Результаты поиска

How histone modifications influence cellular radiosensitivity: Pharmaceutically targeting epigenetic regulators as a promising avenue to overcome radioresistance.

Cancer remains the leading cause of mortality worldwide. Radiotherapy (RT), a cornerstone of oncological treatment for over a century, has achieved great success in various cancers. However, radioresistance remains the primary factor leading to the failure of radiotherapy. Histone modifications in cancer cells are known to play a pivotal role in regulating radiosensitivity by modulating chromatin structure, either by loosening or tightening it. Here, we provide a comprehensive summary of the link between aberrant histone modifications and radiation resistance across various cancer and normal t

Efficacy of repetitive transcranial magnetic stimulation on postoperative pain in patients undergoing video-assisted thoracoscopic surgery: study protocol for a prospective, single-center, randomized controlled trial.

BACKGROUND: Video-assisted thoracoscopic surgery (VATS) is a key treatment for many cardiothoracic issues, but intraoperative factors can lead to acute postoperative pain (APSP), impacting recovery and quality of life. While multimodal analgesic methods are used, they have notable side effects. Repetitive transcranial magnetic stimulation (rTMS) offers a non-invasive pain relief option by stimulating the primary motor cortex (M1), effective in chronic pain management. However, its role in preventing and treating APSP after VATS needs confirmation through high-quality clinical trials. METHODS/

Совпадение в полном тексте источника
… Qi Y Zhou M Zheng W Dong Y Li W Wang L et al . Effect of S-Ketamine on postoperative nausea and vomiting in patients undergoing video-assisted thoracic surgery: a randomized controlled trial. Drug Des Devel Ther. ( 2024 ) 18 : 1189 – 98 . 10.2147/dddt.S449705 38645990 PMC11032156 16. …

Risk Factors for Adverse Outcomes in Cancer Patients With Sepsis.

BACKGROUND: Cancer and its various treatment modalities increase susceptibility to the development of sepsis. Because of the complex relationship between sepsis and cancer, we aimed to study the differences in risk factors and outcomes of sepsis in patients with cancer (SCa) compared to patients without cancer (SnoCa). METHODS: A retrospective cohort analysis of all adult patients who received care for sepsis in an urban tertiary healthcare center was conducted. Risk factors and outcomes were compared between the SCa and SnoCa groups. RESULTS: SCa group (n = 310) was older than SnoCa group (

Совпадение в полном тексте источника
… two-sample Mendelian randomization study Postgrad Med J 2023 99 1178 1266 1271 10.1093/postmj/qgad072 37681245 29 Patel AV Patel KS Teras LR Excess body fatness and cancer risk: a summary of the epidemiologic evidence Surg Obes Relat Dis 2023 19 7 742 745 10.1016/j.soard.2023.01.025 36918326 30 Hou C Qi …

Mapping the research trends and hotspots on solid pulmonary nodules from 2000-2024: insights from bibliometric analysis.

BackgroundDue to extensive low-dose computed tomography (CT) screening, the detection rate of solid pulmonary nodules (PNs) is constantly rising. However, existing studies lack a comprehensive understanding of its emerging research trends and interdisciplinary progress, especially in terms of artificial intelligence (AI) integration and molecular characteristics. In this study, we conduct a comprehensive bibliometric analysis to clarify the current research trends and predict future research hotspots in this field, in order to improve diagnostic accuracy, reduce overtreatment, and promote inno

Совпадение в полном тексте источника
… Liu J, Qi L, Wang Y, et al. Diagnostic performance of a deep learning-based method in differentiating malignant from benign subcentimeter (≤10 mm) solid pulmonary nodules. J Thorac Dis 2023;15:5475-84. 10.21037/jtd-23-985 4. Liu J, Xu H, Qing H, et al. …

Fatty acid synthase in chemoresistance: mechanisms and therapeutic opportunities.

Chemoresistance has been a major obstacle to the efficient treatment of cancer. Recently, targeting lipid metabolism has gained significant attention because of its roles not only in promoting cancer progression but also in inducing chemotherapy resistance. Fatty acid synthase (FAS) is the sole enzyme that is in charge of catalyzing the synthesis of palmitate, a long-chain lipid that is essential for membrane construction and post-translational modification in cell biology. Both FAS and its product, palmitate, have been validated as critical players in mediating or causing chemoresistance in c

Совпадение в полном тексте источника
… B., Qi B., Singh P. K., et al. (2017). Combination treatment with Orlistat-Containing nanoparticles and taxanes is synergistic and enhances microtubule stability in taxane-resistant prostate cancer cells. Mol. Cancer Ther. 16, 1819–1830. 10.1158/1535-7163.MCT-17-0013 Souchek J. …

From induced pluripotent stem cell (iPSC) to universal immune cells: literature review of advances in a new generation of tumor therapies.

