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Integrative multi-omics reveals comprehensive gut-liver-adipose metabolic changes in peak laying hens with high or low egg production.

Eggs serve as an indispensable global nutritional resource, sustaining the economic foundation of the commercial poultry industry. To meet t … carbohydrate degradation and carbohydrate-binding modules, with keystone taxa including Blautia and Bifidobacterium associated with production and lipid markers. Collectively, these findings suggest that high egg production during the peak laying period is associated with coordinated metabolic differences across the liver, abdominal fat tissue, and intestine. The …

Wilson's disease-associated gut dysbiosis: novel insights into microbial functional alterations, virulence changes, and resistance markers.

BACKGROUND: Although the gut microbiota is associated with a variety of metabolic, inflammatory, and neurological disorders through microbia … tance), and cfxA6 (mediating cephamycin resistance). Furthermore, ARG profiles were associated with Bifidobacterium enrichment and showed significant correlations with lipid metabolism markers [e.g., triglycerides (TG), high-density lipoprotein cholesterol (HDL-C)]. Critically, we identified significant enrichment of 60 functional mobile genetic elements (MGEs) i …

[Exploring the mechanism underlying the efficacy differences of "Tiaojing Cuyun Acupuncture"for premature ovarian failure based on vaginal microbiota structure].

OBJECTIVE: To observe the efficacy of "Tiaojing Cuyun Acupuncture" combined with hormone replacement therapy in the treatment of premature o … ia, Bacteroidetes and Proteobacteria compared with the G1 subgroup. At the family and genus levels, Bifidobacterium was enriched in the G0 subgroups of both groups, whereas Lactobacillus predominated in the G1 subgroups. The G0 subgroup of the control group showed higher abundance of Gardnerella, while both Lactobacillus and Gardnerella were concurrently elevated …

Cell cycle gene expression and microbial profiles associated with HPV related cervical neoplasia and cervical microbiome shifts.

Background and objectives The improper regulation of the cell cycle is a significant risk factor for cervical cancer (CC), which is a seriou … tobacillus, Gardnerella, Bacillus, and Streptococcus. There were also genotype-specific patterns in Bifidobacterium, Actinomyces, and Atopobium. Although no significant correlations were found between the microbiome composition and CCNE1/CDK2 transcription, descriptive analysis suggested a potential correlation. Conclusion This study shows that HPV infection, esp …

Microbial imbalances linked to early pregnancy loss: a comparative analysis of vaginal microbiota.

OBJECTIVE: To explore the role and related functions of vaginal microbiota in early pregnancy loss. METHODS: This study was a case-control … nera, Streptococcus and Porphyromonas were significantly more abundant in patients with PL, whereas Bifidobacterium was significantly more prevalent in the reference group. Among the 20 most abundant species, Lactobacillus crispatus was significantly more prevalent in patients with PL, whereas common in the control group. 3. Principal Coordinates Analysis (PCoA) …

Combination of Withania coagulans and Fagonia cretica ameliorates hyperuricemia by re-modulating gut microbiota-derived spermidine and traumatic acid.

BACKGROUND: Hyperuricemia (HU), characterized by elevated serum uric acid (UA) levels, is associated with metabolic disorders, renal disease … 10 was markedly increased. WC extracts restored gut microbial diversity by increasing the levels of Bifidobacterium, while FC increased Eubacterium xylanophilum. Metabolomic analysis of the gut microbiota revealed increased spermidine (SP) levels in WC-treated mice and traumatic acid (TA) levels in FC-treated mice, which contributed to reduced UA synthesis and en …

Effects of defatted rice bran-fortified bread on gut microbiome, cardiovascular risk, gut discomfort, wellbeing and gut physiology in healthy adults with low dietary fibre intake.

BACKGROUND & AIMS: Inadequate dietary fibre (DF) intake is associated with suboptimal gut function and increased risk of several human disea … DRB group had increased relative abundances of Faecalibacterium prausnitzii (unadjusted p = 0.04), Bifidobacterium longum (unadjusted p = 0.12), and Bacteroides ovatus (unadjusted p = 0.10); lower relative abundances in Coprococcus genus (unadjusted p = 0.09), Roseburia faecis (unadjusted p = 0.02) and Prevotella copri species (unadjusted p = 0.05). However, no …

Chronic bile duct hyperplasia is a chronic graft dysfunction following liver transplantation.

AIM: To investigate pathological types and influential factors of chronic graft dysfunction (CGD) following liver transplantation (LT) in ra … he normal group (9.62 ± 1.60, 9.93 ± 1.10) and SGT group (8.95 ± 0.04, 9.02 ± 1.14), the numbers of Bifidobacterium and Lactobacillus in the AGT group (7.83 ± 0.72, 8.87 ± 0.13) were remarkably reduced (both P < 0.01). In addition, metabonomics analysis showed that metabolic profiles of plasma in rats in the AGT group were severe deviated from the normal and SGT …

Gut microbiota shapes cancer immunotherapy responses.

