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Burden, Outcome, and Comorbidities of Extrahepatic Manifestations in Hepatitis B Virus Infections.

Hepatitis B virus (HBV) infections affect approximately 296 million people around the world, and the prevalence of any past or present HBV infection during the years 2015-2018 was as high as 4.3%. Acute HBV infection often presents with nonspecific symptoms and is usually self-limited, but 5% of patients can have persistent infections leading to chronic HBV infection and the risk of turning into chronic HBV infection is significantly higher in babies with vertical transmission (95%). Patients with chronic HBV infection are usually asymptomatic, but 15 to 40% of chronic HBV carriers develop cir

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… Clinical manifestations vary widely and include spontaneous mucosal or cutaneous bleeding due to thrombocytopenia, an increased risk of bacterial or fungal infection due to neutropenia, fatigue, and pallor due to anemia with a low reticulocyte count. …

Plasma Cell Disorders

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… If pallor is present, has any anemia been characterized? If bleeding has been reported, has coagulation been assessed? Could bone pain be a possibility in the patient, with or without imaging evidence of bone lesions? …

Thrombosis in Neuromuscular Medicine: Current Evidence, Unmet Needs, and Future Directions.

Venous thromboembolism (VTE), comprising deep vein thrombosis and pulmonary embolism, is an important but under-recognised complication in neuromuscular diseases. In adults, emerging epidemiological data suggests increased VTE occurrence in conditions such as Amyotrophic Lateral Sclerosis, myotonic dystrophy, myasthenia gravis, inflammatory neuropathies, inflammatory myopathies, and POEMS syndrome. This heightened risk reflects not only disease-related immobility but also disorder-specific biological mechanisms, including inflammation, endothelial dysfunction and cardiomyopathy-related stasis.

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… Clinical features result from the MAHA and thrombocytopenia, causing pallor, jaundice, fatigue, petechiae and bruising. End organ ischaemia ranging from acute kidney injury to neurological complications like strokes and seizures occurs due to endothelial damage and vascular occlusion [ 95 ]. …

Advances in CAR-T-cell therapy in T-cell malignancies.

Significant advances have been made in chimeric antigen receptor T (CAR-T)-cell therapy for the treatment of recurrent or refractory B-cell hematologic malignancies. However, CAR-T-cell therapy has not yet achieved comparable success in the management of aggressive T-cell malignancies. This article reviews the challenges of CAR-T-cell therapy in treating T-cell malignancies and summarizes the progress of preclinical and clinical studies in this area. We present an analysis of clinical trials of CAR-T-cell therapies for the treatment of T-cell malignancies grouped by target antigen classificati

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… Clinically, this toxicity manifests as increased infection risks due to leukopenia, fatigue and pallor from anemia, and increased bleeding risks due to thrombocytopenia. …

TB AND OTHER CHEST INFECTIONS

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Hematopoietic Tumors

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… Inspection of mucous membranes for pallor, icterus, petechiae, and ulceration should be undertaken as these signs may indicate anemia or thrombocytopenia secondary to myelophthisis or immune-mediated disease or may be evidence of major organ failure or uremia. …

Decoding iron deficiency in cancer: mechanisms, immune modulation, and therapeutic potential.

Iron is a vital micronutrient in many biological functions, including DNA metabolism, oxygen transport, and cellular energy generation. In this context, it is intimately linked to cancer biology. However, although many studies have comprehensively investigated and reviewed the effects of excess iron on tumor initiation and progression, the potential interrelations of iron deficiency with tumors have been largely neglected and need to be better defined. Recent studies have highlighted the complex relationship between iron deficiency and tumor biology. Iron deficiency in specific tumor types can

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… Typical symptoms of ID include pallor, cold skin, fatigue, restless leg syndrome, reduced physical performance, brittle nails, dry lips, cognitive impairment, headaches, insomnia, depression, decreased libido, shortness of breath, tachycardia, thrombocytosis, increased risk of thromboembolic complications …

A Novel Approach to Prognostic Factors and Risk Stratification in Pediatric AML: Case Report and Literature Review.

