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Pulmonary hypertension and the potential of 'drug' repurposing: A case for African medicinal plants.

AbstractPulmonary hypertension (PH) is a haemodynamic disorder in which elevated blood pressure in the pulmonary circulation is caused by abnormal vascular tone. Despite advances in treatment, PH mortality remains high, and drug repurposing has been proposed as a mitigating approach. This article reviews the studies that have investigated drug repurposing as a viable option for PH. We provide an overview of PH and highlight pharmaceutical drugs with repurposing potential, based on limited evidence of their mechanisms of action. Moreover, studies have demonstrated the benefits of medicinal plan

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… Han C, Qi J, Gao S, et al. Vasodilation effect of volatile oil from Allium macrostemon Bunge are mediated by PKA/NO pathway and its constituent dimethyl disulfide in isolated rat pulmonary arterials. Fitoterapia. 2017;120:52–57. doi: 10.1016/j.fitote.2017.05.007. 100. Wang X, Cai X, Wang W, et al. …

A Comprehensive Review of Interventional Clinical Trials in Patients with Bone Metastases.

Bone metastasis is one of the most important factors associated with poor prognosis for patients with prostate, breast, thyroid, and lung cancer. In the past two decades, 651 clinical trials, including 554 interventional trials, were being registered in ClinicalTrials.gov and pharma.id.informa.com to combat bone metastases from different perspectives. In this review, we comprehensively analyzed, regrouped, and discussed all the interventional trials on bone metastases. Clinical trials were re-grouped into bone-targeting agents, radiotherapy, small molecule targeted therapy, combination therapy

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… Qi LS, Larson M, Gilbert L, et al. Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression. Cell . 2013;152(5):1173–1183. doi: 10.1016/j.cell.2013.02.022 …

Development and validation of a chemotherapy tolerance prediction model for Chinese multiple myeloma patients: The TM frailty score.

ObjectiveThe physical fitness of older individuals is heterogeneous, making it difficult to know their chemotherapy tolerance. The toxicities may offset the benefits of anti-myeloma therapy in frail patients. The accurate evaluation of frailty status before chemotherapy is essential. We aimed to explore the applicability of the IMWG GA and develop a new frailty screening tool more suitable for Chinese MM patients.Cases and methodsWe performed the IMWG GA and the full CGA in 167 MM patients and validated the applicability of the IMWG GA to chemotherapy and prognosis. The CGA domains were screen

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… Zhang H, Wang ZH, Wang LM, Qi SG, Li ZX. [Study on activities of daily living disability in community-dwelling older adults in China]. Zhonghua Liu Xing Bing Xue Za Zhi (2019) 40:266–71. doi: 10.3760/cma.j.issn.0254-6450.2019.03.003 31. Niti M, Ng TP, Chiam PC, Kua EH. …

Efficacy and Safety of Ixazomib Plus Lenalidomide and Dexamethasone Following Injectable PI-Based Therapy in Relapsed/Refractory Multiple Myeloma.

This nationwide, multicenter, open-label, single-arm study evaluated the efficacy and safety of the oral proteasome inhibitor (PI), ixazomib plus lenalidomide (LEN) and dexamethasone (DEX) (IRd) following injectable PI-based therapy for relapsed/refractory multiple myeloma (RRMM). Of 45 patients enrolled, 36 patients received IRd after achieving at least a minor response to 3 cycles of bortezomib or carfilzomib plus LEN + DEX (VRd, n=6; KRd, n=30). At median follow-up of 20.8 months, the 12-month event-free survival rate (primary endpoint) was 49% (90% CI: 35.9-62.0), counting 11 events of pro

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… Avet-Loiseau H, Casneuf T, Chiu C, Laubach JP, Lee J-J, Moreau P, Plesner T, Nahi H, Khokhar NZ, Qi M, Schecter J, Carlton V, Qin X, Liu K, Wu K, Zhuang SH, Ahmadi T, Sasser AK, San-Miguel J. …

Neurotropin alleviates rat osteocarcinoma pain via P2X3 receptor activation in the midbrain periaqueductal gray.

ObjectivesClinically effective analgesia treatment for patients afflicted with osteocarcinoma lessens the intensity of pain. The midbrain periaqueductal gray (PAG) plays a critical role in pain modulation, and activation of P2X3 receptors in this region mediates pain processing. Neurotropin is a small molecule drug used for analgesic treatment of a number of chronic pain conditions. The present study aims at determining whether P2X3 receptor activation in PAG is responsible for the analgesic effect of neurotropin in rats with osteocarcinoma pain.Materials and methodsThe tibia of female Sprague

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… Sun S, Qi D, Yang Y, Ji P, Kong J, Wu Q. Association of occlusal interference-induced masseter muscle hyperalgesia and P2X3 receptors in the trigeminal subnucleus caudalis and midbrain periaqueductal gray. Neuroreport. 2016;27:277–283. doi: 10.1097/WNR.0000000000000533. 37. Fields RD. …

A Pilot Clinical Study of Hyperacute Serum Treatment in Osteoarthritic Knee Joint: Cytokine Changes and Clinical Effects.

