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A pilot randomised controlled trial of community-led ANtipsychotic Drug REduction for Adults with Learning Disabilities.

BACKGROUND: Data suggest that approximately 50,000 adults with learning disabilities (LDs) in England and Wales are currently prescribed ant … ms (CLDTs) in south Wales and south-west England. PARTICIPANTS: Adults with LDs who are prescribed risperidone for treatment of challenging behaviour with no known current psychosis or previous recurrence of psychosis following prior drug reduction. INTERVENTION: A double-blind drug reduction programme leading to full withdrawal within 6 months. Treatment i …

[Psychiatrists' decision making and monitoring of antipsychotic prescription for elderly schizophrenia patients].

OBJECTIVE: Advancing age entails specific treatment modalities for patients with schizophrenia. The choice of appropriate antipsychotic ther … ribed as first-line of treatment by 87.7% of the psychiatrists. The most frequently used SGAPs were risperidone and olanzapine (respectively preferred by 54.4% and 19.3% of the psychiatrists taking part). At the beginning of treatment, 91.1% of the psychiatrists prescribed a lower dose than for middle-aged patients. Of the psychiatrists taking part, 64.9% pre …

Validation of the interleukin-10 knockout mouse model of colitis: antitumour necrosis factor-antibodies suppress the progression of colitis.

Bipolar II disorder (BP-II) is defined, by DSM-IV, as recurrent episodes of depression and hypomania. Hypomania, according to DSM-IV, requir … ch as lithium and valproate, and the second-generation antipsychotics (i.e. olanzapine, quetiapine, risperidone, ziprasidone, aripiprazole). Hypomania should be treated even if associated with overfunctioning, because a depression often soon follows hypomania (the hypomania-depression cycle). For the treatment of acute BP-II depression, two controlled studies …

Disproportionality analysis of sex-stratified adverse event signals in growth impairment: Insights from the FDA adverse event reporting system.

This study aimed to examine sex-disaggregated adverse event signals associated with growth impairment in pediatric patients, utilizing data from the FDA adverse event reporting system, with a particular focus on growth hormone and related therapeutic agents. A disproportionality analysis was performed on FDA adverse event reporting system data spanning 2004 Q1 to 2025 Q1. The analysis encompassed 3281 growth impairment-related reports, disaggregated by gender, employing Reporting Odds Ratios (ROR) and proportional reporting ratios for signal detection, with temporal patterns assessed via Weibu

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… Lisdexamfetamine | CNS stimulant | 39 | 12.55 | 12.52 | 12.55 (9.15–17.21) | 4.89E-29 | 1.85E-26 | Yes Mycophenolic acid | Immunosuppressant | 36 | 3.47 | 3.47 | 3.47 (2.5–4.82) | 9.03E-15 | 3.42E-12 | Yes Lamotrigine | Anticonvulsant | 35 | 3.91 | 3.91 | 3.91 (2.8–5.46) | 1.98E-17 | 7.50E-15 | Yes Risperidone … 45 | 16.28 | 16.21 | 16.28 (12.1–21.9) | 7.85E-38 | 2.05E-35 | Yes Atomoxetine | Selective norepinephrine reuptake inhibitor | 44 | 15.74 | 15.68 | 15.74 (11.66–21.25) | 1.93E-36 | 5.05E-34 | Yes Imatinib | Tyrosine kinase inhibitor | 30 | 4.17 | 4.17 | 4.17 (2.91–5.99) | 1.65E-16 | 4.30E-14 | Yes Risperidone …

Topiramate as a rare cause of reversible Fanconi syndrome and acute kidney injury: a case report and literature review.

Cervical spine is affected in more than a half of patients with rheumatoid arthritis (RA). Depending on the degree of damage to the individual joints and ligaments RA-related cervical spine instability takes the form of atlanto-axial subluxation, subaxial subluxation or cranial settling. In the advanced cases spinal stenosis can occur as well as spinal cord injuries with typical neurological symptoms. The identification of patients with cervical spine instability before the occurrence of neurological complications still constitutes a diagnostic challenge. The article presents the methods of ce

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… Her medications included aspirin 81 mg daily, pramipexole 0.5 mg at bedtime, albuterol inhaler as needed, buspirone 50 mg/day, risperidone 1 mg at bedtime, and topiramate (TPM) 100 mg twice a day for depression. …

Systematic review of interventions for treating or preventing antipsychotic-induced tardive dyskinesia.