Acute myeloid leukemia (AML), the second most common type of leukemia in children, is a heterogeneous disease known to be caused by genetic, epigenetic, and transcriptional changes, predominantly somatic and germline abnormalities. Despite significant improvement of overall survival rates, the prognosis of pediatric AML remains unfavorable in comparison with acute lymphoblastic leukemia (ALL), especially in relapsed or refractory settings. The current status and future directions are focused on establishing an accurate diagnosis and treatment strategies based on the genomic background. Next-ge

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… Results at Admission On admission, the patient was in semi-good clinical condition, visibly apathic, with skin pallor and minor petechiae present on lower limbs and lower border of the liver palpable over 3 cm below the costal margin. …

Hypoxia-driven angiogenesis and metabolic reprogramming in vascular tumors.

Hypoxia is a hallmark of the tumor microenvironment (TME), and it plays a crucial role in the occurrence and progression in vascular tumors. Under hypoxic conditions, hypoxia-inducible factor 1-alpha (HIF-1α) is stabilized, inducing changes in the expression of various target genes involved in angiogenesis, metabolism, and cell survival. This includes the upregulation of pro-angiogenic factors like VEGF, which promotes the formation of dysfunctional blood vessels, contributing to the worsening of the hypoxic microenvironment. At the same time, hypoxia induces a metabolic shift toward glycolysi

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… Prior to the development of IH lesions, infants often present with early skin changes, such as pallor, blanching, ecchymosis, or capillary dilation ( Drolet and Frieden, 2010 ). …

Galectins in the Pathogenesis of Common Retinal Disease.

Diseases of the retina are major causes of visual impairment and blindness in developed countries and, due to an ageing population, their prevalence is continually rising. The lack of effective therapies and the limitations of those currently in use highlight the importance of continued research into the pathogenesis of these diseases. Vascular endothelial growth factor (VEGF) plays a major role in driving vascular dysfunction in retinal disease and has therefore become a key therapeutic target. Recent evidence also points to a potentially similarly important role of galectins, a family of β-g

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… some forms AMD; Gal-8, -12 downregulated in neuroretina of pre-AMD patients, and Gal-3 upregulated in most forms of AMD Newman et al. (2012) Gal-3 upregulated in choroid samples from advanced dry AMD Yuan et al. (2010) Inherited retinal diseases | Retinitis Pigmentosa (RP) | Signs include optic nerve pallor …

Immune-Mediated Dermatoses in Patients with Haematological Malignancies: A Comprehensive Review.

Haematological malignancies induce important alterations of the immune system, which account for the high frequency of autoimmune complications observed in patients. Cutaneous immune-mediated diseases associated with haematological malignancies encompass a heterogeneous group of dermatoses, including, among others, neutrophilic and eosinophilic dermatoses, autoantibody-mediated skin diseases, vasculitis and granulomatous dermatoses. Some of these diseases, such as paraneoplastic pemphigus, are associated with an increased risk of death; others, such as eosinophilic dermatoses of haematological

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… Non-specific manifestations include: (i) dermatological changes secondary to bone marrow failure, e.g. pallor and ecchymosis; (ii) skin infections; (iii) adverse reactions to anti-neoplastic drugs; and (iv) immune-mediated diseases [ 4 , 5 ]. …

Воспаление и воспаление болезней, маркеры и посредники: роль КПИ в некоторых воспламенительных заболеваниях

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… General examination Patient conscious, restless, and sometimes disoriented | Patient conscious, alert, and cooperative | Patient conscious, alert, and cooperative GCS | 13/15 | 15/15 | 15/15 Pulse/min | 124 | 96 | 104 Temperature ( o F) | 101.4 | 98.1 | 101.4 Pallor | Mild | Positive | Nil BP (mm of …

Neurology

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… B, Cytoplasmic pallor of choroid plexus epithelium due to accumulation of storage material. (Reprinted with permission from DeLahunta A: Degenerative diseases of the central nervous system. In Summers BA, Cummings JF, DeLahunta A, editors: Veterinary neuropathology, St Louis, 1995, Mosby.) …

POSTER PRESENTATIONS

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Биология и болезни крыс

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Inpatient Medicine

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Poster Abstracts

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… On examination, she had hepatosplenomegaly, pallor, and red-colored urine, suggestive of hemolysis. A Direct Coombs Test (DCT) was ordered on 20.02.25. Laboratory findings revealed: Hemoglobin: 7.2 g/dL Hematocrit: 17.8% Platelet count: 30,000/μL. … Clinical findings included pallor, hemoglobinuria, thrombocytopenia, and hepatosplenomegaly. Transfusion was guided by clinical symptoms rather than strict hemoglobin thresholds, using least incompatible PRBCs. …

Abstracts - IANCON 2024

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ИАНКОН 2023 Выдержки из плаката

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C

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