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Keyword Index for Volume 98

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… 1109 nude mice 1525 nutrition 300 O 6 -methylguanine-DNA methyltransferase 1614 odds ratio 1295 oesophageal adenocarcinoma 1102, 1985 oesophageal cancer 547, 689, 974, 1670, 1857 oestrogen 766 oestrogen receptor 370, 571, 636, 766 older patient 517 oncogene 1533 oncology 1046, 1508, 1597 opium …

Консолидация, систематическая оценка и сопоставление руководящих рекомендаций в отношении лечения хронической боли: Протокол для составления карты рекомендаций в отношении цифрового хронического заболевания.

ВВЕДЕНИЕ: Хроническая боль 1 В 5 :: взрослые и дети во всем мире; однако управление попрежнему носит весьма различный характер, и, как правило, обеспечивается низкий уровень медицинского обслуживания. Несогласованность рекомендаций, содержащихся в руководящих принципах клинической практики в отношении лечения хронической боли, способствует неоптимальному лечению пациентов. Мы будем разрабатывать и распространять живую цифровую карту рекомендаций в отношении хронической боли (e-Chronic Bain RecMap) для выявления заслуживающих доверия рекомендаций в three высокоприоритетные области1) опиоиды,2)

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… dezocine or dihydrocodeine or dihydromorphine or enkephalin$ or ethylketocyclazocine or ethylmorphine or etorphine or fentanyl or heroin or hydrocodone or hydromorphone or ketobemidone or levorphanol or lofentanil or meperidine or meptazinol or methadone or methadyl acetate or morphine or nalbuphine or opium … dezocine or dihydrocodeine or dihydromorphine or enkephalin$ or ethylketocyclazocine or ethylmorphine or etorphine or fentanyl or heroin or hydrocodone or hydromorphone or ketobemidone or levorphanol or lofentanil or meperidine or meptazinol or methadone or methadyl acetate or morphine or nalbuphine or opium …

63rd Annual Conference of the Indian Society of Gastroenterology, ISGCON 2022-January 5th - 8th, 2023 in Jaipur.

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Prevalence of Chemotherapy-Induced Peripheral Neuropathy in Multiple Myeloma Patients and its Impact on Quality of Life: A Single Center Cross-Sectional Study.

Bortezomib is a pivotal drug for the management of multiple myeloma. However, bortezomib is a neurotoxic anticancer drug responsible for chemotherapy-induced peripheral neuropathy (CIPN). CIPN is associated with psychological distress and a decrease of health-related quality of life (HRQoL), but little is known regarding bortezomib-related CIPN. This single center, cross-sectional study assessed the prevalence and severity of sensory/motor CIPN, neuropathic pain and ongoing pain medications, anxiety, depression, and HRQoL, in multiple myeloma patients after the end of bortezomib treatment. Pap

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… paracetamol | 3 (8.6) | 2 (8.7) | 1 (8.3) | 3 (11.1) | 0 (0) Pregabalin | 3 (8.6) | 2 (8.7) | 1 (8.3) | 3 (11.1) | 0 (0) Ibuprofen | 2 (5.7) | 2 (8.7) | 0 (0) | 2 (7.4) | 0 (0) Codeine + paracetamol | 2 (5.7) | 0 (0) | 2 (16.7) | 0 (0) | 2 (25.0) Tramadol | 2 (5.7) | 2 (8.7) | 0 (0) | 2 (7.4) | 0 (0) Opium … + paracetamol | 2 (5.7) | 1 (4.4) | 1 (8.3) | 1 (3.7) | 1 (12.5) Paracetamol + opium + caffeine | 1 (2.9) | 1 (4.4) | 0 (0) | 0 (0) | 1 (12.5) Gabapentin | 1 (2.9) | 0 (0) | 1 (8.3) | 0 (0) | 1 (12.5) Amitriptyline | 1 (2.9) | 0 (0) | 1 (8.3) | 1 (3.7) | 0 (0) Codeine | 0 (0) | 0 (0) | 0 (0) | 0 (0) …

Lithium and preventing chemotherapy-induced peripheral neuropathy in breast cancer patients: a placebo-controlled randomized clinical trial.

