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Harnessing the tumor microenvironment: targeted cancer therapies through modulation of epithelial-mesenchymal transition.

The tumor microenvironment (TME) is integral to cancer progression, impacting metastasis and treatment response. It consists of diverse cell types, extracellular matrix components, and signaling molecules that interact to promote tumor growth and therapeutic resistance. Elucidating the intricate interactions between cancer cells and the TME is crucial in understanding cancer progression and therapeutic challenges. A critical process induced by TME signaling is the epithelial-mesenchymal transition (EMT), wherein epithelial cells acquire mesenchymal traits, which enhance their motility and inva

Redefining Chemoresistance: Natural Bioactives as Molecular Modulators at the Cancer-Tumor Microenvironment Interface.

Therapeutic resistance remains a critical barrier in effective cancer treatment, contributing to disease recurrence, progression, and reduced patient survival. In recent years, natural bioactive compounds have emerged as promising adjuncts in oncology due to their ability to modulate multiple biological processes involved in resistance. This review explores current evidence on the role of natural compounds in influencing cancer cell behavior and their interactions with the tumor microenvironment. By organizing these compounds into chemical families, we provide a structured overview of their po

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… Qi Y. Huang Y. Hu F. Dong F. Shu K. Lei T. Signal Pathways Involved in the Interaction Between Tumor-Associated Macrophages/TAMs and Glioblastoma Cells Front. Oncol. 2022 12 822085 10.3389/fonc.2022.822085 35600367 PMC9114701 88. Downs-Canner S.M. Meier J. Vincent B.G. Serody J.S. …

Bortezomib-induced peripheral neuropathy: from molecular mechanisms to clinical management.

Bortezomib (BTZ) is a first-generation proteasome inhibitor that has shown significant efficacy in the treatment of multiple myeloma (MM), providing significant therapeutic benefits without severely compromising overall patient health. However, one of the most common and debilitating side effects associated with BTZ therapy is bortezomib-induced peripheral neuropathy (BIPN). This condition is the leading complication observed in patients undergoing BTZ treatment and has a profound impact on treatment regimens, often necessitating dose reductions or alterations in the dosing schedule. Despite t

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… Therapeutic:b Acupuncture was administered twice weekly for 2 weeks, once weekly for 4 weeks, and then biweekly for 4 weeks (totaling 10 treatments over 10 weeks). c/ | — | Promotes the movement of qi and blood in the diseased area | a NCT00891618 : Completed/( Terpos et al., 2015 ) b NCT01541644 : Completed …

Cancer stem cells in personalized therapy: mechanisms, microenvironment crosstalk, and therapeutic vulnerabilities.

Cancer stem cells (CSCs) drive tumor progression, therapy resistance, and metastasis through unique membrane biology, glycosylation patterns, and metabolic adaptations. CSCs exhibit a distinct glycocalyx profile enriched in hyaluronan, heparan sulfate, and sialylated glycans, facilitating immune evasion, adhesion, and survival. Key signaling pathways-Wnt/β-catenin, Hedgehog, Notch, JAK/STAT, TGF/SMAD, and PI3K/AKT/mTOR-regulate CSC stemness and therapeutic resistance. Emerging biomarkers (CD44, CD133, ALDH1, EpCAM) and targeted therapies (CAR-T cells, miRNA modulation, lipid metabolism inhibit

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… Med. 380 (23), 2237–2245. 10.1056/NEJMra1804280 Cui Y., Ran R., Da Y., Zhang H., Jiang M., Qi X., et al. (2024). The combination of breast cancer PDO and mini-PDX platform for drug screening and individualized treatment. J. Cell Mol. Med. 28 (9), e18374. 10.1111/jcmm.18374 da Costa V. … Rep. 10 (1), 22422. 10.1038/s41598-020-80033-6 Kapeleris J., Zou H., Qi Y., Gu Y., Li J., Schoning J., et al. (2020). Cancer stemness contributes to cluster formation of Colon cancer cells and high metastatic potentials. Clin. Exp. Pharmacol. …

A Comprehensive Review on the Therapeutic Potential of Curcuma longa Linn. in Relation to its Major Active Constituent Curcumin.

