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Effectiveness of nasal irrigation for chronic rhinosinusitis and fatigue in patients with Gulf War illness: protocol for a randomized controlled trial.

INTRODUCTION: Gulf War Illness (GWI) affects 1 in 7 returned Persian Gulf War veterans. Quality-of-life impact is large; there is no cure. Chronic sinus symptoms and fatigue are common. Nasal irrigation with saline (NI-S) or xylitol (NI-X) improve sinus symptoms and fatigue in the general population. This trial will assess the effect of NI-S and NI-X on sinus and fatigue symptoms, economic outcomes and pro-inflammatory milieu among participants with GWI. METHODS: 75 participants (age 35 to 65 years, 25 in each of three arms) with GWI will be recruited from the Veteran's Administration and the…

Monosaccharides in health and disease.

In healthy persons, glucose homeostasis maintains blood glucose levels between 70 and 130 mg/dl despite perturbations by meals, fasting, and … s appears to promote obesity more than glucose because of its lack of stimulation of thermogenesis. Xylitol has been used as a sweetener and as a sugar substitute in total parenteral nutrition. It is a paradox that the most physiological of sugars (glucose) can be a menace at high concentrations. The use of nonphysiological sugars or their derivatives in …

Enzootic and epizootic adrenal medullary proliferative disease of rats: influence of dietary factors which affect calcium absorption.

Adrenal medullary hyperplasia and neoplasia occur both enzootically and epizootically in untreated laboratory rats. The lesions are typicall … ease in rats by the feeding, in high dietary concentration, of certain polyols (sorbitol, mannitol, xylitol, lactitol), or of lactose, suggested that increased absorption of calcium from the gastrointestinal tract may be a risk factor. This evidence is reported and discussed in the light of other evidence linking disturbed calcium homeostasis with adrenal …

Acid resistance of enamel subsurface lesions remineralized by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate.

The aim of this clinical study was to investigate the acid resistance of enamel lesions remineralized in situ by a sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate nanocomplexes (CPP-ACP: Recaldent). The study utilized a double-blind, randomized, crossover design with two treatments: (i) sugar-free gum containing 18.8 mg of CPP-ACP, and (ii) sugar-free gum not containing CPP-ACP as control. Subjects wore removable palatal appliances with insets of human enamel containing demineralized subsurface lesions and chewed the gum for 20 min 4 times per day for 14 day

Фотобиомодулирование для сведения к минимуму талькетамаба, связанного с дисгеюзией и ксеростомией, во многих миеломах: краткий отчет о four Дела.

СПРАВОЧНАЯ ИНФОРМАЦИЯ: Талкетамаб, GPRC5D-targeting bi - специфическая антитела, вызывающая высокие показатели ответов в случае рецидива/отключения множественных миелом (RRMM), но зачастую ассоциируется с оральными негативными последствиями, чаще всего дисгейской и ксеростомии, которые могут отрицательно сказаться на питании и качестве жизни. Никаких мер по оказанию поддержки в связи с этими последствиями, основанных на фактических данных, не предусмотрено. Мы описываем методы. four :: взрослые с RRMM, получившие фотобиомодулирование (PBM) одновременно с талькетамабом, с двойной волновой длино

Совпадение в аннотации оригинала
BACKGROUND: Talquetamab, a GPRC5D-targeting bispecific antibody, produces high response rates in relapsed/refractory multiple myeloma (RRMM) … us saliva on examination; salivary flow was not measured quantitatively. All patients also received xylitol-based mouthwash and saliva substitutes from the start of talquetamab as concomitant standard supportive care. PBM was well tolerated, with no PBM-related adverse events, and no patient discontinued talquetamab because of oral toxicity. CONCLUSIONS: …

Metabolomic Biomarkers of Dietary Approaches to Stop Hypertension (DASH) Dietary Patterns in Pregnant Women.