Background and objectiveTumor therapy is still a tough clinical challenge, and cancer immunotherapy has drawn increasing attention. T cells and natural killer (NK) cells play crucial roles in the immune response. Induced pluripotent stem cell (iPSC) technology opens up a new way to produce functionally improved universal iPSC-derived chimeric antigen receptor (CAR) T (CAR-iT) and iPSC-derived CAR-NK (CAR-iNK) cells. This study aims to comprehensively review the generation and clinical applications of iPSC-derived universal CAR-iT and CAR-iNK cells to explore their potential and future directio

Совпадение в полном тексте источника
… Qi T, Fu J, Zhang W, et al. Mutation of PD-1 immune receptor tyrosine-based switch motif (ITSM) enhances the antitumor activity of cytotoxic T cells. Transl Cancer Res 2020;9:6811-9. 10.21037/tcr-20-2118 39. Peng Y, Zhan M, Karpus A, et al. …

Quantifying hope: an EU perspective of rare disease therapeutic space and market dynamics.

Rare diseases, affecting millions globally, pose a significant healthcare burden despite impacting a small population. While approximately 70% of all rare diseases are genetic and often begin in childhood, diagnosis remains slow and only 5% have approved treatments. The UN emphasizes improved access to primary care (diagnostic and potentially therapeutic) for these patients and their families. Next-generation sequencing (NGS) offers hope for earlier and more accurate diagnoses, potentially leading to preventative measures and targeted therapies. In here, we explore the therapeutic landscape fo

Совпадение в полном тексте источника
… Chavez M Chen X Finn PB Qi LS . Advances in CRISPR therapeutics . Nat Rev Nephrol . ( 2023 ) 19 : 9 – 22 . doi: 10.1038/s41581-022-00636-2 , PMID: 36280707 PMC9589773 34. Li Q Gao Y Wang H . CRISPR-based tools for fighting rare diseases . …

Secondary Neutropenias.

Neutrophils are a critical component of immunity, particularly against bacteria and other pathogens, but also in inflammation and tissue repair. As a consequence, individuals with neutropenia, defined by a reduction in absolute neutrophil counts, exhibit a strong propensity to severe infections that typically present with muted symptoms. Neutropenias encompass a heterogeneous set of disorders, comprising primary neutropenias, in which specific genes are mutated, and the more common secondary neutropenias, which have diverse non-genetic causes. These include hematological and other cancers, inv

Совпадение в полном тексте источника
… Qi Y., Lin W.Q., Liao B., Chen J.W., Chen Z.S. Blood plasma metagenomic next-generation sequencing for identifying pathogens of febrile neutropenia in acute leukemia patients. Sci. Rep. 2023;13:20297. doi: 10.1038/s41598-023-47685-6. 97. …

Создание блокирующей ЭЛИСА, использующей VP1-specific моноклонные антитела для обнаружения антител DHAV3.

Вирус гепатита Утки А (DHAV) вызывает острую и серьезную инфекционную болезнь, характеризующуюся опухолью печени и кровоизлиянием в организм утят. three неделями в возрасте. Эта болезнь приводит к значительным экономическим потерям в уточной промышленности. В Китае широко распространены как DHAV1, так и DHAV3, при этом более доминирующим является DHAV3. В числе three Структурные белки DHAV, белки VP1 являются наиболее критическими, поскольку они вызывают нейтрализующее производство антител, служат связующим белком для вирусной адсорбции рецепторов для конкретных клеток и определяют вирусную ан

Совпадение в полном тексте источника
… Qi L. Li Y. Yu K. Liu C. Qin Z. Wang D. Song M. Li F. Molecular Evolution and Genetic Analysis of the Major Capsid Protein VP1 of Duck Hepatitis A Viruses: Implications for Antigenic Stability PLoS. One 10 2015 e0132982 10.1371/journal.pone.0132982 PMC4501807 26173145 Niu Y. Ma H. Ding Y. Li Z. …

Identifying new biomarkers and potential therapeutic targets for breast cancer through the integration of human plasma proteomics: a Mendelian randomization study and colocalization analysis.

BackgroundThe proteome is a crucial reservoir of targets for cancer treatment. While some targeted therapies have been developed, there are still significant challenges in early diagnosis and treatment, highlighting the need to identify new biomarkers and therapeutic targets for breast cancer. Therefore, we conducted a comprehensive proteome-wide Mendelian randomization (MR) study to identify novel biomarkers and potential therapeutic targets for breast cancer.MethodsProtein quantitative trait locus (pQTL) data were extracted from two published plasma proteome-wide association studies. Genetic

Совпадение в полном тексте источника
… Nature . ( 2023 ) 622 : 329–38 . doi: 10.1038/s41586-023-06592-6 PMC10567551 37794186 21 Zhang H Ahearn TU Lecarpentier J Barnes D Beesley J Qi G . Genome-wide association study identifies 32 novel breast cancer susceptibility loci from overall and subtype-specific analyses . …

Integrative Medicine for Cancer-Related Pain: A Narrative Review.

