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Клинический спектр приобретенных синдромов демилинизации у детей: опыт третичной больницы.

ВВЕДЕНИЕ: Хотя приобретенные синдромы демиелионации (САР) редки у детей, распространенность и распространенность САД в различных странах мира являются неодинаковыми. Поскольку данные о педиатрической АДС в Саудовской Аравии ограничены, цель этого исследования заключалась в том, чтобы описать клинический спектр педиатрической АДС, его клинические характеристики и варианты управления в третичной больнице в Саудовской Аравии. МЕТОДЫ: В период с января в медицинском центре им. короля Абдель Азиза (КАМС) и специализированном детском госпитале им. короля Абдаллы (КАШХ) в Эр-Рияде, Саудовская Аравия,

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… We classified it into minimal disability, score 1–1.5, indicating “abnormal signs only” without disability such as having pyramidal signs, disc pallor, or any functional score grade I; moderate disability, score 2–4; and significant disability, score > 5. … We further analyzed the type of residual deficits among different groups and found that approximately 50% of patients with MS (15 out of 30) had only abnormal signs, i.e., pyramidal signs or disc pallor (EDSS scores of 1.0–1.5), indicating minimal disability, while patients with CIS with residual deficits …

Friday, September 28, 2018, 7:30-10:10 h: Poster Session – 01: Headache and Dementia

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… Examination revealed significant pallor, bilateral Grade IV papilledema with superficial retinal hemorrhages, bilateral lateral rectus palsy, and positive Kernig's. Her noncontrast computed tomography of the head was normal. CECT revealed basal exudates without any other abnormality. …

< < Холистическое управление множественной миеломой > > : доклад по делу < < Терапия Сидды > > как дополнение к режиму Бортезомиба-Леналидомида-Дексаметасона (БЛД).

Множественная миелома (ММ) — сложная гематология, характеризующаяся клональным распространением плазменных клеток в костном мозге. Это вторая по распространенности гематологическая халатность, которая проявляется у пожилых пациентов. Инкорпорирование дополнительной медицины в обычные методы лечения рака все чаще наблюдается среди пациентов, что обусловлено такими факторами, как управление симптомами, целостное благосостояние и культурная увязка. В настоящем докладе представлена информация о комплексном управлении деятельностью 65-year-old Пациент мужского пола диагностировал ММ, который получа

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… Increased Kapham is associated with indigestion, lethargy, fatigue, pallor, and heaviness of the body, while increased Vatham is linked to wasting, constipation, insomnia, and pain. … Discussion MM is characterized by clonal plasma cell proliferation in the bone marrow, leading to a triad of characteristic clinical manifestations: (1) haematologic complications including anaemia (causing fatigue, weakness, and pallor) and immunodeficiency with recurrent infections; (2) skeletal involvement …

Приобретение гепариновых антикоагулянтов, связанных с множественной миеломой: three доклады и обзор литературы.

Множественная миелома (ММ) часто связана с аномалиями коагуляции, которые могут проявляться либо в тромботических, либо в геморрагических осложнениях. Среди них приобщившиеся гепаринноподобные антикоагуланты (HLA), приводящие к крайнему увеличению тромбинного времени (TT) и спонтанному кровотечению, являются крайне редкими. Раннее признание и надлежащее вмешательство имеют решающее значение для терпеливых результатов. Представляемая информация: Three (больные)two мужчины и мужчины one женщины в возрасте 56–63 ) с подтвержденным MM, спонтанным кровотечением: уральное мукосальное кровотечение, ж

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… Physical examination showed pallor, oral mucosal bleeding, and scattered petechiae. Coagulation tests again revealed extreme prolongation of TT (> 540 s), with normal PT and mildly prolonged APTT. Factor assays were within normal limits, and lupus anticoagulant was negative. … Physical examination showed pallor and petechiae on both lower limbs. Laboratory tests revealed renal impairment (creatinine 1.44 mg/dL [127.3 µmol/L]), anemia (Hb 99 g/L), thrombocytopenia (Plt 86 × 10⁹/L), and hyperglobulinemia (globulin 91.8 g/L), and elevated IgG levels (81.4 g/L). …

A comprehensive evaluation of potentially significant drug-drug, drug-herb, and drug-food interactions among cancer patients receiving anticancer drugs.

