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Systematic review of treatments for atopic eczema.

BACKGROUND: Atopic eczema is the commonest inflammatory skin disease of childhood, affecting 15-20% of children in the UK at any one time. A … tion, massage therapy, hypnotherapy, evening primrose oil, emollients, topical coal tar and topical doxepin. (ABSTRACT TRUNCATED)

Oral Mucositis Induced By Anticancer Therapies.

Oral mucositis induced by conventional cytotoxic cancer therapies is a common and significant clinical problem in oncology. Mucositis symptoms, which include severe pain, may lead to dose reductions and unplanned interruptions of chemotherapy and/or radiotherapy, and often affect patients' quality of life. In addition, ulcerative mucositis represents a risk factor for local or systemic infectious complications that may be life-threatening in immunosuppressed patients. The development of biologically based targeted cancer therapies, which aim to block the growth, spread, and survival of tumors

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… radiotherapy, without concomitant chemotherapy, for HNC | Level III Transdermal fentanyl | Pain reduction | Patients receiving conventional or high-dose chemotherapy, with or without TBI | Level III 2 % morphine mouthwash | Pain reduction | Patients receiving chemoradiation for HNC | Level III 0.5 % doxepin … In most cases, pain can be controlled with locally applied products containing lidocaine or doxepin and mucosal coating agents. In persistent cases, treatment with local or systemic corticosteroids can be considered [ 75 ]. Secondary candidiasis is a common side effect of topical steroid therapy. …

Pruritus: an overview. What drives people to scratch an itch?

Pruritus is a common complaint associated with many conditions. It negatively impacts sleep, quality of life, and mortality. Itch is transmitted along both histaminergic and non-histaminergic pathways with a complex interplay between keratinocytes, immune cells and cutaneous neurons. Individuals who present with pruritus should undergo a thorough assessment, especially those over 65 years old, to exclude underlying malignancy. Treatment no longer consists of antihistamines alone. Physicians now have an array of therapies in their armamentarium, to help alleviate this distressing symptom.

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… Other treatments include doxepin, leukotriene antagonists, histamine-2 antagonists, ciclosporin and mycophenolate mofetil. … 0.1% Transdermal patch 8% Pramoxine (with hydrocortisone) | Ion channel blocker (anti-inflammatory) | 1% cream (2.5%) Strontium 4% | Calcimimetic | 4% hydrogel Ketamine/Amitriptyline/Lidocaine | Ion channel blocker | Ketamine 5-10%, Amitriptyline 2-5% Lidocaine 2.5-5% Apply during pruritic episode Doxepin …

Chronic pruritus: a narrative review.

Chronic pruritus encompasses a manifestation of several cutaneous, allergic, infectious, neurological, psychological, and systemic conditions, whose etiological investigation and therapeutic strategy can be challenging. This comprehensive review aims to enhance the understanding of pruritus by highlighting important elements in its pathogenesis, including keratinocytes, Merkel cells and mast cells, nerve fibers, histaminergic and nonhistaminergic pathways, and the interaction of itch signals with the central nervous system. Diagnostic evaluation of chronic pruritus may require a meticulous app

Prescription and use of psychoactive medications among cancer patients and associated factors in lower and upper middle-income countries: systematic review.

PURPOSE: To describe the prescription and use of psychoactive medications among cancer patients in low- and middle-income countries (LMICs) and explore the factors influencing their prescription and use. METHODS: This systematic review was conducted following the PRISMA guidelines. Six electronic databases were searched. We included observational studies that investigated the prescription and use of psychoactive medications among adult cancer patients in low- and middle-income countries (LMICs) according to the 2024 World Bank's classification. Eligible studies specifically focused on the use

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… Benzodiazepines and Z-drugs (14.2%) * Tricyclic antidepressants (TCA), Serotonin reuptake inhibitors (SSRI) (0.9%) *Haloperidol, Droperidol and Chlorpromazine, Olanzapine, Risperidone *Diazepam, Alprazolam, Lorazepam, Oxazepam and Buspirone *Midazolam, Estazolam and Zolpidem, Zopiclone *Amitriptyline, Doxepin … Benzodiazepines and Z-drugs (14.2%) * Tricyclic antidepressants (TCA), Serotonin reuptake inhibitors (SSRI) (0.9%) | *Haloperidol, Droperidol and Chlorpromazine, Olanzapine, Risperidone *Diazepam, Alprazolam, Lorazepam, Oxazepam and Buspirone *Midazolam, Estazolam and Zolpidem, Zopiclone *Amitriptyline, Doxepin …

Aggressive systemic mastocytosis with multiple organ involvement: a case report.

