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Bifidobacterium breve MN15965 Improved Bacterial Diversity, Short-Chain Fatty Acid Production, and Immune Activation in a Cyclophosphamide-Induced Immunosuppression Mouse Model.

The gut microbiota serves as a critical interface for host immunity, making it a promising target for probiotic intervention. In this study, … l diversity, and enriched potentially beneficial SCFA-producing taxa, including Lachnospiraceae and Eubacterium. These findings demonstrate that B. breve MN15965 alleviated CTX-induced immunosuppression by activating immune responses, regulating gut bacterial communities, and boosting SCFA production.

Metataxonomic strategy to decipher gut bacteriome biomarkers of type 2 diabetes and obesity in Tunisian population.

Metabolic disorders are multifactorial diseases and major global health concerns, with many individuals worldwide responding inadequately to … is characterized by a depletion of Asteroleplasma (p = 0.01), Oscillospiraceae UCG 005 ( p = 0.02), Eubacterium ruminantium group (p= 0,0007), and Romboutsia (p = 0.002) beside an enrichment of Fusicatenibacter (p = 0.02). Gut bacteriome alterations in Tunisian T2D and obese subjects may serve as metabolic biomarkers.

Causal Associations between Gut Microbiota and Trigeminal Neuralgia: A Two-sample Mendelian Randomization Study.

OBJECTIVE: Trigeminal neuralgia is one of the most prevalent neurological conditions. The associations between gut microbiota and trigeminal … genetically predicted levels of Ruminococcaceae NK4A214 (IVW: OR: 0.52, 95%CI: 0.29-0.91, P =0.02), Eubacterium hallii (IVW: OR: 1.96, 95%CI: 1.15-3.35, P =0.01), Ruminococcus 2 (IVW: OR: 0.52, 95%CI: 0.29-0.94, P =0.03), Prevotella 7 (IVW: OR: 0.61, 95%CI: 0.4-0.92, P =0.02) and Hungatella (IVW: OR: 0.51, 95%CI: 0.27-0.96, P =0.04). Sensitivity analyses, inc …

The relationship between bacterial changes and dietary intervention in non-alcoholic fatty liver disease.

BACKGROUND AND AIM: This study aimed to investigate the levels of Faecalibacterium prausnitzii (F. prausnitzii) and Eubacterium rectale (E. rectale) in patients with non-alcoholic fatty liver disease (NAFLD) and evaluate the impact of dietary intervention on these bacterial populations. MATERIALS: An interventional study was conducted with 38 NAFLD patients recruited from the Marmara University Gastroenterology Institute. Participants were divided into two groups: a diet intervention group (n = 21) and a control group (n = 17). The dietary intervention consisted of a balanced diet containing …

Bifidobacterium longum Ameliorates Intestinal Inflammation and Metabolic Biomarkers in Mice Fed a High-Fat Diet with Gliadin by Indoleacrylic Acid.

Gliadin, abundant in flour-based foods and processed foods, has been widely researched for allergies. However, the impact of gliadin on the … he duodenum. The abundance of Blautia, Butyricimonas, Ruminococcaceae UCG-010, Parabacterioids, and Eubacterium nodatum in the colon was also increased. The B. longum CCFM1216 and B. longum CCFM1218 reversed the abundance of these strains. Specifically, B. longum CCFM1216 enhanced the duodenal barrier with indoleacrylic acid, beneficial for blood lipids and g …

L-Theanine Ameliorates Metabolic Dysregulation and Adverse Fetal Outcomes in a Mice Model of Gestational Obesity: Association with FXR/FGF15 Signaling.

In this study, we investigated whether L-theanine (LTA) ameliorates adverse pregnancy outcomes in high-fat diet (HFD)-induced gestational ob … tively associated with Bacteroides vulgatus, whereas neonatal body weight inversely correlated with Eubacterium ramulus. In gestational obesity mice, LTA administration reduced weight gain, visceral/gonadal adiposity, metabolic markers (fasting glucose/insulin/cholesterol), gut barrier dysfunction (TNF-α, IL-6, IL-8, Claudin-2), and linked to FXR/FGF15 pathwa …

The gut microbiota-bile acid axis: a crucial regulator of immune function and metabolic health.