Objective: the aim of this study was to identify plasma metabolomic markers of Dietary Approaches to Stop Hypertension (DASH) dietary patter … asparagine, beta-alanine, glycine, taurine, and hydroxycarbamate), 1 organic oxygen compound (i.e., xylitol), and 1 organoheterocyclic compound (i.e., maleimide). Conclusions: our study identified plasma metabolomic markers for DASH dietary patterns in pregnant women, with most of being lipids and lipid-like molecules.

Ultrasound-Assisted Ternary Deep Eutectic Solvent Extraction of Total Flavonoids from Artemisia argyi: GA-ANN Optimization, Greenness Assessment, and In Vitro Bioactivity Evaluation.

Total flavonoids (TF) from Artemisia argyi, a traditional edible-medicinal Asteraceae herb, were extracted via a food-grade ternary deep eutectic solvent (TDES, Glycerol/Levulinic Acid/Xylitol = 1:1:1 molar ratio, 30% w/w water) under ultrasound assistance. A hybrid response surface methodology-genetic algorithm-artificial neural network (RSM-GA-ANN) model optimized parameters to deliver a maximum TF yield of 107.7 mg/g-1.5-1.8-fold higher than conventional hydroalcoholic extraction. Greenness was quantified by AGREEprep (score = 0.70) and MoGAPI (score = 80/100), confirming the method's susta…

Anxiety Disorder Types From a Metabolomics Perspective: A Mendelian Randomization Analysis Based on 1400 Plasma Metabolites.

BACKGROUND: Different anxiety types demonstrate overlapping clinical features while retaining distinct characteristics, often leading to dia … IVW = 0.010) was unique. Potential panic disorder (PD) risk metabolites were identified as arabitol/xylitol (OR = 1.002, PIVW = 0.011), 2-hydroxy-3-methylvalerate (OR = 1.002, PIVW = 0.008), and the AMP to phosphate ratio (OR = 1.003, PIVW = 0.004). Protective factors for GAD included X-17354 (OR = 0.739, PIVW = 0.023) and the salicylate to citrate ratio …

Instant and freshness effect of mouth rinses on type 1 (oral) halitosis.

Hygiene deficiency causes type 1 (oral) halitosis. There are short and long-term studies on the anti-halitosis effect of mouth rinses but le … inses containing ethyl and other alcohols (including glycol, sorbitol, menthol, eucalyptol, thymol, xylitol and eugenol) were found to be less effective on halitosis.

Propolis as a Cariostatic Agent in Lozenges and Impact of Storage Conditions on the Stability of Propolis.

Propolis is known as a source of compounds with strong antibacterial activity. Due to the antibacterial effect against streptococci of the o … determined on cariogenic streptococci related to the occurrence of dental caries. Lozenges based on xylitol, glycerin, gelatin, water, and ethanol extract of propolis (EEP) were prepared. The effect of prepared lozenges on cariogenic bacteria was assessed. Propolis was compared to chlorhexidine which is used in dentistry as the gold standard. In addition, …

Characterization of nitrated sugar alcohols by atmospheric-pressure chemical-ionization mass spectrometry.

RATIONALE: The nitrated sugar alcohols mannitol hexanitrate (MHN), sorbitol hexanitrate (SHN) and xylitol pentanitrate (XPN) are in the same class of compounds as the powerful military-grade explosive pentaerythritol tetranitrate (PETN) and the homemade explosive erythritol tetranitrate (ETN) but, unlike for PETN and ETN, ways to detect MHN, SHN and XPN by mass spectrometry (MS) have not been fully investigated. METHODS: Atmospheric-pressure chemical-ionization mass spectrometry (APCI-MS) was used to detect ions characteristic of nitrated sugar alcohols. APCI time-of-flight mass spectrometry …

A novel arabinose-inducible promoter in the carotenogenic yeast Xanthophyllomyces dendrorhous.

