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Solriamfetol improves daily fatigue symptoms in adults with myalgic encephalomyelitis/chronic fatigue syndrome after 8 weeks of treatment.

BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a long-term illness with no treatment options that address the disease directly. Solriamfetol is a selective dual norepinephrine-dopamine reuptake inhibitor that promotes wakefulness in obstructive sleep apnea and narcolepsy. AIMS: This study evaluated the efficacy and safety of solriamfetol for fatigue symptoms in adults with ME/CFS over 8 weeks of treatment. METHODS: This was a phase 4, double-blind, randomized, placebo-controlled trial of solriamfetol in adults with ME/CFS. Eligible participants (N = 38) were rando…

Can listening-related fatigue influence well-being? Examining associations between hearing loss, fatigue, activity levels and well-being.

OBJECTIVE: Well-being is influenced by the activities we undertake. Hearing loss may reduce well-being directly through increased listening-related fatigue due to cognitive and emotional strain in challenging situations. Hearing loss and hearing device use may also indirectly impact fatigue and well-being by altering the frequency and type of daily-life activities. This review examines the available literature to help understand the relationships. DESIGN: We provide (i) a summary of the extant literature regarding hearing loss, hearing device use and fatigue in adults, as well as regarding fa…

Online eurythmy therapy for cancer-related fatigue: a prospective repeated-measures observational study exploring fatigue, stress, and mindfulness.

INTRODUCTION: Cancer is a debilitating disease with an often chronic course. One of the most taxing and prevalent sequelae in this context is cancer-related fatigue (CRF) resulting from the disease and/or associated treatments. Over the last years mindfulness-based interventions such as eurythmy therapy (ERYT), a mindful-movement therapy from anthroposophic medicine, have emerged as promising adjunct therapies in oncology. This prospective study investigated an online implementation of ERYT for CRF using a single arm repeated-measures design based on two consecutive studies. METHOD: Study 1 c…

Bending Fatigue Behaviour and Fatigue Endurance Limit Prediction of 20Cr2Ni4A Gear Steel after the Ultrasonic Surface Rolling Process.

To study the effect of the surface properties on the bending fatigue performance of heavy-duty gear steel, the authors of this paper used the ultrasonic surface rolling process (USRP) to strengthen 20Cr2Ni4A carburized gear steel. USRP is a novel technique in which the ultrasonic technology is incorporated into the concept of conventional deep rolling. In this study, we illustrated how the surface properties and cross-section mechanical property influence the three-point bending fatigue life of the samples before and after USRP treatment. At the same time, the predicted failure probability-str…

The Nottingham Fatigue after Stroke (NotFAST) study: factors associated with severity of fatigue in stroke patients without depression.

OBJECTIVE: To identify factors associated with post-stroke fatigue in a sample of stroke survivors without depression. DESIGN: Cross-sectional cohort study. SETTING: Recruitment was from four stroke units in the UK. SUBJECTS: Participants were assessed within four to six weeks of first stroke; those with high levels of depressive symptoms (score ⩾7 Brief Assessment Schedule Depression Cards) were excluded. MAIN MEASURES: Participants were assessed after stroke on the Fatigue Severity Scale of the Fatigue Assessment Inventory, the Rivermead Mobility Index, Nottingham Extended Activities of …

Dutch multifactor fatigue scale: a new scale to measure the different aspects of fatigue after acquired brain injury.

OBJECTIVES: To develop the Dutch Multifactor Fatigue Scale (DMFS), a new scale to assess the nature and impact of fatigue and coping with fatigue in the chronic phase after acquired brain injury (ABI) and to analyze the psychometric properties of this scale in a mixed group of patients with ABI. DESIGN: Cross-sectional survey study. SETTING: Academic rehabilitation center. PARTICIPANTS: A mixed sample of patients with ABI (N=134). For the development of the DMFS: community-dwelling adults with stroke (n=9) and traumatic brain injury (n=5). For analyses of the psychometric properties of the …

Evaluating sleepiness-related daytime function by querying wakefulness inability and fatigue: Sleepiness-Wakefulness Inability and Fatigue Test (SWIFT).

