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Acute kidney injury: pathogenesis and therapeutic interventions.

Acute kidney injury (AKI) is a prevalent clinical condition that is associated with unacceptably high morbidity and mortality, as well as the development of chronic kidney disease (CKD). The pathogenesis of AKI is highly complex and heterogeneous, primarily attributed to metabolic disturbances arising from the disease itself and the administration of medications related to treatment. In recent years, AKI in cancer patients is highly concerned. The emergence of AKI caused injuries and dysfunction of remote organs but also enhanced the health-care costs. It's essential for early recognition of A

The evolving roles of Wnt signaling in stem cell proliferation and differentiation, the development of human diseases, and therapeutic opportunities.

The evolutionarily conserved Wnt signaling pathway plays a central role in development and adult tissue homeostasis across species. Wnt proteins are secreted, lipid-modified signaling molecules that activate the canonical (β-catenin dependent) and non-canonical (β-catenin independent) Wnt signaling pathways. Cellular behaviors such as proliferation, differentiation, maturation, and proper body-axis specification are carried out by the canonical pathway, which is the best characterized of the known Wnt signaling paths. Wnt signaling has emerged as an important factor in stem cell biology and is

Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise.

Aging is typified by a gradual loss of physiological fitness and accumulation of cellular damage, leading to deteriorated functions and enhanced vulnerability to diseases. Antiaging research has a long history throughout civilization, with many efforts put forth to understand and prevent the effects of aging. Multiple strategies aiming to promote healthy aging and extend the lifespan have been developed including lifestyle adjustments, medical treatments, and social programs. A multitude of antiaging medicines and remedies have also been explored. Here, we use data from the CAS Content Collect

Musculoskeletal Organs-on-Chips: An Emerging Platform for Studying the Nanotechnology-Biology Interface.

Nanotechnology-based approaches are promising for the treatment of musculoskeletal (MSK) disorders, which present significant clinical burdens and challenges, but their clinical translation requires a deep understanding of the complex interplay between nanotechnology and MSK biology. Organ-on-a-chip (OoC) systems have emerged as an innovative and versatile microphysiological platform to replicate the dynamics of tissue microenvironment for studying nanotechnology-biology interactions. This review first covers recent advances and applications of MSK OoCs and their ability to mimic the biophysic

15th Конгресс Европейской ассоциации клинической фармакологии и терапии (ЕАКПТ)

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Реальное воздействие NVX-CoV2373 COVID-19 вакцина для иммунокомпромиссных людей в Южной Корее.

BackgroundNVX-CoV2373 - наночастица, белковая COVID-19 вакцина. Лица, страдающие от иммунокомпрометированных заболеваний, подвергаются высокому риску инфицирования и серьезных заболеваний; однако в реальном мире NVX-CoV2373 Цель настоящего исследования состояла в том, чтобы оценить, являются ли данные о воздействии в МКС ограниченными. NVX-CoV2373 снижение риска SARS-CoV-2 :: инфекция и серьезные заболевания в ИМС по сравнению с лицами, не имеющими иммунокомпромиссных свойств (не связанными с ИС). Южнокорейский МКС в возрасте ≥12 лет, которые получили первичную серию, третью дозу или четвертую

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… Baud D, Qi X, Nielsen-Saines K, Musso D, Pomar L, Favre G. Real estimates of mortality following COVID-19 infection. Lancet Infect Dis. 2020;20(7):773. 25. Bytyci J, Ying Y, Lee LYW. …

Association between platelet-white cell ratio and all-cause mortality in critically ill patients with atrial fibrillation: a retrospective cohort study.

BACKGROUND: Atrial fibrillation is common in intensive care units and portends poor prognosis. The platelet-to-white blood cell ratio is an emerging inflammatory-coagulatory biomarker with prognostic value in cardiovascular diseases. This study examines the association between platelet-white cell ratio (PWR) and all-cause mortality in this high-risk population. METHODS: In this retrospective cohort study, clinical data were obtained from the MIMIC-IV database. We included adult intensive care unit (ICU) patients with a diagnosis of atrial fibrillation. The PWR was evaluated as the primary expo

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… Qi X, Yu Y, Sun R, Huang J, Liu L, Yang Y, et al. Identification and characterization of neutrophil heterogeneity in sepsis. Crit Care. 2021;25:50. 10.1186/s13054-021-03481-0. 33. Habibzadeh F. Statistical data editing in scientific articles. …

Elranatamab: Роман B-клеточного созревания T-клеточного агента.

