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A Deep Dive Into the Newest Avenues of Immunotherapy for Pediatric Osteosarcoma: A Systematic Review.

Osteosarcoma (OS) is the most common primary bone cancer affecting children and young adults, most often occurring at the metaphysis of long bones. At present, treatment with combinations of surgery and chemotherapy for the localized OS has only brought minuscule improvements in prognosis. In comparison, the advanced, metastatic, or recurrent forms of OS are often non-responsive to chemotherapy, adding to the dire need to develop new and efficient therapies. The question of interest investigated in this systematic review is whether immunotherapy can play a meaningful role in improving the clin

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… Unmet medical needs and future perspectives for leiomyosarcoma patients-a position paper from the National LeioMyoSarcoma Foundation (NLMSF) and Sarcoma Patients EuroNet (SPAEN) Kasper B, Achee A, Schuster K, et al. Cancers (Basel) 2021;13:886. doi: 10.3390/cancers13040886. 37. …

Inoperable Renal Malignant Glomus Tumor, the answers for all the "W's"?

Glomus tumor, arising from glomus bodies (specialized neurovascular structures involved in thermoregulation), commonly occurs in extremities and rarely in viscera. The spectrum of glomus tumors range from benign tumors to tumors with uncertain malignant potential to tumors of the malignant subtype. A vast majority of visceral glomus tumors are benign. Most common visceral tumors arise in the gastrointestinal tract. Glomus tumors of the kidney are a rare entity of which malignant glomus tumors are exceedingly rare. The index patients in the existing case reports were middle-aged males. We repor

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… The latter include angiomyolipoma, juxtaglomerular cell tumor, hemangiomas and leiomyoma, hemangiopericytoma, leiomyosarcoma with epithelioid change, and round cell tumors, such as rhabdomyosarcoma and Ewing’s Sarcoma/Primitive Neuroectodermal tumor (PNET). …

XPO1: From basic research to clinical treatment (Review).

Exportin 1 (XPO1) is a key nuclear export receptor that mediates the nuclear export of tumor suppressor proteins and growth‑regulatory mRNAs from the nucleus to the cytoplasm. In several types of cancer, XPO1 is overexpressed or hyperactivated, leading to aberrant cytoplasmic sequestration of key tumor suppressors such as p53, p21, p73, FOXO and Rb. This mislocalization abrogates their nuclear transcriptional functions, disrupting cell cycle arrest, apoptosis and DNA repair, thereby promoting uncontrolled proliferation, survival and therapy resistance. Targeting XPO1 with selective inhibitors

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… Pui CH Rubnitz JE Phase I study of selinexor, a selective inhibitor of nuclear export, in combination with fludarabine and cytarabine, in pediatric relapsed or refractory acute leukemia J Clin Oncol 34 4094 4101 2016 10.1200/JCO.2016.67.5066 27507877 PMC5477824 123 Ricci S Stone RL Fader AN Uterine leiomyosarcoma … of uterine morcellation Gynecol Oncol 145 208 216 2017 10.1016/j.ygyno.2017.02.019 28209496 124 Zivanovic O Jacks LM Iasonos A Leitao MM Jr Soslow RA Veras E Chi DS Abu-Rustum NR Barakat RR Brennan MF Hensley ML A nomogram to predict postresection 5-year overall survival for patients with uterine leiomyosarcoma …

Amino acid metabolism in primary bone sarcomas.

Primary bone sarcomas, including osteosarcoma (OS) and Ewing sarcoma (ES), are aggressive tumors with peak incidence in childhood and adolescence. The intense standard treatment for these patients consists of combined surgery and/or radiation and maximal doses of chemotherapy; a regimen that has not seen improvement in decades. Like other tumor types, ES and OS are characterized by dysregulated cellular metabolism and a rewiring of metabolic pathways to support the biosynthetic demands of malignant growth. Not only are cancer cells characterized by Warburg metabolism, or aerobic glycolysis, bu

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… Targeting these compensatory pathways with addition of a GLS inhibitor or PHGDH inhibitor has been found to result in synthetic lethality in several models, including leiomyosarcoma ( 126 ). … Early work in 2011 used liquid chromatography-tandem mass spectrometry (LC-MS/MS) in formalin-fixed and paraffin-embedded (FFPE) patient tissue from soft tissue sarcomas, including leiomyosarcoma, liposarcoma, and synovial sarcoma, and showed that 8 metabolites exhibited differential abundances between …

Don't eat me/eat me signals as a novel strategy in cancer immunotherapy.