BACKGROUND: Antipsychotic medication can cause tardive dyskinesia (TD) - late-onset, involuntary, repetitive movements, often involving the … y low quality]. Switching was investigated twice in trials that could not be combined (switching to risperidone vs. antipsychotic withdrawal: one RCT, n = 42, RR 0.45, 95% CI 0.23 to 0.89; low quality; switching to quetiapine vs. haloperidol: one RCT, n = 45, RR 0.80, 95% CI 0.52 to 1.22; low quality). In addition to RCTs, six observational studies compared a …

Drug Repurposing for Cancer Treatment: A Comprehensive Review.

Cancer ranks among the primary contributors to global mortality. In 2022, the global incidence of new cancer cases reached about 20 million, while the number of cancer-related fatalities reached 9.7 million. In Saudi Arabia, there were 13,399 deaths caused by cancer and 28,113 newly diagnosed cases of cancer. Drug repurposing is a drug discovery strategy that has gained special attention and implementation to enhance the process of drug development due to its time- and money-saving effect. It involves repositioning existing medications to new clinical applications. Cancer treatment is a therap

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… Risperidone prevents the proliferation of KATO-III GC cells by increasing the level of ROS and inducing apoptosis. Additionally, this medication inhibits the growth of tumors in vivo. In a population-based cohort study, the anticancer effects of risperidone were demonstrated. … Patients who used risperidone had a lower risk of GC compared to those who did not [ 187 , 188 ]. …

15th Конгресс Европейской ассоциации клинической фармакологии и терапии (ЕАКПТ)

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Миноциклин как лечение психиатрических и неврологических заболеваний: систематический анализ и мета-анализ.

Миноциклин обладает антивоспалительными, антиоксидантами и антиапопотическими свойствами, которые объясняют возобновленный интерес к его использованию в качестве абстрагирующего средства для лечения психических и неврологических заболеваний. После завершения нескольких новых клинических испытаний с использованием микроциклина мы предложили провести обновленный систематический обзор и метаанализ имеющихся данных. Для поиска была использована система ПИКО (клиент/население, вмешательство, сопоставление и результаты) 5 :: базы данных с целью выявления случайных контролируемых испытаний, в ходе ко

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… Minocycline Add-on to Risperidone for Treatment of Negative Symptoms in Patients with Stable Schizophrenia: Randomized Double-Blind Placebo-Controlled Study Psychiatry Res. 2014 215 540 546 10.1016/j.psychres.2013.12.051 24480077 42. Kelly D.L. Sullivan K.M. McEvoy J.P. McMahon R.P. Wehring H.J. … Minocycline Adjunctive Treatment to Risperidone for Negative Symptoms in Schizophrenia: Association with pro-Inflammatory Cytokine Levels Prog. Neuro-Psychopharmacol. Biol. Psychiatry 2018 85 69 76 10.1016/j.pnpbp.2018.04.004 29678772 44. Deakin B. Suckling J. Barnes T.R.E. Byrne K. Chaudhry I.B. …

Role of trazodone in treatment of major depressive disorder: an update.

Major depressive disorder (MDD) is the most common mood disorder and a leading cause of disability worldwide. Trazodone, a triazolopyridine serotonin receptor antagonist and reuptake inhibitor (SARI) antidepressant approved for major depressive disorder (MDD) in adults, has established efficacy that is comparable to other available antidepressants, and is effective for a range of depression symptoms, including insomnia, which is one of the most common and bothersome symptoms of depression. Also, trazodone's pharmacodynamic properties allow it to avoid the side effects of insomnia, anxiety and

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… Trazodone 100 mg/day was among the treatments assessed, along with buspirone 30 mg/day, risperidone 2 mg/day, thyroid hormone 80 mg/day, and valproic acid 600 mg/day. … A pilot study of the efficacy and safety of paroxetine augmented with risperidone, valproate, buspirone, trazodone, or thyroid hormone in adult Chinese patients with treatment-resistant major depression. J Clin Psychopharmacol. 2011;31:638–642. doi: 10.1097/JCP.0b013e31822bb1d9. 35. …

Repurposed Drugs in Gastric Cancer.