Systemic mastocytosis is a rare malignancy whose main diagnostic finding is the abnormal proliferation of clonal mast cells. In this report, a 63-year-old woman is presented who was referred to the emergency department with lower back pain. Due to the hypereosinophilia in blood tests, a bone marrow biopsy was performed, and except for the presence of a large number of mastocytes, no other pathologic findings were seen. Furthermore, the immunohistochemistry test showed positive CD117 and CD25 markers, and the patient's platelet-derived growth factor receptor alpha test was positive. Hence, the

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… For the treatment of itching, hydroxyzine or doxepin can be helpful. Gastrointestinal symptoms, including indigestion, can be treated with H2 receptor antagonists. …

Dermatologic conditions in women receiving systemic cancer therapy.

As advances in cancer therapies have improved cancer-related survival, novel therapeutics have also introduced a variety of dermatologic toxicities, and an increased number of patients are living with these sequalae. Women with cancer in particular experience a spectrum of dermatologic conditions that affect their skin, hair, nail, and mucosal surfaces. Studies have shown that these toxic effects can significantly affect quality of life and alter a woman's self-image, cultural identity, femininity, sexuality, and mental health. In severe instances, dermatologic toxicities may even disrupt canc

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… Pain is the primary manifestation of oral mucositis and can be controlled via saline rinses, ice chips, and other rinses that contain topical anesthetics, diphenhydramine, doxepin, sucralfate, and/or aluminum hydroxide/magnesium hydroxide/simethicone ( Lalla et al., 2008 , Sio et al., 2019 ). … Pruritus can be treated with antihistamines, but gabapentin, pregabalin, aprepitant, phototherapy, doxepin, and/or systemic corticosteroids may be required in more severe cases ( Coleman et al., 2019 , Collins et al., 2017 ). …

Факторы, влияющие на развитие усталости у многочисленных склерозовых пациентов.

Усталость является одним из наиболее распространенных и недействующих симптомов у пациентов с MS, однако в настоящее время проводятся ограниченные исследования по изучению продольных детерминант развития усталости. Цель этого исследования состоит в том, чтобы выявить социально-демографические, поведенческие и клинические характеристики и терапевтические режимы, которые со временем соотносятся с усиливающейся усталостью у пациентов, у которых диагностированы синдромы MS. Это ретроспективная диаграмма 483 пациентов. Главным результатом этого стало изменение результатов по шкале 5 (MFIS-5) с перв

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… The antidepressants analyzed included citalopram, doxepin, duloxetine, escitalopram, fluoxetine, mirtazapine, paroxetine, sertraline, venlafaxine, and vortioxetine. …

The Therapeutic Effects of Acupuncture and Electroacupuncture on Cancer-related Symptoms and Side-Effects.

In addition to cancer-related death, malignant progression also leads to a series of symptoms and side-effects, which would detrimentally affect cancer patients' the quality of life, adversely influence their adherence to treatments, and, therefore, negatively affect their long-term survival. Acupuncture and electroacupuncture (EA), as two classic treatment methods in traditional Chinese medicine, have been widely employed to cure various diseases. Recently, the clinical application of acupuncture and EA in cancer patients has received great attention. In this review, we summarized the clinica

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… Hypnotic agents, including Benzodiazepines (BZDs) and non-BZDs agents, and antidepressants, such as amitriptyline, doxepin, mirtazapine, and trazodone, are commonly used in the pharmacologic treatment of CRI 25 . …

Diagnosis and Management of Chronic Pruritus: An Expert Consensus Review.

The aim of this study is to formulate the best clinical practice in the diagnosis and management of chronic pruritus (CP). We searched PubMed, EMBASE, Scopus, Web of Science, and the WHO's regional databases, for studies on "Diagnosis and management of chronic pruritus" from January 1, 2014, to July 31, 2015. We included programmatic reports and hand-searched references of published reviews and articles. Two independent reviewers screened articles and extracted data. We screened 87 of 95 studies that contained qualitative data. Avoid: Dry climate, heat, alcohol compress, ice packs, frequent ba

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… A double-blind, randomized, controlled trial Ann Intern Med 1995 123 161 7 7598296 10.7326/0003-4819-123-3-199508010-00001 69 Shohrati M Tajik A Harandi AA Davoodi SM Akmasi M Comparison of hydroxyzine and doxepin in treatment of pruritus due to sulfur mustard Skinmed 2007 6 70 2 17361495 10.1111/j.1540 …

Nurses' Perspectives on the Non-Pharmacological Management of Oral Mucositis in Onco-Hematological Care: A Qualitative Content Analysis.

