Результаты поиска

Emerging regulatory roles of opioid peptides, endogenous morphine, and opioid receptor subtypes in immunomodulatory processes: Metabolic, behavioral, and evolutionary perspectives.

Integrated behavioral paradigms such as nociceptive processing coupled to anti-nociceptive responsiveness include systemically-mediated states of alertness, vigilance, motivation, and avoidance. Within a historical and cultural context, opium and its biologically active compounds, codeine and morphine, have been widely used as frontline anti-nociceptive agents. In eukaryotic cells, opiate alkaloids and opioid peptides were evolutionarily fashioned as regulatory factors in neuroimmune, vascular immune, and systemic immune communication and auto-immunoregulation. The significance of opioidergic …

Efficacy of the Natural Clay, Calcium Aluminosilicate Anti-Diarrheal, in Reducing Medullary Thyroid Cancer-Related Diarrhea and Its Effects on Quality of Life: A Pilot Study.

INTRODUCTION: Medullary thyroid cancer (MTC)-related diarrhea can be debilitating, reduces quality of life (QOL), and may be the only indica … d received prior antidiarrheals, and 40% of these had used two or more drugs, including tincture of opium (30%), loperamide (50%), diphenoxylate/atropine (20%), colestipol (10%), or cholestyramine (10%). Of seven evaluable patients, four (56%) had ≥20% reduction in BMs per day. Six out of seven patients discontinued their prior antidiarrheals. Best resp …

Opioids for neonates receiving mechanical ventilation.

BACKGROUND: Mechanical ventilation is a potentially painful and discomforting intervention widely used in neonatal intensive care units. Newborn babies (neonates) demonstrate increased sensitivity to pain, which may affect clinical and neurodevelopmental outcomes. The use of drugs that reduce pain might be important in improving survival and neurodevelopmental outcomes. OBJECTIVES: To determine the effect of opioid analgesics (pain-killing drugs derived from opium e.g. morphine), compared to placebo, no drug, or other non-opioid analgesics or sedatives, on pain, duration of mechanical ventila…

Opioids for neonates receiving mechanical ventilation.

BACKGROUND: Mechanical ventilation is a potentially painful intervention widely used in neonatal intensive care units. Since newborn babies (neonates) demonstrate increased sensitivity to pain, which may affect clinical and neurodevelopmental outcomes, the use of drugs which reduce pain might be very important. OBJECTIVES: To determine the effect of opioid analgesics (pain-killing drugs derived from opium e.g. morphine), compared to placebo, no drug, or other non-opioid analgesics or sedatives, on pain, duration of mechanical ventilation, mortality, growth and neurodevelopmental outcomes in n…

Drugs for mental illnesses in ancient greek medicine.

Drugs with psychedelic, hypnotic, narcotic, analgesic, suppressive, euphoric and stimulating effects were used in various ways during the an … s like black and white hellebore, mandrake, hyoscyamus (henbane), Papaver somniferum (also known as opium poppy), Strychnos, Frankincense-tree and dorycnium. The preparation of narcotics included the addition of other elements, mainly wine, to the opus of plants or to their extracts. Drugs were produced via methods of dehumidification/desiccation, grind …

Psychiatric Onset Alexander Disease: An Important Challenge in Neuropsychiatric Diagnosis: A Case Report.

INTRODUCTION: Alexander disease is a heterogeneous group of diseases with various manifestations based on the age of disease onset. This rar … depression since 17 years ago, a suicidal attempt two years ago, and ingestion of a large amount of opium with the intention of suicide 2 months ago. She was presented with disorientation and probably a delirious state in the last interview. Eventually, in comprehensive investigations, white matter hyperintensity in MRI and leukodystrophy was diagnosed …

[Use of Emerging Drugs in Medellín, Colombia].

INTRODUCTION: The ongoing emergence of new synthetic substances that are used as drugs is a constant challenge to public health. Emerging dr … and Free-Base), with LP, 80%, LYP, 52.1%, and LYP=31.7%. The opiate derivatives (heroine, morphine, opium, codeine, dextromethorphan, meperidine, fentanyl) had an LP, 61.4%; LYP, 26.7% and LMP, 16%. The consumption statistics of the hallucinogens such as mushrooms, scopolamine and "yague", had an LP, 73.5%; LYP, 23.2% and LMP, 12.2%. Finally, use of inh …

Six-month follow-up of Iranian women in methadone treatment: drug use, social functioning, crime, and HIV and HCV seroincidence.

BACKGROUND: In general, information about women who use drugs comes from studies performed in the West. Whether women in countries such as I … ases and Related Health Problems, tenth revision (ICD-10). The sample comprised 78 female heroin or opium users who attended the Persepolis women's drug treatment clinic in Tehran between 2007 and 2008. Participants were followed up in 2009/2010. Heroin and the use of other drugs, social functioning, involvement in crime, and involvement in HIV and HCV …

[Pain--life's dreaded companion. Cultural history of algology and the most important achievements].

Pain is a comprehensive phenomenon which concerns not only physiology, biochemistry and molecular biology but also music, art, religion, philosophy and everyday life. The early contributions to the development of the specificity theory is described, as are some of the important discoveries in the history of algology, such as Baillou's description of rheumatism, Heberden's description of angina pectoris and the development of the gate control theory. Despite a number of important discoveries and a much improved knowledge in basic science pain is still the dreaded companion of mankind.

Частота воздействия факторов риска на презенциальные катаракты среди пациентов в возрасте 30-50 лет: перекрестное исследование в больнице Шафа, Керман (2024-2025 годы).

ЦЕЛЬ: Это исследование было направлено на определение частотности и характеристик ключевых факторов риска для катаракты передозировки у пациентов в возрасте от 30 до 50 лет в Кермане, Иран, регионе, характеризующемся высоким воздействием солнечной энергии и конкретными социально-поведенческими тенденциями. МЕТОДЫ: В 2024 году в отделении офтальмологии больницы Шафа было проведено аналитическое перекрестное исследование. Согласно методу переписи 245 пациентов (468 глаз) нуждались в катаракте. Данные о демографических, профессиональных, системных и поведенческих факторах собирались с использован

Совпадение в полном тексте источника
… Use 85 34.69 Cigarette Smoking 18 7.35 Alcohol Consumption 3 1.22 Opium + Cigarette 24 9.80 Demographic and Clinical Characteristics of the Study Participants As shown in Table 1 , only 3% (7 people) worked in hot environments. … Approximately half (47%, 115 people) reported no high-risk behaviors, while one-third (35%, 85 people) reported opium use. Descriptive statistics for continuous variables are summarized in Table 2 . Participants had a mean age of 44.0 years (SD = 5.8). …

Receptor binding and pharmacological activity of opiates in the guinea-pig intestine.

A comparison was made between the affinities of a wide range of opiate agonists, mixed agonist-antagonists and antagonists for opiate receptor binding sites in the guniea-pig intestine longitudinal muscle and myenteric plexus preparation, and their pharmacological potency in influencing the electrically induced contraction of this in vitro functional system. The relative affinities of drugs and the degree of stereospecificity for intestinal binding sites are closely similar to these properties in the brain. Receptor binding correlates extremely well with pharmacological potency, both for agoni