Cancer stands as one of the prominent global causes of death, with its incidence burden continuously increasing, leading to a substantial rise in mortality rates. Cancer treatment has seen the development of various strategies, each carrying its drawbacks that can negatively impact the quality of life for cancer patients. The challenge remains significant within the medical field to establish a definitive cancer treatment that minimizes complications and limitations. In the forthcoming years, exploring new strategies to surmount the failures in cancer treatment appears to be an unavoidable pur

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… Numerous studies have demonstrated CD47's overexpression in various tumor types, including myeloma, leiomyosarcoma, acute lymphocytic leukemia, non-lymphoma, Hodgkin's breast cancer, osteosarcoma, and head and neck squamous cell carcinoma [ 75 ]. … Antibody therapy targeting the CD47 protein is effective in a model of aggressive metastatic leiomyosarcoma. Proc Natl Acad Sci U S A. 2012;109(17):6656–6661. doi: 10.1073/pnas.1121629109. 47. Xu J.F., et al. CD47 blockade inhibits tumor progression human osteosarcoma in xenograft models. …

Image-Guided Percutaneous Ablation for Primary and Metastatic Tumors.

Image-guided percutaneous ablation methods have been further developed during the recent two decades and have transformed the minimally invasive and precision features of treatment options targeting primary and metastatic tumors. They work by percutaneously introducing applicators to precisely destroy a tumor and offer much lower risks than conventional methods. There are usually shorter recovery periods, less bleeding, and more preservation of organ parenchyma, expanding the treatment options of patients with cancer who may not be eligible for resection. Image-guided ablation techniques are c

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… A case of a patient receiving MWA for a hepatic metastatic leiomyosarcoma in segment V is presented in Figure 8 . Table 2 Comparison of ablation modalities for hepatocellular carcinoma. … RFA | HCC and liver metastasis | N/A | LTP: RR = 0.70; p = 0.02 | NSD in 1-, 3-, and 5-year OS | NSD in 1-, 3-, and 5-year DFS | RR = 1.05; p = 0.75 | N/A Figure 8 Microwave ablation of hepatic metastatic leiomyosarcoma . …

PD-1 Inhibitors in Elderly and Immunocompromised Patients with Advanced or Metastatic Cutaneous Squamous Cell Carcinoma.

Cutaneous squamous cell carcinoma (cSCC) of the skin is the second most common form of skin cancer, with aging and prolonged exposure to ultraviolet rays being the main causes of the disease. Cemiplimab and pembrolizumab recently gained regulatory approval for the treatment of locally advanced and metastatic cSCC-conditions that are not treatable by surgical resection and/or radiotherapy. Although the results from the clinical trials have been promising, these studies have not included immunosuppressed, elderly patients. In this study, we included all immunocompromised and immunocompetent pati

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… Prognostic role of plasma fibrinogen in patients with uterine leiomyosarcoma—A multicenter study Sci. Rep. 2017 7 14474 10.1038/s41598-017-13934-8 29101329 PMC5670177 32. Templeton A.J. Mcnamara M.G. Šeruga B. Vera-Badillo F.E. Aneja P. Ocaña A. Leibowitz-Amit R. Sonpavde G. Knox J.J. Tran B. …

Framework for integrating electronic patient-reported data in routine cancer care: an Oncology Intake Questionnaire.

ObjectiveAs part of ongoing implementation of electronic patient-reported outcome tools at the Dana-Farber Cancer Institute, here we describe the development of the electronic New Patient Intake Questionnaire.Materials and methodsThe original New Patient Intake Questionnaire includes a review of symptoms, oncology history, family history, health behaviors, health and social status, health literacy and numeracy, which was modified for integration into the EHR using content determination, build and configuration, implementation, analytics, and interventions. The engagement of key stakeholders, i

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… | Leiomyosarcoma | GIST/Stromal Other soft tissue sarcoma Ewing’s sarcoma | Other bone sarcoma Other sarcoma | I don’t know [Branched] What type of skin cancer? …

Recursive Partitioning Analysis for Local Control Achieved With Stereotactic Body Radiation Therapy for the Liver, Spine, or Lymph Nodes.

PurposeThis study aims to develop a local control risk stratification using recursive partitioning analysis (RPA) for patients receiving stereotactic body radiation therapy (SBRT) for metastatic cancer.Methods and materialsA single institutional database of 397 SBRT treatments to the liver, spine, and lymph nodes was constructed. All treatments required imaging follow-up to assess for local control. Cox proportional hazards analysis was implemented before the decision tree analysis. The data were split into training (70%), validation (10%), and testing (20%) sets for RPA to optimize the traini

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… . ∗ The “other” primary tumors included: gastric, leiomyosarcoma, urothelial, pancreatic, and others. …

Tabelecleucel in Post-transplant Epstein-Barr Virus-Associated Lymphoproliferative Disease: Patient and Oncologist Perspectives.

