Результаты поиска

Лейкемия в период беременности: диагностика и терапевтический подход (обзор).

Цель настоящего исследования заключается в оценке эпидемиологических, диагностических и терапевтических данных о гематологических заболеваниях в период беременности. Лейкемия в период беременности встречается редко, а литературные данные не являются обширными. Факторы риска, эпидемиология и патогенез этих заболеваний не разработаны в полной мере. Кроме того, имеется подробный доклад о осложнениях в период беременности и об общем (на три месяца) лечении этих заболеваний, в частности о стратегии их лечения. В настоящем исследовании описывается возможность обеспечения в будущем беременности у жен

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… Unspecific symptoms such as fatigue, weakness, dyspnea and pallor are usually physiological changes occurring during pregnancy. The physiological changes associated with pregnancy, such as anemia of pregnancy, leukocytosis or gestational thrombocytopenia, are typically present in AML. …

63rd Annual Conference of the Indian Society of Gastroenterology, ISGCON 2022-January 5th - 8th, 2023 in Jaipur.

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62nd Annual Conference of the Indian Society of Gastroenterology, February 10th - 13th, 2022, Pune.

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Acute lymphoblastic leukemia: an update on treatment and Brazilian perspective.

Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer, representing a major global health concern, particularly in developing countries. This review provides an updated overview of the epidemiology, diagnosis, prognosis, treatment, and a Brazilian perspective for ALL. Despite advances in chemotherapy and immunotherapy, survival disparities remain challenging, driven by socioeconomic and healthcare access inequalities. Present diagnosis incorporates immunophenotyping, cytogenetics, and molecular biology for precise stratification and treatment planning. Treatment has evolved fr

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… Therefore, the patients develop anemia and symptoms such as pallor, tachycardia, dyspnea on exertion, and weakness, as well as leukopenia, which can lead to severe immunodepression and life-threatening infections. …

Malignant Neoplasms Arising in the Cardiac Pacemaker Cavity: A Systematic Review.

Cancer is the abnormal proliferation of physiologically inadequate cells. Studies have identified the cardiac pacemaker pocket as a site of rare neoplasms. To evaluate the clinical outcomes, treatment, prognosis, and individualized management of tumors originating in the cardiac pacemaker pocket, a systematic review was conducted using case reports and case series available in the PubMed/Medline, Science Direct, Cochrane Central, LILACS, and Scientific Electronic Library Online (Scielo) databases. Pacemaker pocket tumors affected patients with a mean age of 72.9 years, with a higher incidence

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… | Man | Medtronic KVDD901 Kappa 900 VDD | Titanium | Atypical fibroxanthoma | Ulcerated skin nodule beneath PP | AV block | 3 years and 9 months (45 months) Hamaker et al. (1976) [ 24 ] | 48 | Man | Medtronic 5841 | Titanium coated | Plasmacytoma | Necrosis of the skin on PM, edema, fatigue, fever, pallor …

Hematopoietic Tumors

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… The mucous membranes should be inspected for pallor, icterus, petechiae, and ulceration, because these signs may indicate anemia or thrombocytopenia secondary to myelophthisis or immune-mediated disease or may be evidence of major organ failure or uremia. …

Oncologic Emergencies: Immune-Based Cancer Therapies and Complications.

Cancer therapies have undergone several recent advancements. Current cancer treatments include immune-based therapies comprised of checkpoint inhibitors, and adoptive immunotherapy; each treatment has the potential for complications that differ from chemotherapy and radiation. This review evaluates immune-based therapies and their complications for emergency clinicians. Therapy complications include immune-related adverse events (irAE), cytokine release syndrome (CRS), autoimmune toxicity, and chimeric antigen receptor (CAR) T-cell-related encephalopathy syndrome (CRES). Immune-related adverse

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… encephalopathy syndrome. 81 – 85 , 90 , 91 Hematologic Checkpoint inhibitors can affect all blood cell lines, resulting in a variety of hematologic abnormalities. 92 – 102 Anemia can be due do an autoimmune hemolytic type or aplastic. 92 – 97 Autoimmune hemolytic anemia can present with weakness, jaundice, pallor …

Feline Coronavirus Infection

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… Other signs include pyrexia, dehydration, mucosal pallor or icterus, a thin body condition, and evidence of ascites. Abdominal palpation may reveal hepatomegaly, irregular renomegaly, and/or abdominal mass lesions that result from mesenteric lymphadenomegaly or intestinal pyogranulomas. …

Magnetic Resonance Imaging in 50 Captive Non-domestic Felids - Technique and Imaging Diagnoses.