BackgroundChemotherapy-induced peripheral neuropathy (CIPN) is a common adverse effect of some chemotherapy regimens. Lithium has been suggested for CIPN in some animal studies. We aimed to study lithium's preventive effect on CIPN in breast cancer patients treated with taxanes and platinum-based medications.MethodA double-blind placebo-controlled randomized clinical trial (RCT) was implemented on 36 breast cancer patients in two equal-size groups by block randomization. Participants in both groups consumed daily tablets, either placebo or lithium (300 mg), for 5 days in each course of chemoth

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… criteria consisted of lack of interest to participate; comorbidities such as diabetes, cardiovascular disorders, renal disorders, bipolar, and thyroid disorders; the presence of peripheral nerve damage due to another illness and/or medication; pregnant or breastfeeding status; planning to become pregnant; opium …

Characteristics of registered clinical trials assessing treatments for COVID-19: a cross-sectional analysis.

OBJECTIVES: The coronavirus disease 2019 (COVID-19) pandemic has prompted many initiatives to identify safe and efficacious treatments, yet little is known regarding where early efforts have focused. We aimed to characterise registered clinical trials assessing drugs or plasma treatments for COVID-19. DESIGN, SETTING AND PARTICIPANTS: Cross-sectional analysis of clinical trials for the treatment of COVID-19 that were registered in the USA or in countries contributing to the WHO's International Clinical Trials Registry Platform. Relevant trial entries of drugs or plasma were downloaded on 26 M

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… Noscapine | 1 | Opium alkaloid. | Cough suppressant. PUL-042 | 2 | Agonists of Toll-like receptors. | Investigational drug. Polyinosinic-polycytidylic acid | 1 | Upregulation of antitumor genes and the induction of cell apoptosis. | Possible anticancer activity. …

Intestinal Coccidian Infections in Cancer Patients: A Case Series.

Introduction Coccidian protozoa and microsporidian fungi are opportunistic pathogens increasingly implicated in infections in immunosuppressed individuals. These parasites typically infect the intestinal epithelium, resulting in secretory diarrhea and malabsorption. The disease burden and timeline are both greater and longer among immunosuppressed patients. Therapeutic options for immunocompromised individuals are limited. As a result, we wanted to better characterize the disease course and treatment efficacy of these parasitic gastrointestinal infections. Methods We performed a single-center,

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… 20mg to 10mg to 5mg QD | 0 | 1 (6%) | 48 days Cyclospora | Am | Ciprofloxacin | 500mg BID | 2 (50%) | 1 (25%) | 14 days TMP-SMX | 160mg/800mg QD or BID | 1 (25%) | 1 (25%) | 12 days Many patients (12/17) received additional treatment for symptom control, such as loperamide, IV saline rehydration, opium …

Sedatives for opioid withdrawal in newborn infants.

BACKGROUND: Neonatal abstinence syndrome (NAS) due to opioid withdrawal may result in disruption of the mother-infant relationship, sleep-wa … ted there may be little or no difference in treatment failure with clonidine and dilute tincture of opium (DTO) versus DTO alone (RR 0.09, 95% CI 0.01 to 1.59; 80 participants; very low-certainty evidence). All five infants with treatment failure were in the DTO group. There may be little or no difference in seizures (RR 0.14, 95% CI 0.01 to 2.68; 80 pa …

Clinical trials and the COVID-19 pandemic.

"...but why think? Why not try the experiment?..." John Hunter (1728-1793), in a letter to Edward Jenner. August 2nd, 1775. When Galen of Pe … Marcus Aurelius, who apparently took daily doses of Theriac, which among other components included opium. Describing the experiment to his friend Pison, Galen wrote, "as I could not possibly conduct a trial on humans, I experimented on roosters" For his experiment, Galen, studied two groups of roosters, but he doesn't tell us how many animals he includ …

Политика и перспективы в отношении амбулаторных программ для аутологической трансплантации клеток и лечения иммуноэффективных клеток.

