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Long-term effects of benazepril on ambulatory blood pressure, left ventricular mass, diastolic filling and aortic flow in essential hypertension.

We investigated the long-term effects of benazepril, a new non-sulfydryl angiotensin converting enzyme inhibitor, on ambulatory blood pressu … uired a single daily dose of benazepril 10 (n = 9) or 20 (n = 2) mg, and two patients of 20 mg plus chlorthalidone 25 mg, to achieve clinical BP control. Average 24 h systolic/diastolic BP was 156/100 mmHg (SD 17/5) basally and 144/90 mmHg (SD 16/7) at the end of the 12th month of treatment (all p less than 0.01), LV mass index was 133 g/m2 basally and 113 g/m2 …

Drug-induced pancreatitis: a critical review.

We critically reviewed the English language literature pertaining to drug-induced pancreatitis and attempted to determine whether the reported association between each drug and pancreatitis was valid. The following drugs seem to cause pancreatitis: azathioprine, thiazides, sulfonamides, furosemide, estrogens, and tetracycline. Less convincing, but suggestive evidence exists for: 1-asparaginase, iatrogenic hypercalcemia, chlorthalidine, corticosteroids, ethacrynic acid, phenformin, and procainamide. Evidence implicating other drugs is either inadequate or contradictory. Little is known about th

Practical issues in pragmatic trials: the implementation of the Diuretic Comparison Project.

BACKGROUND/AIMS: The US Department of Veterans Affairs Point of Care Clinical Trial Program conducts studies that utilize informatics infrastructure to integrate clinical trial protocols into routine care delivery. The Diuretic Comparison Project compared hydrochlorothiazide to chlorthalidone in reduction of major cardiovascular events in subjects with hypertension. Here we describe the cultural, technical, regulatory, and logistical challenges and solutions that enabled successful implementation of this large pragmatic comparative effectiveness Point of Care clinical trial. METHODS: Patients…

Association of Blood Pressure Measurements With Peripheral Artery Disease Events.

BACKGROUND: Current guidelines recommend treating hypertension in patients with peripheral artery disease (PAD) to reduce the risk of cardiac events and stroke, but the effect of reducing blood pressure on lower extremity PAD events is largely unknown. We investigated the association of blood pressure with lower extremity PAD events using data from the ALLHAT trial (Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial). METHODS: ALLHAT investigated the effect of different antihypertensive medication classes (chlorthalidone, amlodipine, lisinopril, or doxazosin) on cardi…

Fixed combination trandolapril/verapamil sustained-release: a review of its use in essential hypertension.

In well designed studies in patients with mild to moderate hypertension, combinations of the sustained-release (SR) formulation of the nondi … to that of other combinations of antihypertensive agents (metoprolol/hydrochlorothiazide, atenolol/chlorthalidone, lisinopril/hydrochlorothiazide, enalapril/hydrochlorothiazide) in patients with hypertension, including those with type 2 diabetes mellitus. Trandolapril/verapamil SR reduced BP in patients with hypertension and type 2 diabetes or primary renal dis …

S-Opsin Contributes to Violet Light-Dependent Refractive Development and Is Associated With Corneal Structural Remodeling in Mice.

IMPORTANCE: Patients with prior myocardial infarction (MI) or stroke have a greater risk of recurrent cardiovascular (CV) events. OBJECTIVE: To evaluate the association of chlorthalidone (CTD) vs hydrochlorothiazide (HCTZ) with CV outcomes and noncancer deaths in participants with and without prior MI or stroke. DESIGN, SETTING, AND PARTICIPANTS: This was a prespecified secondary analysis of the Diuretic Comparison Project (DCP), a pragmatic randomized clinical trial conducted within 72 participating Veterans Affairs health care systems from June 2016 to June 2021, in which patients aged 65 …

Treatment of resistant hypertension.

AIM: Resistant hypertension (RH) is a common clinical problem. Patients with RH have increased cardiovascular risk. These patients also have high risk for having reversible causes of hypertension and may potentially benefit from special diagnostic or therapeutic considerations. The purpose of this review was to discuss RH, its definition, recognition, evaluation and treatment. METHODS: Authors define RH and the implications of this definition. They present latest data on its prevalence, prognostic implications, genetics, and patient characteristics. Elements of pseudoresistance and possible e

Acute interstitial nephritis - a reappraisal and update.