Background/Objectives: Oral mucositis (OM) is a common complication in onco-hematological patients undergoing chemotherapy and hematopoietic stem cell transplantation, negatively affecting comfort, nutrition, and quality of life. Despite existing assessment tools and recommendations, OM management-particularly non-pharmacological approaches-remains inconsistent, and evidence on nurses' perspectives and contextual factors is limited. This study explored nurses' perceptions and experiences regarding non-pharmacological treatments for OM, including educational needs and barriers and facilitators

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… Doxepin Rinse for Management of Mucositis Pain in Patients with Cancer: One Week Follow-up of Topical Therapy. Spec. Care Dent. 2008;28:73–77. doi: 10.1111/j.1754-4505.2008.00015.x. 11. Botti S., Valentini D., Grasselli S., Botti S., Valentini D., Grasselli S. Stem Cell Transplantation. …

Клинические интуиции и радиологические свойства на множестве склероза соединены с мигренью.

Фон: Множественный склероз (МС) и мигрень являются неврологическими заболеваниями, затрагивающими молодых женщин. Мигрейн является наиболее распространенным видом головной боли у людей с MS (PwMS). Цели: Цель настоящего обзора состоит в том, чтобы описать клинические, радиологические и терапевтические особенности МУ и коморбиды мигрени. В клинической части основное внимание уделяется характеристикам мигрени в ПУМС и MS в сопутствии с мигренью, а также на наличии других возможных коморбидов. Радиационная секция занимается дифференциальной диагностикой повреждений белой материи и изменениями в с

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… could also have positive effects on microglia, as demonstrated by in vitro studies: in particular, a significant reduction in the inflammation extension, with the inhibition of microglial activation, was observed in the incubation of inflammatory astrocyte/microglia co-cultures with amitriptyline, doxepin …

Non-diabetic hypoglycemia: bridging gaps in diagnosis and treatment: a position statement report by the Arabic Association for the Study of Diabetes and Metabolism (AASD).

BACKGROUND: Non-diabetic hypoglycemia presents a substantial diagnostic challenge due to its diverse and often nonspecific symptomatology. The resultant delay in diagnosis can lead to a myriad of misdiagnoses. This misidentification not only prolongs patient suffering but also elevates the risk of severe complications, such as permanent neurologic damage and mortality. Recognizing the clinical nuances of non-diabetic hypoglycemia is paramount for timely and accurate diagnosis, which ultimately enhances patient outcomes and safety. MAIN BODY: A position statement has been formulated by the Ara

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… Table 1 Medications associated with non-diabetic hypoglycemia Nonsteroidal anti-inflammatory drugs (NSAIDs) (e.g., ibuprofen, naproxen) Indomethacin: analgesic Tricyclic antidepressants (TCAs): (e.g., doxepin, imipramine, nortriptyline) Antidepressant of selective serotonin re-uptake inhibitors (SSRIs …

Management of Itch in the Elderly: A Review.

Chronic itch is common in the elderly patient and may be caused by a variety of known dermatologic and non-dermatologic conditions and can have a significant effect on quality of life. Age-related changes in barrier function, immunosenescence, and neuronal changes and neuropathies are common predisposing factors to chronic itch in this age group. Certain primary dermatologic conditions are more common in the elderly and can cause chronic itch. Also, co-morbid diseases particularly of the renal, hepatobiliary, or hematologic systems, psychologic conditions, or medications may contribute to chro

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… Antidepressants TCAs such as amitriptyline and doxepin are also recommended against because of their anticholinergic effects as well as orthostatic hypotension [ 91 ]. TCAs have been shown to be effective in the treatment of nocturnal itch and psychogenic itch [ 75 ]. …

Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses.

In this review, we discuss the importance of capsaicin to the current understanding of neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We will focus on the analgesic effects of capsaicin and its clinical applicability in treating pain. Furthermore, we will draw attention to the rationale for other clinical therapeutic uses and implications of capsaicin in diseases such as obesity, diabetes, cardiovascular conditions, cancer, airway diseases, itch, gastric, and urological disorders.

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… The topical association of 3.3% tricyclic antidepressant doxepin and 0.025% capsaicin is able to accelerate the development of analgesia in patients with neuropathic pain compared with the separate use of formulations [ 125 ]. 4. … Topical application of doxepin hydrochloride, capsaicin and a combination of both produces analgesia in chronic human neuropathic pain: A randomized, double-blind, placebo-controlled study Br. J. Clin. Pharmacol. 2000 49 574 579 10.1046/j.1365-2125.2000.00200.x 10848721 PMC2015036 126. …

Pharmacological treatment options for mast cell activation disease.