Magnetic resonance imaging (MRI) is the recognized gold standard for diagnostic imaging of the central nervous system in human and veterinary patients. Information on the use of this modality and possible imaging abnormalities in captive non-domestic felids is currently limited to individual case reports or small case series. This retrospective study provides information on technique and imaging findings in a cohort of cases undergoing MRI at an academic Veterinary Medical Center. The University of Tennessee College of Veterinary Medicine MRI database was searched for non-domestic felids under

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… (C,D) Magnification of the T2-W MRI image paired with the corresponding histopathology image, which shows severe pallor and loss of cerebral white matter. Courtesy of Dr. Mee-Ja Sula. …

Skin manifestations associated with systemic diseases - Part II.

The skin, by reflecting internal processes, externalizes what happens inside the body in many diseases. Thus, the skin, as an organ, extrapolates its functions of protection, barrier and signals the existence of systemic diseases, expanding the importance of the dermatologist beyond the skin surface. Thus, the dermatologist investigates diagnostic hypotheses for conditions related to all systems and refers patients to the appropriate specialty. Combined with examination by a trained eye, the skin, due to its easy access, is still the ideal place for performing biopsies, which often clarify the

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… Hematopoietic: lymphoma (may be the first symptom of the disease), mastocytosis, polycythemia vera (occurs after bathing; associated signs: ecchymosis, mucosal bleeding, headache, hepatosplenomegaly), iron deficiency anemia (angular cheilitis, mucocutaneous pallor; regresses with iron replacement therapy …

Gaucher disease: clinical profile and therapeutic developments.

Gaucher disease is a rare inborn error of glycosphingolipid metabolism due to deficiency of lysosomal acid β-glucocerebrosidase; the condition has totemic significance for the development of orphan drugs. A designer therapy, which harnesses the mannose receptor to complement the functional defect in macrophages, ameliorates the principal clinical manifestations in hematopoietic bone marrow and viscera. While several aspects of Gaucher disease (particularly those affecting the skeleton and brain) are refractory to treatment, enzyme (replacement) therapy has become a pharmaceutical blockbuster.

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… Untreated Gaucher disease leads to progressive misery associated with bleeding, pallor, and anemia, together with visceral enlargement and bone pain; it is associated with disability and markedly reduced life quality, as well as survival. …

Understanding Rare Anemias: Emerging Frontiers for Diagnosis and Treatment.

Background-This review provides a comprehensive overview of rare anemias, emphasizing their hereditary and acquired causes, diagnostic advancements, and evolving treatment strategies. It outlines the significance of rare anemias within public health, historical challenges in recognition and treatment, and the role of European initiatives like ENERCA and EuroBloodNet in advancing care. Content-This document discusses diagnostic technologies like next-generation sequencing and the impact of artificial intelligence, alongside the promising avenues of gene therapy, targeted drug treatments, and st

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… Among these, acquired aplastic anemia (aAA) is the most encountered syndrome, characterized by fatigue, skin pallor, and an increased risk of infections and bleeding due to diminished peripheral blood cells. …

NTP Toxicology and Carcinogenesis Studies 2-Butoxyethanol (CAS NO. 111-76-2) in F344/N Rats and B6C3F1 Mice (Inhalation Studies).

2-Butoxyethanol is a member of a family of ethylene glycol monoalkyl ethers. It is used extensively as a solvent in surface coatings such as … gnificantly less than those of the chamber controls. Clinical findings included abnormal breathing, pallor, red urine stains, nasal and eye discharge, lethargy, and increased salivation and/or lacrimation. Due to vascular thrombosis and infarction in the tail vertebrae of 500 ppm female rats, the tails became necrotic and either sloughed off or were chew …

Hematopoietic Tumors

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… Inspection of mucous membranes for pallor, icterus, petechiae, and ulceration should be undertaken as these signs may indicate anemia or thrombocytopenia secondary to myelophthisis or immune-mediated disease or may be evidence of major organ failure or uremia. …

T-cell Immunotherapies and the Role of Nonclinical Assessment: The Balance between Efficacy and Pathology.

Gene-engineered T-cell therapies have the potential to revolutionize the treatment of cancer. These therapies have shown exceptional clinical efficacy specifically in the field of B-cell malignancies and the first products (Kymriah™ and Yescarta™) have recently been approved in the United States for specific indications. The power of these treatments is also linked with a distinct set of toxicities both predicted and unpredicted, including off-tumor activity, cytokine release syndromes, and neurotoxicity, occasionally with fatal consequences. As these therapies begin to reach more patients, it

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… There was a spectrum of myelin/axonal damage with morphologic changes including white matter spongy vacuolation, myelin pallor, and axonal injury characterized by thickening and axonal spheroids; frankly necrotic areas with myelin and axonal loss and mineralization were also present ( Morgan et al. 2013 …

Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: children and adolescents.

