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Normal Absolute Monocyte Count at the Time of Relapse is Associated with Improved Survival After First Salvage Therapy in Adult Patients with Early Relapsed B-Lineage Acute Lymphoblastic Leukemia.

BackgroundPeripheral monocytes, a key cell type for innate immunity, have been shown to be associated with survival in various types of hematological malignancies. However, no previous studies regarding the prognostic impact of peripheral absolute monocyte count (AMC) in early relapsed B-lineage acute lymphoblastic leukemia (B-ALL) have been reported.MethodsForty-nine cases of early relapsed adult B-ALL were reviewed. The upper (0.80 × 109/L) and lower limits (0.12 × 109/L) of the normal value for AMC were used as cut-off points. Kaplan-Meier curves and Log rank test were used for comparison o

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… Agranulocytosis with fever was treated with empirical antibiotics-piperacillin-tazobactam combination, cefoperazone sodium and sulbactam sodium, imipenem, or meropenem. … Patients who did not respond in 72 hours (or earlier if the evidence of hemodynamic changes) received additional voriconazole or the piperacillin-tazobactam combination (or cefoperazone sodium and sulbactam sodium) was changed to imipenem (or meropenem). …

Audio-Visual Hallucinations in a Patient Poststem Cell Transplant.

Tramadol is the most common weak opioid used today. It has unique pharmacology and is notorious for numerous side effects as well as drug interactions. Patients undergoing stem cell transplant are susceptible to polypharmacy as a result of the generous use of antibiotics and symptom management drugs. Here, we describe a case where concurrent use of tramadol and fluconazole can cause hallucinations as a result of drug interaction.

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… He was investigated with blood cultures and was started on a comprehensive regimen of broad-spectrum antibiotics which included ceftriaxone, amikacin, metronidazole, teicoplanin, piperacillin-tazobactam, and fluconazole, given his immunocompromised status. …

A multicenter prospective study of 515 febrile neutropenia episodes in Argentina during a 5-year period.

For better management of patients with febrile neutropenia, our study investigated the epidemiologic, microbiologic, and clinical characteristics of adult inpatients with febrile neutropenia and their mortality-associated factors. To this end, we carried out a prospective, observational, multicenter study in 28 Argentinian hospitals between 2007 and 2012. We included 515 episodes of febrile neutropenia from 346 patients, median age 49 years. Neutropenia followed chemotherapy in 77% of cases, half of the cases due to hematological malignancies. Most episodes were classified as high-risk accordi

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… The prevailing antibiotic schedule consisted of the combination of ceftazidime plus amikacin, followed by piperacillin/tazobactam and carbapenems. … The commonest antibiotic schedule employed in this patient series consisted of ceftazidime plus amikacin, followed by piperacillin/tazobactam, or carbapenems and cefepime as monotherapy. …

Multidisciplinary approach to prostatitis.

The modern clinical research on prostatitis started with the work of Stamey and coworkers who developed the basic principles we are still us … rins or fluoroquinolones, is recommended in combination with an aminoglycoside. Use of piperacillin-tazobactam and meropenem is justified in presence of multiresistant gramnegative pathogens. The antibiotic treatment of chronic prostatitis is currently based on the use of fluoroquinolones that, given for 2 to 4 weeks, cured about 70% of men with chronic bact …

Hyperammonemic Encephalopathy in Multiple Myeloma: A Case Report.

Multiple myeloma (MM) typically presents as lytic bony lesions, hypercalcemia, anemia, and renal failure. Only a few cases of hyperammonemic encephalopathy (HE) attributed to multiple myeloma have been reported. We report a case of a 68-year-old Hispanic female diagnosed with multiple myeloma and presented with altered mental status and elevated ammonia levels found to have HE. The pathology behind HE is associated with higher ammonia levels produced by myeloma cell lines in the absence of liver disease. Due to the wide range of differentials for altered mental status (AMS), HE often gets miss

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… Despite optimized supportive care with pamidronate, calcitonin, and fluid hydration leading to improvement in hypercalcemia, lactulose, and rifaximin for ammonia and piperacillin-tazobactam antibiotics for UTI, the patient continued to exhibit worsening mentation and repeat ammonia was found to be 107 …

Chronic granulomatous disease secondary to a rare compound heterozygote mutation in an adolescent cured by hematopoietic stem cell transplantation: a case report.