The gut microbiota significantly influences cancer immunotherapy efficacy by modulating immune responses, remodeling the tumor microenvironment (TME), and producing key metabolites. Strategies such as FMT, probiotics, and dietary interventions show promise in enhancing responses to ICIs and ACTs while reducing immune-related adverse events (irAEs). This review summarizes clinical and preclinical findings and discusses microbiota-based interventions and future directions for precision immunotherapy.

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… For example, Bifidobacterium bifidum and Bifidobacterium fragilis promote innate immunity by interacting with DCs and macrophages through their metabolites and stimulating the release of cytokines such as IL-12 and TNF-α 92 , 93 , 123 . … Conversely, microbiota exemplified by Akkermansia muciniphila, Lactobacillus, Bifidobacterium fragilis, and Bifidobacterium bifidum, as well as FMT from healthy donors, which collectively enhanced Treg activity, promoted SCFA production, and upregulated anti-inflammatory cytokines such as IL-10 and TGF-β …

Новальная граница в исследовании оксиса Гут-Брэйна: трансплантация фекалий микробиота в неевродегенеративных расстройствах.

Ось кишечника (GBA) представляет собой сложную двунаправленную систему связи, соединяющую центральную нервную систему (CNS) и желудочно-кишечный тракт (GI). Такое взаимодействие происходит главным образом через нейронные, иммунные и метаболические пути. Дисбиоз в кишечной микробиоте связан с многочисленными нейродегенеративными заболеваниями, такими, как болезнь Паркинсона (PD), болезнь Альцгеймера (AD), множественный склероз (MS) и амиотропический боковой склероз (ALS). В последние годы в качестве новаторского терапевтического подхода к трансплантации фекальной микробиоты (ФМТ) была привлечен

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… Another review corroborated the connection of Akkermansia , Bifidobacterium , and Faecalibacterium with PD, while Alistipes , Bacteroides , Bifidobacterium , and Blautia were associated with AD. Escherichia / Shigella emerged as the most consistently linked microbial group. … Moreover, Bifidobacterium animalis showed potential in suppressing inflammation associated with NLR family pyrin domain containing 3 (NLRP3) inflammasome signaling [ 68 ]. …

Analysis of fecal microbiota and related clinical indicators in ICU patients with sepsis.

BACKGROUND: To analyze the characteristics of fecal microbiota disturbance in the intensive care unit (ICU) patients with sepsis and the cor … The top six genera in relative abundance in the ND_S group were Escherichia-Shigella, Enterococcus, Bifidobacterium, Lactobacillus, Akkermansia, and Klebsiella. Compared with the Clinical Improvement group, the relative abundance of Escherichia-Shigella and Klebsiella in the Death or DAMA group showed an increasing trend with no significant significance, while th …

Effects of Feeding Different Postbiotics Produced by Lactobacillus plantarum on Growth Performance, Carcass Yield, Intestinal Morphology, Gut Microbiota Composition, Immune Status, and Growth Gene Expression in Broilers under Heat Stress.

The effects of feeding different postbiotics on growth performance, carcass yield, intestinal morphology, gut microbiota, immune status, and … and Lactobacillus count and lower Salmonella count compared to the NC and PC treatment groups. The Bifidobacterium population in the NC group was significantly lower compared to the other treatment groups. The postbiotic (RI11, RS5 and UL4) and AA treatment groups showed lower Enterobacteriaceae and E. coli counts and caecal pH than the NC and PC treatment group …

Помимо потери веса: изучение неврологических последствий изменённой микробиоты кишечника послекариатрической хирургии.

В настоящем обзоре обсуждаются результаты, связанные с неврологическими расстройствами, кишечной микробиотой и бариатрической хирургией, с уделением особого внимания нейротрансмиттерам, нейроэндокрину, патофизиологии бактерий, способствующих возникновению нарушений, и возможным терапевтическим вмешательствам. Исследования в области нейротрансмиттеров показывают, что их уровни сильно зависят от кишечного микробиота, которая может связать их с такими неврологическими расстройствами, как болезнь Альцгеймера, болезнь Паркинсона, множественный склероз, депрессия и расстройства спектра аутизма. Пато

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… This enzyme is also present in Bifidobacterium [ 139 ]. … Similar to the diseases discussed above, Bifidobacterium was found to be decreased in patients with ASD [ 243 ]. …

[Clinical study on efficacy and mechanism of separated moxibustion in the treatment of rheumatoid arthritis and related negative emotions based on gut microbiota].