Mast cell activation disease (MCAD) is a term referring to a heterogeneous group of disorders characterized by aberrant release of variable subsets of mast cell (MC) mediators together with accumulation of either morphologically altered and immunohistochemically identifiable mutated MCs due to MC proliferation (systemic mastocytosis [SM] and MC leukemia [MCL]) or morphologically ordinary MCs due to decreased apoptosis (MC activation syndrome [MCAS] and well-differentiated SM). Clinical signs and symptoms in MCAD vary depending on disease subtype and result from excessive mediator release by MC

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… Methohexital Phenobarbital Thiopental Propofol Ketamine Etomidate Midazolam Muscle relaxants Atracurium Mivacurium Rocuronium Cis-atracurium Vecuronium Antibiotics Cefuroxim Gyrase inhibitors Vancomycin Roxithromycin Selective dopamine- and norepinephrine reuptake inhibitors Bupropion Amitriptyline, doxepine … Phenobarbital Thiopental | Propofol Ketamine Etomidate Midazolam Muscle relaxants | Atracurium Mivacurium Rocuronium | Cis-atracurium Vecuronium Antibiotics | Cefuroxim Gyrase inhibitors Vancomycin | Roxithromycin Selective dopamine- and norepinephrine reuptake inhibitors | Bupropion | Amitriptyline, doxepine …

Paroxetine : a review of its pharmacology and therapeutic potential in the management of panic disorder.

SYNOPSIS: Paroxetine is the first selective serotonin (5-hydroxytryptamine; 5-HT) reuptake inhibitor (SSRI) to be approved for the treatment … ot potentiated by the administration of paroxetine 30mg. In contrast to amitriptyline 150 mg/day or doxepin 150 mg/day, 2 to 6 weeks' treatment with paroxetine 20 or 30 mg/day did not produce clinically significant haemodynamic or electrophysiological effects on cardiac function in healthy volunteers or patients with depression. Fewer adverse cardiac effe …

Время отключения в слоях при мукозите и его ассоциация с системными осложнениями у пациентов с пересадкой гематопоэтических стволовых клеток: выводы из национального исследования в стационаре.

ОБЪЕКТ ИССЛЕДОВАНИЯ: Оральные узловатые мукозные инфекции (ОУМИ) являются частой и серьезной осложнением трансплантации гемопоэтических клеток (ТГК). Определено ли то, что длительное время выписки из больницы, используемое как прокси для увеличенного срока пребывания (СПП), идентифицирует большую системную морбидность у пациентов, которые развивают ОУМИ, остается неясным. Настоящее ретроспективное когортное исследование направлено на оценку, у пациентов с документированным ОУМИ среди получателей ТГК, длительное время выписки независимо связано с увеличением системных осложнений.МЕТОДЫ: Настоящ

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… Dietary counseling emphasizing soft, bland, non-acidic foods minimizes mechanical irritation, and multimodal analgesia, including topical agents such as doxepine or lidocaine formulations (benzydamine in countries where available) alleviates discomfort, promotes oral intake, and potentially reduces reliance …

CD38 Is Robustly Induced in Human Macrophages and Monocytes in Inflammatory Conditions.

Macrophages and their monocyte precursors mediate innate immune responses and can promote a spectrum of phenotypes from pro-inflammatory to pro-resolving. Currently, there are few markers that allow for robust dissection of macrophage phenotype. We recently identified CD38 as a marker of inflammatory macrophages in murine in vitro and in vivo models. However, it is unknown whether CD38 plays a similar marker and/or functional role in human macrophages and inflammatory diseases. Here, we establish that CD38 transcript and protein are robustly induced in human macrophages exposed to LPS (±IFN-γ)

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… age (years ± SD) a | 39.9 ± 14.1 | 41.5 ± 16.8 | 32.5 ± 7.3 SLE Disease Activity Index (avg ± SD) | N/A | 0.4 ± 0.8 | 9.6 ± 5.7 Gender (F/M) | 6/3 | 9/2 | 10/0 Race (C/A/U) | 5/3/1 | 5/4/2 | 6/3/1 Therapies | | | Azathioprine | 0 | 2 | 4 Clobetasol 0.05% foam | 0 | 1 | 0 Cyclosporine | 0 | 0 | 1 Doxepin …

Mechanistic Insights into the Metabolic Pathways and Neuroprotective Potential of Pentacyclic Triterpenoids: In-Depth Analysis of Betulin, Betulinic, and Ursolic Acids.

Due to their complexity, both genotypic and phenotypic, neurodegenerative diseases are one of the main causes of death globally nowadays. Among phytochemicals of high scientific interest, based on experimental studies, pentacyclic triterpenoids (TTs), including mainly betulin, betulinic, and ursolic acid, became targets of scientific research in recent years, especially in terms of their biological activity and pharmacological potential. Due to their anti-inflammatory and antioxidant properties, as well as their involvement in cellular signal transductions, they have been observed to act as an

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… Also, a number of synthetic drugs are prescribed to treat neurodegeneration, e.g., idebenone, diazepam, doxepin, and memantine hydrochloride, but all have unwanted side effects. …