BackgroundChronic granulomatous disease (CGD) is a rare inherited primary immunodeficiency characterized by recurrent infections and aberrant inflammation due to defects in the nicotinamide adenine dinucleotide phosphate (NADPH) oxidase complex.Case presentationWe report a case of recurrent pneumonia and significantly elevated IgE levels in an adolescent. Metagenomic next-generation (mNGS) sequencing contributed to the identification of Burkholderia multivorans in bronchoalveolar lavage fluid and the initiation of appropriate treatment. Whole exome sequencing (WES) revealed two point mutations

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… | 32 | 0–15 Immunoglobulin G | 15.95 | 7–17 Immunoglobulin A | 8.17 | 0.7–4 Immunoglobulin M | 1.02 | 0.4–2.3 Immunoglobulin E | > 5,000 | 0–60 He had two prior admissions for pneumonia in the preceding six months, which responded to antibiotics including azithromycin, cephalosporin, piperacillin-tazobactam … Trimethoprim/sulfamethoxazole | Recovered 4 | 2018 | Sweden | 57/M | Urine | None | Dysuria and fever | None | Trimethoprim-sulfamethoxazole | Recovered 5 | 2019 | Canada | 23 month/M | Blood, lung tissue | None | Fever | Liver transplant, biliary atresia and Kasai surgery | Cefotaxime, piperacillin/tazobactam …

Psychiatric Symptoms after H1N1 Influenza Treated with Baloxavir Marboxil in Two Patients with Hematologic Malignancies.

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… Meropenem was discontinued and piperacillin-tazobactam was substituted. The patient’s psychiatric symptoms resolved one week later ( Figure 1B ). Discussion Influenza infection can induce acute neuropsychiatric symptoms, primarily manifesting as delirium and abnormal behavior. …

Rare Presentation and Diagnostic Challenge of a Germ Cell Tumor of the Yolk Sac Type.

Opsoclonus-ataxia paraneoplastic syndrome (OAPS) is a rare neurological disorder often associated with malignancies. This case report highlights an unusual instance of OAPS linked to a yolk sac (germ cell) tumor, a correlation underrepresented in the medical literature. The patient presented with distinct neurological symptoms alongside mediastinal lymphadenopathies. The subsequent diagnostic journey revealed a yolk sac germ cell tumor. Following incisional biopsies and treatment, the patient experienced fluctuations in mental status, leading to challenges in initiating chemotherapy. Despite t

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… A microbiological study revealed the presence of Escherichia coli in blood cultures, and the patient received antibiotic therapy with piperacillin/tazobactam, adjusted according to antibiotic sensitivity testing. …

Panniculitis and pancreatitis: Inflammation and necrotic mechanisms in a patient with alcohol use disorder and alarming suspicion for malignant process.

Panniculitis is an inflammatory process localized to subcutaneous tissue, with etiologies including infection, malignancy, external insults, enzymatic destructive processes, and inflammatory disorders. The incidence of panniculitis manifesting as necrosis of subcutaneous fat tissue associated with pancreatic diseases is low, which may encompass associated periarthritis with bone necrosis and panniculitis (Pancreatitis, panniculitis and polyarthritis syndrome). Pancreatitis, panniculitis and polyarthritis syndrome is considered to derive from the systemic activity of enzymes within the pancreas

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… The patient was treated with Piperacillin-Tazobactam for diverticular abscess and intravenous fluids for his pancreatitis and he was discharged home following clinical improvement and resolution of his diverticular abscess on repeat imaging. …

Гут Микробиота Нарушение гематологовой терапии рака: Молекулярное понимание и последствия для эффективности лечения.