B-клеточное антигенное созревание (BCMA) — высоко выраженный трансмембранный рецептор на злокачественных плазменных клетках, который помогает выжить клеткам. Эти характеристики делают его привлекательной целью для новых клеточных и иммунотерапий. Elranatamab () — антитело, направленное против BCMA на плазменные клетки и CD3 на Т клетки. Это приводит к активации иммунных клеток и высвобождению гранзимов и перфоринов, что сопровождается убийством целевых клеток. Чрезмерная активация иммунной системы может привести к возникновению синдрома цитокина (CRS) и синдрома нейротоксичности иммунных клето

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… Shi M, Wang J, Huang H, Liu D, Cheng H, Wang X, Chen W, Yan Z, Sang W, Qi K, et al. Bispecific CAR T cell therapy targeting BCMA and CD19 in relapsed/refractory multiple myeloma: a phase I/II trial. Nat Commun. 2024;15(1):3371. doi: 10.1038/s41467-024-47801-8. 23. …

Immunization Strategies in Pediatric Patients Receiving Hematopoietic Cell Transplantation (HCT) and Chimeric Antigen Receptor T-Cell (CAR-T) Therapy: Challenges and Insights from a Narrative Review.

BackgroundHematopoietic cell transplantation (HCT) and chimeric antigen receptor T-cell (CAR-T) therapy have markedly improved survival in pediatric patients with hematological malignancies. However, these treatments cause profound immunosuppression, leading to significant susceptibility to vaccine-preventable diseases (VPDs), including invasive pneumococcal disease and measles. Timely and tailored immunization strategies are crucial to mitigate infectious risks in this vulnerable population.MethodsWe conducted a narrative review of the English-language literature from 2000 to 2024, including

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… Wang Y., Li H., Song X., Qi K., Cheng H., Cao J., Shi M., Yan Z., Jing G., Pan B., et al. Kinetics of immune reconstitution after anti-CD19 chimeric antigen receptor T cell therapy in relapsed or refractory acute lymphoblastic leukemia patients. Int. J. Lab. …

Availability, price and affordability of anticancer medicines in Jiangsu Province, China: a cross-sectional survey study.

BackgroundTo evaluate anticancer medicines' availability, price and affordability in nine prefecture-level cities, Jiangsu Province.MethodsBased on the standard methods recommended by the World Health Organization (WHO) and the Health Action International (HAI), a cross-sectional survey was performed to collect information about 24 essential anticancer medicines (EAMs) and 17 innovative anticancer medicines (IAMs) in hospitals and 45 community pharmacies in Jiangsu Province from July to November 2021.ResultsIn general, the availability of EAMs during the study period was higher than that of IA

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… Xu L, Qi Q, Zhang Y, Cui J, Liu R, Li Y. Combination of icotinib and chemotherapy as first-line treatment for advanced lung adenocarcinoma in patients with sensitive EGFR mutations: a randomized controlled study. Lung Cancer. (2019) 133:23–31. doi: 10.1016/j.lungcan.2019.05.008, 37. …

Development and validation of predictive models of early immune effector cell-associated hematotoxicity.

AbstractImmune effector cell-associated hematotoxicity (ICAHT) is associated with morbidity and mortality after chimeric antigen receptor (CAR) T-cell therapy. To date, the factors associated with ICAHT are poorly characterized, and there is no validated predictive model of ICAHT as defined by current consensus criteria. Therefore, we performed comprehensive univariate analyses to identify factors associated with severe (grade 3-4) early ICAHT (eICAHT) in 691 patients who received commercial or investigational CAR T-cell therapy for hematologic malignancies. In univariate logistic regression,

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… Wang Y, Qi K, Cheng H, et al. Coagulation disorders after chimeric antigen receptor T cell therapy: analysis of 100 patients with relapsed and refractory hematologic malignancies. Biol Blood Marrow Transplant. 2020;26(5):865–875. doi: 10.1016/j.bbmt.2019.11.027. 25. …

Personalized Lifestyle Interventions for Prevention and Treatment of Obesity-Related Cancers: A Call to Action.