Высокодозированная химиотерапия с автоматической трансплантацией гематопоиетических клеток (AutoHCT) давно является комплексной формой лечения множественной миеломы и неходгкинской лимфомы. В прошлом 25 Многие учреждения сместили эту практику с госпитализации на one , которые могут быть выполнены в амбулаторном порядке, что приведет к экономии средств и повышению качества жизни пациентов. Недавно появившиеся методы лечения иммуноэффективных клеток (ИЭК) и расширение их масштабов приводят к изменению ландшафта лечения гематологовых и негематологических магнатов. Однако нынешние финансовые модел

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… prochlorperazine, 5-HTRA, benzodiazepine, with potential addition of transdermal scopolamine or olanzapine Mucositis prophylaxis with cryotherapy Anti-diarrheal agents for treatment of diarrhea prescribed in advance including loperamide and diphenoxylate/atropine, potential addition of octreotide or opium …

The treatment landscape in thyroid cancer: a focus on cabozantinib.

Although patients with thyroid cancer generally fare well, there is a subset for which this is not necessarily true. Progress in understanding the molecular aberrations in thyroid cancer has led to a change in the management of these cases. Since 2011, four multikinase inhibitors (MKIs) have been approved by the US Food and Drug Administration for thyroid cancer - cabozantinib and vandetanib for medullary thyroid cancer and sorafenib and lenvatinib for differentiated thyroid cancer. This change in the treatment landscape has raised challenges for practitioners who may not be familiar with the

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… For those whose symptoms are not controlled with this regimen, tincture of opium is often helpful. In more severe cases, other potential options include oral budesonide or parenteral octreotide. However, these two agents have not been evaluated in the context of MKIs. …

Исследование иммуномодуляционных неблагоприятных явлений, связанных с наркотиками, с использованием спонтанных баз данных системы отчетности.

Цель этого исследования состояла в том, чтобы оценить характерную для конкретных стран ситуацию с представлением отчетности о неблагоприятных явлениях, связанных с иммуномодулятивными препаратами (ИМИД), в реальной клинической практике с использованием данных, содержащихся в японских базах данных < < Доклада об антинаркотических событиях > > (ДЖАДЕР) и < < Системы отчетности об отрицательных явлениях > > Управления по контролю за продуктами питания и наркотиками (ДПП). Иммуномодулирующие препараты, включая талидомид и его производные, являются новым классом противораков

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… BfArM (2024) T-prescriptions, https://www.bfarm.de/EN/Federal-Opium-Agency/T-prescriptions/_node.html (accessed 24 January 2024). 8. Kartik A, Joe E, Barry T, et al. (2019) Osimertinib-induced cardiotoxicity: a retrospective review of the FDA adverse events reporting system (FAERS). …

Каннабиноиды в условиях хронической боли: обзор истории, эффективности, применения и рисков.

Справочная информация/цели: Хроническая боль по-прежнему является широко распространенной и сложной проблемой в области здравоохранения, которая зачастую является устойчивой к обычным методам лечения, таким, как опиоиды, которые сопряжены со значительным риском зависимости и неблагоприятных последствий. Каннабиноиды, биоактивные соединения, полученные на заводе Cannabis Sativa, и их синтетические аналоги стали потенциальной альтернативой обезболиванию, используя их взаимодействие с эндоканнабиноидной системой для модуляции боли и воспаления. Методы: Были рассмотрены и обобщены нынешняя, развив

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… As public concerns about addiction to intoxicants such as opium grew, regulations and laws targeting such substances emerged. In 1906, the Pure Food and Drug Act mandated the regulation of labeling and dosages for medications containing cannabis, cocaine, or morphine [ 14 ]. …

Experience of life quality from patients with aplastic anemia: a descriptive qualitative study.

BackgroundDespite the increasing incidence of aplastic anemia in China, few studies have explored its effect on the patients' quality of life from the perspective of these patients. In fact, patients with aplastic disorder live with the disease for a long time, and need to face a variety of difficult realities, including multiple disease symptoms and drug side effects, heavy burden of medical costs, difficulties in social reintegration, and negative emotional distress. Therefore, this study used descriptive qualitative research to explore the direct and rich quality-of-life experiences of pati

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… However, these patients often humorously refer to themselves as “vampires.“ I mean like a man who eats opium, and also a bit like a vampire…but continuous blood transfusion has a great impact on the quality of life! …

Medicine manipulation: An alternative to mitigate therapeutic gaps in the Brazilian Unified Health System?

