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Сердечные эффекты и коморбиды неврологических заболеваний.

Неврологические расстройства охватывают сложный и неоднородный спектр заболеваний, затрагивающих мозг, спинной мозг и периферийные нервные системы, каждая из которых сопряжена с уникальными проблемами, выходящими далеко за рамки первичных неврологических симптомов. Эти расстройства оказывают глубокое воздействие на сердечно-сосудистое здоровье, что приводит к интенсивному изучению сложных взаимосвязей между неврологическими и сердечно-сосудистыми системами. В этом обзоре обобщаются текущие сведения и исследования о сердечно-сосудистых коморбидах, связанных с основными неврологическими заболева

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… In addition to antiepileptics, antipsychotic medications such as haloperidol and risperidone are commonly prescribed to manage psychiatric symptoms in neurological disorders. …

2021 ACMT Annual Scientific Meeting Abstracts-Virtual.

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[Frontal dementia or dementia praecox? A case report of a psychotic disorder with a severe decline].

INTRODUCTION: Many authors have described these last years the difficulty to establish a differential diagnosis between schizophrenia and fr … these characteristics and avolition emphasised, urinary incontinence appeared. The patient receives risperidone 8 mg/day associated with citalopram 40 mg/day during several months of hospitalisation. No significant evolution is observed regarding apathic and stereotyped way of live. The capacity of communication remains very poor. Neurocognitive assessments r …

Scoping Review of Treatment Strategies for Holmes Tremor: Pharmacological and Surgical Interventions.

BACKGROUND: Holmes tremor is a rare neurological condition, first described in 1904, characterized by a low-frequency tremor that manifests at rest, posture, and action. Despite its recognition for over a century, effective treatment strategies for Holmes tremor remain elusive due to its rarity and challenges in conducting robust studies. METHODS: Given that the existent medical literature on Holmes tremor is based on reports and case series, we conducted a survey using the keywords "Holmes tremor" and "Rubral tremor" to analyze the therapeutic approaches utilized, as well as their success ra

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… Unilateral rubral tremor following treatment with risperidone. The World Journal of Biological Psychiatry. 2009. Jan;10(4–2):629–31. DOI: 10.1080/15622970801958349 84. Kiriyama T, Hirano M, Kitauchi T, Saito K, Kataoka H, Ueno S. A case of chemotherapy-responsive paraneoplastic rubral tremor. …

From Lab to Clinic: Success Stories of Repurposed Drugs in Treating Major Diseases.

Drug repurposing, the process of identifying new therapeutic uses for existing drugs, has emerged as a cost-effective and time-saving alternative to traditional drug development. This strategy leverages the known pharmacological and safety profiles of approved or investigational drugs to accelerate their clinical application for other diseases. In recent years, repurposed drugs have played a crucial role in addressing treatment gaps in complex and multifactorial diseases such as cancer, neurodegenerative disorders and infectious diseases. This review highlights prominent examples where repurpo

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… Clozapine, olanzapine and risperidone | Dyskinesia | Neuroprotective and anti‐inflammatory properties, in NDs like PD, Huntington’s disease and traumatic brain injury | [ 99 ]. Lithium | Bipolar disorder | Neuroprotective effects in conditions such as AD, PD and stroke | [ 100 ]. … Moreover, atypical antipsychotics, including clozapine, olanzapine and risperidone, have displayed neuroprotective and antiinflammatory properties, rendering them potential candidates for repurposing in NDs like PD, Huntington’s disease and traumatic brain injury [ 99 ]. …

Post hip fracture orthogeriatric care-a Canadian position paper addressing challenges in care and strategies to meet quality indicators.

INTRODUCTION: Osteoporosis is a major disease state associated with significant morbidity, mortality, and health care costs. Less than half of the individuals sustaining a low energy hip fracture are diagnosed and treated for the underlying osteoporosis. OBJECTIVE: A multidisciplinary Canadian hip fracture working group has developed practical recommendations to meet Canadian quality indicators in post hip fracture care. METHODS: A comprehensive narrative review was conducted to identify and synthesize key articles on post hip fracture orthogeriatric care for each of the individual sections

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… Table 3 Treatment for complications of hyperactive delirium Drug Dose Rout of administration Comments Atypical anti-psychotic Risperidone Initial dose range: 0.25 –0.50 mg every 4–6 h Suggested maximum dose in first 24 h: 2.0 mg Oral • May cause prolonged QT interval on EKG • FDA warning: increased risk … disorder or psychosis EKG , electrocardiogram; FDA , Food and Drug Administration; hrs , hours Table 3 Treatment for complications of hyperactive delirium EKG , electrocardiogram; FDA , Food and Drug Administration; hrs , hours Drug | Dose | Rout of administration | Comments Atypical anti-psychotic Risperidone …

Выявляется высокий уровень использования медицинских услуг после операции на шейном позвоночнике с использованием комплексных методов прогнозирования.