Cancer-related pain (C-RP) is a prevalent and debilitating concern among patients with cancer, with conventional treatments limited in their ability to provide adequate relief, and by the adverse effects associated with their use. Complementary and integrative medicine (CIM) modalities have been shown to be potentially effective and safe for the treatment of pain and related symptoms, when used in conjunction with conventional medications and under medical supervision. An increasing number of oncology centers provide CIM within their conventional supportive and palliative care service, in an "

Совпадение в полном тексте источника
… Zhao Z., Fan H., Higgins T., Qi J., Haines D., Trivett A., Oppenheim J.J., Wei H., Li J., Lin H., et al. Fufang Kushen injection inhibits sarcoma growth and tumor-induced hyperalgesia via TRPV1 signaling pathways. Cancer Lett. 2014;355:232–241. doi: 10.1016/j.canlet.2014.08.037. 75. …

Recent Innovations and Nano-Delivery of Actinium-225: A Narrative Review.

The actinium-225 (225Ac) radioisotope exhibits highly attractive nuclear properties for application in radionuclide therapy. However, the 225Ac radionuclide presents multiple daughter nuclides in its decay chain, which can escape the targeted site, circulate in plasma, and cause toxicity in areas such as kidneys and renal tissues. Several ameliorative strategies have been devised to circumvent this issue, including nano-delivery. Alpha-emitting radionuclides and nanotechnology applications in nuclear medicine have culminated in major advancements that offer promising therapeutic possibilities

Совпадение в полном тексте источника
… Qi Y. Shen Y.-M. Radiosynthesis and micro-SPECT imaging of 99mTc-dendrimer poly (amido)-amine folic acid conjugate Bioorg. Med. Chem. Lett. 2010 20 927 931 10.1016/j.bmcl.2009.12.075 20045643 56. Criscione J.M. Dobrucki L.W. Zhuang Z.W. Papademetris X. Simons M. Sinusas A.J. Fahmy T.M. …

Inhibiting KCNMA1-AS1 promotes osteogenic differentiation of HBMSCs via miR-1303/cochlin axis.

OBJECTIVE: Osteoporosis is a progressive systemic skeletal disorder. Multiple profiling studies have contributed to characterizing biomarkers and therapeutic targets for osteoporosis. However, due to the limitation of the platform of miRNA sequencing, only a part of miRNA can be sequenced based on one platform. MATERIALS AND METHODS: In this study, we performed miRNA sequencing in osteoporosis bone samples based on a novel platform Illumina Hiseq 2500. Bioinformatics analysis was performed to construct osteoporosis-related competing endogenous RNA (ceRNA) networks. Gene interference and osteo

Совпадение в полном тексте источника
… Chen J Jiang T Yu B Li T Zhao P Yuan L Qi J Upregulation of microRNA-1303 is a potential prognostic marker of non-small cell lung cancer Cancer Biomark 2020 28 439 446 10.3233/CBM-201461 32508320 PMC12662373 28. …

Could Local Application of Hypoxia Inducible Factor 1-α Enhancer Deferoxamine Be Promising for Preventing of Medication-Related Osteonecrosis of the Jaw?

This experimental study investigates the prophylactic effect of deferoxamine (DFO) on medication-related osteonecrosis of the jaw (MRONJ). Thirty-six female Sprague Dawley rats received zoledronic acid (ZA) for eight weeks to create an osteonecrosis model. DFO was locally applied into the extraction sockets with gelatin sponge (GS) carriers to prevent MRONJ. The specimens were histopathologically and histomorphometrically evaluated. Hypoxia-inducible factor 1-alpha (HIF-1α) protein levels in the extraction sockets were quantified. New bone formation rate differed significantly between groups (

Совпадение в полном тексте источника
… Jia P., Chen H., Kang H., Qi J., Zhao P., Jiang M., Guo L., Zhou Q., Qian N.D., Zhou H.B., et al. Deferoxamine released from poly(lactic-co-glycolic acid) promotes healing of osteoporotic bone defect via enhanced angiogenesis and osteogenesis. J. Biomed. Mater. Res. …

Impact of the National Health Insurance Coverage Policy on the Utilisation and Accessibility of Innovative Anti-cancer Medicines in China: An Interrupted Time-Series Study.