Despite the various initiatives carried out in Brazil and in the world, the challenge of offering essential medicines in adequate presentations remains, especially to the public affected by diseases considered neglected and the pediatric population, for whom the therapeutic options remain limited. The main objective of this study was to evaluate the production of manipulated medicines as a strategy to mitigate therapeutic and access gaps to essential medicines within the Brazilian public health system, called the Unified Health System (SUS). The evaluation, carried out between 2020 and 2021, i

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… for oral suspension | Nonspecific antidote used in acute exogenous intoxications by: acetylcysteine, phenothiazines, aspirin, mefenamic acid, indomethacin, valproic acid, iodides, amphetamines, ipecac, antidepressant agents, antimony, mercuric chloride, arsenic, morphine, atropine, methylene blue, opium …

Распространение нетрофической боли в многоразовом склерозе - системном обзоре и мета-анализе с использованием алгоритма NeuPSIG.

Множественный склероз (MS) — нейродегенеративное расстройство, часто приводящее к нейропатической боли. Из-за нейродегенеративной природы диагноз нейропатической боли остается сложным. Была разработана система классификации, обеспечивающая обзор диагностической определенности (т.е. возможной, вероятной и определенной). Поскольку ни один из предыдущих обзоров не привел к этому, различия в диагностической определенности, возможно, повлияли на оценки распространенности. Чтобы прояснить этот вопрос, нынешний метаанализ был направлен на оценку распространенности возможной, вероятной и определенной

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… 2.6% b BMS Khan et al. ( 2018 ) | Cross sectional | 73 (34%/66%) | 1.49 ± 1.82 | 7.72 ± 3.97 | 63% RRMS | — 26% SPMS 11% CIS Moisset et al. ( 2013 ) | Cross sectional | 673 (20/80) | 3.7 ± 0.1 | 14.5 ± 0.4 | 74% RRMS | Paracetamol (45%) NSAID (14%) SAID (1%) Nefopam (0.6%) Tramadol (6%) Codeine (1%) Opium …

ESICM LIVES 2016: part two : Milan, Italy. 1–5 October 2016

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Mass spectrometry-based metabolomics in health and medical science: a systematic review.

Metabolomics is the study of the investigation of small molecules derived from cellular and organism metabolism, which reflects the outcomes of the complex network of biochemical reactions in living systems. As the most recent member of the omics family, there has been notable progress in metabolomics in the last decade, mainly driven by the improvement in mass spectrometry (MS). MS-based metabolomic strategies in modern health and medical science studies provide innovative tools for novel diagnostic and prognostic approaches, as well as an augmented role in drug development, nutrition science

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… Opiates are derivatives of opium alkaloids, the most representative of which are morphine, codeine and heroin. Heroin is the second most popular recreational drug, more abusers die each year from heroin abuse than from any other illicit drug, and it causes a great many people to commit crimes. …

Global cancer statistics 2024: GLOBOCAN estimates of incidence and mortality worldwide for 34 cancers in 186 countries.

This article provides updated global cancer statistics for the year 2024 based on the GLOBOCAN estimates of the International Agency for Research on Cancer. The authors describe national cancer incidence and mortality by world region and the Human Development Index and predict the burden in 2050 based on demographic trends. In 2024, an estimated 20.6 million new cancer cases (19.5 million excluding nonmelanoma skin cancer) and 9.8 million deaths (9.7 million excluding nonmelanoma skin cancer) occurred worldwide, equivalent to one in five people developing cancer during their lifetime and one i

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… carcinoma accounts for approximately 84% of all cases and predominates in high‐risk regions, including parts of the regions called central Asian esophageal cancer belt 240 and Eastern Africa’s esophageal cancer corridor , 241 where consumption of very hot beverages (Southern China, Iran), 242 , 243 , 244 opium …

Involvement of the Opioid Peptide Family in Cancer Progression.

Peptides mediate cancer progression favoring the mitogenesis, migration, and invasion of tumor cells, promoting metastasis and anti-apoptotic mechanisms, and facilitating angiogenesis/lymphangiogenesis. Tumor cells overexpress peptide receptors, crucial targets for developing specific treatments against cancer cells using peptide receptor antagonists and promoting apoptosis in tumor cells. Opioids exert an antitumoral effect, whereas others promote tumor growth and metastasis. This review updates the findings regarding the involvement of opioid peptides (enkephalins, endorphins, and dynorphins