Curcuma longa Linn. (C. longa), popularly known as turmeric, belongs to the Zingiberaceae family and has a long historical background of having healing properties against many diseases. In Unani and Ayurveda medicine, C. longa has been used for liver obstruction and jaundice, and has been applied externally for ulcers and inflammation. Additionally, it is employed in several other ailments such as cough, cold, dental issues, indigestion, skin infections, blood purification, asthma, piles, bronchitis, tumor, wounds, and hepatic disorders, and is used as an antiseptic. Curcumin, a major constitu

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… Curcumin administration showed a similar impact to imipramine, a known antidepressant drug, and it has been indicated by various authors to be a feasible alternative source in depression condition ( Mohammed et al., 2019 ; Qi et al., 2020 ). …

Polydatin: Pharmacological Mechanisms, Therapeutic Targets, Biological Activities, and Health Benefits.

Polydatin is a natural potent stilbenoid polyphenol and a resveratrol derivative with improved bioavailability. Polydatin possesses potential biological activities predominantly through the modulation of pivotal signaling pathways involved in inflammation, oxidative stress, and apoptosis. Various imperative biological activities have been suggested for polydatin towards promising therapeutic effects, including anticancer, cardioprotective, anti-diabetic, gastroprotective, hepatoprotective, neuroprotective, anti-microbial, as well as health-promoting roles on the renal system, the respiratory s

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… Qi Z. Zhang Y. Polydatin attenuates ischemia/reperfusion-induced apoptosis in myocardium of the rat Sheng Li Xue Bao 2009 61 367 372 19701589 133. Zhang L.-P. Yang C.-Y. Wang Y.-P. Cui F. Zhang Y. …

Mechanisms of cytokine release syndrome and neurotoxicity of CAR T-cell therapy and associated prevention and management strategies.

Chimeric antigen receptor (CAR) T-cell therapy has yielded impressive outcomes and transformed treatment algorithms for hematological malignancies. To date, five CAR T-cell products have been approved by the US Food and Drug Administration (FDA). Nevertheless, some significant toxicities pose great challenges to the development of CAR T-cell therapy, most notably cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS). Understanding the mechanisms underlying these toxicities and establishing prevention and treatment strategies are important. In this r

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… Jiang M, Qi L, Li L, Li Y. The caspase-3/GSDME signal pathway as a switch between apoptosis and pyroptosis in cancer. Cell Death Discov. 2020;6:112. doi: 10.1038/s41420-020-00349-0. 16. Lowin B, Hahne M, Mattmann C, Tschopp J. …

Efficacy and safety analysis of TACE combined with lenvatinib and icaritin in unresectable hepatocellular carcinoma with poor performance status.

OBJECTIVE: To investigate the efficacy and safety of transarterial chemoembolization (TACE) combined with lenvatinib and icaritin in the treatment of patients with unresectable hepatocellular carcinoma (uHCC) with poor physical condition, aiming to provide a safer and more effective treatment strategy for patients with advanced uHCC and poor physical status. MATERIALS AND METHODS: Clinical data from 49 patients with uHCC and poor physical condition who received treatment between June 2022 and December 2023 were collected. The patients were divided into two groups based on their treatment meth

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… Zhao Y, Cai G, Zhou L, Liu L, Qi X, Bai M, Li Y, Fan D, Han G. Transarterial chemoembolization in hepatocellular carcinoma with vascular invasion or extrahepatic metastasis: A systematic review. Asia Pac J Clin Oncol. 2013;9(4):357–64. 10.1111/ajco.12081 . Epub 2013 May 29. PMID: 23714021. 35. …

Changes in C-Reactive Protein Forecast Infection Risk Following Treatment with Chimeric Antigen Receptor T Cells.