IntroductionDuring the cancer treatment path, cancer patients use numerous drugs, including anticancer, supportive, and other prescribed medications, along with herbs and certain products. This puts them at risk of significant drug interactions (DIs). This study describes DIs in cancer patients and their prevalence and predictors.MethodsA cross-sectional study design was used to achieve the study objectives. The study was carried out in two centers in the northern West Bank, Palestine. The Lexicomp® Drug Interactions tool (Lexi-Comp, Hudson OH, USA) was applied to check the potential DIs. In a

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… However, the most common symptoms reported by the respondents were as follows: generalized weakness (75.5%), body aches (66.4%), pallor (57.2%), anorexia (50.0%), and nausea and vomiting (47.4%) (Table 3 ). … Table 3 Reported symptoms at the time of the interview ( N = 327) Variable Frequency (%) Weakness 247 (75.5%) Body aches 217 (66.4%) Pallor 187 (57.2%) Anorexia 180 (55.0%) Nausea and vomiting 155 (47.4%) Epigastric pain 137 (41.9%) Abdominal distension 136 (41.6%) Abdominal pain 126 (38.5%) Sweating …

Acute Myelin Oligodendrocyte Glycoprotein-IgG Optic Neuritis without Optic Nerve Enhancement.

INTRODUCTION: Optic neuritis (ON) is a common neuro-ophthalmological condition and remains a significant indicator of inflammatory conditions affecting the central nervous system. Varying etiologies exist for ON including multiple sclerosis, NMOSD, and MOGAD. Differential diagnosis is achieved using both radiological and serological testing. MRI characteristics of MOG-ON include T2 hypersensitive lesions, nerve swelling, and gadolinium enhancement of the affected optic nerve. While acute MOG-ON usually presents with optic nerve enhancement, recognizing atypical presentations is critical in acc

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… There was mild right optic disc pallor at that time. 3T orbital MRI with contrast of a 67-year-old woman 5 days after vision loss from right MOG-IgG-ON which showed no optic nerve enhancement. …

Hematology and Immune-Related Disorders

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… Mucous membrane pallor is a common physical finding. If hemolysis is present, the mucous membrane color may be icteric. Decreased peripheral perfusion from causes such as shock or congestive heart failure may also cause pallor, whereas hepatic failure can result in icterus. … Physical findings are not specific for PK deficiency and may include pallor, lethargy, icterus, or weight loss. Mild to moderate splenomegaly is common. …

Выбор дозы Окрелизумаба для лечения педиатрического релапсирующего многообразного склероза: результаты исследования ОПЕРЕТТА I.

В рамках представленного исследования был выявлен соответствующий режим дозирования для пациентов с педиатрическим множественным склерозом (POMS). МЕТОДЫ: Пациенты, достигшие возраста 10-17 лет обучения в когорте 1 (вес тела [BW] < 40 кг, ocrelizumab 300 мг) и группа 2 (БО) ≥ 40 кг, ocrelizumab 600 мг) в течение года 24-week Период исследования дозы (DEP), за которым следует факультативная окролизумаб (представляется каждый 24 неделями) продление. ПРИМЕНИТЕЛЬНЫЕ ЭНАНКИНТЫ: фармакокинетика, фармакодинамика (CD19+B-class) (число клеток); вторичная конечная точка: безопасность; исследовательские

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… 1 3 14  Dose 2 1 6  Dose 3 0 6  Dose 4 0 4  Dose 5 1 5  Dose 6 0 5  Dose 7 0 2  Dose 8 0 2  Dose 9 0 0 Most frequent symptoms of IRRs, n of events (n of patients)  Headache 1 (1) 20 (7)  Throat irritation – 14 (4)  Fatigue – 6 (5)  Rash – 6 (3)  Myalgia – 5 (2)  Dizziness 1 (1) –  Flushing 1 (1) –  Pallor … 1 3 14  Dose 2 1 6  Dose 3 0 6  Dose 4 0 4  Dose 5 1 5  Dose 6 0 5  Dose 7 0 2  Dose 8 0 2  Dose 9 0 0 Most frequent symptoms of IRRs, n of events (n of patients)  Headache 1 (1) 20 (7)  Throat irritation – 14 (4)  Fatigue – 6 (5)  Rash – 6 (3)  Myalgia – 5 (2)  Dizziness 1 (1) –  Flushing 1 (1) –  Pallor …

Factor X deficiency: An overlooked cause of bleeding in the newborn.

