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[A case of left dorsomedial thalamic infarction with unilateral schizophrenia-like auditory hallucinations].

We report a case of a right-handed, 73-year-old woman with auditory hallucinations lateralized to the right ear. A brain MRI revealed a smal … ned out to persistent. On the other hand, the hallucinations did not ameliorate satisfactorily with risperidone (3-6 mg/day), but on augmentation with olanzapine (5-20 mg/day), they lessened gradually and almost disappeared within 6 months. She also slowly developed symptoms similar to those of frontal lobe syndrome, i.e., aspontaneity and apathy. In conclusi …

The Expert Consensus Guideline Series: Medication Treatment of Bipolar Disorder 2000.

OBJECTIVES: New treatments for bipolar disorder have been reported since we first published survey-based expert consensus guidelines in 1996 … as potential adjuncts in non-psychotic episodes. Atypical antipsychotics, especially olanzapine and risperidone, were generally preferred over conventional antipsychotics. Recommendations are also given concerning the use of electroconvulsive therapy (ECT), clozapine, thyroid hormone, stimulants, and various novel agents for patients with treatment-refractory …

Metabolic monitoring for youths initiating use of second-generation antipsychotics, 2003-2011.

OBJECTIVE: In 2004, the American Diabetes Association (ADA) released treatment guidelines recommending metabolic screening for children and adolescents before and after initiation of second-generation antipsychotics. Prior studies showed that the guidelines coincided with a small increase in glucose testing of children and adults but had limited follow-up. This study sought to evaluate changes in metabolic screening of children initiating second-generation antipsychotics around the time of the 2004 guidelines and in the following eight years. METHODS: Study patients (N=52,407) were identified

Parent-rated anxiety symptoms in children with pervasive developmental disorders: frequency and association with core autism symptoms and cognitive functioning.

BACKGROUND: In addition to the core symptoms, children with Pervasive Developmental Disorders (PDD) often exhibit other problem behaviors such as aggression, hyperactivity, and anxiety, which can contribute to overall impairment and, therefore, become the focus of clinical attention. Limited data are available on the prevalence of anxiety in these children. We examined frequency and correlates of parent-rated anxiety symptoms in a large sample of children with PDD. METHODS: The goals of this study were to examine the frequency and correlates of parent-rated anxiety symptoms in a sample of 171

Внутригиппокампальный нейроцитома, представляющая собой синдром Клейне-Левина: исчезновение после резекции и обзор нейрохирургических состояний, связанных с гиперсексуальностью. Иллюстративный случай.

ФОН: Синдром Клине-Левина (СКЛ) — редкое заболевание, характеризующееся повторяющимися приступами гиперсомнии, сопровождающимися одним или несколькими из следующих симптомов: нарушением когнитивных функций, гиперфагией, гиперсексуальностью, апатией и дереализацией/изменением восприятия. Боли в голове и/или рвота могут предшествовать началу гиперсомнии. СКЛ, вызванная поражениями, интересующими нейрохирурга, крайне редко встречается и описывалась только один раз после кровоизлияния, осложновавшего эндоскопическую удаление коллоидной цисты. Наблюдения: 25-летний мужчина без личной или семейной

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… In the majority of cases, both sKLS and HS improved either spontaneously or after therapies with lithium or citalopram or sertraline and risperidone. In all cases except one, the right side of the brain of male patients contained the lesion(s). … 24 HS 34 M Hamartoma Hypothalamus NA Citalopram therapy Gorman & Cummings, 1992 33 HS 76 M Injury by ventricular catheter Septum Rt No Gorman & Cummings, 1992 33 HS 75 M Injury by ventricular catheter Septum Lt No Cao et al., 2010 41 HS 35 F Arteriovenous malformation Occipital lobe Lt Sertraline, risperidone …

When Iron Bites Back: Severe Thrombocytopenia After Intravenous Iron Sucrose Therapy (Venofer).