The gut microbiota and bile acid metabolism are intricately linked, playing a crucial role in immune regulation, metabolic processes, and overall health. The gut microbiome, consisting of diverse bacterial genera such as Bacteroides, Clostridium, Lactobacillus, Bifidobacterium, and Eubacterium, facilitates the conversion of primary bile acids into secondary bile acids through enzymatic modifications. Bile acids, synthesized in the liver and modified by gut microbiota, act as signaling molecules that regulate immune responses via bile acid receptors, including the farnesoid X receptor (FXR), G …

Стул Glial Fibrilar Acidic Protein поднимается в прогрессивном многократном склерозе.

ЦЕЛИ: Кишечная микробиота и видоизмененная кишечная физиология были связаны с множественным склерозом (MS). Интестические глиальные клетки регулируют интестинальную нервную и иммунную функцию и экспресс-гильярный фибриллярный кислотный белок (GFAP) и S100β. Световая цепочка Serum GFAP и нейрофильтров может предсказывать ухудшение состояния заболеваний; однако никаких четких маркеров не отличает от рецидивов. МЕТОДЫ: Для изучения интеритальной глиальной функции в MS мы измерили стул GFAP (st-GFAP) с использованием анализа иммуносорбента, связанного с ферментом, в рамках 31 здорового контроля (H

Совпадение в аннотации оригинала
OBJECTIVES: The gut microbiota and altered intestinal physiology have been implicated in multiple sclerosis (MS). Enteric glial cells regula … nts with RRMS from our Milan cohort. St-GFAP in patients with ProgMS was negatively associated with Eubacterium hallii. DISCUSSION: These exploratory data indicate an altered enteric glial phenotype in patients with ProgMS and suggest that st-GFAP may be a prognostic biomarker.

Psoriasis and gut microbiota: A Mendelian randomization study.

In recent years, an increasing number of observational studies have revealed an association between gut microbiota composition and psoriasis … 01, p = 0.009), genus Candidatus Soleaferrea (OR = 1.123, 95% CI: 1.011-1.247, p = 0.030) and genus Eubacterium fissicatena group (OR = 0.831, 95% CI: 0.755-0.915, p = 0.00016) showed significant associations. Sensitivity analysis did not reveal any abnormalities in SNPs. Currently, we have found some causal relationship between the gut microbiota and psorias …

Pediococcus acidilactici FZU106 alleviates high-fat diet-induced lipid metabolism disorder in association with the modulation of intestinal microbiota in hyperlipidemic rats.

Probiotics have been proved to have beneficial effects in improving hyperlipidemia. The purpose of the current research was to investigate t … ention evidently increased the proportion of Butyricicoccus, Pediococcus, Rothia, Globicatella and [Eubacterium]_coprostanoligenes_group, and decreased the proportion of Corynebacterium_1, Psychrobacter, Oscillospira, Facklamia, Pseudogracilibacillus, Clostridium_innocuum_group, Enteractinococcus and Erysipelothrix in HFD-fed rats. Additionally, P. acidilacti …

Serum antibodies to periodontal bacteria.

The purpose of this study was to determine how serum antibodies reactive with periodontitis-associated bacteria with relates to the diagnosi … d two strains of Actinobacillus actinomycetemcomitans (Y4 and N27), Fusobacterium nucleatum (E1D1), Eubacterium brachy, and Bacteroides gingivalis. The low classification rate of SP subjects suggested heterogeneity. The SP group could be divided into three subgroups using the serological data. One subgroup, with "super" severe attachment loss, generally lacke …

Causal relationships between Burkholderiales, Eubacteriaceae and colorectal cancer mediated by plasma metabolites.

While Burkholderiales and Eubacteriaceae are associated with colorectal cancer, a causal relationship has not yet been fully established. Th … r formigenes was potentially mediated by dihomo-linolenoylcarnitine, while the protective effect of Eubacterium siraeum may involve 1-linoleoyl-GPE. Sensitivity analyses indicated no significant heterogeneity or pleiotropy. This study suggests the potential causal effects of the Burkholderiales and Eubacteriaceae taxa on colorectal cancer, with effects potent …

Unveiling potential driver taxa in subgingival plaque and their roles in mediating periodontitis progression.

BACKGROUND: Periodontitis progression is accompanied by a succession of the oral microbiome. However, the dynamic microbial transitions that … eriodontal clinical indicators. CONCLUSIONS: Capnocytophaga, Paludibacter, Dialister pneumosintes, Eubacterium minutum and Phocaeicola abscessus are proposed as key driver taxa across different periodontal health conditions, and exhibited significant correlations with periodontal clinical indicators.

