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Повсеместность коморбидной мигрени в множестве склерозов: сосуществуют ли множественный склероз и мигрень?

Множественный склероз (MS) является хроническим воспалительным заболеванием, вызывающим многофукаловое демиэлирование и повреждение аксона в центральной нервной системе. Последние исследования свидетельствуют о том, что среди пациентов, страдающих НР, наблюдается более высокий уровень заболеваемости мигренью, чем среди населения в целом. В ходе этого перекрестного исследования, проведенного в одном центре, была проведена оценка распространенности мигрени среди пациентов, проходящих курс лечения с целью изменения болезней (ДМТ). МЕТОДЫ: Всего 205 Включены пациенты с сенсорным синдромом. Все уча

Совпадение в аннотации оригинала
BACKGROUND: Multiple sclerosis (MS) is a chronic inflammatory disease causing multifocal demyelination and axonal damage in the central nervous system. Recent studies indicate that MS patients have a higher prevalence of migraine than the general population. This cross-sectional, single-centre study assessed migraine prevalence in MS patients receiving disea…

Brain hemodynamic responses and fall prediction in older adults with multiple sclerosis.

OBJECTIVE: We examined whether brain hemodynamic responses, gait, and cognitive performances under single- and dual-task conditions predict falls during longitudinal follow-up in older adults with multiple sclerosis (OAMS) with relapsing-remitting and progressive subtypes. METHODS: Participants with relapsing-remitting (n = 53, mean age = 65.02 ± 4.17 years, %female = 75.5) and progressive (n = 28, mean age = 64.64 ± 4.31 years, %female = 50) multiple sclerosis (MS) subtypes completed a dual-task-walking paradigm and reported falls during longitudinal follow-up using a monthly structured tele…

Autologous Hematopoietic Stem Cell Transplantation in Active Multiple Sclerosis: A Real-world Case Series.

OBJECTIVE: To examine outcomes in people with multiple sclerosis (PwMS) treated with autologous hematopoietic stem cell transplantation (AHSCT) in a real-world setting. METHODS: This was a retrospective cohort study of PwMS treated with AHSCT at 2 centers in London, UK, consecutively between 2012 and 2019 who had ≥6 months of follow-up or died at any time. Primary outcomes were survival free of multiple sclerosis (MS) relapses, MRI new lesions, and worsening of Expanded Disability Status Scale (EDSS) score. Adverse events rates were also examined. RESULTS: The cohort includes 120 PwMS; 52% h…

Gray matter microglial activation in relapsing vs progressive MS: A [F-18]PBR06-PET study.

OBJECTIVE: To determine the value of [F-18]PBR06-PET for assessment of microglial activation in the cerebral gray matter in patients with MS. METHODS: Twelve patients with MS (7 relapsing-remitting and 5 secondary progressive [SP]) and 5 healthy controls (HCs) had standardized uptake value (SUV) PET maps coregistered to 3T MRI and segmented into cortical and subcortical gray matter regions. SUV ratios (SUVRs) were global brain normalized. Voxel-by-voxel analysis was performed using statistical parametric mapping (SPM). Normalized brain parenchymal volumes (BPVs) were determined from MRI using

Plasma exchange in severe acute relapses of multiple sclerosis - Results from a Portuguese cohort.

BACKGROUND: Relapses in Multiple Sclerosis (MS) are often associated with significant disability impairment which is resultant from poor response to corticosteroids. In such severe cases, plasma exchange (PLEX) may be used, although only a few studies with MS patients have been reported. Our objective was to evaluate the effectiveness of PLEX in severe relapses of MS. METHODS: Retrospective study of MS patients treated with PLEX in acute relapses. Data regarding EDSS, annualized relapse rate (ARR), treatment with corticosteroids, number of PLEX sessions, adverse events, and gadolinium enhance…

[MusiQol: international questionnaire investigating quality of life in multiple sclerosis: validation results for the German subpopulation in an international comparison].

BACKGROUND: The existing health-related quality of life questionnaires on multiple sclerosis (MS) only partially reflect the patient's point of view on the reduction of activities of daily living. Their development and validation was not performed in different languages. That is what prompted the development of the Multiple Sclerosis International Quality of Life (MusiQoL) Questionnaire as an international multidimensional measurement instrument. This paper presents this new development and the results of the German subgroup versus the total international sample. PATIENTS AND METHODS: A total…

Autologous stem cell transplantation in progressive multiple sclerosis--an interim analysis of efficacy.