Gastric cancer (GC) is one of the major causes of death worldwide, ranking as the fifth most incident cancer in 2020 and the fourth leading cause of cancer mortality. The majority of GC patients are in an advanced stage at the time of diagnosis, presenting a poor prognosis and outcome. Current GC treatment approaches involve endoscopic detection, gastrectomy and chemotherapy or chemoradiotherapy in an adjuvant or neoadjuvant setting. Drug development approaches demand extreme effort to identify molecular mechanisms of action of new drug candidates. Drug repurposing is based on the research of

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… Risperidone inhibits the proliferation of KATO-III GC cells through the induction of apoptosis and increasing the reactive oxygen species level. This drug also suppresses tumour growth in vivo [ 76 ]. … The anticancer effects of risperidone were demonstrated in a population-based cohort study, in which patients that used risperidone presented reduced risks of GC compared to non-users. However, further investigation is necessary [ 76 ]. 5.1.5. …

Clinical innovations and future directions of nanoparticles in the treatment of psychiatric and neurological disorders.

Nanoparticles (NPs) provide a versatile toolkit for psychiatry and neurology by leveraging tunable size, surface chemistry, and payload control to overcome long-standing barriers in central nervous system (CNS) therapy. Lipid, polymeric, inorganic, and hybrid NPs can be engineered to traverse the blood-brain barrier (BBB) via receptor/transporter pathways, target specific cell types, and deliver sustained or stimuli-responsive release. Beyond drug delivery, NPs improve imaging, enable gene/RNA therapeutics, and support anti-inflammatory and neuroprotective strategies, advancing precision medic

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… Schizophrenia Current antipsychotics—typical (e.g., haloperidol, chlorpromazine) and atypical (e.g., risperidone, olanzapine, clozapine)—are often limited by slow onset, restricted efficacy, and substantial side effects, including extrapyramidal symptoms and metabolic syndrome [ 115 , 116 ]. … Accordingly, nanoformulations have been explored for haloperidol, risperidone, paliperidone (the active metabolite of risperidone), olanzapine, and clozapine [ 117 – 119 ]. …

Doubly blind: a systematic review of gender in randomised controlled trials.

BackgroundAlthough observational data show social characteristics such as gender or socio-economic status to be strong predictors of health, their impact is seldom investigated in randomised controlled studies (RCTs).Objective & designUsing a random sample of recent RCTs from high-impact journals, we examined how the most often recorded social characteristic, sex/gender, is considered in design, analysis, and interpretation. Of 712 RCTs published from September 2008 to 31 December 2013 in the Annals of Internal Medicine, British Medical Journal, Lancet, Canadian Medical Association Journal, or

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… | Absolute risk reduction 3.6% with more skin problems in treatment group | N =2,876 Women ~50% Documented ‘overweight’ and ‘lives alone’ | Not blinded Devanand (public) ( 29 ) | Does stopping risperidone precipitate psychosis among Alzheimer's patients? … Relapse risk after discontinuation of risperidone in Alzheimer's disease. N Engl J Med. 2012;367:1497–507. doi: 10.1056/NEJMoa1114058. 30. Doody RS, Raman R, Farlow M, Iwatsubo T, Vellas B, Joffe S, et al. A phase 3 trial of semagacestat for treatment of Alzheimer's disease. …

Leber Hereditary Optic Neuropathy With Magnetic Resonance Imaging Findings Suggestive of Optic Perineuritis and Optic Neuritis: A Diagnostic Challenge.

Leber hereditary optic neuropathy (LHON) is a rare mitochondrial disorder characterized by subacute, painless, and bilateral vision loss, typically affecting young men. LHON is caused by mitochondrial DNA mutations, most commonly m.11778G>A, m.14484T>C, and m.3460G>A. LHON has incomplete penetrance, with a higher prevalence in men, and its diagnosis is often delayed because of clinical overlap with other optic nerve disorders, such as optic neuritis. Herein, we report the case of a 37-year-old man presenting with progressive vision loss in both eyes over two months. Early magnetic resonance im

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… The patient had a history of intellectual disability and autism spectrum disorder, for which he was taking risperidone 0.5 mg daily. He managed his activities of daily living on his own and lived independently. …

Overcoming Drug Resistance in Advanced Prostate Cancer by Drug Repurposing.

Prostate cancer (PCa) is the second most common cancer in men. Common treatments include active surveillance, surgery, or radiation. Androgen deprivation therapy and chemotherapy are usually reserved for advanced disease or biochemical recurrence, such as castration-resistant prostate cancer (CRPC), but they are not considered curative because PCa cells eventually develop drug resistance. The latter is achieved through various cellular mechanisms that ultimately circumvent the pharmaceutical's mode of action. The need for novel therapeutic approaches is necessary under these circumstances. An

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… For example, risperidone, an antipsychotic agent, is used for the treatment of central nervous system disorders owing to its binding affinity for dopamine D2 and serotonin 5-HT2 receptors [ 169 ]. … Since risperidone targets 17HSD10, it is a possible treatment choice for both Alzheimer’s disease and PCa [ 170 ]. …

[Guidelines for the prescription of mood stabilizers for adolescents: A literature review].