Gut microbiome remodeling induced by microplastic exposure in humans.

The impact of microplastics (MPs) on the diversity and composition of the gut microbiome has been extensively documented in animal studies, … roidota, Lactobacillales, Rikenellaceae, Parabacteroides, Roseburia, Coprococcus, Turicibacter, and Eubacterium coprostanoligenes. These changes were associated with a decrease in butyrate production and a decrease in short-chain fatty acid levels. However, for some other bacteria, both inductive (on Oscillospiraceae, Adlercreutzia, Phascolarctobacterium, and …

Distinct Inflammation-Associated Microbiome Signatures in Pediatric Non-IgE-Mediated Food Allergy.

Non-IgE-mediated food allergy is characterized by delayed gastrointestinal manifestations and the absence of reliable non-invasive biomarker … an relative abundances of Pseudobutyrivibrio, Roseburia, Bifidobacterium, Collinsella, Clostridium, Eubacterium, Streptococcus, and Barnesiella. Several genera (Escherichia-Shigella, Agathobacter, and Enterococcus/Streptococcus) were detected only in the allergy cohort. Shannon diversity was higher in patients compared to controls and in the subgroups of pati …

Microbial Shifts in Oral Submucous Fibrosis: Exploring the Role of Oral Microflora.

INTRODUCTION: Oral submucous fibrosis (OSF) is a chronic, progressive scarring disorder of the oral mucosa and a high-risk precancerous cond … eudomonas. Among anaerobes, Prevotella, Porphyromonas, Clostridium, Peptostreptococcus, Parvimonas, Eubacterium, and Peptococcus are more common, while Veillonella, Fusobacterium, and Bifidobacterium are less prevalent. CONCLUSION: It was observed that the variation in abundance of the isolated bacteria is similar to that found in oral cancer. Furthermore, r …

The role of microbiota in bovine tuberculosis: Characterizing bacterial communities across lungs, gut, and lymph nodes.

Animals with bovine tuberculosis (bTB) develop granulomatous lesions as part of a complex immune response to chronic antigenic stimulus invo … er sites. LEfSe and GLM analyses showed different taxa significantly enriched in the control group: Eubacterium ventriosum, Lacticaseibacillus, Paucibacter, Clostridioides, Bdellovibrio/Bdellovibrionaceae and Rhodobacteraceae, some of them suggested by previous findings as taxa of interest in their potential as preventive or diagnostic candidates. Additionall …

The ameliorative effect of hyaluronic acid-astaxanthin nanoparticles on colitis through reducing oxidative stress, enhancing colon barrier, and reshaping intestinal microbiota.

Astaxanthin (AST) is recognize as the most potent antioxidant found in nature; however, its practical applications have been limited due to … tio of Firmicutes/Bacteroidota, increasing the abundance of Paraclostridium, Paeniclostridium, and [Eubacterium]_fissicatena_group, and reducing the population of Comamonas, Dysgonomonas, Sporomusa, and Slistipes. In sum, HA-ASTNPs ameliorated UC involving in oxidative stress, inflammatory reaction, colon barrier, and intestinal microbiota. HA-ASTNPs had the …

Correlations Between Amelioration of Rotenone-Induced Parkinson's Symptoms by Amomum tsaoko Flavonoids and Gut Microbiota in Mice.

Parkinson's disease (PD) is the second most common neurodegenerative disease, but the existing therapeutic drugs for PD have limitations; th … io, Provotellaceae UCG-001, the Lachnospiraceae_NK4A136_group, norank_f_Erysipelotrichacea, and the Eubacterium nodatum group) and an increase in the abundance of probiotics (Bifidobacterium and Faecalibaculum). Interestingly, these genera were found to be significantly associated with PD motor symptoms and constipation indicators. This suggests that ATFs hav …

Trehalose Acts as a Mediator: Imbalance in Brain Proteostasis Induced by Polystyrene Nanoplastics via Gut Microbiota Dysbiosis during Early Life.

As an emerging contaminant, nanoplastics have evolved into a global ecological issue. Studies have shown that nanoplastics induce neurotoxic … s through 16S rDNA analyses and fecal microbiota transplantation. Crucial bacterial species such as Eubacterium coprostanoligenes potentially act as indicators for gut dysbiosis after PS-NPs exposure. Notably, we first estimated the indirect effect of gut microbiota on neurotoxicity attributed to PS-NPs in immature mice as 39.20% by high-dimensional mediation …