BACKGROUND: Immunosuppressive conditioning regimens for chimeric antigen receptor-modified T cell immunotherapy (CARTx) and subsequent T cell dysfunction increase risk for infection. However, it is difficult to discern infection from CRS in the early (up to Day 30) and late (Days 31-180) periods after CARTx due to overlapping signs and symptoms. METHODS: We analyzed infectious complications and predictors of infection during the early and late periods after CARTx in 213 adult patients with malignancies over a 5-year period. RESULTS: Overall, 75 patients (35%) had at least one infection, most

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… Yin L., Lv B., Ge J., Qi Y., Xia J., Ma S., Wang Y., Liu Y., Zhou D., Cao J., et al. The impact of antibiotic use on outcomes of relapsed/refractory multiple myeloma patients treated with CAR-T therapy. Front. Immunol. 2025;16:1566016. doi: 10.3389/fimmu.2025.1566016. 39. …

Influence and Role of Regulatory B Cells in Organ Transplantation: The State of the Art, Prospects, and Emerging Insights.

B cells have attracted increasing interest in the field of organ transplantation due to their newly discovered immunoregulatory properties in alloimmune responses. Traditionally, B cells have been primarily associated with adaptive immunity to foreign substances and alloreactive immune response to allografts, differentiating into antibody-producing plasma cells or memory cells upon antigen recognition and T cell collaboration. However, the existence of B cells with regulatory functions (Bregs) in humans has been widely confirmed, highlighting the presence of this subset, which has immunosuppre

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… Qi L. Chang C. Tumor microenvironment B cells increase bladder cancer metastasis via modulation of the IL-8/androgen receptor (AR)/MMPs signals Oncotarget 2015 6 26065 26078 10.18632/oncotarget.4569 26305549 PMC4694886 36. Mohammed Z.M.A. Going J.J. Edwards J. Elsberger B. Mcmillan D.C. …

Global burden of cancer attributable to high BMI (1990-2031): a multidimensional analysis based on GBD and Mendelian randomization.

ObjectiveObesity-related health burdens have emerged as particularly intractable public health issues on a global scale. This study aims to analyze the association between body mass index (BMI) and 12 types of cancer, examine the regional, gender, and age disparities in cancer burden attributable to high BMI, and project the disease burden trends over the next decade based on available data.MethodsData for this study were sourced from the Integrative Epidemiology Unit (IEU) Open Genome-Wide Association Study (GWAS) Project and the 2021 Global Burden of Disease (GBD) database. Using Mendelian r

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… Qi J, Wu H, Chen H, Han W. Genetically predicted lipid traits mediate the association between folic acid and atherosclerosis. Sci Rep. (2024) 14:19052. doi: 10.1038/s41598-024-69728-2, PMID: 26. Zhang Y, Wang S, Li Q, Liu H, Xuan Z, Li F, et al. …

Paraneoplastic Syndrome After Kidney Transplantation: Frequency, Risk Factors, Differences to Paraneoplastic Occurrence of Glomerulonephritis in the Native Kidney, and Implications on Long-Term Kidney Graft Function.

Posttransplant malignancies are an important complication of solid organ transplantation. Kidney transplant recipients are at particularly high risk of cancer development. The most relevant risk factors of carcinogenesis are the use of immunosuppressive agents and oncogenic viral infections. Additionally, immune dysregulation caused by these factors may predispose to various types of organ damage. Paraneoplastic glomerular diseases are one of the most interesting and understudied cancer manifestations. The appropriate diagnosis of paraneoplastic glomerular damage can be challenging in kidney t

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… Yu C-Y Liu J Qi C-H Wu Z-Y Xiao Y-F Zhang X-G . Minimal Change Disease Associated With Gastrointestinal Stromal Tumor Accompanied by Significantly Elevated Serum IgE Level: A Case Report . BMC Nephrol ( 2022 ) 23 : 139 . 10.1186/s12882-022-02775-x 35410141 PMC8996523 58. …

Effect of N-Acetylcysteine on Cisplatin Toxicity: A Review of the Literature.