Расходы на медицинское обслуживание пациентов с хроническими заболеваниями позвоночника и пациентов, проходящих хирургическую операцию, продолжают расти заметными темпами. Таким образом, выявление пациентов, подверженных риску в плане более широкого использования послеоперационного медицинского обслуживания, имеет решающее значение для оптимизации результатов медицинского обслуживания и распределения ресурсов. Цель нашего исследования заключается в использовании целого ряда предоперабельных характеристик пациентов, включая всеобъемлющую медицинскую, хирургическую и социальную историю, для разр

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… trifluoperazine”, “haloperidol”, “fluphenazine”, “droperidol”, “zuclopenthixol”, “prochlorperazine”, “amisulpride”, “aripiprazole”, “asenapine”, “blonanserine”, “clotiapine”, “clozapine”, “iloperidone”, “lurasidone”, “mosapramine”, “olanzapine”, “paliperidone”, “perospirone”, “quetiapine”, “remoxipride”, “risperidone …

Подготовка, характеристика и испытание имплантируемых устройств на основе коллектора, загруженных тизанидином и лидокаином.

Множественный склероз является хроническим нейромундологическим расстройством, которое вызывает постепенную инвалидность, главным образом у молодых людей. Она ложится тяжелым бременем на системы здравоохранения из-за высоких расходов на лекарства и потребностей в долгосрочном уходе. Интенсивные устройства являются перспективной альтернативой для обеспечения устойчивых доз лекарств при лечении хронических заболеваний. Это исследование представляет собой новый подкожный имплантат длительного действия для доставки двух наркотиков: тизанидин (TZ) для управления спастичностью и лидокаин (LD) для по

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… Equivalent behaviour was reported for other drugs such as risperidone or olanzapine when combined with PCL or PCL/PEG mixtures respectively [ 34 , 61 ]. Polymer/drug interactions and changes in crystallinity can be evaluated using XRD and FTIR spectroscopy. …

Novel Therapeutic Approaches in Pediatric Acute Lymphoblastic Leukemia.

Acute lymphoblastic leukemia (ALL) is the most common pediatric malignancy, characterized by the clonal proliferation of immature lymphoid precursors. The distinction between B-cell ALL (B-ALL) and T-cell ALL (T-ALL) is fundamental, as each subtype exhibits distinct cytomorphological, genetic, and clinical features influencing prognosis and therapeutic strategies. Conventional multi-phase chemotherapy has significantly improved survival rates, yet its efficacy is limited by severe short- and long-term toxicities, highlighting the need for more selective therapeutic approaches. Advances in mole

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… Corticosteroid-induced psychosis has also been documented, though treatment guidelines are lacking; supportive care may include hypnotics, tranquilizers, or antipsychotics like risperidone in severe cases [ 53 , 54 ]. …

Forecasting drug utilization and expenditure in a metropolitan health region.

BackgroundNew pharmacological therapies are challenging the healthcare systems, and there is an increasing need to assess their therapeutic value in relation to existing alternatives as well as their potential budget impact. Consequently, new models to introduce drugs in healthcare are urgently needed. In the metropolitan health region of Stockholm, Sweden, a model has been developed including early warning (horizon scanning), forecasting of drug utilization and expenditure, critical drug evaluation as well as structured programs for the introduction and follow-up of new drugs. The aim of this

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… This is mainly due to patent expiry and generic competition for risperidone. In 2011, we also expect generics to be introduced for the top-selling drug in the group, olanzapine. …

Chronic pruritus: a narrative review.

Chronic pruritus encompasses a manifestation of several cutaneous, allergic, infectious, neurological, psychological, and systemic conditions, whose etiological investigation and therapeutic strategy can be challenging. This comprehensive review aims to enhance the understanding of pruritus by highlighting important elements in its pathogenesis, including keratinocytes, Merkel cells and mast cells, nerve fibers, histaminergic and nonhistaminergic pathways, and the interaction of itch signals with the central nervous system. Diagnostic evaluation of chronic pruritus may require a meticulous app

Trazodone in the Management of Major Depression Among Elderly Patients with Dementia: A Narrative Review and Clinical Insights.