This article is coauthored by the parents of a young patient and the medical team who cared for her.Together, they recount their shared experience with tabelecleucel, a novel therapy for Epstein-Barr virus-associated post-transplant lymphoproliferative disease (EBV + PTLD). The patient's parents offer a deeply personal perspective, reflecting on several years of struggle marked by unwavering hope and trust in the medical professionals who have supported their daughter throughout her journey. The pediatric hemato-oncologist who advocated for the use of tabelecleucel described the case as unique

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… In conclusion, while tabelecleucel is currently approved for EBV + PTLD, its therapeutic framework may serve as a foundation for future immunotherapies targeting EBV-mediated cancers, such as nasopharyngeal cancer, gastric carcinoma, and leiomyosarcoma. …

Salvage of limb salvage in oncological reconstructions of the lower limb with megaprosthesis: how much to push the boundaries?

IntroductionMegaprosthesis represent the most commonly used limb salvage method after musculoskeletal tumor resections. Nevertheless, they are burdened by high complication rate, requiring several surgical revisions and eventually limb amputation. The aims of this study were to evaluate the effect of rescuing the limb with subsequent revisions on complication rates (a), incidence of amputations (b), and whether complications reduce functional outcome after the first surgical revision (c).Materials and methodsWe retrospectively reviewed 444 lower limb megaprosthesis implanted for primary muscul

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… The oncological diagnoses were as follow: osteosarcoma in 23 cases, ten metastatic diseases, nine chondrosarcomas, five Ewing sarcomas, four soft tissue sarcomas, three leiomyosarcomas, two giant-cell tumors of the bone, a giant-cell tumor of the tendon sheaths, a single multiple myeloma, and a Gorham …

Keyword Index for Volume 88

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… injury 760 isolated hepatic perfusion 314 Jak-STAT1 signalling 1995 Japanese 1038 Jurkat 455 Kaposi's sarcoma 1 kidney 327 kidney cancer 84 KOC 699 KRAB 137 kringles 1–5 1492 KSHV/HHV-8 1 Ku80 202 L1210 613 lactacystin 120 LAR 1223 large bowel cancer 84 lauryl gallate 940 LDB1 1543 leiomyosarcoma …

The Proceedings of the 19th International Cancer Imaging Society Meeting and Annual Teaching Course : Verona, Italy. 7 - 9 October 2019.

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… Leiomyosarcomas: Retroperitoneal leiomyosarcomas may arise in the retroperitoneum and inferior vena cava (IVC) [Refs.1,2]. Lymphoma: Non Hodgkin lymphoma involves extra-nodal and nodal sites, and tend to be hypovascular and usually demonstrate homogeneous enhancement. … Central non-enhancement on MRI should raise the suspicion of leiomyosarcoma (LMS) or smooth muscle tumour with uncertain malignant potential (STUMP) against benign fibroids [1]. …

Proceedings of the International Cancer Imaging Society (ICIS) 17th Annual Teaching Course : Berlin, Germany. 02 - 04 October 2017

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RNA N 6-Methyladenosine in Cancer Metastasis: Roles, Mechanisms, and Applications.

Cancer metastasis is a symptom of adverse prognosis, a prime origin of therapy failure, and a lethal challenge for cancer patients. N 6-methyladenosine (m6A), the most prevailing modification in messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs) of higher eukaryotes, has attracted increasing attention. Growing studies have verified the pivotal roles of m6A methylation in controlling mRNAs and ncRNAs in diverse physiological processes. Remarkably, recent findings have showed that aberrant methylation of m6A-related RNAs could influence cancer metastasis. In this review, we illuminate how m6A m

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… Glycolysis has been widely validated to influence tumor progression and metastasis in HCC ( 81 ), BC ( 100 ), Oral squamous cell carcinoma (OSCC) ( 101 ) and leiomyosarcoma ( 102 ). Lin et al. validated that highly metastatic HCC cell lines display elevated glycolytic capacity ( 81 ). … Melatonin Suppression of Aerobic Glycolysis (Warburg Effect), Survival Signalling and Metastasis in Human Leiomyosarcoma . J Pineal Res ( 2016 ) 60 ( 2 ): 167–77 . 10.1111/jpi.12298 26607298 103 Chang YC Chi LH Chang WM Su CY Lin YF Chen CL . …

Validation of nine prognostic models in patients with bone metastases undergoing surgery.