Objective: The study aimed to evaluate the impact of the National Health Insurance Coverage (NHIC) policy on the utilisation and accessibility of innovative anti-cancer medicines in Nanjing, China. Methods: We used the adjusted World Health Organisation and Health Action International methodology to calculate the price and availability of 15 innovative anti-cancer medicines included in the National Health Insurance drug list in 20 tertiary hospitals and six secondary hospitals in Nanjing before and after NHIC policy implementation. Interrupted time-series regression was used to analyse the cha

Совпадение в полном тексте источника
… Yang H, Dib HH, Zhu MM, Qi G, Zhang XP. Prices, availability and affordability of essential medicines in rural areas of Hubei Province, China. Health Policy Plan. (2010) 25:219–229. 10.1093/heapol/czp056 30. Gong SW, Cai HB, Ding YF, Li WJ, Juan X, Peng JL, et al. …

An overview of the potential anticancer properties of cardamonin.

Cancer is one of the leading causes of mortality, contributing to 9.6 million deaths globally in 2018 alone. Although several cancer treatments exist, they are often associated with severe side effects and high toxicities, leaving room for significant advancements to be made in the field. In recent years, several phytochemicals from plants and natural bioresources have been extracted and tested against various human malignancies using both in vitro and in vivo preclinical model systems. Cardamonin, a chalcone extracted from the Alpinia species, is an example of a natural therapeutic agent that

Совпадение в полном тексте источника
… Kong W, Li C, Qi Q, Shen J, Chang K. Cardamonin induces G2/M arrest and apoptosis via activation of the JNK-FOXO3a pathway in breast cancer cells. Cell Biol Int. 2019;[Epub ahead of print]. 10.1002/cbin.11217 18. Nawaz J, Rasul A, Shah MA, Hussain G, Riaz A, Sarfraz I, et al. …

PD-1 as a potential target in cancer therapy.

Recently, an improved understanding of the molecular mechanisms governing the host response to tumors has led to the identification of checkpoint signaling pathways involved in limiting the anticancer immune response. One of the most critical checkpoint pathways responsible for mediating tumor-induced immune suppression is the programmed death-1 (PD-1) pathway, normally involved in promoting tolerance and preventing tissue damage in settings of chronic inflammation. Many human solid tumors express PD ligand 1 (PD-L1), and this is often associated with a worse prognosis. Tumor-infiltrating lymp

Совпадение в полном тексте источника
… .2010.28 PMC4002677 Ahmadzadeh M Johnson LA Heemskerk B Wunderlich JR Dudley ME White DE Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired Blood 2009 114 1537 1544 19423728 10.1182/blood-2008-12-195792 PMC2927090 Shi F Shi M Zeng Z Qi …

Bortezomib in the management of multiple myeloma.

Multiple myeloma (MM) is a B-cell malignancy characterized by clonal expansion of plasma cells within the bone marrow, the presence of a serum and/or urine monoclonal protein, lytic bone lesions, and anemia. On a cellular level, the disease is characterized by complex interactions between tumor cells and the surrounding bone marrow microenvironment. Understanding of the relationship between malignant plasma cells and the microenvironment has sparked ongoing efforts to develop targeted therapeutic agents for treatment of this disease. The successful development of the first-in-class small-molec

Совпадение в полном тексте источника
… Chang H, Trieu Y, Qi X, Xu W, Stewart KA, Reece D. Bortezomib therapy response is independent of cytogenetic abnormalities in relapsed/refractory multiple myeloma. Leuk Res. 2007;31(6):779–782. doi: 10.1016/j.leukres.2006.08.002. 52. Sagaster V, Ludwig H, Kaufmann H, et al. …

Genus Sophora: a comprehensive review on secondary chemical metabolites and their biological aspects from past achievements to future perspectives.

Sophora is deemed as one of the most remarkable genera of Fabaceae, and the third largest family of flowering plants. The genus Sophora comprises approximately 52 species, 19 varieties, and 7 forms that are widely distributed in Asia and mildly in Africa. Sophora species are recognized to be substantial sources of broad spectrum biopertinent secondary metabolites namely flavonoids, isoflavonoids, chalcones, chromones, pterocarpans, coumarins, benzofuran derivatives, sterols, saponins (mainly triterpene glycosides), oligostilbenes, and mainly alkaloids. Meanwhile, extracts and isolated compoun

Evolving strategies for addressing CAR T-cell toxicities.

The field of chimeric antigen receptor (CAR) T-cell therapy has grown from a fully experimental concept to now boasting a multitude of treatments including six FDA-approved products targeting various hematologic malignancies. Yet, along with their efficacy, these therapies come with side effects requiring timely and thoughtful interventions. In this review, we discuss the most common toxicities associated with CAR T-cells to date, highlighting risk factors, prognostication, implications for critical care management, patient experience optimization, and ongoing work in the field of toxicity mit