Acute interstitial nephritis (AIN) is an under recognized and under diagnosed cause of acute kidney injury (AKI). It is estimated to account for 15 - 20% of cases of AKI; it is the reported diagnosis in 2.8% of all kidney biopsies, and 13.5% of biopsies done specifically for acute renal failure. Considerable evidence implicates antigen initiated cell-mediated injury in the pathogenesis of AIN. Drugs account for 70% of all cases, with over 150 different agents incriminated. The remaining cases are due to infections, autoimmune diseases, and rarely idiopathic. The central component of renal inju

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… ranitidine Drug-induced: anti-neoplastic agents Incidence >20 cases reported Ifosfamide Other agents: adriamycin, BCG, bevacizumab, carboplatin, cediranib, gemcitabine, ipilimumab, interferon, lenolidomide, pemetrexed, sorafenib, sunitinib Drug-induced: diuretics Incidence < 10 cases reported Acetazolamide, chlorthalidone … Drug-induced: anti-neoplastic agents | Incidence >20 cases reported Ifosfamide Other agents: adriamycin, BCG, bevacizumab, carboplatin, cediranib, gemcitabine, ipilimumab, interferon, lenolidomide, pemetrexed, sorafenib, sunitinib Drug-induced: diuretics | Incidence < 10 cases reported Acetazolamide, chlorthalidone …

Hirata Syndrome Clinical Presentation and Management: A Single-Centre Experience.

BackgroundHirata syndrome, or Insulin Autoimmune Syndrome (IAS), is a rare condition characterized by hyperinsulinemic hypoglycemia due to autoantibodies targeting endogenous insulin. Its rarity and unique presentation make diagnosis and management challenging.ObjectiveTo analyze the clinical presentation, diagnostic methods, and management of IAS based on a single-center experience.MethodologyThis was a case series, conducted at a tertiary care center in northeast India, involving six cases diagnosed between January 2022 and April 2024. Clinical histories, including drug use and comorbidities

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… He was hypertensive and was taking telmisartan, amlodipine, and chlorthalidone. All hypoglycemia episodes usually occur after 4-5 hours of taking a carbohydrate meal. He was also taking a multivitamin tablet for 2 months which contained α-lipoic acid. …

Amiloride ameliorates muscle wasting in cancer cachexia through inhibiting tumor-derived exosome release.

BACKGROUND: Cancer cachexia (CAC) reduces patient survival and quality of life. Developments of efficient therapeutic strategies are required for the CAC treatments. This long-term process could be shortened by the drug-repositioning approach which exploits old drugs approved for non-cachexia disease. Amiloride, a diuretic drug, is clinically used for treatments of hypertension and edema due to heart failure. Here, we explored the effects of the amiloride treatment for ameliorating muscle wasting in murine models of cancer cachexia. METHODS: The CT26 and LLC tumor cells were subcutaneously in

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… Effectiveness of chlorthalidone plus amiloride for the prevention of hypertension: the PREVER-prevention randomized clinical trial. J Am Heart Assoc. 2016;5(12). 10.1161/JAHA.116.004248. 10.1161/JAHA.116.004248 PMC5210423 27965209 25. … Effectiveness of chlorthalidone/amiloride versus losartan in patients with stage I hypertension and diabetes mellitus: results from the PREVER-treatment randomized controlled trial. Acta Diabetol. 2020. 10.1007/s00592-020-01611-8 33047257 26. …

Drug assessment by a Pharmacy and Therapeutics committee: from drug selection criteria to use in clinical practice.

BackgroundIn Spain, hospital medicines are assessed and selected by local Pharmacy and Therapeutics committees (PTCs). Of all the drugs assessed, cancer drugs are particularly important because of their budgetary impact and the sometimes arguable added value with respect to existing alternatives. This study analyzed the PTC drug selection process and the main objective was to evaluate the degree of compliance of prescriptions for oncology drugs with their criteria for use.MethodsThis was a retrospective observational study (May 2007 to April 2010) of PTC-assessed drugs. The variables measured

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… (V08CA) | | Emtricitabine/tenofovir (J05AR) | | Trastuzumab (L01XC) b | | Cetuximab (L01XC) b | | Eptacog alfa (B02BD) | | Bevacizumab (L01XC) b | May 2008 to April 2009 | Ibandronic acid (M05BA) | Fosfomycin-trometamol (J01XX) | Insulin analogs (aspart, glulisine and detemir) (A10A) | Chlorthalidone …

Выявляется высокий уровень использования медицинских услуг после операции на шейном позвоночнике с использованием комплексных методов прогнозирования.