ObjectiveMajor depressive disorder (MDD) often co-occurs with dementia and other neurological disorders, and treatment with antidepressants can improve symptoms, quality of life, and survival in these patients. This narrative review provides an expert opinion about the role and effectiveness of trazodone in the treatment of older adults with MDD and cognitive impairment due to physical illnesses, such as dementia.ResultsBecause of its mechanism of action, trazodone can treat several depression symptoms often seen in people with dementia, including insomnia, agitation, anxiety, cognitive impair

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… In urgent scenarios, the initial approach includes oral second-generation antipsychotics such as aripiprazole and risperidone. …

Innovative therapeutic concepts of progressive multifocal leukoencephalopathy.

Progressive multifocal leukoencephalopathy (PML) is an opportunistic viral disease of the brain-caused by human polyomavirus 2. It affects patients whose immune system is compromised by a corresponding underlying disease or by drugs. Patients with an underlying lymphoproliferative disease have the worst prognosis with a mortality rate of up to 90%. Several therapeutic strategies have been proposed but failed to show any benefit so far. Therefore, the primary therapeutic strategy aims to reconstitute the impaired immune system to generate an effective endogenous antiviral response. Recently, an

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… In addition to cidofovir, risperidone, and mefloquine, IL-7 and CMX001, an investigational oral agent, were used [ 49 ]. The patient benefited from the treatment, but which therapeutic agent was the possibly decisive one remained unanswered. …

Risk sharing arrangements for pharmaceuticals: potential considerations and recommendations for European payers.

BackgroundThere has been an increase in 'risk sharing' schemes for pharmaceuticals between healthcare institutions and pharmaceutical companies in Europe in recent years as an additional approach to provide continued comprehensive and equitable healthcare. There is though confusion surrounding the terminology as well as concerns with existing schemes.MethodsA literature review was undertaken to identify existing schemes supplemented with additional internal documents or web-based references known to the authors. This was combined with the extensive knowledge of health authority personnel from

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… This includes the so called target agreements Current schemes include the insulin analogues, olanzapine, risperidone, clopidogrel, zolendronate (Aclasta ® ), mycophenolic acid (Myfortic ® ), everolimus(Certican ® ), and cyclosporine (Sandimmun ® ) There is though typically secrecy between the Sickness …

BCR-ABL1 tyrosine kinase inhibitors for the treatment of chronic myeloid leukemia.

The management of chronic myeloid leukemia with BCR-ABL1 tyrosine kinase inhibitors has evolved chronic myeloid leukemia into a chronic, manageable disease. A patient-centered approach is important for the appropriate management of chronic myeloid leukemia and optimization of long-term treatment outcomes. The pharmacist plays a key role in treatment selection, monitoring drug-drug interactions, identification and management of adverse events, and educating patients on adherence. The combination of tyrosine kinase inhibitors with unique safety profiles and individual patients with unique medica

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… that prolong QT intervals, such as antiarrhythmic medicines (e.g. quinidine, procainamide, disopromide, dofetilide, ibutilide, sotalol), 2 , 3 , 47 antiemetics (e.g. metoclopramide, serotonin receptor antagonists), antifungals, and several medications targeting the nervous system (e.g. haloperidol, risperidone …

A geriatrician's approach to managing the complex older adult with obesity.

The prevalence of obesity in older adults is rapidly increasing due to the demographic shift occurring globally. Older adults with obesity face health care challenges due to multimorbidity, functional dependency, and disability. This population often has prior history of struggles through weight-loss attempts during the middle years of life. Therefore, weight-loss intervention needs a personalized approach, taking into consideration weight-loss attempts, relapse, and life events, including bariatric surgery, functional limitations, psychosocial status, and current residential environment. Raci

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… | Metformin, GLP‐1 agonists, GIP/GLP‐1 agonists β‐blockers | Propranolol, metoprolol, atenolol | Carvedilol Antidepressants/antimanic agents | Amitriptyline, mirtazapine, paroxetine, sertraline, citalopram, fluoxetine, lithium | Bupropion Atypical antipsychotics | Olanzapine, clozapine, quetiapine, risperidone …

Prevalence, Attributes, and Risk Factors of QT-Interval-Prolonging Drugs and Potential Drug-Drug Interactions in Cancer Patients: A Prospective Study in a Tertiary Care Hospital.