Iron deficiency anemia (IDA) commonly presents with normal or elevated platelet counts, while thrombocytopenia is rare. Intravenous iron sucrose (Venofer) is widely used and generally well tolerated. We report the case of a 71-year-old female with chronic IDA who developed severe thrombocytopenia following iron sucrose therapy. Baseline hemoglobin was 6.3 g/dL with a platelet count of 229 × 10³/µL. After two doses of intravenous iron, hemoglobin improved to 9.3 g/dL, but platelets rapidly declined to 11 × 10³/µL. Extensive workup excluded thrombotic microangiopathy, autoimmune disease, infecti

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… Her past medical history was significant for atrial fibrillation on apixaban for CHA₂DS₂-VASc-guided anticoagulation, prior pulmonary embolism on aspirin 81 mg, cerebrovascular accident with no residual deficits, schizophrenia managed with risperidone 2 mg nightly, hypertension on amlodipine 10 mg daily … Risperidone, prescribed for schizophrenia management, was discontinued given its rare association with thrombocytopenia. Infectious etiologies were considered unlikely contributors to the thrombocytopenia given the absence of leukocytosis, pyrexia, or systemic inflammatory symptoms. …

Antipsychotic prescriptions in people with dementia in primary care: a cohort study investigating adherence of dose and duration to UK clinical guidelines.

BACKGROUND: In the UK, it is recommended by the National Institute for Health and Care Excellence (NICE) that if antipsychotics are initiate … ] on low dose, 14·8% [13·9-15·6] on moderate or high dose of haloperidol, olanzapine, quetiapine or risperidone; and 14·6% [13·8-15·5] on other antipsychotics). Of the 5547 individuals eligible to restart treatment after initial discontinuation, 3106 (56%) restarted with a median treatment duration of 2·6 months (IQR 0·0-9·9). INTERPRETATION: This study high …

Emergency Department Management of Common End-of-Life and Palliative Care Symptoms: Three Cases

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… For nausea-refractory cases, atypical antipsychotics, such as olanzapine or risperidone, can be initiated [ 12 ]. For patients with brain tumors, corticosteroids are first-line therapy, given their ability to decrease cerebral edema [ 12 ]. … Alternatively, olanzapine and risperidone are also effective treatments [ 15 ]. For patients with Parkinson's disease, quetiapine would be the preferred antipsychotic [ 15 ]. Benzodiazepines such as lorazepam should be avoided if possible, as they may exacerbate symptoms (Figure 5 ) [ 24 ]. …

Prescription and use of psychoactive medications among cancer patients and associated factors in lower and upper middle-income countries: systematic review.

PURPOSE: To describe the prescription and use of psychoactive medications among cancer patients in low- and middle-income countries (LMICs) and explore the factors influencing their prescription and use. METHODS: This systematic review was conducted following the PRISMA guidelines. Six electronic databases were searched. We included observational studies that investigated the prescription and use of psychoactive medications among adult cancer patients in low- and middle-income countries (LMICs) according to the 2024 World Bank's classification. Eligible studies specifically focused on the use

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… Antipsychotics, such as haloperidol (first-generation), and second-generation antipsychotics including quetiapine, olanzapine, risperidone, and aripiprazole, were used for managing psychotic symptoms and acute agitation. Across studies, psychotropic medication use showed marked variability. … (18%) *Benzodiazepines (56.8) *Tricyclic antidepressant, atypical antidepressant and Serotonin reuptake inhibitors (SSRI) (31.8%) *Atypical antipsychotics (43.1%) *Conventional antipsychotics. (13.6%) *Alprazolam, Lorazepam, Clonazepam *Amitriptyline, Mirtazapine and SSRIs *Quetiapine, Olanzapine, Risperidone …

Challenges in Treating Cancer Patients With Unstable Psychiatric Disorder.

In this review, we first present a case of chronic myeloid leukemia with acute psychosis, and then we will discuss the incidence of cancer in patients with psychotic disorders, the manifestations of new-onset psychosis, and the prevalence of preexisting psychosis in cancer patients, coupled with their impact on the treatment, diagnosis, and prognosis of cancer. This was a case that presented with acute psychosis and was found to have an elevated white blood cell count upon admission to an inpatient psychiatric unit. He was diagnosed with chronic myeloid leukemia and successfully managed with i

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… Haloperidol is the first-line drug for psychosis in cancer patients, followed by risperidone and low-dose quetiapine in general hospital settings [ 72 ]. Antipsychotic medications are known to have high rates of adverse effects. … Treatment of delirium with risperidone in cancer patients. Psychiatry Clin Neurosci. 2012;66(5):411–417. doi: 10.1111/j.1440-1819.2012.02346.x. 58. Reutfors J, Wingard L, Brandt L, Wang Y, Qiu H, Kieler H, Bahmanyar S. Risk of breast cancer in risperidone users: A nationwide cohort study. …

Agitated Psychiatric Patient.