Based on the good results of experimental transplantation in animal models of multiple sclerosis and of other autoimmune diseases, we have treated 24 patients suffering from chronic progressive multiple sclerosis with high-dose chemotherapy (BEAM regimen) followed by autologous blood stem cell rescue and antithymocyte globulin. Blood stem cells were mobilised with cyclophosphamide at 4g/m2 and G- (or GM-) CSF. In 9 cases, additional CD34+ cell-selection of the graft was performed. Here we update previously published results of this novel treatment, mainly with regard to clinical efficacy, as t…

[Modern methods of rehabilitation of patients with different degrees of multiple sclerosis. (Literature review)].

Multiple sclerosis is a chronic autoimmune disease that causes damage to the myelin sheath of the nerve fibers, which leads to various neurological symptoms. Over the past 30 years, a significant advance in studying the pathogenesis of multiple sclerosis has been achieved and progress in symptomatic treatment of the disease, including control of secondary manifestations, has been noted. Rehabilitation plays an important role in the management of this disease. Physical rehabilitation, which includes physiotherapy and therapeutic exercise, is the main part of rehabilitation. Psychological rehabi…

Increased levels of circulating soluble CD226 in multiple sclerosis.

BACKGROUND: The glycoprotein CD226 plays a key role in regulating immune cell function. Soluble CD226 (sCD226) is increased in sera of patients with several chronic inflammatory diseases but its levels in neuroinflammatory diseases such as multiple sclerosis (MS) are unknown. OBJECTIVE: To investigate the presence and functional implications of sCD226 in persons with multiple sclerosis (pwMS) and other neurological diseases. METHODS: The mechanisms of sCD226 production were first investigated by analyzing CD226 surface expression levels and supernatants of CD3/CD226-coactivated T cells. The …

Advances in specific therapy for multiple sclerosis.

During the past year, two new agents have been demonstrated to be of value in multiple sclerosis. The first agent, a form of recombinant interferon beta (Betaseron; Berlex Labs, Cedar Knolls, NJ), is effective in reducing relapses and also prevent accumulation of brain lesions over time, but has no demonstrated effect on the accumulation of disability over time. The second agent, methylprednisolone (Solumedrol; The Upjohn Co., Kalamozoo, MI), administered in megadose pulses over several days and followed by an oral prednisone taper, reduces the conversion rate of patients with optic neuritis t…

[Mitoxantrone role in treatment of primary progressive multiple sclerosis].

Multiple sclerosis is a chronic, autoimmunological disease of central nervous system in which axonal damage in brain and spinal cord is observed. It is second most common cause of disability in young adults in West Europe and North America after injuries. There is 2.5 million people suffered from multiple sclerosis worldwide. The worse prognosis is connected with primary progressive MS in which recovery after first symptoms of central nervous system damage isn't observed. That subtype of disease is seen in case of 10-20% people with MS. MTX is a synthetic antracycline with antineoplastic, immu…

Disease course after pregnancy in women with progressive multiple sclerosis symptoms.

BACKGROUND: The impact of pregnancy on disease outcomes has not been characterised in women with progressive multiple sclerosis (MS) phenotypes. This study aimed to describe the clinical characteristics and disease course of women who experienced a pregnancy after a diagnosis of primary progressive MS (PPMS) or secondary progressive MS (SPMS). METHODS: This multicentre observational cohort study utilised data from the international MSBase Registry extracted on 2 June 2024. Expanded Disability Status Scale (EDSS) scores of women with progressive MS were assessed up to 10 years postpartum and c…

VEGF and vascular changes in chronic neuroinflammation.

A vascular component has long been associated with the pathological changes in multiple sclerosis (MS) and its animal model, experimental allergic encephalomyelitis (EAE). Despite the codependence of angiogenesis and many chronic inflammatory disorders, only circumstantial evidence is available to support the existence of angiogenesis in MS or EAE. To determine if angiogenesis occurs in conjunction with clinical and pathological signs of CNS inflammatory disease we evaluated temporal and spatial blood vessel counts, VEGF immunoreactivity, and histopathological changes in the spinal cord of gui…

Anti-BCMA CAR-T therapy in patients with progressive multiple sclerosis.

Progressive multiple sclerosis (PMS), which is characterized by relentless disease progression, lacks effective treatment. While recent studies have highlighted the importance of B cells in driving compartmentalized central nervous system (CNS) inflammation in PMS pathogenesis, current B cell depletion therapies, such as CD20 monoclonal antibodies, face challenges in targeting plasma cells within the CNS. Here, we treated five patients with PMS (one primary PMS and four secondary PMS) with anti-B cell maturation antigen (BCMA) chimeric antigen receptor T (CAR-T) cell therapy in an ongoing phas…

Нацеливание на прорастающую микроглию в прогрессивном множественном склерозе: подход, основанный на геронаучной информации.