N-acetylcysteine (NAC) is a membrane-permeable cysteine precursor capable of enhancing the intracellular cysteine pool, enhancing cellular glutathione (GSH) synthesis, and thus potentiating the endogenous antioxidant mechanism. Late administration of NAC after cisplatin has been shown in different in vivo studies to reduce the side effects caused by various toxicities at different levels without affecting the antitumor efficacy of platinum, improving total and enzymatic antioxidant capacity and decreasing oxidative stress markers. These characteristics provide NAC with a rationale as a potenti

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… Qi L, Luo Q, Zhang Y, Jia F, Zhao Y, Wang F. Advances in toxicological research of the anticancer drug cisplatin. Chem Res Toxicol . 2019;32(8):1469–1486. doi: 10.1021/acs.chemrestox.9b00204 5. Raghu G, Berk M, Campochiaro PA, et al. …

Ремдезивирско-ассоциированные результаты выживания среди иммунокомпромиссных пациентов, госпитализированных COVID-19: Реальные улики о микродоминантной эпохе.

Пациенты с иммунокомпромиссными заболеваниями подвергаются повышенному риску заболевания коронавирусом 2019 (В тыс.COVID-19) связанная с этим госпитализация и смерть. Случайные клинические испытания обеспечивают ограниченное число пациентов, если таковые имеются, для получения информации о результатах лечения таких пациентов ремдезивиром. COVID-19 в период с декабря 2021 и февраль 2024. Главным результатом этого стало то, что стационарная смертность была проверена у пациентов, у которых характерные показатели сравниваются с оценками, в группах ремдесивир против нередесивирных групп. Были прове

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… Ao G, Wang Y, Qi X, et al. The association between severe or death COVID-19 and solid organ transplantation: a systematic review and meta-analysis. Transplant Rev (Orlando) 2021; 35:100628. 4. Wang Y, Feng R, Xu J, Shi L, Feng H, Yang H. …

Evaluation of the Effect of Loratadine versus Diosmin/Hesperidin Combination on Vinca Alkaloids-Induced Neuropathy: A Randomized Controlled Clinical Trial.

Neurological injury is a crucial problem that interferes with the therapeutic use of vinca alkaloids as well as the quality of patient life. This study was conducted to assess the impact of using loratadine or diosmin/hesperidin on neuropathy induced by vinca alkaloids. Patients were randomized into one of three groups as follows: group 1 was the control group, group 2 received 450 mg diosmin and 50 mg hesperidin combination orally twice daily, and group 3 received loratadine 10 mg orally once daily. Subjective scores (numeric pain rating scale, douleur neuropathique 4, and functional assessme

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… Qi G. Clinical efficacy of montelukast sodium combined with budesonide or combined with loratadine in treating children with cough variant asthma and influence on inflammatory factors in the serum Exp. Ther. Med. 2019 18 411 417 10.3892/etm.2019.7574 31258680 PMC6566116 56. Cata J.P. Weng H.-R. …

Exploring versatile applications of a vacuum-assisted bone harvester in orthopedic surgery.

BACKGROUND: Orthopedic procedures often require removing bone or pathological tissue, with traditional methods involving instruments like curettes and rongeurs. However, these methods can be time-consuming and lead to increased blood loss. To mitigate these side effects, vacuum-assisted tools have been developed to aid in tissue removal. These devices enable surgeons to suction tissue without discarding it, potentially improving outcomes in conditions such as osteomyelitis or tumor removal while enabling collection of the material for downstream applications. Despite limited research, vacuum-a

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… Li J, Zhang H, Qi B, Pan Z. Outcomes of vacuum sealing drainage treatment combined with skin flap transplantation and antibiotic bone cement on chronic tibia osteomyelitis: a case series study. Med Sci Monit. 2019;25:5343–9. 10.12659/MSM.915921 30. …

Питание N-6 Полиненасыщенное содержание жира в кислоте и здоровье мозга у взрослых людей среднего и старшего возраста.