AUDIENCE: This scenario was developed to educate emergency medicine residents about the diagnosis and management of the agitated psychiatric … chotics (eg, haloperidol and droperidol), second-generation antipsychotics (olanzapine, quetiapine, risperidone, aripiprazole, and ziprasidone), benzodiazipenes (eg, lorazepam and midazolam), and N-methyl-D-aspartic acid (NMDA) receptor antagonists (eg, ketamine).7,8 It is important to exclude other medical causes of agitation, consider the differential diagn …

Clinical effectiveness and patient perspectives of different treatment strategies for tics in children and adolescents with Tourette syndrome: a systematic review and qualitative analysis.

BACKGROUND: Tourette syndrome (TS) is a neurodevelopmental condition characterised by chronic motor and vocal tics affecting up to 1% of sch … young people with TS. The balance of benefits and harms favours the most commonly used medications: risperidone (Risperdal(®), Janssen), clonidine and aripiprazole (Abilify(®), Otsuka). Larger and better-conducted trials addressing important clinical uncertainties are required. Further research is needed into widening access to behavioural interventions throu …

Use of real-world evidence in the Medicare Drug Price Negotiation Program: A checklist for the Centers for Medicare and Medicaid Services and manufacturers.

Under the Inflation Reduction Act's (IRA's) - Medicare Drug Price Negotiation Program, the Centers for Medicare & Medicaid Services' (CMS's) "maximum fair price" must be informed by evidence on factors such as therapeutic advance of the selected drug compared with its alternative, comparative effectiveness across clinical and patient-reported outcomes, the impact on specific populations, and the ability to address unmet medical needs. This paper describes how real-world evidence could improve CMS decision-making and creates a best practices checklist to help CMS evaluate the quality of any man

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… Comparative efficacy and safety of long-acting risperidone and risperidone oral tablets. Eur Neuropsychopharmacol. 2005;15(1):111–117. 10.1016/j.euroneuro.2004.07.003 19. Lin D, Thompson-Leduc P, Ghelerter I, et al. …

Manic and hypomanic states in cancer patients: A systematic review.

OBJECTIVES: While there have been reports on the relationship between cancer and depression, reports on the association between cancer and manic states, a reciprocal state of depression, have been relatively few. Therefore, we conducted a systematic review on the relationships between cancer and manic states, focusing on their etiology, clinical course, and impact on cancer treatments. METHODS: A systematic review was conducted using four electronic databases, following the PRISMA guidelines. The scope of the study included research on manic or hypomanic states associated with cancer in patie

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… | 10 | 300–600 | | Benzodiazepines | | Lorazepam | 6 | 1–4 | | 10–40 Clonazepam | 4 | 0.5–2 | | 10–40 Among the antipsychotics, haloperidol was predominantly used, followed by risperidone and olanzapine. … Molecular Psychiatry 27 ( 2 ), 1136 – 1144 . doi: 10.1038/s41380-021-01334-4 . 34642461 PMC9054678 Kramer TM and Cottingham EM ( 1999 ) Risperidone in the treatment of steroid-induced psychosis . …

Progressive gray matter reduction of the superior temporal gyrus during transition to psychosis.

CONTEXT: Longitudinal magnetic resonance imaging studies have shown progressive gray matter reduction in the superior temporal gyrus during the earliest phases of schizophrenia. It is unknown whether these progressive processes predate the onset of psychosis. OBJECTIVE: To examine gray matter reduction of the superior temporal gyrus over time in individuals at risk for psychosis and in patients with first-episode psychosis. DESIGN: Cross-sectional and longitudinal comparisons. SETTING: Personal Assessment and Crisis Evaluation Clinic and Early Psychosis Preventions and Intervention Centre.