The Brazilian Nutritional Consensus in Hematopoietic Stem Cell Transplantation: Children and Adolescents was developed by dietitians, physicians, and pediatric hematologists from 10 Brazilian reference centers in hematopoietic stem cell transplantation. The aim was to emphasize the importance of nutritional status and body composition during treatment, as well as the main characteristics related to patient´s nutritional assessment. This consensus is intended to improve and standardize nutrition therapy during hematopoietic stem cell transplantation. The consensus was approved by the Brazilian

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… p.46-51. ( 23 ) Area | Clinical signs | Diagnosis Hair | Loss of natural shine | Kwashiorkor and, less frequently, marasmus Thin and sparse Brittle hair Depigmented Loose Flag sign Face | Nasolabial seborrhea (dry skin around nostrils) | Riboflavin deficiency Swollen face (moon face) | Kwashiorkor Pallor … | Iron deficiency Eyes | Conjunctival pallor | Anemia Red membranes | Bitot’s spots | Vitamin A deficiency Conjunctival xerosis | Corneal xerosis | Keratomalacia | Red and cracked skin around the eyes | Riboflavin and pyridoxine Corneal arcus (white arc around eyes) | Hyperlipidemia Xanthelasma …

Influenza-Associated Cardiac Manifestations: A Systematic Review of Case Reports and Case Series.

Background: Influenza is primarily a respiratory illness, but it is increasingly linked to acute cardiovascular complications, including myocarditis and sudden cardiac death. Evidence on influenza-associated cardiac involvement remains fragmented and largely derived from case-based reports. Methods: This systematic review followed PRISMA guidelines and was registered with PROSPERO (CRD420251249130). PubMed, Web of Science, and Google Scholar were searched for eligible studies. Case reports and case series were included to characterize rare, severe, or atypical cardiac manifestations that are n

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… Several pediatric cases presented with non-specific signs including pallor and dry mucous membranes [ 31 , 33 ], consistent with patterns reported in influenza-associated myocarditis in children. …

Heyde Syndrome Unveiled: A Case Report with Current Literature Review and Molecular Insights.

Heyde syndrome, marked by aortic stenosis, gastrointestinal bleeding from angiodysplasia, and acquired von Willebrand syndrome, is often underreported. Shear stress from a narrowed aortic valve degrades von Willebrand factor multimers, leading to angiodysplasia formation and von Willebrand factor deficiency. This case report aims to raise clinician awareness of Heyde syndrome, its complexity, and the need for a multidisciplinary approach. We present a 75-year-old man with aortic stenosis, gastrointestinal bleeding from angiodysplasia, and acquired von Willebrand syndrome type 2A. The patient w

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… Symptoms of anemia, such as fatigue, shortness of breath, palpitations, and pallor, may also be present [ 93 ]. Indicators of AVWD include easy bruising, mucosal bleeding, hemarthrosis, and hematomas [ 92 ]. 3.3.2. …

Stem Cells Collection and Mobilization in Adult Autologous/Allogeneic Transplantation: Critical Points and Future Challenges.

Achieving successful hematopoietic stem cell transplantation (HSCT) relies on two fundamental pillars: effective mobilization and efficient collection through apheresis to attain the optimal graft dose. These cornerstones pave the way for enhanced patient outcomes. The primary challenges encountered by the clinical unit and collection facility within a transplant program encompass augmenting mobilization efficiency to optimize the harvest of target cell populations, implementing robust monitoring and predictive strategies for mobilization, streamlining the apheresis procedure to minimize colle

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… Beyond vital sign changes, vasovagal reactions can manifest with pallor, diaphoresis, nausea and vomiting, syncope, potential convulsions, and urinary or fecal incontinence. …

The Bloody Crossroads: Interactions between Periodontitis and Hematologic Diseases.

Periodontitis is a common oral condition that can have a significant impact on the overall health of the body. In recent years, attention has been paid to potential relationships between periodontitis and various hematological disorders. This publication aims to present information available in the literature on this relationship, focusing on examples of red blood cell disorders (such as aplastic anemia and sickle cell anemia) and white blood cell disorders (such as cyclic neutropenia, maladaptive trained immunity, clonal hematopoiesis, leukemia, and multiple myeloma). Understanding these asso

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… These include petechial lesions, swelling, spontaneous gingival bleeding, ulceration, pallor of the gingiva, and severe periodontal disease. …