STUDY OBJECTIVES: Routine assessment of daytime function in Sleep Medicine has focused on "tendency to fall asleep" in soporific circumstances, to the exclusion of "wakefulness inability" or inability to maintain wakefulness, and fatigue/tiredness/lack of energy. The objective was to establish reliability and discriminant validity of a test for wakefulness inability and fatigue, and to test its superiority against the criterion standard for evaluation of sleepiness-the Epworth Sleepiness Scale (ESS). METHODS: A 12-item self-administered instrument, the Sleepiness-Wakefulness Inability and Fat…

Fatigue in Parkinson's disease and management with NIBS.

BACKGROUND: Fatigue is a common and debilitating non-motor symptom in Parkinson's disease (PD), significantly impairing patient quality of life and often observed in clinical management. Its pathophysiology involves complex interactions among dopaminergic, non-dopaminergic, and neuroinflammatory pathways. Although fatigue is highly prevalent, evidence-based treatment strategies remain limited. METHODS: This review is based on a targeted literature search focusing on recent advances in research on PD-related fatigue. Using a combination of keywords such as "Parkinson's disease", "fatigue", "no…

A mouse model to study persistent fatigue.

Fatigue is characterized as a feeling of exhaustion or lack of energy, is a common symptom of multiple chronic illnesses and interferes with daily activities and quality of life. There is a limited availability of animal models to examine potential underlying mechanisms ultimately limiting development of potential therapeutic strategies. The primary purpose of this study was to develop a mouse model of persistent fatigue. A secondary purpose was to characterize potential measures of "fatigue-like" behaviors. An exploratory goal was to examine for immune and metabolic changes in the model. We e…

Fatigue in COPD: a Longitudinal, Multidimensional Perspective.

BACKGROUND: Fatigue is a pervasive, debilitating symptom of chronic obstructive pulmonary disease (COPD) that significantly impacts patients' overall health and quality of life. However, its underlying mechanisms and associations with physical, psychological, behavioral, and other health factors remain unclear. This study investigated longitudinal associations between fatigue and these factors in COPD. METHOD: A total of 247 COPD patients (mean age, 67.3 ± 8.1 years; 60% male; mean forced expiratory volume in 1 s (FEV1) 57 ± 21% predicted) from primary and secondary care were enrolled in a lo…

Purpose in life and concurrent and incident fatigue.

Fatigue, the experience of extreme tiredness, is common and associated with poor health outcomes and worse quality of life. The present study examines purpose in life and the likelihood of concurrent fatigue and risk of developing fatigue over time. Participants from the Health and Retirement Study (N = 6,865) reported on their purpose in life and fatigue concurrently and their fatigue again every four years up to 12 years later. Controlling for sociodemographic covariates, higher purpose in life was associated with lower likelihood of concurrent fatigue (OR = .65, 95% CI = .61, .69, p < .001)…

Fatigue in acromegaly patients: a scoping review.

PURPOSE: This scoping review systematically examines current evidence on fatigue in acromegaly patients, with a particular focus on incidence, risk factors, hazards, assessment tools and therapeutic interventions, to inform evidence-based interventions aimed at improving rehabilitation outcomes. METHODS: A scoping review was conducted following the PRISMA-ScR guidelines. We systematically searched five international databases (PubMed, Embase, CINAHL, Web of Science, and the Cochrane Library) and three Chinese databases (CNKI [China National Knowledge Infrastructure], WanFang, and Sinomed) fro…

Investigation of Mental Fatigue in Individuals With Tinnitus.

OBJECTIVE: Mental fatigue is a common but understudied symptom in individuals with tinnitus. This study aimed to examine the relationship between tinnitus-related distress, anxiety symptoms, and mental fatigue. METHODS: A total of 119 participants (52 with tinnitus, 67 healthy controls) were included. All participants completed the Mental Fatigue Scale (MFS) and Generalized Anxiety Disorder-7 (GAD-7). The tinnitus group also completed the Tinnitus Handicap Inventory (THI), Visual Analog Scales (VAS), and psychoacoustic assessments (pitch matching, loudness level, minimum masking level). Group…

Imaging of Fatigue Fractures in the Adult Athlete.