A Transcriptome-Based Drug Discovery Paradigm for Neurodevelopmental Disorders.

Advances in genetic discoveries have created substantial opportunities for precision medicine in neurodevelopmental disorders. Many of the genes implicated in these diseases encode proteins that regulate gene expression, such as chromatin-associated proteins, transcription factors, and RNA-binding proteins. The identification of targeted therapeutics for individuals carrying mutations in these genes remains a challenge, as the encoded proteins can theoretically regulate thousands of downstream targets in a considerable number of cell types. Here, we propose the application of a drug discovery

New directions in the treatment of autism spectrum disorders from animal model research.

INTRODUCTION: Currently, there is not an effective pharmacotherapy for the core symptoms of the autism spectrum disorders (ASD), which include aberrant social behavior, delayed communication and repetitive behavior and/or restricted interests. There are several drugs that treat the symptoms associated with autism including irritability, aggressiveness and hyperactivity. Current drug research is based on the ongoing genetic, animal model and neuropathologic research. Two areas in particular, the glutamate and oxytocin systems, provide exciting new avenues for drug discovery. AREAS COVERED: Thi

Antipsychotics with inverse agonist activity at the dopamine D3 receptor.

In NG 108-15 cells expressing the recombinant human D3 receptor, dopamine agonists enhance [3H]thymidine incorporation and decrease cAMP accumulation. In these cells, but not in wild type cells, haloperidol, fluphenazine, and various other antipsychotics inhibited basal [3H]thymidine incorporation in a concentration-dependent manner. In contrast, other dopamine antagonists such as nafadotride or (+)AJ 76, two D3-preferring antagonists, were without effect. The concentration-response curve of haloperidol was shifted to the right in presence of nafadotride, with a potency compatible with its nan

Глубокая стимуляция мозга в гипоталамической области: систематический обзор.

КОЛИЧЕСТВО: Глубокая стимуляция мозга (БРС) успешно используется для лечения циклопатии, включая движение, беспокойство и поведенческие расстройства. Гипоталамус является важнейшим интеграционным центром для многих периферийных и центральных путей, связанных с сердечно - сосудистыми, метаболическими и поведенческими функциями, и представляет собой потенциальную цель нейромодуляции в лечебных условиях. Проведение систематического обзора, изучение гипоталамических целей в ДБС, их признаков и основных клинических результатов.МЕТОДЫ: База данных PubMed, Scopus и Web of Science была подвергнута обы

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… Olanzapine (4, 57.1%), levomepromazine (3, 42.9%), clorazepate (3, 42.9%), valproate (2, 28.6%), topiramate (2, 28.6%), risperidone (2, 28.6%), gabapentin (2, 28.6%), clotiapine (2, 28.6%), biperiden (2, 28.6%), zuclopentixol (1, 14.3%), valproic (1, 14.3%), simvastatin (1, 14.3%), rivotril (1, 14.3% … Olanzapine (4, 57.1%), levomepromazine (3, 42.9%), clorazepate (3, 42.9%), valproate (2, 28.6%), topiramate (2, 28.6%), risperidone (2, 28.6%), gabapentin (2, 28.6%), clotiapine (2, 28.6%), biperiden (2, 28.6%), zuclopentixol (1, 14.3%), valproic (1, 14.3%), simvastatin (1, 14.3%), rivotril (1, 14.3% …

Effect of psychotropic medications on suicide-related outcomes: a systematic review and meta-analysis of observational studies.

BACKGROUND: Psychiatric disorders are associated with increased risk of suicide-related outcomes, and the impact of pharmacological treatmen … uced risks of suicide attempts: olanzapine (OR = 0.76; 0.60-0.98; I2 = 84%, moderate certainty) and risperidone (OR = 0.61; 0.52-0.72; I2 = 57%, moderate certainty). In bipolar disorder, lithium (OR = 0.38; 0.28-0.50; I2 = 67%, moderate certainty) and valproic acid (OR = 0.66; 0.59-0.75; I2 = 0%, high certainty) were associated with lower suicide risks, and l …