Xanthophyllomyces dendrorhous is a basidiomycetous yeast capable of synthesizing astaxanthin, a powerful antioxidant carotenoid pigment. Des … ol dehydrogenase (LAD), isocitrate lyase (ICL), alpha glucosidase (AG), glycerol kinase (GUT1), and xylitol dehydrogenase (XDH) genes were screened and evaluated. The promoter sequences were cloned into a plasmid containing the encoding sequence for Enhanced Yellow Fluorescent Protein (EYFP) for functional assessment. Promoter activity was quantified by f …

Metabolism of Malus halliana Roots Provides Insights into Iron Deficiency Tolerance Mechanisms.

Iron (Fe) deficiency is one of the most common micronutrient imbalances limiting plant growth globally, especially in arid and saline alkali … at the first (R12h vs. R0h) and third time points (R3d vs. R0h). Carbohydrates (digalacturonate, L-xylitol, ribitol, D-xylulose, glucose, and glycerol) are degraded into pyruvate through glycolysis and pentose phosphate, which participate in the TCA. Glutathione metabolism and the TCA cycle coordinate with each other, actively respond to Fe deficiency st …

Differences between reversible (self-association) and irreversible aggregation of rHuG-CSF in carbohydrate and polyol formulations.

Severe immunogenic and other debilitating human disorders potentially induced by protein aggregates have brought this phenomenon into the fo … formulation stabilisers, selected from the group of carbohydrates and polyols including trehalose, xylitol, cellobiitol, turanose, cellobiose, leucrose, lactitol, lyxose, and sorbitol, against both irreversible protein aggregation and reversible self-association processes of the rHuG-CSF. The formation of irreversible aggregates was thermally induced and …

Biotechnological applications of D-xylose-fermenting autochthonous yeasts in lignocellulosic biorefineries.

The efficient fermentation of D-xylose by yeasts remains a major bottleneck for the sustainable production of second-generation bioethanol, … production, D-xylose metabolism in yeasts can be redirected toward value-added bioproducts such as xylitol and organic acids, broadening the economic potential of lignocellulosic feedstocks. Advances in molecular taxonomy, adaptive evolution, metabolic engineering, and omics-based analyses have substantially improved fermentation performance and robustne …

A Case-Control Comparison of Salivary pH, Dental and Periodontal Health, and Bacterial Counts of Porphyromonas gingivalis and Streptococcus mutans in Patients With Systemic Lupus Erythematosus.

BACKGROUND: Patients with systemic lupus erythematosus (SLE) may exhibit increased oral health vulnerabilities. This study aimed to compare … ive caries prevention in SLE. Strategies such as hydration guidance, pH-regulating mouthwashes, and xylitol-containing products may be beneficial, although their efficacy in SLE populations was not tested.

Green Extraction and Characterization of Collagen from Different Fish Scales and Cell Culture-Based Bioactive Evaluation of Its Combinations with Zingiber officinale.

Fish processing by-products represent a valuable and sustainable source of collagen for biomedical and functional applications. In the present study, collagen was extracted from the scales of red mullet (Mullus barbatus), gilthead sea bream (Sparus aurata), and European sea bass (Dicentrarchus labrax) using a green extraction approach based on a natural deep eutectic solvent (NADES) system composed of citric acid, xylitol, and water. The extracted collagens were comprehensively characterized by SDS-PAGE, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and X-…

Natural Deep Eutectic Solvents (NADESs) for the Extraction of Bioactive Compounds from Quinoa (Chenopodium quinoa Willd.) Leaves: A Semi-Quantitative Analysis Using High Performance Thin-Layer Chromatography.

Natural deep eutectic solvents (NADESs) have emerged as a promising eco-friendly alternative to petrochemicals for extracting plant metaboli … propanediol-chcl-w (1:1:1, N5), lactic acid-glucose-w (5:1:3, N6), glycerol-chcl-w (2:1:1, N7), and xylitol-chcl-w (1:2:3, N8). Rheological measurements of all NADESs confirmed their pseudoplastic behaviors. To improve the extraction processes, differential scanning calorimetry (DSC) allowed us to determine the maximum amount of water that could be added …