The serum fraction of platelet-rich fibrin (hyperacute serum) has been shown to improve cartilage cell proliferation in in vitro osteoarthritic knee joint models. We hypothesize that hyperacute serum may be a potential regenerative therapeutic for osteoarthritic knees. In this study, the cytokine milieu at the synovial fluid of osteoarthritic knee joints exposed to hyperacute serum intraarticular injections was investigated. Patients with knee osteoarthritis received three injections of autologous hyperacute serum; synovial fluid was harvested before each injection and clinical monitoring was

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… Li C., Chen K., Kang H., Yan Y., Liu K., Guo C., Qi J., Yang K., Wang F., Guo L., et al. Double-stranded RNA released from damaged articular chondrocytes promotes cartilage degeneration via Toll-like receptor 3-interleukin-33 pathway. Cell Death Dis. 2017;8:e3165. doi: 10.1038/cddis.2017.534. 64. …

Multiple Extramedullary-Bone Related and/or Extramedullary Extraosseous Are Independent Poor Prognostic Factors in Patients With Newly Diagnosed Multiple Myeloma.

BackgroundExtramedullary (EM) lesions are common in multiple myeloma (MM) and are often related to the poor prognosis of MM but are scarcely understood.MethodsIn this retrospective study, the baseline characteristics of 357 newly diagnosed patients with extramedullary multiple myeloma (EMM) and their impact on the prognosis were analyzed. All patients received first-line treatment with bortezomib-based regimen.ResultsThe overall incidence rate of EM was 22.4%, and the detection rate of PET/CT was significantly higher than other imaging methods (P = 0.015). The cohorts consisted of 10 cases of

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… Blood ( 2011 ) 117 ( 6 ): 2009–11 . 10.1182/blood-2010-07-295105 20962323 21 Chang H Qi X Yeung J Reece D Xu W Patterson B . Genetic Aberrations Including Chromosome 1 Abnormalities and Clinical Features of Plasma Cell Leukemia . …

Discovery and validation of surface N-glycoproteins in MM cell lines and patient samples uncovers immunotherapy targets.

BackgroundMultiple myeloma (MM) is characterized by clonal expansion of malignant plasma cells in the bone marrow. While recent advances in treatment for MM have improved patient outcomes, the 5-year survival rate remains ~50%. A better understanding of the MM cell surface proteome could facilitate development of new directed therapies and assist in stratification and monitoring of patient outcomes.MethodsIn this study, we first used a mass spectrometry (MS)-based discovery-driven cell surface capture (CSC) approach to map the cell surface N-glycoproteome of MM cell lines. Next, we developed t

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… Yang S, Qi F, Tang C, et al. CD147 promotes the proliferation, invasiveness, migration and angiogenesis of human lung carcinoma cells. Oncol Lett 2017;13:898–904. 10.3892/ol.2016.5502 40. Chen S, Zhang Y, Wang H, et al. …

Profile of elotuzumab and its potential in the treatment of multiple myeloma.

Although the introduction of novel drugs has improved outcome significantly in multiple myeloma (MM), many patients still eventually relapse. Monoclonal antibodies (mAbs) targeting MM-related antigens can complement currently available therapies. CS1 (also known as CD2 subunit 1, SLAMF7, CD319, and CRACC), a cell surface glycoprotein receptor that is a member of the signaling lymphocytic activation molecule (SLAM) family, is highly and nearly uniformly expressed in myeloma cells at the gene and protein level, but not expressed in other tissues, including hematopoietic stem cells, making CS1 a

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… and regulates NK cell function Mol Immunol 2002 39 1–2 1 8 12213321 10.1016/s0161-5890(02)00094-9 29 Cannons JL Tangye SG Schwartzberg PL SLAM family receptors and SAP adaptors in immunity Annu Rev Immunol 2011 29 665 705 21219180 10.1146/annurev-immunol-030409-101302 30 Schwartzberg PL Mueller KL Qi …

CoREST in pieces: Dismantling the CoREST complex for cancer therapy and beyond.