Расходы на медицинское обслуживание пациентов с хроническими заболеваниями позвоночника и пациентов, проходящих хирургическую операцию, продолжают расти заметными темпами. Таким образом, выявление пациентов, подверженных риску в плане более широкого использования послеоперационного медицинского обслуживания, имеет решающее значение для оптимизации результатов медицинского обслуживания и распределения ресурсов. Цель нашего исследования заключается в использовании целого ряда предоперабельных характеристик пациентов, включая всеобъемлющую медицинскую, хирургическую и социальную историю, для разр

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… levetiracetam”, “oxcarbazepine”, “tiagabine”, “topiramate”, “bupropion” | Bisphosphonates | “risedronate”, “alendronate”, “ibandronate”, “zoledronicacid”, “pamidronate”, “etidronate” | Loop diuretics | “bumetanide”, “ethacrynicacid”, “furosemide”, “torsemide” | Thiazide diuretics | “chlorothiazide”, “chlorthalidone …

Alpha-lipoic acid as a trigger of insulin autoimmune syndrome: Current evidence, a case-based approach, diagnostic pitfalls, and practical management.

Insulin autoimmune syndrome (IAS), also known as Hirata disease, is a rare immune-mediated cause of endogenous hyperinsulinemic hypoglycemia characterized by circulating insulin autoantibodies (IAAs). It typically develops in individuals without prior exposure to exogenous insulin. Although IAS has been associated with viral infections and, less commonly, with autoimmune and hematologic disorders, medications and dietary supplements are considered the most frequent precipitating factors. Sulfhydryl-containing compounds are the most commonly implicated triggers. Methimazole represents the class

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… C-peptide: 23.02 ng/ml ✔ Serum insulin >1000 μIU/mL ✔ IAAs: 98 IU/mL | ✔ ALA discontinuation ✔ MNT with acarbose 25 mg 3 times/daily with meals for 6 months ✔ Clinical remission Mudagall, 2025 [ 76 ] | ✔ A 64-year-old male ✔ History of hypertension under treatment with telmisartan, amlodipine, and chlorthalidone …

Left Ventricular Hypertrophy: Etiology-Based Therapeutic Options.

Determining the etiologies of left ventricular hypertrophy (LVH) can be challenging due to the similarities of the different manifestations in clinical presentation and morphological features. Depending on the underlying cause, not only left ventricular mass but also left ventricular cavity size, or both, may increase. Patients with LVH remain asymptomatic for a few years, but disease progression will lead to the development of systolic or diastolic dysfunction and end-stage heart failure. As hypertrophied cardiac muscle disrupts normal conduction, LVH predisposes to arrhythmias. Distinguishin

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… “CHIP” diuretics (CHlorthalidone, Indapamide, and Potassium-sparing diuretic/hydrochlorothiazide) were compared with hydrochlorothiazide and found to be more effective in reducing LVM. …

CSI position statement on management of heart failure in India.

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… If inadequate diuresis consider: • Increasing iv dose or • Switching to continuous iv infusion or • Add diuretic with different mechanism (e.g. metolazone, hydrochlorthiazide, chlorthalidone) Table 12 Comparison of commonly used Diuretics available for management of HF. … If inadequate diuresis consider: • Increasing iv dose or • Switching to continuous iv infusion or • Add diuretic with different mechanism (e.g. metolazone, hydrochlorthiazide, chlorthalidone) Table 12 Comparison of commonly used Diuretics available for management of HF. …

The prince and the pauper. A tale of anticancer targeted agents.

Cancer rates are set to increase at an alarming rate, from 10 million new cases globally in 2000 to 15 million in 2020. Regarding the pharmacological treatment of cancer, we currently are in the interphase of two treatment eras. The so-called pregenomic therapy which names the traditional cancer drugs, mainly cytotoxic drug types, and post-genomic era-type drugs referring to rationally-based designed. Although there are successful examples of this newer drug discovery approach, most target-specific agents only provide small gains in symptom control and/or survival, whereas others have consiste

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… In this trial, the doxazosin-treatment arm of the study was terminated early, because increased cardiovascular endpoints were observed when compared with chlorthalidone. …