patients Affected by Acute Myeloid Leukemia Ineligible for Induction Chemotherapy and Impact of Oral Formulation Introduction: A Micro-Costing Study in Italy.

PurposeIntravenous (IV) decitabine is a therapeutic option for patients with newly diagnosed acute myeloid leukemia (AML) ineligible for induction chemotherapy. Recently, the oral formulation of decitabine-cedazuridine demonstrated comparable efficacy and safety to IV decitabine, and pharmacokinetic equivalence. This study estimates the direct non-drug healthcare costs of IV decitabine administration in Italy, including central venous catheter (CVC) and infection management, and assesses the economic impact of oral decitabine introduction.MethodsA micro-costing analysis from the Italian Nation

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… Notes : a It refers to the administration of prophylactic treatments with cortisone and antihistamines suddenly before IV administration to prevent adverse events; b Lower overhead cost means applying overhead costs as 20% of the cost of non-drug consumables and HCP time; 13 cIV decitabine clinical trial … Notes : a It refers to the administration of prophylactic treatments with cortisone and antihistamines suddenly before IV administration to prevent adverse events; b Lower overhead cost means applying overhead costs as 20% of the cost of non-drug consumables and HCP time; 13 cIV decitabine clinical trial …

Анализ МРТ на основе АИ показывает атрофию мозга в доброкачественном релапсирующем многократном склерозе.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Существование и определение доброкачественного множественного склероза (МС) остаются противоречивыми, особенно с учетом расхождений между клиническим представлением и основополагающими изменениями в изображениях. В этом исследовании мы стремились изучить атрофию мозга, связанную с доброкачественными релапсирующими MS (BRRMS), особенно в том, что касается местоположения и масштабов. Мы проанализировали объемы глобальных и региональных серых веществ (GM) и белого вещества (WM), нагрузку на WM, индекс каллосум корпус (CCI) и площадь каллосум корпусов (CCA) в четко определен

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… All patients were clinically stable within 1 month before MRI scanning (neither clinical relapses nor cortisone treatments) and with no Gd-enhancing lesions in MRI. Table 1 Demographics of the BRRMS patients. …

Real-practice management and treatment of idiopathic multicentric Castleman disease with siltuximab: a collection of clinical experiences.

Castleman disease (CD) is a group of lymphoproliferative disorders that share common histopathological features yet have widely different aetiologies, clinical features and grades of severity as well as treatments and outcomes. Siltuximab is currently the only therapy approved by the FDA and EMA for idiopathic multicentric CD and is recommended as first-line therapy in treatment guidelines. Despite the extensive characterization of siltuximab treatment in clinical trials, available evidence from real-world practice is still scant. This collection of clinical experiences focuses on patients tre

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… From September to December 2014, the patient was on cortisone therapy with no benefit. In December 2014, a biopsy of the axillary lymph node was repeated with confirmation of the diagnosis of hyaline-vascular iMCD disease, and treatment with non-steroidal anti-inflammatory drugs was resumed. …

Целесообразность Two- Дифференциальный гель электрофорез в диагностике множественного склероза

Two- размерная разница в геле электрофорезе (2D-DIGE) используется для идентификации возможных биомаркеров в цереброспиновой жидкости (CSF) пациентов с множественным склерозом (MS). Однако в различных исследованиях были получены противоречивые результаты. Мы хотели проанализировать диагностическую ценность 2D-DIGE на ранних пациентах MS путем сопоставления белковых структур между одиночными и объединенными образцами пациентов MS и контроля. Образцы CSF 20 Психиатрические заболевания и 10 :: Обработка вопросов контроля 2D-DIGE. Полученные таким образом белковые рисунки были проанализированы с D

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… Another pre-analytical confounder that has to be considered is, whether CSF collection was performed before or during an intravenous cortisone therapy [ 9 ] as this could influence presence of particular proteins as well. …

Integrated transcriptomics of multiple sclerosis peripheral blood mononuclear cells explored potential biomarkers for the disease.

BACKGROUND: Despite their importance, blood RNAs have not been comprehensively studied as potential diagnostic markers for multiple sclerosis (MS). Herein, by the integration of GSE21942 and GSE203241 microarray profiles of peripheral blood mononuclear cells, this study explored potential biomarkers for the disease. METHODS: After identification of differentially expressed genes (DEGs), functional enrichment analyses were performed, and PPI and miRNA-mRNA regulatory networks were constructed. After implementing weighted gene co-expression network analysis (WGCNA) and discovering MS-specific m

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… Of the twelve female patients in the study, four patients had received immunomodulatory treatment, such as cortisone or interferon-beta (β-interferon), when samples were collected [ 21 ]. Table 2 Demographic data of the retrieved datasets. …

Interplay between stress and cancer-A focus on inflammation.