OBJECTIVES: To investigate the clinical efficacy of separated moxibustion in the treatment of rheumatoid arthritis (RA) and related negative … on indices) and the abundances of beneficial bacteria (Bacteroidota, Faecalibacterium, Bacteroides, Bifidobacterium) in the observation and control groups were significantly lower (P<0.01), while the Firmicutes/Bacteroidota (F/B) ratio and the abundances of opportunistic pathogenic bacteria (Firmicutes, Prevotella, Proteobacteria, Actinobacteriota, Escherichia-Sh …

Effect of caloric restriction with probiotic supplementation on body composition, quality of life, and psychobiological factors of obese men: A randomized, double-blinded placebo-controlled clinical trial.

BACKGROUND & AIMS: Obesity is a chronic disease characterized by an excess of fat mass. It is accompanied by a low-grade chronic systemic in … : Lactobacillus acidophilus NCFM, Lactobacillus rhamnosus HN001, Lactobacillus paracasei Lpc-37 and Bifidobacterium lactis HN019, totaling 8 billion CFU/day. CR and probiotic (or placebo) supplementation intervention lasted 12 weeks. Body composition and psychobiological-related parameters (e.g., sleep, anxiety, stress, and depression) were assessed at baseline a …

Efficacy and safety of herbal formulas with the function of gut microbiota regulation for gastric and colorectal cancer: A systematic review and meta-analysis.

BACKGROUND: Currently, gastric cancer (GC) and colorectal cancer (CRC) are the most common causes of cancer-related mortality worldwide. Gut … were included. These trials involve seven herbal formulas that could regulate the gut microbiota of Bifidobacterium, Lactobacillus, Escherichia coli, Bacteroides, and Enterococcus faecalis. The meta-analysis results were subgrouped to three different stages in GC and CRC. 1) For the perioperative stage, HFGMR combined with conventional therapy could shorten the t …

[Analysis of intestinal patients' flora changes with severe pneumonia based on 16SrDNA sequencing technology].

OBJECTIVE: To investigate the characteristics of gut microbiota dysbosis in patients with severe pneumonia using 16SrDNA sequencing. METHOD … 1)%, all P < 0.05]. (5) Analysis of genus difference gut microflora showed that, the proportions of Bifidobacterium, Ruminococcus, Pseudobutyrivibrio, Coprococcus, Lachnospira and Prevotella in the severe pneumonia group were significantly lower than those in healthy control group [0.18 (0.01, 0.25)% vs. 3.40 (0.46, 5.78)%, 0.01 (< 0.01, 0.29)% vs. 2.26 (0.84, 4. …

Application of IgA-Seq in schizophrenia to identify key gut bacteria that promote abnormal behavior in mice.

Schizophrenia (SCZ) has a complex etiology, and growing evidence implicates the microbiota-gut-brain axis. Because abundance-based profiling … occus, Pseudomonas, and Parabacteroides, whereas IgA- candidates included Collinsella, Eggerthella, Bifidobacterium, Bacteroides, Enterococcus, and Clostridium. In experiment 1, the GF IgA+ and GF IgA- groups differed in open-field center-zone time (P = 0.032). Marble-burying behavior showed a significant overall difference among the five groups (P = 0.040), with …

Natural products targeting the gut-brain axis for the treatment of post-cardiac procedures anxiety or depression.

BACKGROUND: Post-cardiac surgery anxiety or depression (PCPAD) is a common neuropsychiatric complication following cardiovascular interventi … ultiple targets. Specifically, they include increasing the abundance of beneficial bacteria such as Bifidobacterium and Lactobacillus, promoting the production of anti-inflammatory metabolites such as short-chain fatty acids, repairing intestinal barrier function, inhibiting pro-inflammatory pathways such as NF-κB and NLRP3 inflammasome, and regulating the levels …

Gut Microbiota Dysbiosis and Dietary Interventions in Non-Hodgkin B-Cell Lymphomas: Implications for Treatment Response.

Non-Hodgkin B-cell lymphomas are a heterogeneous group of lymphoid malignancies with variable biological behavior, clinical presentation and treatment response. While chemoimmunotherapy remains the cornerstone of their management, growing evidence implicates the gut microbiota as a critical modulator of both lymphomagenesis and therapeutic efficacy. Gut microbiota dysbiosis, characterized by reduced microbial diversity and pathogenic taxonomic shifts, has been observed also in newly diagnosed patients and not just after therapy. This microbial imbalance contributes to mucosal barrier disruptio

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… Multiple studies have documented a decline in beneficial microbial populations—including Bifidobacterium spp., Lactobacillus , and Faecalibacterium prausnitzii —during and after chemoimmunotherapy. … Additionally, there was an increase in Enterococcus , Lactobacillus , and Actinomyces , while Bifidobacterium and Lachnospira levels declined. …