Fatigue fractures, also known as stress fractures, are frequent overuse injuries among athletes. They result from repetitive mechanical loads that exceed the bone's adaptive capacity, leading to microdamage and eventual fracture. Early and accurate diagnosis, primarily through magnetic resonance imaging, prevents complications and facilitates optimal recovery. This article provides a comprehensive review of the imaging of fatigue fractures.

Сетевая локализация усталости в множестве склерозов.

Усталость является одним из наиболее распространенных симптомов и одним из основных факторов, определяющих качество жизни при множественном склерозе (МС). Однако нейробиологические механизмы, лежащие в основе усталости, не вполне понятны. Здесь мы изучали места поражения и их связи с людьми с MS в целях выявления сетей мозга, связанных с усталостью. МЕТОДЫ: В исследование были включены 38 пациентов с синдромом MS и 21 пациент без усталости. Были исследованы связи между местами усталости и повреждения с помощью картирования симптомов воксель-лесония и подключения к сети поражения с использовани

Совпадение в аннотации оригинала
BACKGROUND: Fatigue is among the most common symptoms and one of the main factors determining the quality of life in multiple sclerosis (MS). However, the neurobiological mechanisms underlying fatigue are not fully understood. Here we studied lesion locations and their connections in individuals with MS, aiming to identify brain networks associated with fati…

[Effect of ECT on chronic fatigue syndrome].

This is a case report of a 71-year-old woman with periodic depression manifested by atypical symptoms, i.e. extreme fatigue, who was successfully treated with ECT. At the onset of symptoms, about 30 years earlier, the patient had been diagnosed with chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) and had been unable to walk for six years until she was successfully treated with ECT. The misdiagnosis of CFS/ME as depression is well described in the literature. The opposite - depression being diagnosed as CFS/ME - does not seem to have been previously reported.

Biomarkers of fatigue in oncology: A systematic review.

Cancer-related fatigue (CRF) is a distressing side effect of cancer and treatment, affecting both patients during active treatment and survivors, negatively impacting quality of life. While its exact cause remains uncertain, various mechanisms such as immune dysfunction, HPA-axis dysfunction, and treatment toxicity are proposed. Inflammatory biomarkers of CRF have been explored in previous research, but non-inflammatory markers have not been comprehensively studied. This systematic review analysed 33 studies to identify non-inflammatory peripheral blood biomarkers associated with CRF. Promisin…

Biomolecules of Muscle Fatigue in Metabolic Myopathies.

Metabolic myopathies are a group of genetic disorders that affect the normal functioning of muscles due to abnormalities in metabolic pathways. These conditions result in impaired energy production and utilization within muscle cells, leading to limitations in muscle function with concomitant occurrence of related signs and symptoms, among which fatigue is one of the most frequently reported. Understanding the underlying molecular mechanisms of muscle fatigue in these conditions is challenging for the development of an effective diagnostic and prognostic approach to test targeted therapeutic i…

Unveiling the burden of compassion fatigue in nurses.

BACKGROUND: The COVID-19 pandemic has placed an unprecedented burden on nurses who have been at the forefront of patient care. The continuous exposure to suffering, death, and overwhelming demands has the potential to lead to compassion fatigue, a state of emotional, physical, and cognitive exhaustion. RESEARCH AIM: The study aimed to explore and understand the phenomenon of compassion fatigue in nurses as the effect of the COVID-19 pandemic. RESEARCH DESIGN: A constructivist grounded theory design was used. PARTICIPANTS AND RESEARCH CONTEXT: The research data were collected from 20 nurses …

Pathophysiology and Management of Fatigue in Neuromuscular Diseases.

Fatigue is a major determinant of quality of life and motor function in patients affected by several neuromuscular diseases, each of them characterized by a peculiar physiopathology and the involvement of numerous interplaying factors. This narrative review aims to provide an overview on the pathophysiology of fatigue at a biochemical and molecular level with regard to muscular dystrophies, metabolic myopathies, and primary mitochondrial disorders with a focus on mitochondrial myopathies and spinal muscular atrophy, which, although fulfilling the definition of rare diseases, as a group represe…