ПАФА играет важную роль в возникновении и развитии нейродегенеративных заболеваний. С тех пор, как нейрозащитные эффекты n-3 ПУФА получил широкую поддержку, роль n-6 ПУФА по-прежнему обсуждается, а их основополагающие механизмы до сих пор не в полной мере понятны. В этом исследовании 169,295 Участники из Биобанка Соединенного Королевства были включены для анализа связей между питанием n-6 Поступление ПУФА и нейродегенеративные заболевания с использованием моделей коксовой регрессии с полной корректировкой для потенциальных сомнителей. Кроме того, для оценки воздействия различных моделей линейн

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… Qi L. Adherence to a Healthy Sleep Pattern and Incident Heart Failure: A Prospective Study of 408 802 UK Biobank Participants Circulation 2021 143 97 99 10.1161/CIRCULATIONAHA.120.050792 33190528 PMC7775332 27. Wei B.Z. Li L. Dong C.W. Tan C.C. Xu W. …

The Impact of Histone Modifications in Endometriosis Highlights New Therapeutic Opportunities.

Endometriosis is a chronic disorder of the female reproductive system which afflicts a great number of women worldwide. Histone deacetylases (HDACs) prevent the relaxation of chromatin, thereby positively or negatively modulating gene transcription. The current review aims at studying the impact of histone modifications and their therapeutic targeting in endometriosis. In order to identify relevant studies, a literature review was conducted using the MEDLINE and LIVIVO databases. The current manuscript represents the most comprehensive, up-to-date review of the literature focusing on the parti

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… Wang M., Wu Y., He Y., Liu J., Chen Y., Huang J., Qi G., Li P. SIRT1 upregulation promotes epithelial-mesenchymal transition by inducing senescence escape in endometriosis. Sci. Rep. 2022;12:12302. doi: 10.1038/s41598-022-16629-x. 38. …

Combating challenges in CAR-T cells with engineering immunology.

Chimeric antigen receptors (CAR) T cells (CAR-T) mark a significant step towards producing safe and effective personal anticancer treatments. CAR-T strategies engineers the T cells from the patients to allow specific binding to a tumour-specific antigen. CAR-Ts are a second-wave offensive strategy to clear out remaining chemotherapy-resistant tumour cells. Though showing practical antitumor abilities in multiple haematological malignancies and solid tumour cancers, the issues of antigen escape, tumour infiltration/penetration, and toxicity side effects limit the usage of prolonged CAR-T therap

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… Cancer 121 , 837 – 845 . 10.1038/s41416-019-0578-3 31570753 PMC6889154 Zhu Yangmin Tan Youping Ou Ruiming Qi Zhong Zheng Liling Du Yuanyuan ( 2015 ). Anti-CD19 chimeric antigen receptor-modified T cells for B-cell malignancies: A systematic review of efficacy and safety in clinical trials . Eur. …

Forkhead box F2 as a novel prognostic biomarker and potential therapeutic target in human cancers prone to bone metastasis: a meta-analysis.

ObjectiveTo undertake a systematic review and meta-analysis to evaluate the prognostic value of Forkhead box F2 (FOXF2) levels in different types of cancers prone to bone metastasis.MethodsA systematic search of publications listed in electronic databases (The Web of Science, EMBASE®, PubMed®, PMC, Science Direct and CNKI) from inception to 5 November 2020 was conducted. The hazard ratios (HRs) and 95% confidence intervals (95% CIs) were used to assess the relationship between FOXF2 levels and patient prognosis including overall survival (OS) and disease-free survival (DFS).ResultsSixteen stud

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… Chen Y, Qi X, Bian C, et al. The association of FOXP3 gene polymorphisms with cancer susceptibility: a comprehensive systemic review and meta-analysis. Biosci Rep 2019; 39: BSR20181809. DOI: 10.1042/bsr20181809. 62. Zhang Z, Chen Y, Jiang Y, et al. …