The increasing global burden of cancer necessitates innovative approaches to prevention and treatment. Lifestyle factors such as diet, physical activity, and smoking significantly contribute to cancer. At the same time, current guidelines are based on a one-size-fits-all approach, which limits their effectiveness across diverse populations. Obesity is a well-documented risk factor for cancer, directly affecting 13 types of cancer. The complex interplay of genetic, metabolic, hormonal, and environmental factors in obesity's etiology highlights the need for more tailored approaches to obesity-re

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… Qi S., Kumar N., Xu J.Y., Patel J., Damaraju S., Shen-Tu G., Greiner R. Personalized Breast Cancer Onset Prediction from Lifestyle and Health History Information. PLoS ONE. 2022;17:e0279174. doi: 10.1371/journal.pone.0279174. 103. …

A Pilot Randomized Controlled Trial and Multi-Omics Analysis of Electrolysed Alkaline Water: Impacts on Gut Microbiota and Metabolic Signatures in Hyperuricemia.

Background/Objectives: Hyperuricemia (HUA) is the second most common metabolic disease in China (24.5% in males, 3.6% in females), which can induce multiple complications such as gout and diabetes. Existing urate-lowering drugs have significant hepatorenal toxicity, necessitating safe lifestyle interventions. Electrolyzed alkaline water (EAW) as daily drinking water has shown preliminary effectiveness, but it lacks randomized controlled evidence and mechanistic studies at the microbiome-metabolome interface. Methods: We conducted a 12-week randomized controlled trial in 40 adults aged 18-65 ye

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… Qi L. Chen H. Gao P. Zhang Q. Leng R. Fan Y. Li B. Pan H. Ye D. The Interaction Between Dietary Fructose and Gut Microbiota in Hyperuricemia and Gout Front. Nutr. 2022 9 890730 10.3389/fnut.2022.890730 35811965 PMC9257186 23. Caliceti C. Calabria D. Roda A. Cicero A. …

Design and implementation of mHealth applications for older people with cancer: A scoping review.

ObjectiveThis scoping review aimed to systematically synthesize the evidence on the functions, design, implementation strategies, and evaluation approaches of mobile health (mHealth) applications (apps) developed for older adults with cancer, to inform future research and practice.MethodsA scoping review was conducted using Arksey and O'Malley's methodological framework, with an updated systematic search of five databases (Medline, Web of Science, CINAHL, Embase, and the Cochrane Library) from January 1, 2008, to February 28, 2025. The review adhered to the PRISMA-ScR guidelines for scoping re

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… CRediT authorship contribution statement Qi Sun : Conceptualization, Methodology, Software, Data Curation, Writing – Original Draft, Visualization; Danyu Li : Data Curation, Writing – Review & Editing; Tingting Cai : Investigation, Writing Review & Editing; Jing Luo : Writing – Review & Editing; Qing …

A SWOT-Consensus for CAR-T in Follicular Lymphoma: Fine Tuning of Patient Journey and Selection.

Over the past 2 decades, advancements in follicular lymphoma (FL) treatment, particularly with anti-CD20 antibodies, have significantly improved patient survival. However, a subset of FL patients experiences early relapse and progression within 24 months (POD24) after first line treatment, which is a sign of poor prognosis. Current guidelines recommend various second-line treatments, but there is no consensus on an optimal treatment sequence for relapsed/refractory (r/r) FL. Moreover, despite available treatments, reduced survival after second-line therapies and diminishing responses with each

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… Wang Y., Zhou S., Qi X., et al., “Efficacy of Front‐Line Immunochemotherapy for Follicular Lymphoma: A Network Meta‐Analysis of Randomized Controlled Trials,” Blood Cancer Journal 12, no. 1 (January 2022): 1: PMID: 34987165; PMCID: PMC8728708, 10.1038/s41408-021-00598-x. 12. …

Cancer burden and risk in the Chinese population aged 55 years and above: A systematic analysis and comparison with the USA and Western Europe.