Гематологическая магнелезность (ГМ), включая лейкемию, лимфому и множественные миеломы, связана с бесконтрольным распространением аномальных кровеносных клеток, что создает серьезные клинические проблемы из-за их неоднородности и различных методов лечения. Несмотря на недавние достижения в области лечения, благодаря которым повысились показатели выживаемости, особенно в случае хронической лимфоцитической лейкемии и острой лимфоболической лейкемии, такие методы лечения, как химиотерапия и трансплантация стволовых клеток, часто нарушают микробиоту, что может негативно сказаться на результатах ле

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… the intestinal microbiota score could predict survival following allo-SCT. | [ 115 ] Ruminococcaceae | Decrease Erysipelotrichaceae | Decrease Enterobacteriaceae | Increase Allogeneic stem cell transplant | 96 patients | AML ALL LP MM | Family | Lachnospiraceae | Decrease | Antibiotics: piperacillin–tazobactam … ecosystem can be a relevant factor for the success of SCT. | [ 119 ] Ruminococcus | Decrease Enterococcus | Increase Anti-CD19 CAR T-cell therapy | 228 patients 30 controls | NHL ALL | Genus | Enterococcus | Increase | Antibiotic: trimethoprim-sulfamethoxazole, intravenous vancomycin, piperacillin–tazobactam …

Rhabdomyolysis and pandemic (H1N1) 2009 pneumonia in adult.

Аннотация не предоставлена источником. Откройте карточку для перехода к публикации.

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… He was intubated at the time of initial visit to the ED for influenza symptoms, and broad-spectrum antimicrobial drugs were administered (vancomycin 1,000 mg every 12 h, piperacillin-tazobactam 4.5 gm every 6 h, and levofloxacin 750 mg 1×/d). …

Gut Microbiota Dysbiosis and Dietary Interventions in Non-Hodgkin B-Cell Lymphomas: Implications for Treatment Response.

Non-Hodgkin B-cell lymphomas are a heterogeneous group of lymphoid malignancies with variable biological behavior, clinical presentation and treatment response. While chemoimmunotherapy remains the cornerstone of their management, growing evidence implicates the gut microbiota as a critical modulator of both lymphomagenesis and therapeutic efficacy. Gut microbiota dysbiosis, characterized by reduced microbial diversity and pathogenic taxonomic shifts, has been observed also in newly diagnosed patients and not just after therapy. This microbial imbalance contributes to mucosal barrier disruptio

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… Chemotherapy induces mucosal injury, alters bile acid flux, and reduces luminal carbohydrates, while broad-spectrum and anti-anaerobic antibiotics (e.g., carbapenems, piperacillin–tazobactam, some cephalosporins) deplete SCFA, producing commensals such as Faecalibacterium, Blautia, and other Clostridiales … In patients with non-Hodgkin B-cell lymphoma, those who received high-risk antibiotics such as meropenem, cefepime, ceftazidime, and piperacillin–tazobactam during therapy exhibited poorer treatment responses. …

Machine learning-based prognostic model for bloodstream infections in hematological malignancies using Th1/Th2 cytokines.

OBJECTIVE: Bloodstream infection (BSI) is a significant cause of mortality in patients with hematologic malignancies(HMs), particularly amid rising antibiotic resistance. This study aimed to analyze pathogen distribution, drug-resistance patterns and develop a novel predictive model for 30-day mortality in HM patients with BSIs. METHODS: A retrospective analysis of 231 HM patients with positive blood cultures was conducted. Logistic regression identified risk factors for 30-day mortality. Th1/Th2 cytokines were collected at BSI onset, with LASSO regression and restricted cubic spline analysis

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… This study found that common gram-negative bacteria were most sensitive to amikacin, meropenem, imipenem, and piperacillin-tazobactam. Escherichia coli exhibited the highest resistance to ampicillin, cefotaxime, and ceftriaxone, with nearly 50% resistance to levofloxacin and 35.62% to ceftazidime. … Klebsiella pneumoniae showed 24.53% resistance to meropenem and imipenem, 35.85% to ceftazidime, and 45.28% to piperacillin-tazobactam. Pseudomonas aeruginosa demonstrated high resistance (89.47%) to ceftriaxone, cefotaxime, and tigecycline, while it remained sensitive to ceftazidime. …

Impact of Antibiotic Time-Outs in Multidisciplinary ICU Rounds for Antimicrobial Stewardship Program on Patient Survival: A Controlled Before-and-After Study.