INTRODUCTION: Adolescence is a unique phase of the human developmental process. In adolescents, psychotropic medications may have different … he USA, aripiprazole is licensed from the age of 10 for acute mania and preventive treatment, while risperidone and quetiapine are licensed from the age of 10 for acute mania, and olanzapine is licensed from the age of 13 for acute mania. The AACAP recommends second generation antipsychotics as a first line treatment for bipolar disorder. Moreover, the AACAP …

[What is the interest of Klinefelter's syndrome for (child) psychiatrists?].

Klinefelter's syndrome (KS) concerns men and is usually characterized by tallness, underdeveloped testes and sterility. It is generally due … ist confirmed the diagnosis of KS and found very low blood testosterone levels. Besides lithium and risperidone which had already been introduced before the hospitalization, androgens (testosterone undecanoate) were very progressively given to Mr X with a daily psychiatric evaluation. One month after discharge, a major depressive episode led to the adjunction …

Krukenberg's Spindle-Like Corneal Changes in a Patient With Prolonged ICU Admission: A Case Report.

Krukenberg's spindles are vertical, spindle-shaped pigment deposits on the posterior cornea and are primarily associated with pigment dispersion syndrome (PDS). We present a case of Krukenberg's spindle-like corneal changes in a 39-year-old male patient following prolonged ICU management for thyroid storm complicated by infective endocarditis. The patient's complex ICU course included mechanical ventilation, veno-arterial extracorporeal membrane oxygenation (VA-ECMO), and multiple medications. Ophthalmological examination revealed bilateral, brownish, linear changes in the central corneal stro

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… October 8 | Potassium gluconate | Oral August 25 | October 4 | Warfarin potassium | Oral August 25 | October 10 | Thiamazole | Oral August 31 | November 6 | Trazodone hydrochloride | Oral September 2 | November 6 | Sodium gualenate hydrate and sodium bicarbonate | Oral September 12 | September 12 | Risperidone …

An expanding horizon of complex injectable products: development and regulatory considerations.

There has been a constant evolution in the pharmaceutical market concerning the new technologies imbibed in delivering drug substances for various indications. This is either market-driven or technology-driven to improve the overall therapeutic efficacy and patients' quality of life. The pharmaceutical industry has experienced rapid growth in the area of complex injectable products because of their effectiveness in the unmet market. These novel parenteral products, viz, the nanoparticles, liposomes, microspheres, suspensions, and emulsions, have proven their worth as "Safe and Effective" produ

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… . | Risperdal Costa ® | Risperidone | Small molecule | Extended release microsphere | 12.5 mg/vial, 25 mg/vial, 37.5 mg/vial, 50 mg/vial | Risperidone microencapsulated in PLGA Diluent: polysorbate 20, Na-CMC, disodium hydrogen phosphate dihydrate, citric acid anhydrous, sodium chloride, sodium hydroxide … Similarly, Risperdal Consta ® , a long-acting injection of risperidone PLGA (75:25) microspheres for intramuscular administration, is employed for the treatment of schizophrenia and bipolar I disorder. …

Olanzapine versus aprepitant for the prophylaxis of chemotherapy-induced nausea and vomiting in breast cancer patients receiving doxorubicin-cyclophosphamide regimen: A prospective, nonrandomized, open-label study.

OBJECTIVE: Despite the guideline-directed therapy, complete absence of nausea was noted only in 33% of breast cancer patients on anthracycline-cyclophosphamide regimen. Hence, we sought to compare the efficacy of aprepitant (APT) versus olanzapine (OLP) in preventing chemotherapy-induced nausea and vomiting (CINV) in breast cancer patients on doxorubicin-cyclophosphamide regimen. PATIENTS AND METHODS: A prospective, open-label, nonrandomized study was conducted at the Department of Oncology. Eighty-three patients completed the study with 43 in the APT group and 40 in OLP group. Data about nau

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… as an antiemetic prophylaxis regimen Concurrent radiation therapy scheduled within 8 days of day 1 of the study Patients suffering from tumors with brain metastasis, gastrointestinal tumors Patients diagnosed with serious psychiatric conditions Patients on antipsychotic drugs such as chlorpromazine, risperidone …