Stress is an integral part of life. While acute responses to stress are generally regarded as beneficial in dealing with immediate threats, chronic exposure to threatening stimuli exerts deleterious effects and can be either a contributing or an aggravating factor for many chronic diseases including cancer. Chronic psychological stress has been identified as a significant factor contributing to the development and progression of cancer, but the mechanisms that link chronic stress to cancer remain incompletely understood. Psychological stressors initiate multiple physiological responses that re

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… Primary adrenal insufficiency during Lenvatinib or Vandetanib and improvement of fatigue after cortisone acetate therapy . J. Clin. Endocrinol. Metab. 104 , 779 – 784 . 10.1210/jc.2018-01836 30383218 PMC6402317 Colyn L. Venzala E. Marco S. Perez-Otaño I. Tordera R. M. ( 2019 ). …

Combating Methotrexate Resistance in Cancer Treatment: A Review on Navigating Pathways and Enhancing Its Efficacy With Fat-Soluble Vitamins.

Methotrexate (MTX), a potent analogue and antagonist of folic acid, is a first-line treatment for rheumatoid arthritis, IBD and cancer. The development of MTX resistance contributes to the reduced efficacy and development of adverse reactions, forcing clinicians to withdraw treatment early. This drawback requires combinational approaches to combat the resistance and enhance the efficacy and safety of MTX. To provide a brief overview of MTX resistance and strategies to mitigate its aftereffects in cancer therapy, a literature-based search was conducted using keywords such as cancer pathology, M

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… American laboratories discovered that cortisone and aminopterin inhibited the proliferation of mesenchymal cells in the 1950s. … In 1951, aminopterin's antianabolic, anti-inflammatory and antiproliferative effects in connective tissue were demonstrated by Gubner and associated to be similar to those of cortisone. …

Saliva как матрица для терапевтического мониторинга наркотиков и биомаркеров заболеваний у детей и подростков.

Saliva — более доступная, менее напряженная и менее дорогостоящая биологическая матрица, чем кровь, и она может применяться в терапевтическом мониторинге лекарственных средств (ПТМ). Концентрации слюны отражают фармацевтический активный ненавязанный препарат. В этом обзоре содержится последняя информация о слюне в качестве матрицы для лечебного контроля за наркотиками и определения биомаркеров у младенцев, детей и подростков. К октябрю 2024 года по базе данных PubMed были проведены обыски литературы, 64 исследования были включены в TDM, стероиды, добавки, биомаркеры заболеваний, стоматология,

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… 0.16 ng/mL 404 children, aged 12 to 48 months cortisol showed an inverted U-shaped association with four growth indexes; early life daytime cortisol levels, as a reflection of hypothalamic- pituitary-adrenal axis development, might influence growth in early infancy not defined [ 31 ] Cortisol and cortisone … on-line solid-phase extraction: mixing and centrifuging of a 96-deep well sample plate; clean-up and removal of saliva matrix, injection of extract onto the analytical column [ 79 ] 100 µL [ 79 ] LC- MS/MS; positive- ionization mode LLOQ: 0.03 µg/dL (0.8 nmol/L) for both salivary cortisol and salivary cortisone …

Fanconi syndrome developing and worsening during anti-myeloma therapy in multiple myeloma: a case report and literature review.

BACKGROUND: Fanconi syndrome (FS) is a rare renal complication of monoclonal gammopathies including multiple myeloma (MM), typically diagnosed before or at the time of MM presentation. Onset and progression of FS during anti-myeloma treatment are extremely rare and easily misdiagnosed, resulting in delayed electrolyte correction and clinical deterioration. CASE PRESENTATION: We report a 55-year-old woman with κ light chain MM who developed FS during induction therapy and experienced recurrence after autologous stem cell transplantation (ASCT). Initial workup showed subclinical tubular dysfunc

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… years) | Sex | Underlying disease | Type of monoclonal gammopathy | Time to presentation | Typical symptoms | Sequence of FS and MG onset | Treatments | Hematological response | Renal response | Follow-up ( 5 ) | 38 | Male | MM | NA | 3 years | Fatigue, nocturia | Simultaneous | Supplement treatment cortisone …

Role of Radiotherapy in the Era of Novel Immune-Based Treatment Strategies for Multiple Myeloma.

Radiotherapy (RT) constitutes an important treatment modality in multiple myeloma (MM), traditionally used for the management of symptomatic osteolytic and extramedullary lesions. Objectives of RT are symptom alleviation and prevention of complications such as neurological deficits and pathological fractures. Over the past decade, systemic therapy (ST) for MM has undergone substantial advancements, notably with the incorporation of monoclonal antibodies in frontline regimens, as well as the emergence of bispecific antibodies and chimeric antigen receptor T-cells (CAR-T) for relapsed and refrac

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… From conventional cortisone‐containing chemotherapy approaches including melphalan and/or doxorubicin, bendamustine and vincristine [ 19 , 20 ], treatment strategies have progressed with the implementation of immunomodulatory drugs such as thalidomide and lenalidomide, as well as proteasome inhibitors …