The antimicrobial stewardship program (ASP) is an important quality improvement initiative that is recommended in the ICU. However, the shortage of infectious disease physicians in Japan has led to the need for simpler methods for implementing ASPs. We investigated whether antibiotic time-outs (ATOs) during multidisciplinary rounds as part of an ASP can improve patient survival and reduce the number of days of therapy (DOT) with antibiotics.DesignSingle-center controlled before-and-after study.SettingMedical/surgical ICU in a tertiary university medical center in Tokyo, Japan.PatientsAll patie

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… B , DOT with antipseudomonal antibiotics, including tazobactam/piperacillin, ceftazidime, cefepime, cefozopran, meropenem, doripenem, imipenem, ciprofloxacin, levofloxacin, and pazufloxacin. C , DOT with carbapenems, including meropenem, doripenem, and imipenem. … Graber CJ, Jones MM, Glassman PA, et al. : Taking an antibiotic time-out: Utilization and usability of a self-stewardship time-out program for renewal of vancomycin and piperacillin-tazobactam. Hosp Pharm 2015; 50:1011–1024 14. …

Risk factors and characteristics of blood stream infections in patients with newly diagnosed multiple myeloma.

BackgroundPatients with multiple myeloma are generally immune-compromised either due to pronounced depression in primary antibody responses or because of anti-myeloma therapy. Infection is a major risk factor for early deaths among these patients. The impact of blood stream infections (BSI) on newly diagnosed myeloma patients has been less studied. We aimed to study the incidence and risk factors of BSI within 3 months after diagnosis of multiple myeloma in a tertiary referral center.MethodsBetween November 2002 and December 2008, consecutive patients with multiple myeloma in Taipei Veterans G

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… Non-tunneled CVC - Yeast like-Trichosporon asahii Cefepime/azithromycin Y 18 (18) Y VAD - - Yeast like-Candida albicans Ceftazidime/teicoplanin Y Non-nosocomial BSI 1 (221) - - - - Coagulase-negative Staphylococcus species Flomoxef - 2 (41) Y VAD - - Coagulase-negative Staphylococcus species Piperacillin/tazobactam … | Cefepime/azithromycin | Y 18 (18) | Y | VAD | - | - | Yeast like-Candida albicans | Ceftazidime/teicoplanin | Y Non-nosocomial BSI 1 (221) | - | - | - | - | Coagulase-negative Staphylococcus species | Flomoxef | - 2 (41) | Y | VAD | - | - | Coagulase-negative Staphylococcus species | Piperacillin/tazobactam …

Radiologically Guided Renal Artery Embolization with an Amplatzer Vascular Plug as a Rescue Therapy for Refractory Nephrotic Syndrome in AL-Amyloidosis.

Nephrotic syndrome is common in immunoglobulin light-chain (AL) amyloidosis and successful therapy may pose a challenge. We report the case of a 63-year-old patient with severe nephrotic syndrome due to primary renal AL-amyloidosis with well-preserved renal function at first presentation. Therapy with high dose steroids, loop diuretics, and ACE-inhibitors did not affect his proteinuria and he was seriously disabled because of symptomatic orthostatic hypotension and anasarca. With the patient's informed consent, medical nephrectomy was tried with nonsteroidal-anti-inflammatory drugs (NSAIDs), c

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… During the procedure, the patient received an epidural anaesthesia with bupivacaine and a prophylactic antibiotic treatment with piperacillin/tazobactam. Despite his severe illness, the patient tolerated the intervention well. …

Best Practices in the Management of Infectious Complications for Patients With Cancer: Management of Febrile Neutropenia.