Множественный склероз (MS) — нервно-воспалительное и нейродегенеративное расстройство центральной нервной системы (КНС). Возраст является самым сильным прогнозом фенотипа заболеваний, при этом большинство пожилых людей переходят к прогрессивной форме, характеризующейся необратимым неврологическим спадом. Эта клиническая прогрессия связана с охлаждением, отсеиванием CNS воспаления и нейродегенерацией, для которых в настоящее время не существует эффективных методов лечения, позволяющих регулировать заболевания. Клеточная сенесцензия, характеризующаяся секрецией посредников, выступающих за воспла

Совпадение в аннотации оригинала
Multiple sclerosis (MS) is a neuroinflammatory and neurodegenerative disorder of the central nervous system (CNS). Age is the strongest predictor of disease phenotype, with the majority of older adults transitioning to a progressive form marked by irreversible neurological decline. This clinical progression is associated with smoldering, CNS-compartmentalize…

Неврологические расстройства и атрофия серой материи мозга в первичном прогрессивном множественном склерозе определяются микроструктурными изменениями, но не нагрузкой на повреждение.

ИСТОРИЯ ВОПРОСА: Обычные МРТ, такие, как количество и объем повреждений MS, являются гистологически неконкретными и не могут в достаточной степени объяснить клиническую инвалидность или атрофию головного мозга в MS. Тем не менее в демиелионирующих досках проявляются различные гистопатологические особенности в подтипах релапсирующих и прогрессивных множественных склерозов (MS). Цель этого исследования заключалась в оценке микроструктурных характеристик MS-повреждений с использованием количественных МРТ и изучении их связей с атрофией серой материи (GM) и клинической инвалидностью.МЕТОДЫ: 56 кон

Совпадение в аннотации оригинала
BACKGROUND: Conventional MRI measures, such as the number and volume of MS lesions, are histologically non-specific and cannot sufficiently explain clinical disability or brain atrophy in MS. Nevertheless, demyelinating plaques exhibit distinct histopathological features in relapsing and progressive multiple sclerosis (MS) subtypes. The aim of this study was…

Влияние скорости обработки информации на процессы памяти пациентов с повторным излучением и первичным постепенным множественным склерозом.

Замедленная скорость обработки информации (IPS) является основным когнитивным расстройством у людей с множественным склерозом (pwMS). Хотя известно, что это влияет на процессы памяти, взаимосвязи между устным обучением (VL), устной памятью (VM) и IPS в различных фенотипах множественного склероза (MS) остаются недостаточно изученными. Цель этого бицентрического исследования состояла в подробном изучении IPS, VL и VM, а также взаимосвязей между этими когнитивными областями в обширной выборке из 92 PwMS (61 с ранним восстановлением эмиссий MS (pwRMS), 31 с первичным прогрессивным MS (pwPPMS)) и 6

Совпадение в аннотации оригинала
Slowed information processing speed (IPS) is the primary cognitive impairment in people with multiple sclerosis (pwMS). Although it is known to affect memory processes, the relationships between verbal learning (VL), verbal memory (VM) and IPS in different phenotypes of multiple sclerosis (MS) remain underexplored. This bicentric study aimed to investigate i…

Multiple sclerosis clinical course and cardiovascular disease risk - Swedish cohort study.

BACKGROUND AND PURPOSE: Cardiovascular disease (CVD) risk amongst multiple sclerosis (MS) patients appears raised, but few studies have examined CVD risk amongst an unselected MS patient group. MS course may be relevant for CVD risk. Our aim was to assess CVD risk and variation by course in MS patients. METHODS: The Multiple Sclerosis Register identified 7667 patients who received an MS diagnosis between 1964 and 2005. They were matched by age, period, region and sex with 76 045 members of the general population without MS using Swedish registers. Poisson regression compared the two cohorts t…

Reactivity to AQP4 epitopes in relapsing-remitting multiple sclerosis.

Autoantibodies against the water channel AQP4, expressed predominately in central nervous system astrocytes, are markers and pathogenic factors in Devic's disease. In this study we examined whether Multiple Sclerosis (MS) patients recognize antigenic epitopes on AQP4 that may define distinct disease subsets. We screened sera from 45 patients with relapsing-remitting MS (RRMS) and 13 patients with primary progressive MS (PMS). 23 Neuromyelitis Optica (NMO) patients previously characterized were used as assay positive/negative controls. Sera from 23 patients with Systemic Lupus Erythematosus, 23…

Advances in Multiple Sclerosis.

Multiple sclerosis is a chronic autoimmune disorder that affects the central nervous system, causing episodes of neurologic dysfunction and often gradual disease progression. The immune system primarily targets myelin, the protective covering of nerve fibers, leading to inflammation and damage, and secondary neurodegeneration is a major cause of long-term disability. Common symptoms include vision problems, sensory disturbances, muscle weakness, balance difficulties, and bladder dysfunction. Important advances in treatment have improved outcomes in patients with relapsing forms of multiple scl…