BackgroundWe analysed the cancer burden among elderly Chinese people over the age of 55 years and compared them to USA and Western Europe to explore the cancer model in China.MethodsWe retrieved data on 29 cancers with 34 risk factors from the 2019 Global Burden of Disease database to evaluate the cancer burden in Chinese elderly individuals aged 55 years and older. We then used the age-standardised incidence rate (ASIR), age-standardised death rate (ASDR), age-standardised disability-adjusted life year (DALY) rate, and average annual percentage change (AAPC) to compare the characteristics and

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… Wang W, Yin P, Liu YN, Liu JM, Wang LJ, Qi JL, et al. Mortality and years of life lost of colorectal cancer in China, 2005-2020: findings from the national mortality surveillance system. Chin Med J (Engl). 2021;134:1933–40. 10.1097/CM9.0000000000001625 30. …

Intervention and application of drawing therapy in cancer patients: a scoping review.

BACKGROUND: Cancer itself and its treatment process cause a range of physical and psychological discomforts to patients. Drawing therapy, as a form of complementary alternative medicine, has been proven to be effective in alleviating the physical and psychological discomforts of cancer patients, such as chemotherapy-associated nausea and vomiting, and negative emotions such as anxiety and depression. OBJECTIVE: This scoping review aims to organize and describe the literature on drawing therapy in cancer patients, including implementers, intervention methods, and effects. It strives to provide

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… Peng X, Chen J, Huang L, Wen Q, Yan Qi, Du L. Study on the effect of drawing therapy on breast cancer chemotherapy patients. Chin J Nurs. 2017;52(10):1200–3. 26. Zhang W. Effects of painting art therapy on nausea and vomiting, life functioning and anxiety in tumor chemotherapy patients. …

Change in Neurocognitive Function in Patients Who Receive CAR-T Cell Therapies: A Steep Hill to Climb.

Immunotherapy with chimeric antigen receptor T (CAR-T) cell therapies has brought substantial improvement in clinical outcomes in patients with relapsed/refractory B cell neoplasms. However, complications such as cytokine release syndrome (CRS) and immune effector cell-associated neurotoxicity syndrome (ICANS) limit the therapeutic efficacy of this treatment approach. ICANS can have a broad range of clinical manifestations, while various scoring systems have been developed for its grading. Cognitive decline is prevalent in CAR-T therapy recipients including impaired attention, difficulty in it

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… Zhang R., Zhou M., Qi J., Miao W., Zhang Z., Wu D., Han Y. Efficacy and Safety of Eculizumab in the Treatment of Transplant-Associated Thrombotic Microangiopathy: A Systematic Review and Meta-Analysis. Front. Immunol. 2020;11:564647. doi: 10.3389/fimmu.2020.564647. 76. Mailloux Z. …

The impact of obesity: a narrative review.

Obesity is a disease with a major negative impact on human health. However, people with obesity may not perceive their weight to be a significant problem and less than half of patients with obesity are advised by their physicians to lose weight. The purpose of this review is to highlight the importance of managing overweight and obesity by discussing the adverse consequences and impact of obesity. In summary, obesity is strongly related to >50 medical conditions, with many of them having evidence from Mendelian randomisation studies to support causality. The clinical, social and economic burde

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… 23584084 10.3390/nu5041218 PMC3705344 28 Bays HE Toth PP Kris-Etherton PM Abate N Aronne LJ Brown WV Obesity, adiposity, and dyslipidemia: A consensus statement from the National Lipid Association J Clin Lipidol 2013 7 304 83 23890517 10.1016/j.jacl.2013.04.001 29 He C Zhang M Li J Wang Y Chen L Qi …

Цифровая двойная модель для подкрепления клинического решения на основе фактических данных при многократном лечении миэломы.

За последнее десятилетие в области лечения миеломы (ММ) был достигнут значительный прогресс. Несмотря на эффективность новых веществ, реакция пациентов, как правило, остается весьма непредсказуемой. С ростом когнитивной нагрузки, создаваемой за счет сложного и меняющегося ландшафта лечения, инструменты оказания помощи, основанные на данных, становятся все более популярными. Подходы, основанные на модели, такие как цифровые близнецы (ДТ), позволяют имитировать возможные ответы на набор входных параметров, основанных на ретроспективных наблюдениях. В контексте поддержки принятия решений о лечени

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… Zhongguo Yi Liao Qi Xie Za Zhi . ( 2019 ) 43 ( 6 ): 410 – 3 . 10.3969/j.issn.1671-7104.2019.06.005 31854524 15. Walsh JR Smith AM Pouliot Y Li-Bland D Loukianov A Fisher CK . Generating digital twins with multiple sclerosis using probabilistic neural networks . …