Introduction Cancer chemotherapy regimens include multiple classes of adjuvant drugs as supportive therapy. Because of the concurrent intake of other drugs (like antiemetics, antidepressants, analgesics, and antimicrobials), there is a heightened risk for possible QT interval prolongation. There is a dearth of evidence in the literature regarding the usage of QT-prolonging anticancer drugs and associated risk factors that have the propensity to prolong QT interval. The purpose was to explore the extent of the use of QT-interval-prolonging drugs and potential QT-prolonging drug-drug interaction

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… Torsade de pointes during combined treatment with risperidone and citalopram. Blaschke D, Parwani AS, Huemer M, Rolf S, Boldt LH, Dietz R, Haverkamp W. Pharmacopsychiatry. 2007;40:294–295. doi: 10.1055/s-2007-992147. 93. Loperamide abuse associated with cardiac dysrhythmia and death. …

Utilities measured by rating scale, time trade-off, and standard gamble: review and reference for health care professionals.

Utility is a simple expression of health-related quality of life in individuals with different states of health. A number of studies on utility measurements were conducted and published in the past. We retrieved 164 English-language articles which appeared in 1966 through 1999 for a systematic review. The number of reports has been increasing at an accelerating pace, especially during the past decade. The most widely used method of utility measurement was time trade-off, TTO (40%), followed by rating scale, RS (31%) and standard gamble, SG (29%). The utility of chronic health status was more f

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… Economic and health state utility determinations for schizophrenic patients treated with risperidone or haloperidol . J Clin Psychopharmacol , 1997 ; 17 : 298 - 307 . 9241010 10.1097/00004714-199708000-00010 122 Hatziandreu EJ , Brown RE , Revicki DA , . …

Engineering with Biomedical Sciences Changing the Horizon of Healthcare-A Review.

In the dynamic realm of healthcare, the convergence of engineering and biomedical sciences has emerged as a pivotal frontier. In this review we go into specific areas of innovation, including medical imaging and diagnosis, developments in biomedical sensors, and drug delivery systems. Wearable biosensors, non-wearable biosensors, and biochips, which include gene chips, protein chips, and cell chips, are all included in the scope of the topic that pertains to biomedical sensors. Extensive research is conducted on drug delivery systems, spanning topics such as the integration of computer modelin

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… PLGA Abbvie Advanced prostatic cancer 12 Sandostatin Lar 1998 Octreotide acetate PLGA Novartis Acromegaly 13 Trelstar 2000 Triptorelin pamoate PLGA Allergen Advanced prostate cancer 14 Definity 2001 Perflutren DPPA, DPPC and MPEG-5000-DPPE Lantheus Ultrasound contrast agent 15 Risperdal Consta 2003 Risperidone … Sandostatin Lar | 1998 | Octreotide acetate | PLGA | Novartis | Acromegaly 13 | Trelstar | 2000 | Triptorelin pamoate | PLGA | Allergen | Advanced prostate cancer 14 | Definity | 2001 | Perflutren | DPPA, DPPC and MPEG-5000-DPPE | Lantheus | Ultrasound contrast agent 15 | Risperdal Consta | 2003 | Risperidone …

Evaluation and Treatment of Obesity and Its Comorbidities: 2022 Update of Clinical Practice Guidelines for Obesity by the Korean Society for the Study of Obesity.

The goal of the 8th edition of the Clinical Practice Guidelines for Obesity is to help primary care physician provide safe, effective care to patients with obesity by offering evidence-based recommendations to improve the quality of treatment. The Committee for Clinical Practice Guidelines comprised individuals with multidisciplinary expertise in obesity management. A steering board of seven experts oversaw the entire project. Recommendations were developed as the answers to key questions formulated in patient/problem, intervention, comparison, outcomes (PICO) format. Guidelines underwent mult

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… (POMC) deficiency | Melanocortin 4 receptor (MC4R) deficiency | Other Congenital syndromic obesity | Prader-Willi syndrome | Laurence-Moon-Biedl syndrome | Alström syndrome | Cohen syndrome | Carpenter syndrome | Other Drugs | Antipsychotics: thioridazine, olanzepine, clozapine, quetiapine, risperidone …