Several landmark studies over the past decade have uncovered a critical role of the CRL3KBTBD4 ubiquitin ligase complex in regulating stability of corepressor of repressor element 1 silencing transcription factor (CoREST) complex proteins and normal hematopoietic stem cell self-renewal. There is now mounting evidence that the CoREST complex plays oncogenic roles, although the contributions of its catalytic versus noncatalytic functions remain unclear. Here, we summarize and discuss mechanisms whereby the CoREST complex coopts tissue-specific transcription factors to elicit pathogenic activity

Chronic stress: a fourth etiology in tumorigenesis?

Chronic stress, driven by persistent psychological, environmental, or physiological factors, is a prolonged heightened state of stress response that disrupts homeostasis. When unmanaged, it will lead to sustained negative emotions such as depression, loneliness, anxiety, and emotional adversity. This persistent emotional distress not only exacerbates mental health disorders but also poses significant risks to physical health. Increasing evidence suggests a strong link between chronic stress, stress-related hormones, and the rising incidence of malignancies. As a result, chronic stress might be

Immune reprogramming in the bone marrow microenvironment: a new perspective on the bone immune microenvironment of postmenopausal osteoporosis.

Research on postmenopausal osteoporosis (PMOP), a common bone metabolic disease, has traditionally focused on bone loss and imbalance in bone remodeling. However, with the development of bone immunology, the complex interactions between immune cells and bone cells in the bone marrow microenvironment have gradually been revealed, and "immune reprogramming" is considered a key factor driving the persistent bone loss in PMOP. Current evidence indicates that the postmenopausal bone marrow microenvironment undergoes significant structural and functional changes. These changes are characterized by a

Targeting the NLRP3 inflammasome in kidney disease: molecular mechanisms, pathogenic roles, and emerging small-molecule therapeutics.

Inflammatory responses represent a core pathological process driving the progression of both acute and chronic kidney diseases. As a key effector of the innate immune system, the NLRP3 inflammasome is widely activated in renal resident cellsand infiltrating immune cells, positioning it as a critical nexus linking metabolic dysregulation, cellular stress, and tissue injury. Accumulating preclinical and clinical evidence in recent years demonstrates that aberrant activation of the NLRP3 inflammasome directly promotes glomerular damage, tubulointerstitial inflammation, fibrosis, and vascular dysf

Beneath the surface in autoimmune hemolytic anemia: pathogenetic networks, therapeutic advancements and open questions.

In recent years, the pathophysiologic framework of autoimmune hemolytic anemias (AIHAs) has evolved considerably, extending beyond the simplistic paradigm of antibody-mediated red blood cell (RBC) destruction, which is now recognized as a downstream consequence of a broader immune dysregulation. AIHA is fundamentally orchestrated by a complex interplay between innate and adaptive immune components, including autoreactive B and T lymphocytes, macrophages, and the reticuloendothelial system. Central to disease pathogenesis are two interrelated mechanisms: clonal B-cell expansion with autoantibod

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… Blood . ( 2024 ) 144 : 1581–94 . doi: 10.1182/blood.2024024230 , PMID: 39102659 PMC11487644 82 Qi J Liu C Bai Z Li X Yao G . T follicular helper cells and T follicular regulatory cells in autoimmune diseases . … Blood . ( 2022 ) 139 : 369–83 . doi: 10.1182/blood.2021012924 , PMID: 34424963 PMC8777200 85 Liu X Yao J Zhao Y Wang J Qi H . Heterogeneous plasma cells and long-lived subsets in response to immunization, autoantigen and microbiota . …

Targeting Metal Ion Homeostasis for Regulated Cell Death-Amplified Tumor Nanomedicine.

Amidst escalating global health challenges, neoplastic diseases remain a predominant cause of morbidity and mortality, exerting complex and far-reaching effects on human health and societal well-being. The advent of precision medicine has ushered in an era of tailored therapeutic strategies, leveraging individual genetic profiles, tumor microenvironmental features, and exogenous factors to redefine oncology care. Central to these advances is the understanding of cell death, a fundamental biological process encompassing both programmed and non-programmed forms. Programmed cell death is orchestr

Bone Effects of Anti-Cancer Treatments in 2024.

Considerable progress has been made in the management of cancer patients in the last decade with the arrival of anti-cancer immunotherapies (immune checkpoint inhibitors) and targeted therapies. As a result, a broad spectrum of cancers, not just hormone-sensitive ones, have seen several patients achieve profound and prolonged remissions, or even cures. The management of medium- and long-term side-effects of treatment and quality of life of patients are essential considerations. This is especially true for bone, as bone fragility can lead to increased fractures and loss of autonomy, ultimately

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… Goss PE Qi S Josse RG Pritzker KP Mendes M Hu H The steroidal aromatase inhibitor exemestane prevents bone loss in ovariectomized rats Bone 2004 34 384 392 15003786 10.1016/j.bone.2003.11.006 Goss PE, Qi S, Josse RG, Pritzker KP, Mendes M, Hu H et al (2004) The steroidal aromatase inhibitor exemestane …

Epigenetic Regulation of Autophagy in Bone Metabolism.