Inherited factor X (FX) deficiency is a rare autosomal recessive bleeding disorder, presenting with various bleeding manifestations ranging from nonspecific bruising to life-threatening intracranial hemorrhage. It is often misdiagnosed as hemorrhagic disease of the newborn. It is characterized by prolonged prothrombin time, as well as activated partial thromboplastin time, and needs FX level assay for definitive diagnosis. Here, we describe a case of a newborn with FX deficiency who presented with frank umbilical stump bleeding.

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… Figure 1 Pedigree chart of the family showing pattern of inheritance On examination, the baby had significant pallor, heart rate was 180/min, respiratory rate was 62/min, capillary refill time was prolonged (4 s), and saturation was 97% on room air with active umbilical stump bleeding. …

Случай критической дигит-изхимии у пациента с предполагаемой Серонегативной Склеродермой диагностирован через "Найлфолд" "Кастероскопия".

Системный склероз (scleroderma) может проявляться с помощью современных симптомов ишемической васкулопатии, включая развитие цифровой язвы. Эти язвы могут быть невосприимчивыми и вредными для качества жизни пациента, поэтому быстрый диагноз, дифференциация с другими сосудистыми этиологиями и лечение имеют важное значение для спасения этой ткани. Однако диагностика склеродермы может быть трудной при возникновении серонгегирующего заболевания. Капиллероскопия с капильероскопией Nailwold является жизненно важным инструментом, который может помочь с диагностикой в серонегативных случаях. Склеродер

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… At the time of her last visit with her primary care provider in December 2025, the patient was completing a prednisone taper prescribed by her outside rheumatologist with physical exam documentation noting no evidence of color change, pallor, or wounds. 3. …

Mucormycosis during Imatinib treatment: case report.

UnlabelledPhiladelphia chromosome positive acute lymphoblastic leukemia is classified as a very high-risk group and it requires an intensive chemotherapy regimen associated with tyrosine-kinase inhibitors and allogeneic hematopoietic stem cell transplant from related or unrelated HLA matched donor. Most times, intensive chemotherapy regimens are associated with prolonged and profound pancytopenia when the risk of invasive fungal infection increases. After Candida and Aspergillus species, Mucormycosis is the third frequent fungal infection in hematology patients and it is associated with a redu

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… On admission: good performance status, no fever, mild pallor, no active bleeding, no lymphadenopathies, no hepatomegaly, spleen at 2 cm under costal rebord. The blood count showed: Hb=12.6 g/ dl, Ht=36.8%, MCV=79 fL, Wbc=3910/ mm3 Plt=10000/ mm3. …

Cancer of the prostate presenting with diffuse osteolytic metastatic bone lesions: a case report.

UnlabelledIntroductionProstate cancer is the second most common cancer in men and the fifth most common cancer worldwide. In the USA it is more common in African-American men than in Caucasian men. Prostate cancer frequently metastasizes to bone and the lesions appear osteoblastic on radiographs. Presentation with diffuse osteolytic bone lesions is rare. We describe an unusual presentation of metastatic prostate cancer with diffuse osteolytic bone lesions.Case presentationA 65-year-old Namibian man presented with anemia, thrombocytopenia and worsening back pains. In addition he had complaints

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… On examination the patient had moderate pallor and mild wasting. The right shoulder joint was swollen and tender with limited range of movement (Figure 1 ). He had tenderness to percussion over the thoracic and lumbar spines with no swelling or deformity noted. …

Идиопатический цервициальный трансверсальный миелит, преобладающий с нижним Лимбом слабая и автономная дисфункция: доклад о реалистическом случае.

Трансверсный миелит (TM) — это редкое нервно-воспалительное расстройство, которое может привести к значительной заболеваемости, если не диагностировать и не лечить. Мы сообщаем о случае 40-летней женщины, которая в течение двух месяцев испытывала постепенную двустороннюю слабость нижних конечностей и недержание мочеиспускания. Неврологическая экспертиза выявила верхние моторные нейроны и определенный уровень сенсорности, что вызывает подозрения в патологии спинного мозга. МРТ шейного отдела позвоночника выявила гиперинтенсивные повреждения, взвешенные на Т2 и Коротком тау инверсионном восстано

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… Mild pallor was observed, and vital signs were within normal limits. Neurological examination revealed increased muscle tone in all four limbs, more pronounced in the lower extremities. …

Dermatologic Emergencies

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… EM minor is generally induced by HSV or other viral reactivation and the lesions have a classic target appearance with three zones: dusky center, erythema, and outer pallor. Lesions tend to be acrally distributed. … Classic target lesion of erythema multiforme has a dusky center surrounded by erythema and pallor. The central portion represents epidermal damage and can also present as bullous or crusted lesions Fig. 22.9 Erythema multiforme. …

Celiac Disease Emerging After ASCT in Multiple Myeloma: A Rare Diagnostic Intersection and Literature Review.