BACKGROUND: We aimed to 1) assess the prognostic performance of established prediction models for mortality in patients with spine and extremity bone metastases, 2) evaluate their performance in clinically relevant subgroups, and 3) study the importance of relevant patient characteristics for mortality prediction. METHODS: Between 29th May, 2000 and 21st April, 2022, a total of 526 patients (median age 67.0 years, interquartile range [IQR] 58.1 - 74.0 years], 271 males; median follow-up 267 days [IQR 86 - 856 days]) undergoing surgery for spine or extremity bone metastases were retrospectivel

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… | 0 Myeloic sarcoma | 1 | 1 | 0 Neuroblastoma | 1 | 1 | 0 Neuroendocrine cancer | 1 | 0 | 1 Ovarian cancer | 1 | 1 | 0 Pancreas/pancreaticobilliariy cancer | 6 | 4 | 2 Penile cancer | 1 | 1 | 0 Phaeochromocytoma | 1 | 1 | 0 Seminoma | 1 | 1 | 0 Thymoma | 1 | 0 | 1 Uterine cancer | 4 | 0 | 4 Uterine leiomyosarcoma …

Preoperative embolization in surgical treatment of long bone metastasis: a systematic literature review.

Surgery of long bone metastases is associated with a significant risk of perioperative blood loss, which may necessitate blood transfusion.Successful embolization (> 70% obliteration of vascularity) can be achieved in 36-75% of cases.The reported rate of embolization-related complications is 0-9%.Three out of six level III evidence studies showed a reduction in perioperative blood loss and/or blood transfusion requirement after preoperative embolization of renal cell carcinoma metastasis in long bones; three out of six studies did not.One level III evidence study did not show a reduction in pe

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… carcinoma | Femoral/acetabular region (17) Humerus (9) Pubic ramus (1) Scapula (1) | 26 | 28 * | Complete devascularization vs incomplete devascularization | Blood loss Transfusion requirements | 3 | 11 Kickuth et al, 2008 30 | Case-cohort | Multiple: renal cell carcinoma (18), malignant melanoma (1), leiomyosarcoma …

Reprogramming of nitrogen metabolism in tumors: mechanisms and therapeutic implications.

Nitrogen metabolism plays a key role in maintaining normal physiological functions of the organism and cell proliferation and differentiation. Nitrogen metabolism in normal human body maintains a dynamic balance to meet the body's demand for synthesis of biological macromolecules such as proteins and nucleic acids. However, in the process of tumor development, the nitrogen metabolism of tumor cells is reprogrammed to meet the demand of rapid proliferation, showing significantly different metabolic characteristics from normal cells. Key enzymes in the tumor microenvironment affect nitrogen meta

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… Furthermore, excessive activation of the PI3K/mTOR pathway correlates with lymphocyte depletion and a wound-healing-like immune microenvironment in uterine leiomyosarcoma, thereby facilitating tumour immune evasion(De Wispelaere et al. 2024 ). … Delfini M, Berardi E, Van Brussel T, Schepers R, Philips G, Boeckx B, Baietti MF, Congedo L, HoWangYin KY, Bayon E, Van Rompuy AS, Leucci E, Tabruyn SP, Bosisio F, Mazzone M, Lambrechts D, Amant F (2024) Pi3k/mtor inhibition induces tumour microenvironment remodelling and sensitises ps6(high) uterine leiomyosarcoma …

Review of oncological emergencies in small animal patients.

Oncological emergencies can occur at any time during the course of a malignancy and need to be recognized promptly to maximize successful outcomes. Emergencies are characterized as chemotherapy-induced, paraneoplastic syndromes, or directly related to the neoplasm. Prompt identification with treatment of these emergencies can prolong survival and improve quality of life, even in the setting of terminal illness. This review aims to educate the reader on the pathophysiology, clinical presentation and treatment of some of these emergencies, and to review the current veterinary literature to help

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… Hypoglycaemia Insulinoma is the most common malignancy associated with hypoglycaemia (HG); however, it has been reported with non‐islet cell tumours including hepatocellular carcinoma, hepatoma, LSA, leiomyosarcoma, adenocarcinoma and haemangiosarcoma among others (Patnaik et al . 1981; Cohen et al … Clinical Orthopaedics and Related Research 415 , 279 – 288 . 10.1097/01.blo.0000093059.96273.56 14600620 Cohen M. , Post G.S. & Wright J.C. ( 2003 ) Gastrointestinal leiomyosarcoma in 14 dogs . …

Устные бесплатные бумажные сессии.

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