Managing infection in patients with neutropenia is a difficult challenge, as fever is often the only clinical symptom. At JADPRO Live 2022, Kyle C. Molina, PharmD, BCIDP, AAVHIP, of the University of Colorado Hospital, discussed the epidemiology and pathophysiology associated with febrile neutropenia in patients with cancer. He reviewed appropriate treatment settings and empiric antimicrobial regimens for a patient and how to formulate a plan to safely de-escalate and target therapy for patients with febrile neutropenia.

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… OPTIONS FOR INITIAL INPATIENT ANTIMICROBIALS When selecting an antimicrobial regimen for a patient, the first approach is to use cefepime, piperacillin-tazobactam, or carbapenem monotherapy, but this may not be effective at certain centers due to high rates of resistance among Pseudomonas bacteria. …

The Role of the Gut Microbiome in Pathogenesis, Biology, and Treatment of Plasma Cell Dyscrasias.

In response to emerging discoveries, questions are mounting as to what factors are responsible for the progression of plasma cell dyscrasias and what determines responsiveness to treatment in individual patients. Recent findings have shown close interaction between the gut microbiota and multiple myeloma cells. For instance, that malignant cells shape the composition of the gut microbiota. We discuss the role of the gut microbiota in (i) the development and progression of plasma cell dyscrasias, and (ii) the response to treatment of multiple myeloma and highlight faecal microbiota transplantat

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… Administration of imipenem–cilastatin or piperacillin–tazobactam for neutropenic fever resulted in gut microbial perturbation and increased graft- versus -host disease-related mortality compared with aztreonam or cefepime, both of which decreased activity against commensal, anaerobic bacteria ( 86 ). … microbiota, while BSBL antibiotics caused a reduction of alpha diversity ( 80 ) Administration of broad-spectrum antibiotics efficient against commensal microbiota resulted in higher transplant-related mortality and decreased overall survival ( 85 ) Patients treated with imipenem–cilastatin or piperacillin–tazobactam …

Синдром высвобождения цитокина, связанный с Teclistamab, в множестве миеломы: анализ литературы на основе конкретных примеров о механизмах, управлении и клинических последствиях.

Синдром высвобождения цитокина (CRS) — потенциально опасное для жизни состояние, которое может возникнуть после иммунной терапии, как, например, биконкретные антитела. Мы представляем пример 66-year-old Женщина с повторной/редактированной миеломой, разработавшая смертельные ДУС после лечения с помощью Teclistamab, биконкретного антитела, нацеленного на CD3 на клетки Т, и антигена созревания B-клеток на клетки миеломы. Ранее пациент достиг ремиссии с ритуксимабом, борцезомибом и аутологической трансплантацией стволовых клеток, однако после этого он столкнулся с рецидивом. eight Годы. Teclistama

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… The patient was hospitalized with a diagnosis of sepsis and started on antibiotic treatment with piperacillin/tazobactam and vancomycin. …

A Case of Multiple Myeloma Associated with Extramedullary Plasmacytoma of the Gallbladder Manifesting as Acute Cholecystitis.

Multiple myeloma (MM) is a common hematological malignancy that represents 1% of all cancers. MM is distinguished from other plasma cell disorders by prominent bone marrow involvement and systemic organ damage. Extramedullary plasmacytomas of the gall bladder (GB) or biliary ducts, whether solitary or in association with MM, are very rare. We report a case of a 66-year-old female with a history of refractory MM who presented with right upper quadrant abdominal pain. Her laboratory evaluation revealed an abnormal liver panel and lactic acidosis. Abdominal ultrasonography was consistent with acu

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… Intravenous piperacillin-tazobactam 3.37 g every eight hours was initiated, and the patient was referred for open cholecystectomy given her overall condition and lactic acidosis. Intra-operatively, the GB was thickened and firm but not overly distended or perforated. …