The skeletal system is crucial for supporting bodily functions, protecting vital organs, facilitating hematopoiesis, and storing essential minerals. Skeletal homeostasis, which includes aspects such as bone density, structural integrity, and regenerative processes, is essential for normal skeletal function. Autophagy, an intricate intracellular mechanism for degrading and recycling cellular components, plays a multifaceted role in bone metabolism. It involves sequestering cellular waste, damaged proteins, and organelles within autophagosomes, which are then degraded and recycled. Autophagy's i

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… Qi Q , Wang Y , Wang X et al. Histone demethylase KDM4A regulates adipogenic and osteogenic differentiation via epigenetic regulation of C/EBPα and canonical Wnt signaling . Cell Mol Life Sci . 2020 ; 77 ( 12 ): 2407 – 2421 . 31515577 10.1007/s00018-019-03289-w PMC11105029 88. …

Ограниченные данные о преимуществах упражнений у пожилых людей с гематологическими отклонениями: систематический обзор и мета-анализ.

Пожилые пациенты, получающие антинеопластическое лечение, сталкиваются с такими проблемами, как слабость и снижение физической способности и функциональности. Цель этого систематического обзора и метаанализа заключалась в оценке воздействия практических занятий на результаты физической деятельности, качество жизни, связанное со здоровьем (QoL), и бремя симптомов у пожилых пациентов выше. 65 годы, когда гематологические заболевания проходят антинеопластическую терапию. Этот обзор соответствует руководящим принципам Кокрана, а поиск литературы последний раз обновлялся. 27 Март 2024, включая иссл

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… I: No advice to exercise outside of normal habits, nor asked to avoid activity L: 50 min, 3x/week Huberty 2019 USA [ 59 ] | MPN: Polycythaemia Vera, Essential, Thrombocythemia, Myelofibrosis | RCT Pilot | 62 (34/28) (93.7) | Mean 56.9 IG: 58.3 CG: 55.0 | Reported performing tai chi, qi gong, or yoga … 42 , 43 , 49 , 50 , 54 , 57 , 58 , 60 , 62 , 63 , 65 , 66 , 67 , 68 , 69 , 70 , 73 , 76 , 77 , 78 , 82 , 86 ], followed by aerobic exercise (n = 11) [ 44 , 46 , 51 , 52 , 55 , 61 , 74 , 79 , 80 , 81 , 83 ], resistance exercise (n = 6) [ 55 , 56 , 71 , 72 , 75 , 81 ], and CAM practices such as yoga, Qi …

Систематический обзор эпидемиологии и вариантов лечения нескольких миелом в Азии.

Множественная миелома (ММ) почти 15 % из всех неопластических магнатов по всему миру. Целью этого систематического обзора является анализ данных об обработке и управлении ММ в отдельных регионах Азии в целях выявления и приоритизации областей, требующих внимания. Всеобъемлющий обзор оригинальных статей, опубликованных на английском языке 2005 в адрес 2022, почерпнутые из базы данных PubMed/MedLINE, были проведены на основе руководящих принципов, касающихся предпочтительных элементов отчетности для системных обзоров и мета-анализов (PRISMA). Там были 98 - исследования из отдельных регионов Азии

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… Qi K. Shi M. Cao J. Bhansali R. Wang X. Liu Y. Li H. Zhang H. Yan Z. Sang W. Cheng H. Zhu F. Sun H. Li D. Jing G. Zheng J. Li Z. Xu K. Efficacy and safety of chimeric antigen receptor T-cell therapy for relapsed/refractory Immunoglobulin D multiple myeloma, transplant Cell. …

Advanced 3D Magnetic Scaffolds for Tumor-Related Bone Defects.

The need for bone substitutes is a major challenge as the incidence of serious bone disorders is massively increasing, mainly attributed to modern world problems, such as obesity, aging of the global population, and cancer incidence. Bone cancer represents one of the most significant causes of bone defects, with reserved prognosis regarding the effectiveness of treatments and survival rate. Modern therapies, such as hyperthermia, immunotherapy, targeted therapy, and magnetic therapy, seem to bring hope for cancer treatment in general, and bone cancer in particular. Mimicking the composition of

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… Qi J., Yu T., Hu B., Wu H., Ouyang H. Current Biomaterial-Based Bone Tissue Engineering and Translational Medicine. Int. J. Mol. Sci. 2021;22:10233. doi: 10.3390/ijms221910233. 84. …