BackgroundAutologous stem cell transplantation (ASCT) is a standard component of therapy for eligible patients with multiple myeloma. Persistent gastrointestinal symptoms after ASCT are commonly attributed to infection, medication-related toxicity, or disease relapse, whereas autoimmune enteropathies such as celiac disease are rarely considered.Case presentationWe report a 53-year-old woman with lambda light-chain multiple myeloma who achieved complete remission after bortezomib, lenalidomide, and dexamethasone induction followed by ASCT and lenalidomide maintenance. Four months after transpla

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… Physical examination revealed pallor and swelling localized to the right forearm. …

An adult patient with systemic mastocytosis and B-acute lymphoblastic leukemia.

Mastocytosis is a myeloproliferative neoplasm characterized by clonal expansion of abnormal mast cells, ranging from the cutaneous forms of the disease to mast cell leukemia. In a significant proportion of patients, systemic mastocytosis (SM) coexists with another hematologic malignancy, termed systemic mastocytosis with an associated hematologic nonmast cell lineage disorder (SM-AHNMD). Despite the pronounced predominance of concomitant myeloid neoplasms, the much more unusual coexistence of lymphoproliferative diseases has also been reported. Imatinib mesylate (IM) has a role in the treatmen

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… Case Report A 40-year-old Caucasian female was admitted displaying symptoms of weakness and fatigue, being febrile (37.9°C) with moderate pallor. Her liver was palpable, as well as a slightly enlarged left inguinal lymph node. …

Acute Esophageal Necrosis: A Case Series From a Safety Net Hospital.

Acute esophageal necrosis (AEN) or "black esophagus" is a rare clinical condition, endoscopically characterized by diffuse circumferential black esophageal mucosa. Etiologies include hypoperfusion, infections, and corrosive injury. Consideration of this condition as a differential diagnosis is important, as early diagnosis and treatment has implications on survival. In this article, we present four unique cases of acute esophageal necrosis who were managed conservatively.

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… The patient may appear cachectic, have pallor, fever, hypoxia, and abdominal tenderness, with guaiac-positive stools. Laboratory studies often show leukocytosis. …

Calcium channel blockers for primary and secondary Raynaud's phenomenon.

BACKGROUND: Raynaud's phenomenon is a vasospastic disease characterized by digital pallor, cyanosis, and extremity pain. Primary Raynaud's phenomenon is not associated with underlying disease, but secondary Raynaud's phenomenon is associated with connective tissue disorders such as systemic sclerosis, systemic lupus erythematosus, and mixed connective tissue disease. Calcium channel blockers promote vasodilation and are commonly used when drug treatment for Raynaud's phenomenon is required. OBJECTIVES: To assess the benefits and harms of calcium channel blockers (CCBs) versus placebo for trea…

Exploring the Rare Etiology of Severe Anemia in an Immunocompromised Patient.

Pure red cell aplasia (PRCA) is a rare cause of profound anemia, marked by very low reticulocyte count and near to complete absence of erythroid precursor cells in the bone marrow. PRCA can be congenital such as in the case of children with Diamond- Blackfan anemia or acquired, which is often triggered by exposure to certain viruses or drugs. Management depends on the underlying etiology of PRCA. Here, we present the case of a young male with underlying acquired immunodeficiency syndrome, who presented with a hemoglobin of 2.6 g/dL, initially thought to be secondary to gastrointestinal blood l

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… Clinically, PRCA has an insidious presentation; most individuals are asymptomatic until the Hgb is severely reduced with manifestations of significant pallor and decreased exercise tolerance. …

Multiple myeloma revealed by spinal cord compression and herpes zoster in a 36-year-old Cameroonian.

Multiple myeloma is a malignant plasma cell disorder occurring mostly in people above 60 years old. The authors describe a case of multiple myeloma in a 36-year-old patient revealed by spinal cord compression and Herpes zoster with a rapidly unfavourable outcome.

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… Her physical examination on admission revealed altered general state with weight loss, pallor and fever (38.5°C). There was spastic paraparesis with a 2/5 muscle strength in both lower limbs, hypoesthesia with sensory level at T8 dermatome. …